Reaction

Cardioactive Drug Level Increased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,311 reports · 39 co-occurring drugs

As of the last recalculation, Cardioactive Drug Level Increased appears in 1,311 FAERS reports alongside 39 co-occurring drug terms. The strongest observed disproportionality signal is DIGOXIN (PRR 982.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Digoxin	1,013	982.6	996.8
Posaconazole Delayed-Release	22	32.3	32.4
Metolazone	22	31.6	31.6
Posaconazole	30	30.0	30.0
Enalapril Maleate	42	27.8	27.8
Spironolactone	190	24.9	25.0
Warfarin Sodium	69	24.9	24.9
Furosemide	430	24.9	24.9
Atropine	12	23.2	23.2
Clarithromycin	48	23.0	23.0
Eplerenone	17	21.3	21.4
Diltiazem Hydrochloride	44	20.9	20.9
Carvedilol	154	20.4	20.4
Captopril	12	20.0	20.0
Atropine Sulfate	12	17.8	17.8
Potassium Chloride, Dextrose Monohydrate	92	16.9	16.9
Potassium Chloride Oral	92	16.9	16.9
Potassium Chloride Extended-Release	92	16.9	16.9
Quinine	9	16.8	16.8
Warfarin	121	16.6	16.6
Bumetanide	27	16.6	16.6
Potassium Chloride	109	16.5	16.5
Sotalol Hydrochloride	17	16.4	16.4
Amiodarone Hydrochloride	11	15.7	15.7
Nitroglycerin	51	15.7	15.7
Enalapril	48	14.2	14.2
Human Insulin	11	14.1	14.1
Isosorbide Dinitrate	16	13.2	13.2
Bisoprolol Fumarate	92	11.5	11.5
Dronedarone	7	10.9	11.0
Allopurinol	99	10.8	10.8
Isosorbide Mononitrate	13	10.0	10.0
Bimatoprost	18	10.0	10.0
Metformin Hcl	27	7.9	7.9
Rivastigmine	9	7.6	7.6
Miconazole Nitrate	4	7.3	7.3
Vemurafenib	4	5.3	5.3
Ledipasvir And Sofosbuvir	5	4.1	4.1
Enzalutamide	14	3.8	3.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.