Methotrexate vs Cyclophosphamide For: side effects in FDA adverse event reports
At a glance
| Methotrexate | Cyclophosphamide For | |
|---|---|---|
| Drug class | – | – |
| Brand names | – | Cyclophosphamide |
| FAERS reports | 483,097 | 175,993 |
| Serious | 73% | 96% |
| Death outcome | 37,640 | 35,641 |
| Boxed warning | Yes WARNING: EMBRYO-FETAL TOXICITY, HYPERSENSITIVITY REACTIONS, BENZYL ALCOHOL TOXICITY, and OTHER SERIOUS ADVERSE REACTIONS • Methotrexate Injection can cause embr | No |
Signals both drugs share
No strong shared signal after removing coding and lab terms.
Labeled signals distinctive to Methotrexate
- Pericarditis — n=6,863, PRR 30.0 Labeled adverse reaction
- Duodenal ulcer perforation — n=5,067, PRR 97.3 Labeled (related wording)
- Bone erosion — n=2,084, PRR 61.7 Labeled (related wording)
- Lymphoproliferative disorder — n=1,503, PRR 44.9 Labeled (related wording)
- Rheumatoid lung — n=451, PRR 37.7 Labeled (related wording)
Labeled signals distinctive to Cyclophosphamide For
- Cytomegalovirus infection reactivation — n=1,352, PRR 55.1 Labeled (related wording)
- Cystitis haemorrhagic — n=1,125, PRR 46.1 Labeled (related wording)
- Hepatitis b reactivation — n=791, PRR 39.3 Labeled (related wording)
- Viral haemorrhagic cystitis — n=284, PRR 80.2 Labeled (related wording)
- Secondary immunodeficiency — n=283, PRR 36.8 Labeled (related wording)
- Cystitis viral — n=177, PRR 103.7 Labeled (related wording)
- Ovarian failure — n=143, PRR 42.7 Labeled adverse reaction
- Cystitis bacterial — n=100, PRR 49.4 Labeled (related wording)
Common questions
Which has more reported side effects, Methotrexate or Cyclophosphamide For?
Methotrexate has 483,097 FAERS reports and Cyclophosphamide For 175,993. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (73% vs 96%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Methotrexate and Cyclophosphamide For share?
They share no strong flagged signal after artifacts and lab terms are removed.
Is Methotrexate or Cyclophosphamide For safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.