Reaction

Which drugs are most reported with Skin swelling?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,397 reports · 161 co-occurring drugs

As of the last recalculation, Skin Swelling appears in 8,397 FAERS reports alongside 161 co-occurring drug terms. The strongest observed disproportionality signal is ADAPALENE (PRR 43.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Adapalene	2,310	43.0	43.5
Salicylic Acid	730	37.4	37.9
Sulfur	95	28.2	28.6
Dupilumab	2,554	18.4	18.5
Clobetasol Propionate Ointment Usp, 0.05%	55	13.3	13.4
Clobetasol Propionate	54	13.0	13.1
Triamcinolone Acetonide Ointment Usp, 0.05%	90	9.6	9.7
Triamcinolone Acetonide	93	7.5	7.6
Hydroxyzine Hydrochloride	39	7.4	7.4
Hydroxyzine Hydrochloride Oral	39	7.4	7.4
Nemolizumab-Ilto	31	6.1	6.1
Mometasone	42	5.7	5.7
Cetirizine Hcl	21	5.7	5.7
Sarilumab	50	4.7	4.7
Mupirocin	23	4.2	4.2
Ketoconazole Foam	25	4.2	4.2
Terbinafine Hydrochloride	15	4.2	4.2
Ketoconazole Cream, 2%	25	4.2	4.2
Mupirocin Calcium	23	4.2	4.2
Hydroxyzine	75	3.9	3.9
Ketoconazole	25	3.6	3.6
Hydrocortisone Cream	95	3.5	3.5
Anti-Itch	94	3.5	3.5
Anti-Pruritic	94	3.5	3.5
Antipruritic (Anti-Itch)	94	3.5	3.5
Cool Relief Gel With Aloe	94	3.5	3.5
Drs. Hydrocortisone	94	3.5	3.5
Hydrocortisone Continuous Spray	94	3.5	3.5
Hydrocortisone Spray	94	3.5	3.5
Anti-Itch Cream	94	3.5	3.5
Hydrocortisone Lotion	94	3.5	3.5
Hydrocortisone Cream 1%	94	3.5	3.5
Hydrocortisone Cream 1/2%	94	3.5	3.5
Hydrocortisone 1%	94	3.5	3.5
Fexofenadine	23	3.5	3.5
Hydrocortisone Acetate	99	3.4	3.4
Tretinoin	11	3.4	3.4
Azelastine	24	3.3	3.3
Fexofenadine Hydrochloride	29	3.3	3.3
Cyclobenzaprine Hydrochloride	12	3.3	3.3
Crisaborole	12	3.1	3.1
Buspirone Hydrochloride	13	2.9	2.9
Hydrocortisone	104	2.9	2.9
Fluticasone Propionate Nasal	35	2.9	2.9
Epoetin Alfa	13	2.7	2.7
Montelukast	91	2.7	2.7
Mometasone Furoate	45	2.7	2.7
Loratadine Oral	50	2.5	2.5
Dronedarone	10	2.4	2.4
Omalizumab	83	2.4	2.4
Fexofenadine Hcl	9	2.4	2.4
Rotigotine	14	2.4	2.4
Felodipine Extended-Release Tablets	11	2.4	2.4
Felodipine	11	2.4	2.4
Progesterone	22	2.4	2.4
Dapsone	10	2.3	2.3
Zinc	23	2.3	2.3
Zinc Chloride	23	2.3	2.3
Miconazole Nitrate	8	2.3	2.3
Fluticasone Propionate	117	2.3	2.3
Brimonidine Tartrate	16	2.2	2.2
Diphenhydramine Hcl	10	2.2	2.2
Secukinumab	143	2.2	2.2
Adrenalinum	37	2.2	2.2
Rosuvastatin Calcium	25	2.2	2.2
Zinc Gluconate	23	2.2	2.2
Levocetirizine Dihydrochloride	21	2.2	2.2
Losartan Potassium	66	2.1	2.1
Methocarbamol Tablets	14	2.1	2.1
Dextrose	11	2.1	2.1
Canakinumab	9	2.1	2.1
Dextrose Monohydrate	11	2.0	2.0
Doxyclycline Hyclate	14	2.0	2.0
Metoprolol Succinate Er Tablets	50	2.0	2.0
Asfotase Alfa	8	2.0	2.0
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	24	2.0	2.0
