Reaction

Bone Erosion reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,497 reports · 221 co-occurring drugs

As of the last recalculation, Bone Erosion appears in 3,497 FAERS reports alongside 221 co-occurring drug terms. The strongest observed disproportionality signal is DICLOFENAC POTASSIUM, FILM COATED (PRR 531.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Diclofenac Potassium, Film Coated	619	531.8	574.2
Diclofenac Potassium Tablets	619	531.4	573.7
Diclofenac Potassium	619	414.1	439.3
Desoximetasone	793	320.1	334.0
Pseudoephedrine Hydrochloride	450	299.0	312.8
Cortisone Acetate	508	286.4	298.7
Pseudoephedrine Hcl	454	281.7	293.8
Tofacitinib Citrate	413	212.5	219.4
Naproxen Sodium Tablet, Coated	402	199.5	205.6
Naproxen Sodium, Coated Tablets	402	199.5	205.6
Naproxen Sodium 220Mg	402	199.2	205.3
Sulfasalazine	1,423	181.8	185.2
Chlorhexidine Gluconate	239	167.0	171.5
Leflunomide	1,595	166.0	168.5
Tocilizumab	1,573	148.3	150.4
Cetirizine Hydrochloride Allergy	608	144.4	147.4
Cetirizine Hydrochloride Tablets	608	144.4	147.4
Diclofenac Sodium 1%	689	142.7	145.5
Diclofenac Sodium Topical	689	142.7	145.5
Diclofenac Sodium Topical Gel, 1%	689	142.4	145.2
Doxyclycline Hyclate	352	136.7	139.6
Adalimumab-Fkjp	799	132.8	135.1
Adalimumab-Aaty	797	129.5	131.7
Adalimumab-Adaz	866	129.5	131.7
Hydrocortisone Sodium Succinate	189	126.4	129.0
Acetaminophen And Codeine	216	112.4	114.4
Hydroxychloroquine Sulfate	1,129	108.4	109.8
Calcium Gluconate	206	108.1	109.9
Golimumab	1,080	108.0	109.4
Diltiazem Hydrochloride Extended-Release Tablets	188	103.9	105.6
Sarilumab	400	101.6	103.2
Hydroxychloroquine	929	100.5	101.8
Abatacept	1,361	95.1	96.1
Minocycline	175	94.0	95.4
Aprepitant	250	86.7	87.9
Diphenhydramine Hydrochloride Capsule, Liquid Filled	261	78.5	79.5
Certolizumab Pegol	1,053	76.1	76.8
Fosaprepitant Dimeglumine	165	74.9	75.8
Diclofenac	824	74.2	74.9
Isopropyl Alcohol	374	73.6	74.4
Azathioprine	814	71.4	72.0
Quetiapine Fumarate	317	70.2	71.0
Cetirizine	710	68.1	68.7
Tofacitinib	1,294	65.7	66.1
Alcohol	373	63.9	64.5
Triamcinolone Acetonide Ointment Usp, 0.05%	233	63.4	64.0
Methotrexate Sodium	2,084	61.7	62.0
Alendronate Sodium	801	61.0	61.5
Botulinum Toxin Type A	121	60.1	60.6
Ustekinumab	767	56.9	57.3
Antacid	395	55.7	56.1
Methotrexate	1,850	54.4	54.7
Erythromycin	160	53.2	53.6
Doxycycline Hyclate	510	52.5	52.9
Calcium Carbonate	505	52.1	52.5
Rituximab	1,218	52.1	52.4
Doxycycline	510	51.9	52.3
Infliximab	1,235	51.5	51.8
Methylprednisolone Sodium Succinate	359	51.2	51.6
Risedronate Sodium	247	50.8	51.2
Tramadol Hydrochloride	287	49.3	49.7
