Reaction

Which drugs are most reported with Skin hyperpigmentation?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,460 reports · 198 co-occurring drugs

As of the last recalculation, Skin Hyperpigmentation appears in 8,460 FAERS reports alongside 198 co-occurring drug terms. The strongest observed disproportionality signal is ADAPALENE (PRR 54.3).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Adapalene	2,742	54.3	55.1
Sulfur	163	48.5	49.4
Bimatoprost	481	43.5	44.2
Minocycline	188	40.6	41.2
Salicylic Acid	679	34.3	34.7
Epoetin Alfa	84	17.6	17.7
Dapsone	28	6.5	6.5
Nemolizumab-Ilto	32	6.2	6.2
Rifampicin	24	5.9	5.9
Rifampin	34	5.7	5.8
Daspone	22	5.6	5.6
Dapsone Gel, 5%	22	5.6	5.6
Mometasone	37	5.0	5.0
Amikacin	34	4.9	4.9
Tenofovir Disoproxil Fumarate Tablets	17	4.9	4.9
Hydroxyurea	41	4.8	4.8
Pyrazinamide	18	4.7	4.7
Ketoconazole	33	4.7	4.7
Capecitabine	172	4.7	4.7
Imatinib	33	4.6	4.6
Paricalcitol	26	4.5	4.5
Ketoconazole Foam	27	4.5	4.5
Ketoconazole Cream, 2%	27	4.5	4.5
Terbinafine Hydrochloride	16	4.4	4.4
Tretinoin	14	4.2	4.3
Lapatinib	25	4.0	4.0
Iron Sucrose	15	3.9	3.9
Crisaborole	15	3.9	3.9
Dolutegravir Sodium	14	3.8	3.8
Erlotinib	15	3.8	3.8
Panitumumab	23	3.6	3.6
Hydrocortisone Cream	93	3.4	3.4
Colchicine	36	3.4	3.4
Isoniazid	22	3.3	3.4
Anti-Itch	90	3.3	3.3
Anti-Pruritic	90	3.3	3.3
Antipruritic (Anti-Itch)	90	3.3	3.3
Cool Relief Gel With Aloe	90	3.3	3.3
Drs. Hydrocortisone	90	3.3	3.3
Hydrocortisone Continuous Spray	90	3.3	3.3
Hydrocortisone Spray	90	3.3	3.3
Anti-Itch Cream	90	3.3	3.3
Hydrocortisone Lotion	90	3.3	3.3
Hydrocortisone Cream 1%	90	3.3	3.3
Hydrocortisone Cream 1/2%	90	3.3	3.3
Hydrocortisone 1%	90	3.3	3.3
Hydrocortisone Acetate	92	3.1	3.1
Busulfan	20	3.1	3.1
Erythropoietin	26	3.1	3.1
Pemetrexed Disodium	48	3.1	3.1
Bleomycin Sulfate	13	3.1	3.1
Doxycycline	85	3.1	3.1
Encorafenib	12	3.0	3.0
Drs. Clotrimazole	14	3.0	3.0
Family Wellness Clotrimazole	14	3.0	3.0
Clotrimazole Topical	14	3.0	3.0
Doxycycline Hyclate	81	3.0	3.0
Erlotinib Hydrochloride	15	3.0	3.0
Hydrocortisone	102	2.8	2.8
Clotrimazole	14	2.8	2.8
Abacavir Sulfate	11	2.8	2.8
Triamcinolone Acetonide Ointment Usp, 0.05%	26	2.7	2.7
Exemestane	23	2.6	2.6
Clobetasol Propionate Ointment Usp, 0.05%	11	2.6	2.6
Clobetasol Propionate	11	2.6	2.6
Fluconazole	71	2.5	2.5
Levofloxacin	61	2.5	2.5
Levofloxacin In 5% Dextrose	61	2.5	2.5
Gefitinib	9	2.5	2.5
Lamivudine Oral	25	2.4	2.4
Efavirenz	11	2.4	2.4
Brentuximab Vedotin	10	2.4	2.4
Triamcinolone Acetonide	30	2.4	2.4
Cephalexin	21	2.4	2.4
Mesna Injection	8	2.4	2.4
Mesna	8	2.3	2.3
Quinine	8	2.3	2.3
Clindamycin Phosphate	31	2.3	2.3
Hydroxychloroquine	69	2.3	2.3
Cyclosporine	101	2.2	2.2
Fam-Trastuzumab Deruxtecan-Nxki	9	2.2	2.2
Ribociclib	28	2.2	2.2
Anastrozole Tablets	19	2.2	2.2
Dorzolamide Hydrochloride And Timolol Maleate	7	2.2	2.2
Prednisolone Acetate	9	2.1	2.1
Amlodipine Besylate And Benazepril Hydrochloride	8	2.1	2.1
Bisacodyl Suppositories	11	2.1	2.1
Valganciclovir	16	2.1	2.1
Valganciclovir Hydrochloride	16	2.1	2.1
