OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Adapalene

739 flagged reaction(s) · 428,164 total co-reports · max PRR 282.2
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Chemical Burn Of Skin 1,801 282.2 285.0 signal
2 Chemical Peel Of Skin 18 203.9 203.9 signal
3 Skin Fragility 1,480 179.9 181.4 signal
4 Skin Burning Sensation 41,912 167.8 218.1 signal
5 Skin Irritation 26,485 159.6 186.7 signal
6 Acne 39,434 125.0 159.5 signal
7 Acne Cystic 1,447 106.6 107.4 signal
8 Pain Of Skin 12,321 97.4 104.5 signal
9 First Degree Chemical Burn Of Skin 11 95.9 95.9 signal
10 Dilated Pores 39 86.6 86.7 signal
11 Seborrhoea 1,575 86.5 87.2 signal
12 Sensitive Skin 2,824 74.0 75.2 signal
13 Acne Pustular 287 62.3 62.4 signal
14 Skin Hypopigmentation 610 61.6 61.9 signal
15 Dry Skin 45,426 61.0 81.1 signal
16 Skin Discomfort 861 55.3 55.6 signal
17 Skin Hyperpigmentation 2,742 54.3 55.1 signal
18 Skin Swelling 2,310 43.0 43.5 signal
19 Skin Exfoliation 21,395 40.0 45.2 signal
20 Chemical Burn 247 32.0 32.1 signal
21 Skin Tightness 903 27.5 27.6 signal
22 Erythema 38,589 26.7 33.6 signal
23 Rash Papular 4,148 26.1 26.7 signal
24 Second Degree Chemical Burn Of Skin 8 17.4 17.4 signal
25 Periorbital Irritation 38 15.5 15.5 signal
26 Eyelid Exfoliation 91 15.1 15.1 signal
27 Rash Macular 3,915 14.6 14.9 signal
28 Skin Fissures 2,038 13.9 14.1 signal
29 Dermatitis 2,058 12.7 12.8 signal
30 Skin Warm 569 12.5 12.5 signal
31 Scar 1,632 12.1 12.2 signal
32 Inappropriate Schedule Of Product Administration 16,235 11.6 12.7 signal
33 Scab 1,036 11.6 11.6 signal
34 Skin Injury 290 11.1 11.1 signal
35 Eyelid Irritation 191 9.7 9.7 signal
36 Eyelid Skin Dryness 89 9.5 9.5 signal
37 Third Degree Chemical Burn Of Skin 3 8.9 8.9 signal
38 Skin Reaction 968 8.5 8.5 signal
39 Underdose 4,949 8.3 8.6 signal
40 Skin Texture Abnormal 62 8.1 8.1 signal
41 Skin Haemorrhage 893 7.6 7.6 signal
42 Overdose 13,210 7.5 8.0 signal
43 Rosacea 263 6.9 6.9 signal
44 Skin Discolouration 2,514 6.6 6.7 signal
45 Perioral Dermatitis 33 6.5 6.5 signal
46 Sunburn 392 6.4 6.4 signal
47 Rash Erythematous 2,441 6.3 6.4 signal
48 Skin Wrinkling 132 5.9 5.9 signal
49 Hypersensitivity 8,394 5.4 5.7 signal
50 Sticky Skin 18 5.4 5.4 signal
51 Drug Ineffective 52,992 4.8 6.4 signal
52 Skin Erosion 127 4.8 4.8 signal
53 Periorbital Inflammation 9 4.7 4.7 signal
54 Milia 14 4.7 4.7 signal
55 Swelling Face 2,511 4.6 4.7 signal
56 Skin Discharge 14 4.6 4.6 signal
57 Eyelid Rash 36 4.6 4.6 signal
58 Rash 15,728 4.3 4.6 signal
59 Skin Induration 73 4.2 4.2 signal
60 Dermal Cyst 82 4.0 4.0 signal
61 Drug Administered To Patient Of Inappropriate Age 242 4.0 4.0 signal
62 Eye Swelling 1,197 3.8 3.9 signal
63 Pruritus 11,881 3.7 3.9 signal
64 Purging 3 3.4 3.4 no signal
65 Swelling Of Eyelid 176 3.4 3.4 signal
66 Inappropriate Schedule Of Drug Administration 2,054 3.4 3.4 signal
67 Lip Erythema 22 3.4 3.4 signal
68 Application Site Dryness 95 3.3 3.3 signal
69 Tanning 4 3.3 3.3 signal
70 Blister 1,481 3.1 3.1 signal
71 Furuncle 201 3.0 3.0 signal
72 Burns First Degree 7 2.9 2.9 signal
73 Periorbital Swelling 130 2.8 2.8 signal
74 Periorbital Pain 19 2.8 2.8 signal
75 Erythema Of Eyelid 115 2.5 2.5 signal
76 Miliaria 36 2.5 2.5 signal
77 Urticaria 3,311 2.3 2.4 signal
78 Keratosis Pilaris 5 2.3 2.3 no signal
79 Skin Infection 210 2.2 2.2 signal
80 Skin Abrasion 87 2.2 2.2 signal
81 Eyelid Pain 36 2.2 2.2 signal
82 Ephelides 10 2.1 2.1 signal
83 Condition Aggravated 5,272 2.0 2.1 signal
84 Skin Indentation 8 2.0 2.0 no signal
85 Therapeutic Product Effect Decreased 753 2.0 2.0 no signal
86 Product Use In Unapproved Indication 3,977 1.9 1.9 no signal
87 Lip Exfoliation 21 1.9 1.9 no signal
88 Post Inflammatory Pigmentation Change 7 1.8 1.8 no signal
89 Acne Fulminans 3 1.8 1.8 no signal
90 Chloasma 7 1.8 1.8 no signal
91 Pustule 34 1.7 1.7 no signal
92 Discharge 20 1.7 1.7 no signal
93 Eye Irritation 769 1.6 1.6 no signal
