OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Buprenorphine Hydrochloride, Naloxone Hydrochloride

1,130 flagged reaction(s) · 94,042 total co-reports · max PRR 357.5
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Drug Detoxification 258 357.5 361.3 signal
2 Tooth Erosion 295 306.3 310.1 signal
3 Inappropriate Schedule Of Product Discontinuation 125 284.2 285.7 signal
4 Therapy Naive 20 175.9 176.0 signal
5 Intentional Underdose 1,027 143.6 149.9 signal
6 Child Neglect 29 137.3 137.5 signal
7 Selective Abortion 24 137.0 137.1 signal
8 Substance Abuse 1,008 123.4 128.7 signal
9 Oral Administration Complication 106 111.3 111.8 signal
10 Drug Screen Negative 174 95.6 96.3 signal
11 Product Dosage Form Issue 44 87.8 87.9 signal
12 Tremor Neonatal 37 78.3 78.5 signal
13 Diarrhoea Neonatal 10 73.7 73.7 signal
14 Vision Abnormal Neonatal 30 66.6 66.7 signal
15 Drug Withdrawal Syndrome Neonatal 913 56.8 59.0 signal
16 Dental Caries 660 55.5 57.1 signal
17 Brief Psychotic Disorder With Marked Stressors 9 51.4 51.4 signal
18 Neonatal Hypoacusis 13 51.2 51.2 signal
19 Poor Feeding Infant 57 49.2 49.3 signal
20 Crime 14 48.3 48.3 signal
21 Weight Decrease Neonatal 10 47.1 47.1 signal
22 Detoxification 17 44.8 44.8 signal
23 Learning Disability 259 44.1 44.5 signal
24 Alcohol Abuse 122 41.4 41.6 signal
25 Jaundice Neonatal 80 38.5 38.6 signal
26 Theft 26 35.3 35.3 signal
27 Drug Withdrawal Syndrome 3,345 34.2 39.6 signal
28 Product Preparation Error 775 34.0 35.1 signal
29 Exposure During Breast Feeding 125 33.7 33.9 signal
30 Tongue Blistering 83 33.6 33.7 signal
31 Drug Diversion 195 30.8 31.0 signal
32 Victim Of Abuse 9 30.1 30.1 signal
33 Exposure Via Body Fluid 26 29.6 29.7 signal
34 Exposure To Allergen 10 29.0 29.0 signal
35 Piloerection 34 28.1 28.2 signal
36 Developmental Delay 280 27.7 28.1 signal
37 Euphoric Mood 302 26.4 26.7 signal
38 Victim Of Sexual Abuse 14 24.3 24.3 signal
39 Teeth Brittle 28 23.8 23.8 signal
40 Drug Dependence 4,302 23.7 28.7 signal
41 Sudden Infant Death Syndrome 13 23.4 23.4 signal
42 Exposure Via Father 33 22.4 22.4 signal
43 Selective Eating Disorder 22 21.6 21.6 signal
44 Imprisonment 43 21.5 21.5 signal
45 Dental Restoration Failure 17 21.1 21.1 signal
46 Tooth Fracture 253 20.5 20.7 signal
47 Yawning 61 20.4 20.4 signal
48 Exposure Via Breast Milk 89 20.3 20.4 signal
49 Ankyloglossia Congenital 9 19.7 19.7 signal
50 Legal Problem 16 19.4 19.4 signal
51 Feeling Of Body Temperature Change 125 19.0 19.1 signal
52 Hyperaesthesia Teeth 26 18.9 18.9 signal
53 Victim Of Crime 25 18.8 18.9 signal
54 Drug Screen Positive 165 18.7 18.8 signal
55 Drug Tolerance Increased 16 18.2 18.2 signal
56 Periodontitis 42 17.5 17.5 signal
57 Pulpitis Dental 18 17.3 17.3 signal
58 Substance Dependence 13 17.3 17.3 signal
