Reaction

Drug Tolerance Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,764 reports · 247 co-occurring drugs

As of the last recalculation, Drug Tolerance Decreased appears in 2,764 FAERS reports alongside 247 co-occurring drug terms. The strongest observed disproportionality signal is PSEUDOEPHEDRINE HYDROCHLORIDE (PRR 295.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Pseudoephedrine Hydrochloride	352	295.5	306.0
Tofacitinib Citrate	412	277.9	287.0
Pseudoephedrine Hcl	352	275.5	284.7
Cortisone Acetate	383	271.0	279.7
Desoximetasone	503	242.8	249.4
Diclofenac Potassium, Film Coated	221	214.9	220.7
Diclofenac Potassium Tablets	221	214.7	220.5
Diclofenac Potassium	221	167.3	170.8
Naproxen Sodium Tablet, Coated	238	144.7	147.3
Naproxen Sodium, Coated Tablets	238	144.7	147.3
Naproxen Sodium 220Mg	238	144.5	147.1
Sulfasalazine	916	131.4	132.9
Cetirizine Hydrochloride Allergy	397	115.1	116.6
Cetirizine Hydrochloride Tablets	397	115.1	116.6
Leflunomide	998	111.8	112.9
Diclofenac Sodium 1%	421	104.5	105.8
Diclofenac Sodium Topical	421	104.5	105.7
Diclofenac Sodium Topical Gel, 1%	421	104.3	105.5
Calcium Gluconate	155	102.6	103.9
Doxyclycline Hyclate	199	94.8	95.9
Tocilizumab	919	90.4	91.1
Hydroxychloroquine Sulfate	783	89.9	90.7
Hydrocortisone Sodium Succinate	106	88.3	89.3
Alendronate Sodium	792	82.4	83.1
Hydroxychloroquine	627	81.5	82.2
Abatacept	973	81.1	81.7
Chlorhexidine Gluconate	92	78.4	79.2
Adalimumab-Fkjp	410	78.1	78.8
Golimumab	671	77.5	78.1
Sarilumab	247	77.2	78.0
Adalimumab-Aaty	410	76.4	77.1
Adalimumab-Adaz	431	72.7	73.3
Risedronate Sodium	245	65.0	65.5
Acetaminophen And Codeine	94	60.1	60.6
Erythromycin	139	58.7	59.1
Aprepitant	136	58.3	58.7
Diclofenac	522	56.0	56.4
Certolizumab Pegol	645	53.8	54.0
Febuxostat Tablets 40 Mg	70	53.2	53.5
Febuxostat Tablets 80 Mg	70	53.2	53.5
Rituximab	972	52.9	53.1
Cetirizine	456	52.8	53.1
Fosaprepitant Dimeglumine	92	52.1	52.4
Dimenhydrinate	71	51.5	51.8
Quetiapine Fumarate	187	51.1	51.4
Infliximab	936	48.3	48.5
Tofacitinib	831	48.1	48.3
Diltiazem Hydrochloride Extended-Release Tablets	67	45.4	45.7
Hydrocortisone Acetate	378	45.2	45.4
Febuxostat	89	41.3	41.5
Ustekinumab	454	39.8	39.9
Isopropyl Alcohol	164	38.8	39.0
Anti-Itch	283	35.3	35.4
Anti-Pruritic	283	35.3	35.4
Antipruritic (Anti-Itch)	283	35.3	35.4
Cool Relief Gel With Aloe	283	35.3	35.4
Drs. Hydrocortisone	283	35.3	35.4
Hydrocortisone Continuous Spray	283	35.3	35.4
Hydrocortisone Spray	283	35.3	35.4
Anti-Itch Cream	283	35.3	35.4
Hydrocortisone Lotion	283	35.3	35.4
Hydrocortisone Cream 1%	283	35.3	35.4
Hydrocortisone Cream 1/2%	283	35.3	35.4
Hydrocortisone 1%	283	35.3	35.4
Hydrocortisone Cream	283	35.1	35.3
Diphenhydramine Hydrochloride Capsule, Liquid Filled	96	35.0	35.2
Azathioprine	355	34.7	34.8