94 Chapped Lips 59 1.6 1.6 no signal
95 Dark Circles Under Eyes 20 1.6 1.6 no signal
96 Product Intolerance 3 1.6 1.6 no signal
97 Skin Wound 22 1.5 1.5 no signal
98 Eyelids Pruritus 40 1.5 1.5 no signal
99 Scratch 129 1.4 1.4 no signal
100 Skin Ulcer 318 1.4 1.4 no signal
101 Papule 83 1.4 1.4 no signal
102 Eczema 559 1.3 1.3 no signal
103 Adverse Reaction 143 1.3 1.3 no signal
104 Post Cholecystectomy Syndrome 3 1.2 1.2 no signal
105 Carbuncle 3 1.2 1.2 no signal
106 Product Used For Unknown Indication 13 1.2 1.2 no signal
107 Rash Pustular 76 1.2 1.2 no signal
108 Ingrown Hair 7 1.2 1.2 no signal
109 Skin Mass 67 1.2 1.2 no signal
110 Product Use Issue 1,854 1.2 1.2 no signal
111 Skin Atrophy 55 1.1 1.1 no signal
112 Application Site Exfoliation 39 1.1 1.1 no signal
113 Skin Bacterial Infection 7 1.0 1.0 no signal
114 Perfume Sensitivity 5 1.0 1.0 no signal
115 Skin Hypertrophy 25 1.0 1.0 no signal
116 Blepharal Pigmentation 4 0.9 0.9 no signal
117 Skin Ulcer Haemorrhage 3 0.9 0.9 no signal
118 Capillary Fragility 4 0.9 0.9 no signal
119 Lacrimation Increased 233 0.9 0.9 no signal
120 Ocular Hyperaemia 363 0.9 0.9 no signal
121 Ileitis 3 0.9 0.9 no signal
122 Lip Dry 66 0.9 0.9 no signal
123 Thermal Burn 51 0.8 0.8 no signal
124 Eye Allergy 11 0.8 0.8 no signal
125 Biliary Dyskinesia 12 0.8 0.8 no signal
126 Slow Response To Stimuli 9 0.8 0.8 no signal
127 Staphylococcal Skin Infection 8 0.7 0.7 no signal
128 Skin Lesion 174 0.7 0.7 no signal
129 Breast Feeding 5 0.7 0.7 no signal
130 Application Site Acne 3 0.7 0.7 no signal
131 Facial Pain 56 0.7 0.7 no signal
132 Dermatitis Contact 70 0.7 0.7 no signal
133 Pigmentation Disorder 36 0.7 0.7 no signal
134 Drug Ineffective For Unapproved Indication 319 0.7 0.7 no signal
135 Burns Third Degree 6 0.7 0.7 no signal
136 Eczema Eyelids 3 0.6 0.6 no signal
137 Dermatitis Allergic 69 0.6 0.6 no signal
138 Rash Pruritic 297 0.6 0.6 no signal
139 Rash Vesicular 26 0.6 0.6 no signal
140 Impetigo 8 0.6 0.6 no signal
141 Lip Swelling 178 0.6 0.6 no signal
142 Eyelid Oedema 61 0.6 0.6 no signal
143 Burns Second Degree 9 0.6 0.6 no signal
144 Eye Pruritus 166 0.6 0.6 no signal
145 Eye Burns 3 0.6 0.6 no signal
146 Paraesthesia 792 0.6 0.6 no signal
147 Wound Secretion 19 0.6 0.6 no signal
148 Thyroid Hormones Increased 5 0.5 0.5 no signal
149 Cyst 59 0.5 0.5 no signal
150 Hypotrichosis 3 0.5 0.5 no signal
151 Therapy Cessation 227 0.5 0.5 no signal
152 Exposure During Pregnancy 273 0.5 0.5 no signal
153 Skin Laceration 46 0.5 0.5 no signal
154 Solar Lentigo 4 0.5 0.5 no signal
155 Skin Sensitisation 4 0.4 0.4 no signal
156 Superficial Injury Of Eye 4 0.4 0.4 no signal
157 Seborrhoeic Dermatitis 6 0.4 0.4 no signal
158 Acarodermatitis 4 0.4 0.4 no signal
159 Enterobacter Infection 6 0.4 0.4 no signal
160 Incision Site Complication 3 0.4 0.4 no signal
161 Application Site Burn 17 0.4 0.4 no signal
162 Jugular Vein Thrombosis 6 0.4 0.4 no signal
163 Pneumomediastinum 6 0.4 0.4 no signal
164 Feeling Hot 206 0.4 0.4 no signal
165 Nasal Oedema 6 0.4 0.4 no signal
166 Ear Swelling 7 0.4 0.4 no signal
167 Eye Contusion 7 0.4 0.4 no signal
168 Application Site Hypersensitivity 4 0.4 0.4 no signal
169 Mouth Swelling 19 0.4 0.4 no signal
170 Pulpitis Dental 3 0.4 0.4 no signal
171 Photosensitivity Reaction 53 0.4 0.4 no signal
172 Product Administered To Patient Of Inappropriate Age 19 0.4 0.4 no signal
173 Blood Alkaline Phosphatase Decreased 3 0.4 0.4 no signal
174 Lip Haemorrhage 4 0.4 0.4 no signal
175 Subcutaneous Abscess 15 0.4 0.4 no signal
176 Cholecystitis Chronic 21 0.4 0.4 no signal
177 Gallbladder Injury 6 0.4 0.4 no signal
178 Skin Weeping 10 0.3 0.3 no signal
179 Skin Oedema 3 0.3 0.3 no signal
180 Application Site Inflammation 4 0.3 0.3 no signal
181 Product Ineffective For Unapproved Use 4 0.3 0.3 no signal
182 Purulent Discharge 12 0.3 0.3 no signal
183 Maternal Exposure During Breast Feeding 11 0.3 0.3 no signal
184 Lip Pain 8 0.3 0.3 no signal
