Missouri school vaccine requirements, exemptions & schedule
United States · MO
Last updated: 2026-11-01
💉 Vaccination Schedule
2 months
4 months
6 months
May be given at 6–18 months
(opens in a new tab) 💉 Hib Dose 3Depending on product
(opens in a new tab) 💉 PCV (Pneumococcal) Dose 3 (opens in a new tab) 💉 Rotavirus Dose 3Depending on product
(opens in a new tab) 💉 Hepatitis B Dose 36–18 months
(opens in a new tab) 💉 Influenza AnnualFrom 6 months annually
(opens in a new tab) 💉 COVID-19 Per current guidanceFrom 6 months
(opens in a new tab)12–15 months
15–18 months
4–6 years
11–12 years
🏫 School & Institutional Requirements
▶ 🏫 Public Schools (K–12)
Missouri Revised Statutes §167.181 and 19 CSR 20-28 require DTaP (5 doses), Polio (4 doses), MMR (2 doses), Hepatitis B (3 doses), Varicella (2 doses or proof of disease), and Tdap (grade 8). Meningococcal (MenACWY) required for grades 8 and 12.
▶ 🏛 Private Schools
Missouri's immunization requirements apply to all public, private, and parochial schools. Non-accredited private schools (homeschool) are exempt.
▶ 👶 Daycare / Child Care
Licensed child-care facilities require DTaP, Polio, Hib, PCV, MMR, Varicella, Hepatitis B, and Hepatitis A (age-appropriate) per Missouri Department of Health and Senior Services regulations.
▶ 🎓 Postsecondary / University
Missouri public universities require MMR (2 doses). The University of Missouri system requires meningococcal vaccination for students in campus housing (RSMo §174.335 — Missouri's meningitis education law).
▶ 🏥 Healthcare Workers
Missouri follows CDC guidelines. Hepatitis B per OSHA standard. Influenza vaccination recommended. No state-level healthcare worker vaccine mandate.
📊 Required Vaccines by Setting
| DTaP / Tdap | ✓ | ✓ | — | View → (opens in a new tab) |
| Hepatitis A | — | ✓ | — | View → (opens in a new tab) |
| Hepatitis B | ✓ | ✓ | — | View → (opens in a new tab) |
| Hib | — | ✓ | — | View → (opens in a new tab) |
| Influenza | — | — | — | View → (opens in a new tab) |
| Meningococcal | ✓ | — | ✓ | View → (opens in a new tab) |
| MMR | ✓ | ✓ | ✓ | View → (opens in a new tab) |
| PCV (Pneumococcal) | — | ✓ | — | View → (opens in a new tab) |
| Polio (IPV) | ✓ | ✓ | — | View → (opens in a new tab) |
| Varicella | ✓ | ✓ | — | View → (opens in a new tab) |
📝 Vaccine Exemptions
🏥 Medical
AvailableFor medical contraindications
Documentation: Submit Missouri DHSS form Imm.P.12 signed by a licensed physician (MD/DO) to the school. Sources differ on whether other clinicians may sign, so a licensed physician's signature is the safest choice. Confirm with the school or the Missouri Department of Health and Senior Services before using another clinician.
Renewal: Based on physician's recommendation.
Approving authority: Licensed physician (MD or DO); confirm before using another clinician
🔗 Medical Immunization Exemption (Imm.P.12) → (opens in a new tab)Link verified on 2026-11-01
🙏 Religious
AvailableFor religious beliefs
Documentation: Parent/guardian completes the exemption form and submits it to the school. Notarization not required.
Renewal: No yearly renewal for school. The signed Imm.P.11A stays on file with the school's immunization record.
Approving authority: Parent/guardian
🔗 Religious Immunization Exemption (Imm.P.11A) → (opens in a new tab)Link verified on 2026-11-01
✋ Personal Belief
Not AvailableFor philosophical or personal convictions
🏠 Homeschool Information
Requirements
Missouri does not require immunization for homeschool students. Under Missouri Revised Statutes §167.181, immunization requirements apply to students 'attending any public, private, parochial, or parish school,' and Missouri homeschool statute §167.031 separates homeschool from school attendance for immunization and other regulatory purposes.
Reporting
No immunization reporting required for homeschool students.
Exemptions
Not applicable — homeschool students are exempt. Missouri allows medical and religious exemptions for school-attending students.
Notes
Missouri courts have consistently held that homeschool programs are distinct from 'schools' for purposes of the immunization statute. The Missouri Department of Health and Senior Services homeschool FAQ confirms this exemption.
🔗 Official Government Resources
📅 Recent Legislative & Policy Changes
2026-07-01
Missouri immunization data added to Parent Decision Center.
🔬 Related Vaccine Evidence Pages
Each card links to the full VaccineDataNavigator evidence page — including clinical trials, data, pharmacovigilance, ingredients, and references.
❓ Frequently Asked Questions
▶ What vaccines are required for kindergarten and school in Missouri?
Missouri Revised Statutes §167.181 and 19 CSR 20-28 require DTaP (5 doses), Polio (4 doses), MMR (2 doses), Hepatitis B (3 doses), Varicella (2 doses or proof of disease), and Tdap (grade 8). Meningococcal (MenACWY) required for grades 8 and 12. Source: Missouri Department of Health & Senior Services.
▶ What vaccines does Missouri require for daycare and preschool?
Licensed child-care facilities require DTaP, Polio, Hib, PCV, MMR, Varicella, Hepatitis B, and Hepatitis A (age-appropriate) per Missouri Department of Health and Senior Services regulations.
▶ Does Missouri allow religious or personal-belief vaccine exemptions?
Missouri allows medical and religious exemptions; personal-belief exemptions are not available. Uses a unified parent/guardian exemption form for religious objections.
▶ How do I get a vaccine exemption in Missouri?
Medical: Submit Missouri DHSS form Imm.P.12 signed by a licensed physician (MD/DO) to the school. Sources differ on whether other clinicians may sign, so a licensed physician's signature is the safest choice. Confirm with the school or the Missouri Department of Health and Senior Services before using another clinician. Religious: Parent/guardian completes the exemption form and submits it to the school. Notarization not required. Official forms and links for every state and province are in the exemption forms directory.
▶ What vaccines are required for college in Missouri?
Missouri public universities require MMR (2 doses). The University of Missouri system requires meningococcal vaccination for students in campus housing (RSMo §174.335 — Missouri's meningitis education law).