Alcohol	165	34.0	34.1
Diclofenac Sodium	537	33.1	33.2
Pantoprazole Sodium In 0.9% Sodium Chloride	247	32.8	33.0
Pantoprazole Sodium Injection	247	32.8	33.0
Hydrocortisone	335	32.0	32.1
Naproxen	297	31.8	31.9
Cetiirizine	168	31.7	31.9
Iron Sucrose	39	31.2	31.4
Telmisartan	71	30.7	30.8
Cyanocobalamin	128	30.6	30.8
Celecoxib	445	30.1	30.2
Antacid	177	29.9	30.0
Doxycycline Hyclate	241	29.4	29.5
Doxycycline	241	29.0	29.1
Colchicine	94	27.8	27.9
Methotrexate	1,004	27.6	27.7
Oxycodone And Acetaminophen Tablets	41	26.3	26.4
Naproxen Sodium	422	26.1	26.1
Calcium Carbonate	214	25.9	26.0
Cetirizine Hydrochloride	465	25.3	25.4
Methotrexate Sodium	1,041	25.3	25.3
Secukinumab	454	25.2	25.2
Triamcinolone Acetonide Ointment Usp, 0.05%	76	25.1	25.2
Folic Acid	618	23.8	23.8
Alendronate Sodium Tablet	56	23.2	23.3
0Xygen	143	23.0	23.1
Oxygen	143	23.0	23.1
Meloxicam	163	22.4	22.5
Icosapent Ethyl	24	21.4	21.5
Pramipexole	42	20.9	21.0
Ramipril	306	20.8	20.8
Prednisone	938	20.7	20.8
Esomeprazole Magnesium Capsule, Delayed Release	39	20.5	20.6
Esomeprazole Magnesium Delayed Release Capsules	39	20.5	20.6
Esomeprazole Magnesium Dihydrate	39	20.4	20.5
Treprostinil	286	19.0	19.1
Triamcinolone Acetonide	76	19.0	19.1
Magnesium	193	18.9	19.0
Etanercept	983	18.6	18.7
Pantoprazole	511	18.4	18.5
Acetaminophen Tablet Extended Release	512	18.3	18.4
Pain Reliever	512	18.3	18.4
Acetaminophen 500Mg	512	18.3	18.3
Ascorbic Acid	54	17.8	17.9
Ibuprofen And Diphenhydramine Citrate	53	17.5	17.5
Apremilast	282	16.0	16.1
Adalimumab	994	16.0	16.0
Vitamin C	179	15.6	15.6
Diltiazem Hydrochloride	69	15.4	15.4
Morphine	144	15.3	15.3
Magnesium Oxide	82	15.2	15.2
Pantoprazole Sodium	264	14.7	14.7
Cyclosporine	199	14.4	14.5
Mycophenolate Mofetil Hydrochloride	235	14.1	14.1
Oxycodone And Acetaminophen	43	14.1	14.1
Mycophenolate Mofetil	234	14.1	14.1
Dexlansoprazole	75	13.9	13.9
Ibuprofen Capsule	324	13.7	13.7
Ibuprofen Tablet, Film Coated	324	13.7	13.7
Ibupfrofen	324	13.7	13.7
Ibuprofen Tablets Usp, 200Mg	324	13.7	13.7
Ibuprofen Oral	324	13.7	13.7
Ibuprofen Capsules 200 Mg	324	13.7	13.7
Ibuprofen 200 Mg	324	13.7	13.7
Ibuprofen 200Mg	324	13.7	13.7
Mesalamine	98	13.6	13.6
Botulinum Toxin Type A	22	13.4	13.5
Rosuvastatin Calcium	48	13.0	13.1
Tramadol Hydrochloride	62	12.7	12.7
Methylprednisolone Sodium Succinate	76	12.6	12.7
Moxifloxacin Hydrochloride	32	12.0	12.0
Quetiapine	275	11.8	11.8
Acetaminophen	566	11.7	11.7
Minocycline	18	11.7	11.7
Oxycodone	264	11.7	11.7
Anakinra	25	11.4	11.5
Lorazepam	250	11.4	11.4
Paroxetine Hydrochloride Hemihydrate	49	11.3	11.3
Calcium	207	11.3	11.3
Paroxetine	49	11.0	11.0
Diphenhydramine Hydrochloride	224	11.0	11.0
Ibuprofen	344	10.7	10.8
Budesonide	80	10.5	10.5
Methylprednisolone Acetate	11	10.4	10.4
Tretinoin	11	10.2	10.3