Pantoprazole Sodium In 0.9% Sodium Chloride	442	48.4	48.8
Pantoprazole Sodium Injection	442	48.4	48.8
Triamcinolone Acetonide	233	48.0	48.4
Cetiirizine	305	46.9	47.2
Apremilast	854	45.6	45.9
Oxycodone And Acetaminophen Tablets	88	45.1	45.4
Diclofenac Sodium	835	43.1	43.3
Adalimumab	2,023	39.0	39.1
Secukinumab	806	38.3	38.5
Hydrocortisone Acetate	406	37.5	37.7
Celecoxib	670	37.2	37.4
Hydrocortisone	456	34.8	35.0
Diltiazem Hydrochloride	190	34.5	34.7
Rosuvastatin Calcium	156	34.5	34.6
Folic Acid	1,021	34.0	34.1
Etanercept	1,731	33.1	33.2
Cetirizine Hydrochloride	715	32.2	32.3
Mesalamine	272	31.2	31.3
Ascorbic Acid	112	29.6	29.7
Anti-Itch	303	29.4	29.5
Anti-Pruritic	303	29.4	29.5
Antipruritic (Anti-Itch)	303	29.4	29.5
Cool Relief Gel With Aloe	303	29.4	29.5
Drs. Hydrocortisone	303	29.4	29.5
Hydrocortisone Continuous Spray	303	29.4	29.5
Hydrocortisone Spray	303	29.4	29.5
Anti-Itch Cream	303	29.4	29.5
Hydrocortisone Lotion	303	29.4	29.5
Hydrocortisone Cream 1%	303	29.3	29.5
Hydrocortisone Cream 1/2%	303	29.3	29.5
Hydrocortisone 1%	303	29.3	29.5
Hydrocortisone Cream	303	29.2	29.3
Mycophenolate Mofetil Hydrochloride	551	28.4	28.5
Vitamin C	386	28.0	28.1
Mycophenolate Mofetil	538	27.7	27.8
Naproxen Sodium	550	27.0	27.1
Meloxicam	243	26.7	26.8
Candesartan	153	26.7	26.8
Atomoxetine Hydrochloride	99	25.5	25.6
Moxifloxacin	58	24.9	25.0
Tretinoin	33	24.4	24.5
Oxycodone And Acetaminophen	89	23.3	23.4
Ramipril	427	23.2	23.3
Moxifloxacin Hydrochloride	74	22.2	22.3
Morphine	254	21.8	21.8
Naproxen	265	21.6	21.7
Methylprednisolone Acetate	28	21.0	21.0
Prednisone	1,189	20.8	20.9
Pantoprazole Sodium	450	20.6	20.6
Pantoprazole	693	20.1	20.1
Trimethoprim	37	18.9	18.9
Bupropion	136	18.9	18.9
Calcium	417	18.8	18.9
Magnesium	240	18.6	18.6
Acetaminophen Tablet Extended Release	644	18.2	18.2
Pain Reliever	644	18.2	18.2
Acetaminophen 500Mg	644	18.2	18.2
Methylprednisolone	366	17.5	17.5
Hydromorphone Hydrochloride	251	17.4	17.5
Diphenhydramine Hydrochloride	400	16.1	16.1
Erenumab-Aooe	140	15.7	15.7
Quetiapine	441	15.5	15.5
Oxycodone	429	15.4	15.5
Morphine Sulfate	287	15.3	15.3
Vedolizumab	203	14.8	14.9
Mirabegron	93	14.7	14.7
Bupropion Hydrochloride	217	13.9	13.9
Mepolizumab	110	13.6	13.6
Lorazepam	364	13.3	13.4
Acetaminophen	787	13.2	13.2
Indomethacin	29	13.1	13.2
Thiamine Hydrochloride	27	13.0	13.0
Alendronate Sodium Tablet	40	13.0	13.0
Diphenhydramine	130	12.7	12.7
Icosapent Ethyl	18	12.6	12.7
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	63	12.6	12.6
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	301	12.2	12.2
Lansoprazole	324	11.8	11.9