185 Somatic Symptom Disorder 3 0.3 0.3 no signal
186 Intracranial Venous Sinus Thrombosis 3 0.3 0.3 no signal
187 Perirectal Abscess 3 0.3 0.3 no signal
188 Pharyngeal Swelling 25 0.3 0.3 no signal
189 Application Site Erythema 68 0.3 0.3 no signal
190 Application Site Pain 56 0.3 0.3 no signal
191 Blepharitis 10 0.3 0.3 no signal
192 Eyelid Margin Crusting 7 0.3 0.3 no signal
193 Xerosis 3 0.3 0.3 no signal
194 Application Site Irritation 30 0.3 0.3 no signal
195 Allergy To Chemicals 3 0.3 0.3 no signal
196 Application Site Swelling 12 0.3 0.3 no signal
197 Lip Discolouration 3 0.3 0.3 no signal
198 Dermatitis Acneiform 14 0.3 0.3 no signal
199 Wisdom Teeth Removal 3 0.3 0.3 no signal
200 Exposure Via Breast Milk 9 0.3 0.3 no signal
201 Application Site Paraesthesia 3 0.3 0.3 no signal
202 Exfoliative Rash 6 0.3 0.3 no signal
203 Dandruff 5 0.3 0.3 no signal
204 Skin Papilloma 9 0.3 0.3 no signal
205 Skin Depigmentation 3 0.3 0.3 no signal
206 Dry Eye 106 0.3 0.3 no signal
207 Hyperkeratosis 12 0.2 0.2 no signal
208 Eye Pain 119 0.2 0.2 no signal
209 Hypertrichosis 4 0.2 0.2 no signal
210 Inflammatory Bowel Disease 21 0.2 0.2 no signal
211 Adverse Event 194 0.2 0.2 no signal
212 Supraventricular Extrasystoles 7 0.2 0.2 no signal
213 Multi-organ Disorder 4 0.2 0.2 no signal
214 Skin Striae 3 0.2 0.2 no signal
215 Secretion Discharge 24 0.2 0.2 no signal
216 Therapeutic Response Decreased 117 0.2 0.2 no signal
217 Multiple-drug Resistance 6 0.2 0.2 no signal
218 Product Odour Abnormal 20 0.2 0.2 no signal
219 Hordeolum 8 0.2 0.2 no signal
220 Crohn's Disease 13 0.2 0.2 no signal
221 Oral Discomfort 26 0.2 0.2 no signal
222 Rash Maculo-papular 41 0.2 0.2 no signal
223 Lip Blister 5 0.2 0.2 no signal
224 Oesophageal Ulcer 7 0.2 0.2 no signal
225 Skin Disorder 60 0.2 0.2 no signal
226 Mitral Valve Prolapse 3 0.2 0.2 no signal
227 Idiopathic Intracranial Hypertension 4 0.2 0.2 no signal
228 Pallor 47 0.2 0.2 no signal
229 Aphthous Stomatitis 4 0.2 0.2 no signal
230 Drug Delivery System Issue 3 0.2 0.2 no signal
231 Eye Inflammation 15 0.2 0.2 no signal
232 Patient Dissatisfaction With Treatment 3 0.2 0.2 no signal
233 Folliculitis 16 0.2 0.2 no signal
234 Product Size Issue 8 0.2 0.2 no signal
235 Joint Crepitation 3 0.2 0.2 no signal
236 Cheilitis 8 0.2 0.2 no signal
237 Expired Product Administered 49 0.2 0.2 no signal
238 Migraine With Aura 4 0.2 0.2 no signal
239 Application Site Discolouration 6 0.2 0.2 no signal
240 Hair Growth Abnormal 10 0.2 0.2 no signal
241 Application Site Scab 3 0.2 0.2 no signal
242 Faeces Pale 3 0.2 0.2 no signal
243 Crepitations 4 0.2 0.2 no signal
244 Keratitis 4 0.2 0.2 no signal
245 Papilloedema 6 0.2 0.2 no signal
246 Application Site Rash 18 0.1 0.1 no signal
247 Thrombophlebitis Superficial 4 0.1 0.1 no signal
248 Nasal Dryness 8 0.1 0.1 no signal
249 Therapeutic Product Effect Incomplete 89 0.1 0.1 no signal
250 Fungal Skin Infection 5 0.1 0.1 no signal
251 Tenderness 13 0.1 0.1 no signal
252 Swelling 116 0.1 0.1 no signal
253 Application Site Pruritus 28 0.1 0.1 no signal
254 Self Esteem Decreased 3 0.1 0.1 no signal
255 Melanocytic Naevus 5 0.1 0.1 no signal
256 Madarosis 13 0.1 0.1 no signal
257 Pre-existing Condition Improved 7 0.1 0.1 no signal
258 Temporomandibular Joint Syndrome 3 0.1 0.1 no signal
259 Gastrointestinal Injury 3 0.1 0.1 no signal
260 Burning Sensation 77 0.1 0.1 no signal
261 Intracranial Pressure Increased 6 0.1 0.1 no signal
262 Anal Haemorrhage 3 0.1 0.1 no signal
263 Hypoaesthesia Oral 16 0.1 0.1 no signal
264 Abortion Induced 10 0.1 0.1 no signal
265 Therapeutic Response Unexpected 47 0.1 0.1 no signal
266 Biliary Colic 3 0.1 0.1 no signal
267 Contusion 99 0.1 0.1 no signal
268 Skin Odour Abnormal 4 0.1 0.1 no signal
269 Eye Injury 3 0.1 0.1 no signal
270 Eye Infection 11 0.1 0.1 no signal
271 Throat Tightness 26 0.1 0.1 no signal
272 Hair Colour Changes 12 0.1 0.1 no signal
273 Anal Fistula 5 0.1 0.1 no signal
