Serotonin-1b and Serotonin-1d Receptor Agonist side effects compared: 3 drugs, 70,141 FDA adverse event reports
Members
| Drug | FAERS reports | Serious | Death outcome | Boxed warning | Top labeled signals | Unlabeled (unassessed) |
|---|---|---|---|---|---|---|
| Sumatriptan (Tosymra) | 37,870 | 50% | 899 | – | Serotonin syndrome; Medication overuse headache; Tension headache | Pharmaceutical product complaint; Arteriospasm coronary |
| Sumatriptan (Tosymra) | 25,117 | 58% | 768 | – | Medication overuse headache; Vasospasm | Colitis ischaemic; Endometriosis |
| Zolmitriptan | 7,154 | 64% | 169 | – | Angioedema; Throat tightness; Serotonin syndrome | Dysphonia; Swelling face |
Class-wide signals (flagged in at least 2 of 3 members)
| Reaction | Members flagged | Median PRR | Reports (sum) | In label |
|---|---|---|---|---|
| Migraine | 3/3 | 16.8 | 5,669 | 0/3 members' labels |
| Medication overuse headache | 2/3 | 125.0 | 261 | 2/2 members' labels |
| Iiird nerve paresis | 2/3 | 115.0 | 52 | 0/2 members' labels |
| Migraine without aura | 2/3 | 69.6 | 53 | 0/2 members' labels |
| Coronary artery dissection | 2/3 | 45.7 | 105 | 0/2 members' labels |
| Reversible cerebral vasoconstriction syndrome | 2/3 | 41.3 | 218 | 0/2 members' labels |
| Post-traumatic neck syndrome | 2/3 | 35.7 | 77 | 0/2 members' labels |
| Cluster headache | 2/3 | 35.6 | 134 | 0/2 members' labels |
| Soft tissue injury | 2/3 | 33.9 | 67 | 0/2 members' labels |
| Arteriospasm coronary | 2/3 | 23.1 | 259 | 0/2 members' labels |
| Sternal fracture | 2/3 | 20.8 | 69 | 0/2 members' labels |
| Vasospasm | 2/3 | 20.3 | 53 | 2/2 members' labels |
| Endometriosis | 2/3 | 16.4 | 214 | 0/2 members' labels |
| Migraine with aura | 2/3 | 14.1 | 112 | 0/2 members' labels |
| Pituitary tumour benign | 2/3 | 13.8 | 64 | 0/2 members' labels |
| Colitis ischaemic | 2/3 | 12.9 | 244 | 0/2 members' labels |
| Clonus | 2/3 | 12.7 | 98 | 0/2 members' labels |
| Microcephaly | 2/3 | 12.7 | 45 | 0/2 members' labels |
| Renal infarct | 2/3 | 12.5 | 51 | 0/2 members' labels |
| Binge eating | 2/3 | 12.3 | 38 | 0/2 members' labels |
| Serotonin syndrome | 2/3 | 7.2 | 305 | 2/2 members' labels |
Member-specific signals (flagged in exactly one drug)
No strong single-member signals (n ≥ 50) in this class.
Common questions
Which serotonin-1b and serotonin-1d receptor agonist has the most FDA adverse event reports?
Sumatriptan has the most FAERS co-reports in this class (37,870), followed by Sumatriptan (25,117). Report volume tracks how widely and how long a drug has been used, and how much attention it has had, far more than its risk.
Which side effects are shared across serotonin-1b and serotonin-1d receptor agonist drugs?
Reaction terms flagged in at least half of the 3 members include migraine, medication overuse headache, iiird nerve paresis, migraine without aura, coronary artery dissection. A term shared across a class usually reflects the shared mechanism (or the shared patient population) rather than one product.
Does a FAERS signal mean the drug causes the reaction?
No. These are disproportionality signals from voluntary reports with no denominator. Each is screened against the FDA label (known vs unlabeled) on the drug pages; causality needs temporality, dose-response, plausibility and trial or cohort evidence.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, seriousness and death counts from openFDA count queries. Generated 2026-10-08. Not medical advice.