Calcitriol Capsules 0.25 Mcg	17	2.1	2.1
Calcitriol Capsules 0.5 Mcg	17	2.1	2.1
Trastuzumab	58	2.1	2.1
Biscodyl	11	2.1	2.1
Lamivudine	26	2.1	2.1
Calcitriol	17	2.1	2.1
Thiotepa	8	2.1	2.1
Fluorouracil	64	2.0	2.0
Fluorouracil Cream, 0.5%	63	2.0	2.0
Ursosiol	16	2.0	2.0
Voclosporin	7	2.0	2.0
Amphotericin B	10	2.0	2.0
Oxaliplatin	59	2.0	2.0
Cinacalcet Hydrochloride	37	2.0	2.0
Cefazolin	7	1.9	1.9
Sulfamethoxazole And Trimethoprim	64	1.9	1.9
Hydroxychloroquine Sulfate	69	1.9	1.9
Tenofovir Disoproxil Fumarate	25	1.9	1.9
Doxazosin	21	1.8	1.8
Labetalol	10	1.8	1.8
Meropenem	24	1.8	1.8
Goserelin	10	1.8	1.8
Carboxymethylcellulose Sodium	7	1.8	1.8
Anastrozole	27	1.8	1.8
Ursodiol	16	1.8	1.8
Bevacizumab	90	1.8	1.8
Posaconazole Delayed-Release	8	1.8	1.8
Darunavir	11	1.8	1.8
Indapamide	13	1.8	1.8
Tacrolimus	111	1.8	1.8
Timolol Maleate	7	1.7	1.7
Darbepoetin Alfa	38	1.7	1.7
Docetaxel Anhydrous	47	1.7	1.7
Docetaxel	47	1.7	1.7
Latanoprost	35	1.7	1.7
Travoprost	6	1.7	1.7
Vancomycin	40	1.7	1.7
Doxazosin Mesylate	25	1.7	1.7
Voriconazole	21	1.7	1.7
Voriconazole Injection	15	1.7	1.7
Brinzolamide	6	1.7	1.7
Niacin	8	1.7	1.7
Nilotinib	20	1.7	1.7
Amlodipine Besylate	99	1.7	1.7
Posaconazole	11	1.7	1.7
Linezolid	20	1.7	1.7
Ruxolitinib	48	1.7	1.7
Letrozole	41	1.6	1.6
Vemurafenib	8	1.6	1.6
Pertuzumab	18	1.6	1.6
Pemetrexed	14	1.6	1.6
Tacrolimus Ointment 0.1%	81	1.6	1.6
Ifosfamide	14	1.6	1.6
Tacrolimus Extended-Release Capsules	81	1.6	1.6
Daptomycin	6	1.6	1.6
Secukinumab	104	1.6	1.6
Imatinib Mesylate	18	1.6	1.6
Niraparib	14	1.6	1.6
Vancomycin Hydrochloride	41	1.5	1.5
Cabotegravir	5	1.5	1.5
Onabotulinumtoxina	47	1.5	1.5
Gemcitabine	24	1.5	1.5
Multivitamin	30	1.5	1.5
Ado-Trastuzumab Emtansine	5	1.5	1.5
Prochlorperazine	16	1.4	1.4
Cisplatin	45	1.4	1.4
Acetaminophen And Codeine	7	1.4	1.4
Isotretinoin	28	1.4	1.4
Dupilumab	269	1.4	1.4
Siponimod	5	1.4	1.4
Bosutinib	5	1.4	1.4
Cetuximab	17	1.3	1.3
Levocetirizine Dihydrochloride	13	1.3	1.3
Carboplatin	67	1.3	1.3
Paclitaxel	52	1.3	1.3
Sevelamer Carbonate	6	1.3	1.3
Minoxidil Foam 5% (Womens)	17	1.3	1.3
Gemcitabine Hydrochloride	27	1.3	1.3
Fludarabine Phosphate	20	1.3	1.3
Brimonidine Tartrate	9	1.2	1.2
Abemaciclib	10	1.2	1.2
Doxorubicin Hydrochloride	16	1.2	1.2
Pegaspargase	6	1.2	1.2
Eltrombopag Olamine	11	1.2	1.2
Paclitaxel (Aibumin-Bound)	39	1.2	1.2
Emtricitabine And Tenofovir Alafenamide	5	1.1	1.1
Dabrafenib	9	1.1	1.1
Minoxidil	19	1.0	1.0
Alteplase	6	1.0	1.0
Doxorubicin	35	1.0	1.0
Lenalidomide	165	1.0	1.0
Blinatumomab	4	0.9	0.9
Fremanezumab-Vfrm	4	0.9	0.9
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	3	0.8	0.8
Avapritinib	4	0.8	0.8
Cortisone Acetate	4	0.8	0.8
Voxelotor	7	0.8	0.8
Pazopanib Hydrochloride	8	0.7	0.7
Emtricitabine And Tenofovir Disoproxil Fumarate	13	0.7	0.7
Osimertinib	9	0.7	0.7
Etonogestrel	13	0.7	0.7
Apalutamide	3	0.6	0.6
Durvalumab	5	0.6	0.6
Ixazomib	7	0.6	0.6
Dulaglutide	18	0.5	0.5
Pirfenidone	8	0.5	0.5
Apremilast	28	0.5	0.5
Levonorgestrel	37	0.4	0.4
Pegfilgrastim	16	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.