274 Pharyngolaryngeal Pain 5 0.1 0.1 no signal
275 Asthenopia 5 0.1 0.1 no signal
276 Otitis Media 3 0.1 0.1 no signal
277 Poor Quality Product Administered 9 0.1 0.1 no signal
278 Dyspareunia 4 0.1 0.1 no signal
279 Neurodermatitis 3 0.1 0.1 no signal
280 Tibia Fracture 4 0.1 0.1 no signal
281 Vaginal Infection 4 0.1 0.1 no signal
282 Hormone Level Abnormal 4 0.1 0.1 no signal
283 Wound 23 0.1 0.1 no signal
284 Blood Phosphorus Decreased 3 0.1 0.1 no signal
285 Intentional Underdose 6 0.1 0.1 no signal
286 Oral Herpes 16 0.1 0.1 no signal
287 Inflammation 42 0.1 0.1 no signal
288 Snoring 3 0.1 0.1 no signal
289 Face Injury 3 0.1 0.1 no signal
290 Oesophageal Disorder 3 0.1 0.1 no signal
291 Gingival Disorder 3 0.1 0.1 no signal
292 Anhedonia 20 0.1 0.1 no signal
293 Anal Fissure 4 0.1 0.1 no signal
294 Anal Abscess 4 0.1 0.1 no signal
295 Product Physical Consistency Issue 4 0.1 0.1 no signal
296 Infective Pulmonary Exacerbation Of Cystic Fibrosis 4 0.1 0.1 no signal
297 Intestinal Haemorrhage 4 0.1 0.1 no signal
298 Application Site Reaction 5 0.1 0.1 no signal
299 Abnormal Sensation In Eye 3 0.1 0.1 no signal
300 Enterocolitis 4 0.1 0.1 no signal
301 Social Avoidant Behaviour 4 0.1 0.1 no signal
302 Eye Discharge 7 0.1 0.1 no signal
303 Drug Effective For Unapproved Indication 20 0.1 0.1 no signal
304 Ventricular Extrasystoles 7 0.1 0.1 no signal
305 Gallbladder Disorder 12 0.1 0.1 no signal
306 Urine Abnormality 3 0.1 0.1 no signal
307 Bundle Branch Block Right 3 0.1 0.1 no signal
308 Laceration 6 0.1 0.1 no signal
309 Drug Hypersensitivity 122 0.1 0.1 no signal
310 Paraesthesia Oral 9 0.1 0.1 no signal
311 Sneezing 14 0.1 0.1 no signal
312 Blood Triglycerides Increased 11 0.1 0.1 no signal
313 Nodule 8 0.1 0.1 no signal
314 Crying 22 0.1 0.1 no signal
315 Post-traumatic Stress Disorder 4 0.1 0.1 no signal
316 Quality Of Life Decreased 8 0.1 0.1 no signal
317 Vein Disorder 3 0.1 0.1 no signal
318 Adverse Drug Reaction 53 0.1 0.1 no signal
319 Osteopenia 9 0.1 0.1 no signal
320 Temperature Intolerance 6 0.1 0.1 no signal
321 Trismus 3 0.1 0.1 no signal
322 Pharyngeal Oedema 9 0.1 0.1 no signal
323 Irritable Bowel Syndrome 12 0.1 0.1 no signal
324 Injury 39 0.1 0.1 no signal
325 Oral Disorder 4 0.1 0.1 no signal
326 Dental Caries 6 0.1 0.1 no signal
327 Product Packaging Issue 5 0.1 0.1 no signal
328 Personality Change 5 0.1 0.1 no signal
329 Sputum Discoloured 5 0.1 0.1 no signal
330 Cholecystectomy 6 0.1 0.1 no signal
331 Discomfort 32 0.1 0.1 no signal
332 Psoriasis 69 0.1 0.1 no signal
333 Hyperhidrosis 68 0.1 0.1 no signal
334 Concussion 4 0.1 0.1 no signal
335 Fungal Infection 17 0.1 0.1 no signal
336 Coeliac Disease 5 0.1 0.1 no signal
337 Flushing 52 0.1 0.1 no signal
338 Frustration Tolerance Decreased 4 0.1 0.1 no signal
339 Sluggishness 5 0.1 0.1 no signal
340 Conjunctivitis 9 0.1 0.1 no signal
341 Infusion Site Swelling 3 0.1 0.1 no signal
342 Blepharospasm 3 0.1 0.1 no signal
343 Pharyngitis 6 0.1 0.1 no signal
344 Hereditary Angioedema 5 0.1 0.1 no signal
345 Sleep Apnoea Syndrome 9 0.1 0.1 no signal
346 Anaphylactic Shock 12 0.1 0.1 no signal
347 Vitamin D Decreased 4 0.1 0.1 no signal
348 Skin Cancer 10 0.1 0.1 no signal
349 Ocular Discomfort 5 0.1 0.1 no signal
350 Hidradenitis 4 0.1 0.1 no signal
351 Wrong Product Administered 3 0.1 0.1 no signal
352 Throat Irritation 20 0.1 0.1 no signal
353 Postoperative Wound Infection 3 0.1 0.1 no signal
354 Pneumothorax 7 0.1 0.1 no signal
355 Maternal Exposure Before Pregnancy 3 0.1 0.1 no signal
356 Rebound Effect 5 0.1 0.1 no signal
357 Dermatitis Atopic 22 0.1 0.1 no signal
358 Sleep Disorder Due To A General Medical Condition 7 0.0 0.0 no signal
359 Bacterial Infection 8 0.0 0.0 no signal
360 Photophobia 8 0.0 0.0 no signal
361 Drug Effect Less Than Expected 6 0.0 0.0 no signal
362 Product Supply Issue 3 0.0 0.0 no signal
363 Supraventricular Tachycardia 4 0.0 0.0 no signal
364 Acute Respiratory Failure 8 0.0 0.0 no signal