59 Tooth Impacted 9 17.2 17.2 signal
60 Wrong Technique In Drug Usage Process 662 16.0 16.4 signal
61 Agoraphobia 23 14.9 14.9 signal
62 Social Anxiety Disorder 11 14.8 14.8 signal
63 Skull Fracture 27 14.7 14.7 signal
64 Substance Use Disorder 50 14.4 14.5 signal
65 Tooth Loss 337 14.3 14.5 signal
66 Post-traumatic Stress Disorder 107 14.1 14.2 signal
67 Drug Level Fluctuating 14 14.1 14.1 signal
68 Disability 312 14.0 14.2 signal
69 Premature Separation Of Placenta 24 13.7 13.7 signal
70 Oral Mucosal Blistering 97 13.4 13.5 signal
71 Gingival Recession 29 13.4 13.4 signal
72 Placenta Praevia 12 13.4 13.4 signal
73 Hepatitis C 179 13.0 13.1 signal
74 Glossitis 52 13.0 13.0 signal
75 Tongue Ulceration 49 12.8 12.8 signal
76 Periodontal Disease 20 12.6 12.6 signal
77 Microcephaly 18 12.6 12.6 signal
78 Borderline Personality Disorder 10 12.5 12.5 signal
79 Toothache 253 12.4 12.5 signal
80 Agitation Neonatal 13 12.1 12.1 signal
81 Personal Relationship Issue 9 11.9 11.9 signal
82 Drug Abuse 1,111 11.8 12.3 signal
83 Cytokine Storm 9 11.7 11.7 signal
84 Limb Crushing Injury 10 11.6 11.6 signal
85 Dental Discomfort 11 11.6 11.7 signal
86 Foetal Exposure During Pregnancy 1,053 11.5 11.9 signal
87 Antisocial Behaviour 13 11.4 11.4 signal
88 Alcohol Withdrawal Syndrome 11 11.1 11.1 signal
89 Non-alcoholic Steatohepatitis 13 11.0 11.0 signal
90 Emotional Distress 1,484 10.8 11.4 signal
91 Suppressed Lactation 9 10.5 10.5 signal
92 Accidental Drug Intake By Child 18 10.2 10.2 signal
93 Accidental Exposure To Product By Child 78 10.1 10.1 signal
94 Neonatal Disorder 18 10.0 10.0 signal
95 Therapeutic Product Ineffective 44 9.9 9.9 signal
96 Tooth Discolouration 33 9.8 9.8 signal
97 Pre-existing Condition Improved 70 9.8 9.8 signal
98 Self Esteem Decreased 27 9.8 9.8 signal
99 Accidental Exposure 46 9.6 9.6 signal
100 Tongue Injury 10 9.4 9.4 signal
101 Tooth Disorder 233 9.2 9.3 signal
102 Noninfective Gingivitis 15 9.2 9.2 signal
103 Neonatal Respiratory Distress 9 9.2 9.2 signal
104 Low Birth Weight Baby 80 8.9 8.9 signal
105 Gun Shot Wound 19 8.8 8.8 signal
106 Homicide 18 8.8 8.8 signal
107 Formication 69 8.7 8.8 signal
108 Mental Disorder 428 8.7 8.8 signal
109 Drug Screen False Positive 27 8.5 8.5 signal
110 Judgement Impaired 14 8.4 8.4 signal
111 Road Traffic Accident 399 8.4 8.5 signal
112 Withdrawal Syndrome 402 8.4 8.5 signal
113 Feeding Disorder Neonatal 10 8.3 8.3 signal
114 Impaired Driving Ability 104 8.1 8.1 signal
115 Logorrhoea 32 8.0 8.0 signal
116 Tooth Injury 39 7.9 7.9 signal
117 Drug Tolerance 45 7.8 7.8 signal
118 Tongue Discomfort 37 7.7 7.8 signal
119 Drug Exposure During Pregnancy 302 7.7 7.8 signal
120 Overdose 1,864 7.6 8.1 signal
121 Energy Increased 51 7.6 7.6 signal
122 Oral Disorder 62 7.4 7.4 signal