Lansoprazole	224	10.2	10.2
Iron	88	10.2	10.2
Sildenafil	76	10.1	10.1
Candesartan	47	10.1	10.1
Nintedanib	40	9.7	9.7
Ergocalciferol	428	9.7	9.7
Pregabalin	312	9.6	9.6
Levothyroxine Sodium Anhydrous	120	9.4	9.4
Fish Oil	108	9.3	9.3
Diphenhydramine	75	9.2	9.2
Indomethacin	16	9.1	9.2
Prednisolone	200	8.9	8.9
Prednisolone Oral	200	8.9	8.9
Prednisolone Oral Solution	200	8.9	8.9
Propranolol Hydrochloride	80	8.6	8.6
Trimethoprim	13	8.3	8.3
Esomeprazole	67	8.3	8.3
Macitentan	74	8.2	8.2
Moxifloxacin	15	8.1	8.1
Torsemide	35	8.0	8.1
Albuterol	120	7.8	7.8
Lapatinib	16	7.8	7.8
Paroxetine Hydrochloride	91	7.8	7.8
Fluticasone Propionate Nasal	30	7.5	7.5
Atomoxetine Hydrochloride	23	7.3	7.3
Ixekizumab	35	7.2	7.2
Morphine Sulfate	111	7.1	7.1
Bupropion	41	7.0	7.0
Oxycodone Hydrochloride And Acetaminophen	89	7.0	7.0
Lisinopril	255	6.8	6.8
Riociguat	29	6.8	6.8
Metolazone	10	6.7	6.7
Cabozantinib	41	6.5	6.5
Erenumab-Aooe	46	6.4	6.4
Ketoprofen	11	6.3	6.3
Albuterol Sulfate	220	6.0	6.0
Cyclobenzaprine Hydrochloride	7	5.9	5.9
Cetirizine Hcl	7	5.8	5.8
Temozolomide	16	5.7	5.7
Butalbital, Acetaminophen, And Caffeine	8	5.7	5.7
Bisoprolol Fumarate	99	5.7	5.7
Sulfamethoxazole And Trimethoprim	61	5.5	5.5
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	22	5.5	5.5
Oxycodone Hydrochloride	150	5.4	5.4
Atenolol	92	5.3	5.3
Fluticasone Furoate	8	5.0	5.0
Selexipag	17	5.0	5.0
Bumetanide	17	4.9	4.9
Sildenafil Citrate	80	4.8	4.8
Atorvastatin Calcium, Film Coated	44	4.8	4.8
Tadalafil	62	4.7	4.7
Imatinib	11	4.7	4.7
Pravastatin Sodium	12	4.6	4.6
Abemaciclib	12	4.5	4.5
Vedolizumab	48	4.3	4.3
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	23	4.2	4.2
Benzonatate	9	4.1	4.1
Mirabegron	21	4.1	4.1
Letrozole Tablets	26	4.1	4.1
Ibuprofen Tablets, Coated	23	4.1	4.1
Ibuprofen Sodium	23	4.1	4.1
Epoprostenol	7	4.0	4.0
Thiotepa	5	3.9	3.9
Pemetrexed	11	3.9	3.9
Ribociclib	16	3.8	3.8
Guanfacine	4	3.8	3.8
Mepolizumab	24	3.7	3.7
Cenobamate	4	3.6	3.6
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	3.6	3.6
Paliperidone	11	3.6	3.6
Dasatinib	17	3.5	3.5
Paclitaxel (Aibumin-Bound)	37	3.4	3.4
Capecitabine	40	3.3	3.3
Pirfenidone	17	3.2	3.2
Bortezomib	37	3.1	3.1
Carboplatin	52	3.1	3.1
Acalabrutinib	5	3.1	3.1
Paclitaxel	39	3.0	3.0
Trastuzumab	27	3.0	3.0
Irinotecan Hydrochloride	5	2.9	2.9
Azacitidine For	7	2.9	2.9
Gemcitabine	15	2.9	2.9
Azacitidine	11	2.8	2.8
Pemetrexed Disodium	14	2.8	2.8
Bosutinib	3	2.5	2.5
Acetaminophen, Aspirin, And Caffeine	7	2.5	2.5
Ambrisentan	40	2.4	2.4
Buprenorphine	28	2.3	2.3
Daratumumab	12	2.3	2.3
Umeclidinium Bromide And Vilanterol Trifenatate	5	2.3	2.3
Ranitidine Hydrochloride	14	1.9	1.9
Paliperidone Palmitate	8	1.9	1.9
Olaparib	5	1.8	1.8
Droxidopa	5	1.7	1.7
Salicylic Acid	8	1.1	1.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.