Lisinopril vs Metoprolol: side effects in FDA adverse event reports
At a glance
| Lisinopril | Metoprolol | |
|---|---|---|
| Drug class | – | – |
| Brand names | – | Metoprolol Tartrate |
| FAERS reports | 304,208 | 271,764 |
| Serious | 61% | 70% |
| Death outcome | 25,263 | 30,898 |
| Boxed warning | Yes FETAL TOXICITY See full prescribing information for complete boxed warning. When pregnancy is detected, discontinue lisinopril as soon as possible. ( 5.1 ) Drug | No |
Signals both drugs share
| Reaction | Lisinopril | Metoprolol | Label screen (A / B) |
|---|---|---|---|
| Chronic kidney disease | 9,125 · PRR 9.2 | 5,602 · PRR 6.0 | Labeled adverse reaction / Likely indication confounding |
| End stage renal disease | 2,831 · PRR 12.4 | 2,145 · PRR 10.0 | Not in label — unassessed / Not in label — unassessed |
| Nephrogenic anaemia | 1,334 · PRR 27.2 | 1,014 · PRR 21.2 | Not in label — unassessed / Not in label — unassessed |
| Hyperparathyroidism secondary | 682 · PRR 25.1 | 532 · PRR 20.3 | Not in label — unassessed / Not in label — unassessed |
| Rebound acid hypersecretion | 729 · PRR 21.3 | 415 · PRR 11.9 | Not in label — unassessed / Not in label — unassessed |
| Brash syndrome | 211 · PRR 12.5 | 595 · PRR 60.1 | Not in label — unassessed / Not in label — unassessed |
| Chronic kidney disease-mineral and bone disorder | 386 · PRR 38.3 | 223 · PRR 20.0 | Not in label — unassessed / Not in label — unassessed |
| Essential hypertension | 289 · PRR 8.5 | 196 · PRR 6.2 | Likely indication confounding / Likely indication confounding |
Labeled signals distinctive to Lisinopril
- Angioedema — n=6,693, PRR 12.2 Labeled — boxed warning
- Intestinal angioedema — n=265, PRR 86.6 Labeled — boxed warning
- Subcutaneous drug absorption impaired — n=203, PRR 40.6 Labeled (related wording)
Labeled signals distinctive to Metoprolol
- Bradycardia — n=3,427, PRR 5.3 Labeled adverse reaction
- Coronary artery disease — n=2,442, PRR 6.6 Labeled adverse reaction
- Sinus bradycardia — n=625, PRR 5.3 Labeled (related wording)
- Angina unstable — n=543, PRR 6.9 Labeled (related wording)
- Coronary arterial stent insertion — n=352, PRR 5.7 Labeled (related wording)
- Rhinitis allergic — n=337, PRR 6.3 Labeled (related wording)
- Hypertensive emergency — n=168, PRR 12.8 Labeled (related wording)
Common questions
Which has more reported side effects, Lisinopril or Metoprolol?
Lisinopril has 304,208 FAERS reports and Metoprolol 271,764. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (61% vs 70%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Lisinopril and Metoprolol share?
Both drugs carry disproportionality signals for chronic kidney disease, end stage renal disease, nephrogenic anaemia, hyperparathyroidism secondary, rebound acid hypersecretion. Shared signals often reflect a shared drug class or the condition both are used for.
Is Lisinopril or Metoprolol safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.