365 Impaired Quality Of Life 6 0.0 0.0 no signal
366 Haemorrhoids 8 0.0 0.0 no signal
367 Small Intestinal Obstruction 5 0.0 0.0 no signal
368 Deep Vein Thrombosis 26 0.0 0.0 no signal
369 Dry Throat 4 0.0 0.0 no signal
370 Hypoaesthesia 59 0.0 0.0 no signal
371 Product Administration Interrupted 3 0.0 0.0 no signal
372 Maternal Drugs Affecting Foetus 3 0.0 0.0 no signal
373 Congenital Anomaly 3 0.0 0.0 no signal
374 Renal Failure Chronic 3 0.0 0.0 no signal
375 Swollen Tongue 12 0.0 0.0 no signal
376 Affective Disorder 3 0.0 0.0 no signal
377 Blood Albumin Decreased 3 0.0 0.0 no signal
378 Abortion Spontaneous 15 0.0 0.0 no signal
379 Dysarthria 14 0.0 0.0 no signal
380 Sensory Loss 3 0.0 0.0 no signal
381 Urinary Incontinence 11 0.0 0.0 no signal
382 Emotional Distress 45 0.0 0.0 no signal
383 Pharyngitis Streptococcal 4 0.0 0.0 no signal
384 Bipolar Disorder 4 0.0 0.0 no signal
385 Sensation Of Foreign Body 3 0.0 0.0 no signal
386 Atrial Septal Defect 3 0.0 0.0 no signal
387 Panic Attack 13 0.0 0.0 no signal
388 Pulmonary Embolism 34 0.0 0.0 no signal
389 Product Container Issue 3 0.0 0.0 no signal
390 Sinus Disorder 7 0.0 0.0 no signal
391 Intentional Product Use Issue 31 0.0 0.0 no signal
392 Treatment Noncompliance 19 0.0 0.0 no signal
393 Dysphagia 33 0.0 0.0 no signal
394 Blood Magnesium Decreased 3 0.0 0.0 no signal
395 Groin Pain 3 0.0 0.0 no signal
396 Colitis Ulcerative 15 0.0 0.0 no signal
397 Cholelithiasis 11 0.0 0.0 no signal
398 Oropharyngeal Pain 31 0.0 0.0 no signal
399 Bursitis 4 0.0 0.0 no signal
400 Anaphylactic Reaction 18 0.0 0.0 no signal
401 Restlessness 12 0.0 0.0 no signal
402 Migraine 31 0.0 0.0 no signal
403 Intervertebral Disc Degeneration 3 0.0 0.0 no signal
404 Erythema Multiforme 3 0.0 0.0 no signal
405 Diarrhoea Haemorrhagic 3 0.0 0.0 no signal
406 Drug Exposure During Pregnancy 11 0.0 0.0 no signal
407 Bone Density Decreased 10 0.0 0.0 no signal
408 Respiratory Tract Congestion 5 0.0 0.0 no signal
409 Stevens-johnson Syndrome 7 0.0 0.0 no signal
410 Abscess 5 0.0 0.0 no signal
411 Lymphadenopathy 11 0.0 0.0 no signal
412 Affect Lability 3 0.0 0.0 no signal
413 Vitreous Floaters 3 0.0 0.0 no signal
414 Vitamin D Deficiency 3 0.0 0.0 no signal
415 Dysmenorrhoea 4 0.0 0.0 no signal
416 Eye Disorder 10 0.0 0.0 no signal
417 Ligament Sprain 3 0.0 0.0 no signal
418 Multiple Fractures 5 0.0 0.0 no signal
419 Product Administration Error 6 0.0 0.0 no signal
420 Amenorrhoea 5 0.0 0.0 no signal
421 Anxiety 85 0.0 0.0 no signal
422 Hair Texture Abnormal 4 0.0 0.0 no signal
423 Product Substitution Issue 17 0.0 0.0 no signal
424 Rhinorrhoea 19 0.0 0.0 no signal
425 Depression 67 0.0 0.0 no signal
426 Neutrophil Count Increased 3 0.0 0.0 no signal
427 Poor Venous Access 3 0.0 0.0 no signal
428 Peripheral Coldness 4 0.0 0.0 no signal
429 Neuralgia 7 0.0 0.0 no signal
430 Mental Impairment 7 0.0 0.0 no signal
431 Seasonal Allergy 4 0.0 0.0 no signal
432 Acute Respiratory Distress Syndrome 5 0.0 0.0 no signal
433 Hot Flush 21 0.0 0.0 no signal
434 Haemorrhage 29 0.0 0.0 no signal
435 Back Injury 3 0.0 0.0 no signal
436 Toothache 5 0.0 0.0 no signal
437 Gastroenteritis Viral 5 0.0 0.0 no signal
438 Mental Disorder 12 0.0 0.0 no signal
439 Oesophagitis 3 0.0 0.0 no signal
440 Malnutrition 3 0.0 0.0 no signal
441 Insurance Issue 4 0.0 0.0 no signal
442 Obstructive Airways Disorder 3 0.0 0.0 no signal
443 Osteoporosis 11 0.0 0.0 no signal
444 Therapy Partial Responder 4 0.0 0.0 no signal
445 Ear Infection 7 0.0 0.0 no signal
446 Dyspnoea 149 0.0 0.0 no signal
447 Feeling Jittery 5 0.0 0.0 no signal
448 Neoplasm 3 0.0 0.0 no signal
449 Upper Respiratory Tract Infection 12 0.0 0.0 no signal
450 Muscle Twitching 6 0.0 0.0 no signal
451 Economic Problem 4 0.0 0.0 no signal
452 Dry Mouth 21 0.0 0.0 no signal
453 Pain 159 0.0 0.0 no signal
454 Fear 7 0.0 0.0 no signal
455 Palpitations 30 0.0 0.0 no signal
456 Basal Cell Carcinoma 4 0.0 0.0 no signal