Montelukast Sodium	95	1.9	1.9
Cetirizine	60	1.9	1.9
Vitamin C	71	1.9	1.9
Tizanidine Hydrochloride	14	1.9	1.9
Biotin	24	1.9	1.9
Mometasone Furoate And Formoterol Fumarate Dihydrate	12	1.9	1.9
Cetirizine Hydrochloride	125	1.9	1.9
Quinapril Hydrochloride	6	1.9	1.9
Meloxicam	44	1.9	1.9
Epinephrine	49	1.9	1.9
Anastrozole Tablets	16	1.9	1.9
Tamsulosin Hydrochloride	15	1.8	1.8
Cetirizine Hydrochloride Allergy	22	1.8	1.8
Cetirizine Hydrochloride Tablets	22	1.8	1.8
Sorafenib	15	1.8	1.8
Loratadine	76	1.8	1.8
Atorvastatin Calcium, Film Coated	49	1.7	1.7
Liothyronine Sodium	6	1.7	1.7
Minocycline	8	1.7	1.7
Budesonide, Glycopyrrolate, And Formoterol Fumarate	7	1.7	1.7
Hydroxychloroquine Sulfate	60	1.6	1.6
Leflunomide	68	1.6	1.6
Infliximab-Dyyb	19	1.6	1.6
Estradiol Gel 0.1%	29	1.6	1.6
Estradiol Transdermal	29	1.6	1.6
Panitumumab	10	1.6	1.6
Minoxidil Foam 5% (Womens)	21	1.6	1.6
Iron Sucrose	6	1.6	1.6
Tiotropium Bromide Inhalation Spray	7	1.5	1.5
Metoprolol Succinate	53	1.5	1.5
Iohexol	5	1.5	1.5
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	21	1.5	1.5
Estradiol	51	1.5	1.5
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	12	1.4	1.4
Naproxen Sodium, Pseudoephedrine Hydrochloride	12	1.4	1.4
Losartan	101	1.4	1.4
Botulinum Toxin Type A	7	1.4	1.4
Multivitamin	28	1.4	1.4
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	23	1.4	1.4
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	23	1.4	1.4
Oral Semaglutide	40	1.4	1.4
Sevelamer Carbonate	6	1.3	1.3
Regorafenib	6	1.3	1.3
Teriflunomide	23	1.3	1.3
Oseltamivir	4	1.2	1.2
Bendamustine Hydrochloride	6	1.2	1.2
Vibegron	4	1.2	1.2
Minoxidil	22	1.2	1.2
Linaclotide	13	1.2	1.2
Pegvaliase-Pqpz	4	1.2	1.2
Glatiramer Acetate	29	1.2	1.2
Certolizumab Pegol	56	1.2	1.2
Lisdexamfetamine Dimesylate	15	1.1	1.1
Romosozumab-Aqqg	6	1.1	1.1
Lifitegrast	7	1.1	1.1
Apalutamide	5	1.1	1.1
Nicotine	17	1.0	1.0
Vemurafenib	5	1.0	1.0
Alirocumab	10	1.0	1.0
Prasugrel Hydrochloride	4	1.0	1.0
Upadacitinib	32	1.0	1.0
Azacitidine For	7	1.0	1.0
Ranolazine	4	0.9	0.9
Acetaminophen, Aspirin, And Caffeine	8	0.9	0.9
Bimekizumab	8	0.9	0.9
Etanercept	223	0.9	0.9
Onabotulinumtoxina	28	0.9	0.9
Acetaminophen, Aspirin (Nsaid) And Caffeine	6	0.9	0.9
Eltrombopag Olamine	8	0.9	0.9
Risankizumab-Rzaa	26	0.8	0.8
Benralizumab	6	0.7	0.7
Lenvatinib	9	0.7	0.7
Erenumab-Aooe	15	0.7	0.7
Ixazomib	7	0.6	0.6
Ixekizumab	9	0.6	0.6
Abaloparatide	7	0.6	0.6
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	7	0.6	0.6
Relugolix	5	0.5	0.5
Tirzepatide	33	0.5	0.5
Cinacalcet Hydrochloride	9	0.5	0.5
Galcanezumab-Gnlm	6	0.5	0.5
Evolocumab	30	0.5	0.5
Apremilast	26	0.4	0.4
Etonogestrel	6	0.3	0.3
Valbenazine	3	0.3	0.3

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.