Leucovorin Calcium	37	11.6	11.7
Ergocalciferol	626	11.6	11.6
Oxycodone Hydrochloride And Acetaminophen	183	11.6	11.6
Cyanocobalamin	62	11.4	11.4
Ibuprofen Capsule	342	11.2	11.2
Ibuprofen Tablet, Film Coated	342	11.2	11.2
Ibupfrofen	342	11.2	11.2
Ibuprofen Tablets Usp, 200Mg	342	11.2	11.2
Ibuprofen Oral	342	11.2	11.2
Ibuprofen Capsules 200 Mg	342	11.2	11.2
Ibuprofen 200 Mg	342	11.2	11.2
Ibuprofen 200Mg	342	11.2	11.2
Pregabalin	426	10.5	10.5
Fluticasone Furoate	21	10.4	10.4
Albuterol	198	10.3	10.4
Cyclobenzaprine Hydrochloride	15	10.0	10.0
Ibuprofen	407	10.0	10.0
Lisinopril	415	9.0	9.0
Cyclobenzaprine	73	8.9	8.9
Fluticasone Propionate Nasal	43	8.5	8.5
Sulfamethoxazole And Trimethoprim	114	8.3	8.3
Metronidazole Topical	65	8.3	8.3
Mycophenilic Acid	28	8.1	8.1
Ibuprofen Tablets, Coated	57	8.1	8.1
Telmisartan	24	8.1	8.1
Ibuprofen Sodium	57	8.0	8.0
Anakinra	22	7.9	7.9
Ranitidine Hydrochloride	68	7.6	7.6
Rabeprazole	28	7.6	7.6
Buprenorphine	114	7.5	7.6
Mometasone	23	7.5	7.5
Salicylic Acid	63	7.2	7.2
Topiramate	109	7.2	7.2
Ciprofolxacin	81	6.9	6.9
Ciprofloxacin Tablets	81	6.9	6.9
Lamotirigine	81	6.9	6.9
Lamotrigine Extended-Release	81	6.9	6.9
Lamotrigine Chewable Dispersible	81	6.9	6.9
Metronidazole	72	6.8	6.8
Magnesium Hydroxide	15	6.6	6.7
Canakinumab	12	6.6	6.6
Canagliflozin	33	6.6	6.6
Prednisolone	191	6.6	6.6
Prednisolone Oral	191	6.6	6.6
Prednisolone Oral Solution	191	6.6	6.6
Zinc Gluconate	28	6.4	6.4
Ciprofloxacin Hydrochloride	100	6.3	6.3
Fish Oil	93	6.3	6.3
Oxycodone Hydrochloride	212	6.1	6.1
Albuterol Sulfate	277	5.9	6.0
Metformin Hydrochloride Tablets	56	5.9	5.9
Metformin Hydrochloride Extended-Release Tablets	56	5.9	5.9
Metformin Hydrochloride Tablet	56	5.9	5.9
Levothyroxine Sodium Anhydrous	94	5.7	5.7
Metformin Hydrochloride	56	5.7	5.7
Magnesium Sulfate In Water For	12	5.6	5.6
Ciprofloxacin	84	5.6	5.6
Magnesium Sulfate Heptahydrate	12	5.5	5.5
Magnesium Sulfate	12	5.5	5.5
Mycophenolic Acid	29	5.4	5.4
Lamotrigine	114	5.3	5.3
Cephalexin	19	5.2	5.3
Epoetin Alfa	10	5.0	5.0
Methocarbamol Tablets	14	5.0	5.0
Candesartan Cilexetil	21	4.8	4.8
Rabeprazole Sodium	21	4.6	4.6
Cyclosporine	84	4.6	4.6
Dorzolamide Hydrochloride And Timolol Maleate	6	4.5	4.5
Methocarbamol	17	4.5	4.5
Crisaborole	7	4.3	4.4
Olmesartan Medoxomil	25	4.2	4.2
Tenofovir Disoproxil Fumarate Tablets	6	4.1	4.1
Chlorthalidone	8	4.1	4.1
Prednisolone Acetate	7	4.0	4.0
Oxybutynin	16	3.3	3.3
Estrogens, Conjugated	30	3.0	3.0
Nevirapine	4	2.6	2.6
Upadacitinib	34	2.5	2.5
Gefitinib	3	2.0	2.0
Ixekizumab	12	1.9	1.9
Orlistat	7	1.6	1.6
Lifitegrast	3	1.1	1.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.