457 Cyanosis 4 0.0 0.0 no signal
458 Cholecystitis 3 0.0 0.0 no signal
459 Blood Lactate Dehydrogenase Increased 4 0.0 0.0 no signal
460 Mood Swings 8 0.0 0.0 no signal
461 Stress 18 0.0 0.0 no signal
462 Infection 36 0.0 0.0 no signal
463 Pregnancy 5 0.0 0.0 no signal
464 Therapy Non-responder 11 0.0 0.0 no signal
465 Staphylococcal Infection 8 0.0 0.0 no signal
466 Psychomotor Hyperactivity 4 0.0 0.0 no signal
467 Blood Creatine Phosphokinase Increased 7 0.0 0.0 no signal
468 Nasal Congestion 14 0.0 0.0 no signal
469 Gastrointestinal Disorder 21 0.0 0.0 no signal
470 Wheezing 14 0.0 0.0 no signal
471 Face Oedema 4 0.0 0.0 no signal
472 Impaired Gastric Emptying 3 0.0 0.0 no signal
473 Retching 5 0.0 0.0 no signal
474 Hiatus Hernia 3 0.0 0.0 no signal
475 Neurotoxicity 4 0.0 0.0 no signal
476 Intervertebral Disc Protrusion 5 0.0 0.0 no signal
477 Immune System Disorder 3 0.0 0.0 no signal
478 Tooth Infection 3 0.0 0.0 no signal
479 Lymphocyte Count Decreased 4 0.0 0.0 no signal
480 Alopecia 44 0.0 0.0 no signal
481 Asthma 25 0.0 0.0 no signal
482 Osteomyelitis 4 0.0 0.0 no signal
483 Mood Altered 6 0.0 0.0 no signal
484 Maternal Exposure During Pregnancy 19 0.0 0.0 no signal
485 Feeling Cold 6 0.0 0.0 no signal
486 Aphonia 3 0.0 0.0 no signal
487 Sinusitis 22 0.0 0.0 no signal
488 Sinus Tachycardia 3 0.0 0.0 no signal
489 Suicidal Ideation 19 0.0 0.0 no signal
490 Aspartate Aminotransferase Increased 11 0.0 0.0 no signal
491 Anger 7 0.0 0.0 no signal
492 Gastroenteritis 3 0.0 0.0 no signal
493 Ear Pain 4 0.0 0.0 no signal
494 Brain Fog 3 0.0 0.0 no signal
495 Spinal Fracture 4 0.0 0.0 no signal
496 Osteonecrosis Of Jaw 5 0.0 0.0 no signal
497 Sleep Disorder 14 0.0 0.0 no signal
498 Respiratory Disorder 6 0.0 0.0 no signal
499 Systemic Lupus Erythematosus 7 0.0 0.0 no signal
500 Neck Pain 11 0.0 0.0 no signal
501 Intentional Product Misuse 17 0.0 0.0 no signal
502 Hyponatraemia 11 0.0 0.0 no signal
503 Body Temperature Increased 4 0.0 0.0 no signal
504 Thyroid Disorder 3 0.0 0.0 no signal
505 Drug Dispensing Error 3 0.0 0.0 no signal
506 Abdominal Pain 45 0.0 0.0 no signal
507 Rash Generalised 5 0.0 0.0 no signal
508 Vision Blurred 26 0.0 0.0 no signal
509 Dysuria 7 0.0 0.0 no signal
510 Eating Disorder 4 0.0 0.0 no signal
511 Product Dispensing Error 4 0.0 0.0 no signal
512 Pruritus Generalised 4 0.0 0.0 no signal
513 Ventricular Tachycardia 3 0.0 0.0 no signal
514 Pleural Effusion 11 0.0 0.0 no signal
515 Viral Infection 6 0.0 0.0 no signal
516 Accidental Exposure To Product 18 0.0 0.0 no signal
517 Blood Urea Increased 3 0.0 0.0 no signal
518 Headache 111 0.0 0.0 no signal
519 Chromaturia 4 0.0 0.0 no signal
520 Drug Intolerance 17 0.0 0.0 no signal
521 Agitation 13 0.0 0.0 no signal
522 Pyrexia 61 0.0 0.0 no signal
523 Lethargy 10 0.0 0.0 no signal
524 Herpes Zoster 10 0.0 0.0 no signal
525 Metrorrhagia 3 0.0 0.0 no signal
526 Surgery 10 0.0 0.0 no signal
527 Depressed Mood 9 0.0 0.0 no signal
528 Liver Function Test Abnormal 5 0.0 0.0 no signal
529 Treatment Failure 14 0.0 0.0 no signal
530 Drug Eruption 3 0.0 0.0 no signal
531 Disease Recurrence 8 0.0 0.0 no signal
532 Leukocytosis 3 0.0 0.0 no signal
533 Aphasia 5 0.0 0.0 no signal
534 Pelvic Pain 3 0.0 0.0 no signal
535 Fibromyalgia 4 0.0 0.0 no signal
536 End Stage Renal Disease 3 0.0 0.0 no signal
537 Gastrooesophageal Reflux Disease 13 0.0 0.0 no signal
538 Tubulointerstitial Nephritis 3 0.0 0.0 no signal
539 Thinking Abnormal 3 0.0 0.0 no signal
540 Epistaxis 12 0.0 0.0 no signal
541 Colitis 6 0.0 0.0 no signal
542 Unevaluable Event 12 0.0 0.0 no signal
543 Angioedema 7 0.0 0.0 no signal
544 Chest Discomfort 16 0.0 0.0 no signal
545 Chronic Kidney Disease 12 0.0 0.0 no signal
546 Chest Pain 29 0.0 0.0 no signal
547 Night Sweats 5 0.0 0.0 no signal
548 Choking 3 0.0 0.0 no signal
549 Respiratory Tract Infection 4 0.0 0.0 no signal
550 Drug Prescribing Error 3 0.0 0.0 no signal
551 Mucosal Inflammation 4 0.0 0.0 no signal
