Gabapentin vs Celecoxib: side effects in FDA adverse event reports
At a glance
| Gabapentin | Celecoxib | |
|---|---|---|
| Drug class | – | Nonsteroidal Anti-inflammatory Drug |
| Brand names | – | – |
| FAERS reports | 362,501 | 130,858 |
| Serious | 63% | 70% |
| Death outcome | 34,219 | 12,399 |
| Boxed warning | No | Yes RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS Cardiovascular Thrombotic Events Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased ris |
Signals both drugs share
No strong shared signal after removing coding and lab terms.
Labeled signals distinctive to Gabapentin
- Infusion site pain — n=1,220, PRR 6.0 Labeled (related wording)
- Infusion site erythema — n=754, PRR 5.7 Labeled (related wording)
- Infusion site swelling — n=569, PRR 5.8 Labeled (related wording)
- Suspected suicide — n=441, PRR 5.8 Labeled (related wording)
- Infusion site infection — n=232, PRR 6.5 Labeled (related wording)
- Accidental death — n=229, PRR 8.0 Labeled (related wording)
Labeled signals distinctive to Celecoxib
- Synovitis — n=3,119, PRR 33.4 Labeled adverse reaction
- Duodenal ulcer perforation — n=2,204, PRR 68.7 Labeled — boxed warning
- Sleep disorder due to general medical condition, insomnia type — n=1,072, PRR 31.9 Labeled (related wording)
- Peripheral venous disease — n=999, PRR 53.3 Labeled (related wording)
- Drug tolerance decreased — n=445, PRR 30.1 Labeled (related wording)
Common questions
Which has more reported side effects, Gabapentin or Celecoxib?
Gabapentin has 362,501 FAERS reports and Celecoxib 130,858. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (63% vs 70%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Gabapentin and Celecoxib share?
They share no strong flagged signal after artifacts and lab terms are removed.
Is Gabapentin or Celecoxib safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.