123 Substance Use 13 7.4 7.4 signal
124 Tachyphrenia 29 7.4 7.4 signal
125 Maternal Exposure During Pregnancy 737 7.4 7.6 signal
126 Generalised Anxiety Disorder 12 7.2 7.2 signal
127 Somnambulism 53 7.1 7.1 signal
128 Drug Use Disorder 66 7.0 7.0 signal
129 General Physical Condition Abnormal 54 7.0 7.0 signal
130 Psychomotor Hyperactivity 131 6.9 6.9 signal
131 Blood Testosterone Decreased 54 6.9 6.9 signal
132 Autism 8 6.8 6.8 signal
133 Oral Mucosal Erythema 12 6.8 6.8 signal
134 Prescribed Overdose 148 6.7 6.8 signal
135 Attention Deficit/hyperactivity Disorder 25 6.7 6.7 signal
136 Multiple Congenital Abnormalities 11 6.7 6.7 signal
137 Premature Labour 43 6.6 6.6 signal
138 Maternal Drugs Affecting Foetus 58 6.6 6.6 signal
139 Neck Injury 22 6.6 6.6 signal
140 Attention Deficit Hyperactivity Disorder 31 6.6 6.6 signal
141 Narcolepsy 14 6.5 6.5 signal
142 Sensitivity Of Teeth 13 6.5 6.5 signal
143 Jaw Fracture 16 6.5 6.5 signal
144 Major Depression 54 6.5 6.5 signal
145 Bipolar Disorder 80 6.4 6.4 signal
146 Respiratory Rate Decreased 23 6.4 6.4 signal
147 Gingival Swelling 32 6.4 6.4 signal
148 Foetal Distress Syndrome 15 6.2 6.2 signal
149 Appendix Disorder 10 6.2 6.2 signal
150 Pre-eclampsia 33 6.1 6.1 signal
151 Alcoholism 30 6.1 6.1 signal
152 Back Injury 75 6.1 6.1 signal
153 Respiratory Disorder Neonatal 11 6.1 6.1 signal
154 Homicidal Ideation 28 6.0 6.1 signal
155 Suicidal Ideation 628 6.0 6.2 signal
156 Bipolar I Disorder 15 6.0 6.0 signal
157 Emotional Poverty 12 6.0 6.0 signal
158 Uterine Disorder 16 6.0 6.0 signal
159 Feeling Guilty 9 6.0 6.0 signal
160 Premature Delivery 108 5.9 6.0 signal
161 Physical Assault 14 5.9 5.9 signal
162 Tobacco User 10 5.9 5.9 signal
163 Miosis 53 5.8 5.9 signal
164 Therapeutic Response Unexpected 298 5.8 5.9 signal
165 Small For Dates Baby 33 5.8 5.8 signal
166 Oral Mucosal Exfoliation 10 5.8 5.8 signal
167 Tongue Disorder 48 5.8 5.8 signal
168 Tongue Discolouration 29 5.8 5.8 signal
169 Tooth Abscess 67 5.8 5.8 signal
170 Cold Sweat 115 5.7 5.8 signal
171 Endocarditis 32 5.5 5.5 signal
172 Product Solubility Abnormal 31 5.5 5.5 signal
173 Alcohol Use 23 5.4 5.4 signal
174 Congenital Anomaly 48 5.4 5.4 signal
175 Paranoia 106 5.4 5.4 signal
176 Intentional Drug Misuse 129 5.3 5.4 signal
177 Axillary Pain 9 5.3 5.3 signal
178 Abortion Spontaneous 244 5.3 5.4 signal
179 Knee Deformity 9 5.3 5.3 signal
180 Abnormal Sleep-related Event 8 5.3 5.3 signal
181 Social Avoidant Behaviour 35 5.3 5.3 signal
182 Convulsion 349 5.3 5.3 signal
183 Premature Baby 181 5.3 5.3 signal
184 Intentional Product Misuse 513 5.2 5.3 signal
185 Mouth Injury 9 5.2 5.2 signal
186 Oral Mucosal Eruption 9 5.2 5.2 signal
187 Loose Tooth 19 5.2 5.2 signal
188 Sleep Talking 10 5.1 5.1 signal