552 Amnesia 10 0.0 0.0 no signal
553 Heart Rate Increased 15 0.0 0.0 no signal
554 Haematocrit Decreased 3 0.0 0.0 no signal
555 Urinary Retention 5 0.0 0.0 no signal
556 Syncope 15 0.0 0.0 no signal
557 Abdominal Discomfort 25 0.0 0.0 no signal
558 Irritability 9 0.0 0.0 no signal
559 Psoriatic Arthropathy 6 0.0 0.0 no signal
560 Injury Associated With Device 3 0.0 0.0 no signal
561 Disturbance In Attention 8 0.0 0.0 no signal
562 Bronchitis 11 0.0 0.0 no signal
563 Oedema 8 0.0 0.0 no signal
564 Blood Bilirubin Increased 4 0.0 0.0 no signal
565 Drug Effect Decreased 8 0.0 0.0 no signal
566 Nasopharyngitis 27 0.0 0.0 no signal
567 Respiratory Distress 4 0.0 0.0 no signal
568 Tooth Loss 3 0.0 0.0 no signal
569 Pulmonary Hypertension 3 0.0 0.0 no signal
570 Haemoptysis 4 0.0 0.0 no signal
571 Dizziness 71 0.0 0.0 no signal
572 Poor Quality Sleep 3 0.0 0.0 no signal
573 Impaired Work Ability 3 0.0 0.0 no signal
574 General Physical Health Deterioration 16 0.0 0.0 no signal
575 Cellulitis 7 0.0 0.0 no signal
576 Musculoskeletal Stiffness 12 0.0 0.0 no signal
577 Ascites 4 0.0 0.0 no signal
578 Transaminases Increased 3 0.0 0.0 no signal
579 Pancreatitis Acute 3 0.0 0.0 no signal
580 Tooth Disorder 3 0.0 0.0 no signal
581 Intestinal Obstruction 5 0.0 0.0 no signal
582 Renal Injury 4 0.0 0.0 no signal
583 Loss Of Consciousness 17 0.0 0.0 no signal
584 Lower Respiratory Tract Infection 6 0.0 0.0 no signal
585 Heart Rate Irregular 3 0.0 0.0 no signal
586 Suicide Attempt 8 0.0 0.0 no signal
587 Abdominal Pain Upper 27 0.0 0.0 no signal
588 Alanine Aminotransferase Increased 8 0.0 0.0 no signal
589 Myalgia 22 0.0 0.0 no signal
590 Limb Discomfort 4 0.0 0.0 no signal
591 Back Pain 30 0.0 0.0 no signal
592 Cognitive Disorder 6 0.0 0.0 no signal
593 Emotional Disorder 4 0.0 0.0 no signal
594 Wrong Technique In Product Usage Process 26 0.0 0.0 no signal
595 Blood Cholesterol Increased 6 0.0 0.0 no signal
596 Insomnia 34 0.0 0.0 no signal
597 Haematochezia 7 0.0 0.0 no signal
598 Weight Increased 28 0.0 0.0 no signal
599 Nausea 99 0.0 0.0 no signal
600 Influenza 14 0.0 0.0 no signal
601 Multiple Sclerosis 6 0.0 0.0 no signal
602 Feeling Abnormal 30 0.0 0.0 no signal
603 Blood Pressure Fluctuation 3 0.0 0.0 no signal
604 Joint Swelling 15 0.0 0.0 no signal
605 Presyncope 3 0.0 0.0 no signal
606 Peripheral Swelling 19 0.0 0.0 no signal
607 Injection Site Urticaria 3 0.0 0.0 no signal
608 Encephalopathy 3 0.0 0.0 no signal
609 Dyspepsia 12 0.0 0.0 no signal
610 Visual Impairment 15 0.0 0.0 no signal
611 Product Dose Omission 8 0.0 0.0 no signal
612 Blood Alkaline Phosphatase Increased 3 0.0 0.0 no signal
613 Rhabdomyolysis 5 0.0 0.0 no signal
614 Dehydration 16 0.0 0.0 no signal
615 Dysphonia 7 0.0 0.0 no signal
616 Aggression 6 0.0 0.0 no signal
617 Injection Site Swelling 9 0.0 0.0 no signal
618 Product Quality Issue 16 0.0 0.0 no signal
619 Haematemesis 3 0.0 0.0 no signal
620 Cough 33 0.0 0.0 no signal
621 Vomiting 55 0.0 0.0 no signal
622 Hepatitis 3 0.0 0.0 no signal
623 Erectile Dysfunction 3 0.0 0.0 no signal
624 Off Label Use 101 0.0 0.0 no signal
625 Rectal Haemorrhage 5 0.0 0.0 no signal
626 Diplopia 3 0.0 0.0 no signal
627 Sedation 3 0.0 0.0 no signal
628 Deafness 3 0.0 0.0 no signal
629 Nervousness 6 0.0 0.0 no signal
630 Tachycardia 10 0.0 0.0 no signal
631 Malaise 49 0.0 0.0 no signal
632 Jaundice 3 0.0 0.0 no signal
633 Weight Decreased 31 0.0 0.0 no signal
634 Intentional Dose Omission 3 0.0 0.0 no signal
635 Nephrolithiasis 5 0.0 0.0 no signal
636 Procedural Pain 3 0.0 0.0 no signal
637 Flatulence 6 0.0 0.0 no signal
638 Loss Of Personal Independence In Daily Activities 5 0.0 0.0 no signal
639 Arrhythmia 5 0.0 0.0 no signal
640 Neoplasm Malignant 7 0.0 0.0 no signal
641 Somnolence 21 0.0 0.0 no signal
642 Injection Site Reaction 7 0.0 0.0 no signal
643 Memory Impairment 14 0.0 0.0 no signal
644 Disorientation 4 0.0 0.0 no signal
645 Illness 10 0.0 0.0 no signal
646 Hepatic Failure 3 0.0 0.0 no signal