189 Urinary Hesitation 14 5.1 5.1 signal
190 Feeling Of Despair 27 5.1 5.1 signal
191 Pulmonary Function Test Abnormal 9 5.1 5.1 signal
192 Abortion Induced 54 5.0 5.0 signal
193 Restless Legs Syndrome 104 5.0 5.0 signal
194 Gingival Disorder 22 5.0 5.0 signal
195 Panic Disorder 22 5.0 5.0 signal
196 Craniocerebral Injury 17 5.0 5.0 signal
197 Glossodynia 125 4.9 4.9 signal
198 Breakthrough Pain 13 4.9 4.9 signal
199 Hyperhidrosis 718 4.9 5.0 signal
200 Endodontic Procedure 14 4.8 4.8 signal
201 Excoriation 14 4.8 4.8 signal
202 Hallucination, Auditory 85 4.7 4.7 signal
203 Oral Discomfort 74 4.7 4.7 signal
204 Panic Attack 193 4.6 4.7 signal
205 Loss Of Employment 16 4.6 4.6 signal
206 Product Use Issue 979 4.6 4.8 signal
207 Injection Site Abscess 13 4.6 4.6 signal
208 Facial Bones Fracture 19 4.6 4.6 signal
209 Ligament Rupture 23 4.6 4.6 signal
210 Brain Injury 52 4.5 4.6 signal
211 Concussion 40 4.5 4.5 signal
212 Apathy 75 4.5 4.5 signal
213 Aphthous Stomatitis 12 4.5 4.5 signal
214 Abortion 15 4.5 4.5 signal
215 Tooth Infection 67 4.5 4.5 signal
216 Libido Decreased 62 4.4 4.4 signal
217 Slow Speech 12 4.4 4.4 signal
218 Dependence 274 4.3 4.4 signal
219 Incoherent 32 4.3 4.3 signal
220 Psychotic Symptom 10 4.3 4.3 signal
221 Vomiting Projectile 14 4.3 4.3 signal
222 Oral Pain 110 4.3 4.3 signal
223 Injection Site Necrosis 10 4.3 4.3 signal
224 Biliary Colic 14 4.3 4.3 signal
225 Reading Disorder 11 4.2 4.2 signal
226 Suicidal Behaviour 20 4.2 4.2 signal
227 Anxiety 1,361 4.2 4.4 signal
228 Hallucinations, Mixed 20 4.2 4.2 signal
229 Respiratory Depression 58 4.2 4.2 signal
230 Therapy Cessation 239 4.1 4.1 signal
231 Cleft Palate 9 4.1 4.1 signal
232 Gingivitis 25 4.1 4.1 signal
233 Hypopnoea 16 4.1 4.1 signal
234 Restlessness 169 4.0 4.1 signal
235 Mastication Disorder 14 4.0 4.0 signal
236 Animal Bite 12 4.0 4.0 signal
237 Self-injurious Ideation 19 4.0 4.0 signal
238 Depression 1,034 4.0 4.1 signal
239 Accident At Work 10 4.0 4.0 signal
240 Inappropriate Schedule Of Product Administration 794 3.9 4.0 signal
241 Anxiety Disorder 15 3.9 3.9 signal
242 Food Craving 22 3.9 3.9 signal
243 Pharyngeal Oedema 68 3.8 3.8 signal
244 Hypoaesthesia Oral 65 3.8 3.8 signal
245 Drug Prescribing Error 84 3.8 3.8 signal
246 Impaired Work Ability 92 3.8 3.8 signal
247 Near Death Experience 14 3.8 3.8 signal
248 Bruxism 23 3.7 3.7 signal
249 Hallucination 319 3.7 3.8 signal
250 Feeling Abnormal 1,016 3.7 3.8 signal
251 Neonatal Respiratory Distress Syndrome 15 3.7 3.7 signal
252 Mental Impairment 102 3.7 3.7 signal
253 Pain 2,563 3.7 4.0 signal
254 Serotonin Syndrome 79 3.6 3.6 signal
255 Swollen Tongue 129 3.6 3.6 signal
256 Drug Effect Less Than Expected 58 3.6 3.6 signal
257 Retroperitoneal Haematoma 9 3.6 3.6 signal