647 Stomatitis 6 0.0 0.0 no signal
648 Injection Site Rash 3 0.0 0.0 no signal
649 Ill-defined Disorder 6 0.0 0.0 no signal
650 Vertigo 6 0.0 0.0 no signal
651 Product Dose Omission Issue 28 0.0 0.0 no signal
652 Oedema Peripheral 12 0.0 0.0 no signal
653 Blood Pressure Increased 15 0.0 0.0 no signal
654 Abdominal Distension 10 0.0 0.0 no signal
655 Nervous System Disorder 3 0.0 0.0 no signal
656 Bradycardia 5 0.0 0.0 no signal
657 Device Expulsion 6 0.0 0.0 no signal
658 Blood Creatinine Increased 6 0.0 0.0 no signal
659 Osteonecrosis 3 0.0 0.0 no signal
660 Liver Disorder 4 0.0 0.0 no signal
661 Visual Acuity Reduced 3 0.0 0.0 no signal
662 Hepatic Enzyme Increased 6 0.0 0.0 no signal
663 Delirium 3 0.0 0.0 no signal
664 Fatigue 67 0.0 0.0 no signal
665 Pain In Extremity 25 0.0 0.0 no signal
666 Productive Cough 4 0.0 0.0 no signal
667 Incorrect Dose Administered 19 0.0 0.0 no signal
668 Cerebral Haemorrhage 3 0.0 0.0 no signal
669 Renal Impairment 7 0.0 0.0 no signal
670 Electrocardiogram Qt Prolonged 3 0.0 0.0 no signal
671 C-reactive Protein Increased 3 0.0 0.0 no signal
672 Urinary Tract Infection 14 0.0 0.0 no signal
673 Arthralgia 34 0.0 0.0 no signal
674 Drug Interaction 13 0.0 0.0 no signal
675 Muscle Spasms 15 0.0 0.0 no signal
676 Lung Disorder 4 0.0 0.0 no signal
677 Wrong Technique In Drug Usage Process 3 0.0 0.0 no signal
678 Hepatic Function Abnormal 3 0.0 0.0 no signal
679 Dyspnoea Exertional 3 0.0 0.0 no signal
680 Constipation 17 0.0 0.0 no signal
681 Speech Disorder 4 0.0 0.0 no signal
682 White Blood Cell Count Decreased 8 0.0 0.0 no signal
683 Gait Disturbance 14 0.0 0.0 no signal
684 Therapy Interrupted 5 0.0 0.0 no signal
685 Medication Error 4 0.0 0.0 no signal
686 Oxygen Saturation Decreased 4 0.0 0.0 no signal
687 Withdrawal Syndrome 3 0.0 0.0 no signal
688 Muscular Weakness 8 0.0 0.0 no signal
689 Seizure 8 0.0 0.0 no signal
690 Decreased Appetite 16 0.0 0.0 no signal
691 Convulsion 4 0.0 0.0 no signal
692 Confusional State 11 0.0 0.0 no signal
693 Renal Failure 9 0.0 0.0 no signal
694 Diarrhoea 43 0.0 0.0 no signal
695 Hypertension 14 0.0 0.0 no signal
696 Platelet Count Decreased 7 0.0 0.0 no signal
697 Tinnitus 3 0.0 0.0 no signal
698 Pneumonia 21 0.0 0.0 no signal
699 Renal Disorder 3 0.0 0.0 no signal
700 Fall 21 0.0 0.0 no signal
701 Thrombosis 5 0.0 0.0 no signal
702 Foetal Exposure During Pregnancy 5 0.0 0.0 no signal
703 Tremor 10 0.0 0.0 no signal
704 Injection Site Pruritus 4 0.0 0.0 no signal
705 Chills 7 0.0 0.0 no signal
706 Hospitalisation 9 0.0 0.0 no signal
707 Neutropenia 8 0.0 0.0 no signal
708 Musculoskeletal Pain 3 0.0 0.0 no signal
709 Pancreatitis 3 0.0 0.0 no signal
710 Drug Withdrawal Syndrome 5 0.0 0.0 no signal
711 Anaemia 10 0.0 0.0 no signal
712 Atrial Fibrillation 5 0.0 0.0 no signal
713 Bone Pain 3 0.0 0.0 no signal
714 Asthenia 19 0.0 0.0 no signal
715 Injection Site Haemorrhage 4 0.0 0.0 no signal
716 Injection Site Pain 15 0.0 0.0 no signal
717 Cardiac Failure Congestive 4 0.0 0.0 no signal
718 Influenza Like Illness 4 0.0 0.0 no signal
719 Blood Glucose Increased 9 0.0 0.0 no signal
720 Device Issue 4 0.0 0.0 no signal
721 Covid-19 8 0.0 0.0 no signal
722 Cardiac Disorder 4 0.0 0.0 no signal
723 Mobility Decreased 3 0.0 0.0 no signal
724 Cerebrovascular Accident 7 0.0 0.0 no signal
725 Injection Site Erythema 5 0.0 0.0 no signal
726 Dysgeusia 3 0.0 0.0 no signal
727 Cardiac Failure 3 0.0 0.0 no signal
728 Cardiac Arrest 3 0.0 0.0 no signal
729 Drug Dose Omission 6 0.0 0.0 no signal
730 Completed Suicide 3 0.0 0.0 no signal
731 Balance Disorder 3 0.0 0.0 no signal
732 Disease Progression 4 0.0 0.0 no signal
733 No Adverse Event 6 0.0 0.0 no signal
734 Malignant Neoplasm Progression 3 0.0 0.0 no signal
735 Haemoglobin Decreased 3 0.0 0.0 no signal
736 Myocardial Infarction 5 0.0 0.0 no signal
737 Acute Kidney Injury 3 0.0 0.0 no signal
738 Death 13 0.0 0.0 no signal
739 Hypotension 3 0.0 0.0 no signal