258 Product Formulation Issue 27 3.6 3.6 signal
259 Thermal Burn 29 3.6 3.6 signal
260 Maternal Exposure During Breast Feeding 16 3.6 3.6 signal
261 Allergic Reaction To Excipient 8 3.6 3.6 signal
262 Insomnia 1,080 3.6 3.7 signal
263 Lip Blister 11 3.5 3.5 signal
264 Spinal Column Injury 9 3.5 3.5 signal
265 Wrong Technique In Product Usage Process 810 3.5 3.6 signal
266 Anger 136 3.5 3.5 signal
267 Dissociation 30 3.5 3.5 signal
268 Hepatic Pain 17 3.5 3.5 signal
269 Lumbar Vertebral Fracture 18 3.5 3.5 signal
270 Intervertebral Disc Disorder 17 3.5 3.5 signal
271 Affective Disorder 31 3.5 3.5 signal
272 Irritability 238 3.5 3.5 signal
273 Stomatitis 237 3.4 3.4 signal
274 Quality Of Life Decreased 52 3.4 3.4 signal
275 Back Disorder 63 3.4 3.4 signal
276 Pancreatitis Chronic 9 3.4 3.4 signal
277 Speech Disorder Developmental 11 3.3 3.3 signal
278 Foetal Growth Restriction 23 3.3 3.3 signal
279 Rib Fracture 77 3.3 3.3 signal
280 Abscess Limb 16 3.3 3.3 signal
281 Intentional Product Use Issue 328 3.3 3.3 signal
282 Decreased Interest 22 3.3 3.3 signal
283 Premature Rupture Of Membranes 9 3.3 3.3 signal
284 Feeling Cold 103 3.2 3.2 signal
285 Psychotic Disorder 109 3.2 3.2 signal
286 Hangover 13 3.2 3.2 signal
287 Injection Site Infection 12 3.2 3.2 signal
288 Urine Analysis Abnormal 11 3.2 3.2 signal
289 Oedema Mouth 12 3.2 3.2 signal
290 Retching 77 3.2 3.2 signal
291 Feeling Drunk 27 3.2 3.2 signal
292 Muscle Twitching 83 3.1 3.2 signal
293 Oligohydramnios 12 3.1 3.1 signal
294 Appendicitis Perforated 9 3.1 3.1 signal
295 Talipes 11 3.1 3.1 signal
296 Thinking Abnormal 66 3.1 3.1 signal
297 Unevaluable Event 266 3.1 3.1 signal
298 Stillbirth 17 3.1 3.1 signal
299 Obsessive-compulsive Disorder 28 3.0 3.0 signal
300 Crying 126 3.0 3.0 signal
301 Hypoxic-ischaemic Encephalopathy 9 3.0 3.0 signal
302 Behaviour Disorder 18 3.0 3.0 signal
303 Intervertebral Disc Protrusion 74 3.0 3.0 signal
304 Sneezing 75 2.9 2.9 signal
305 Hormone Level Abnormal 16 2.9 2.9 signal
306 Oral Infection 13 2.9 2.9 signal
307 Mouth Swelling 19 2.9 2.9 signal
308 Drug Level Above Therapeutic 15 2.9 2.9 signal
309 Abdominal Hernia 15 2.9 2.9 signal
310 Fluid Intake Reduced 16 2.8 2.8 signal
311 Arthritis Infective 15 2.8 2.8 signal
312 Intervertebral Disc Degeneration 30 2.8 2.8 signal
313 Skin Abrasion 15 2.8 2.8 signal
314 Cervical Vertebral Fracture 11 2.8 2.8 signal
315 Hallucination, Visual 67 2.8 2.8 signal
316 Accident 38 2.8 2.8 signal
317 Activities Of Daily Living Impaired 64 2.8 2.8 signal
318 Procedural Pain 88 2.8 2.8 signal
319 Forced Expiratory Volume Decreased 9 2.8 2.8 signal
320 Suicide Attempt 191 2.8 2.8 signal
321 Impaired Quality Of Life 45 2.7 2.7 signal
322 Clavicle Fracture 12 2.7 2.7 signal
323 Cerebral Disorder 23 2.7 2.7 signal
324 Therapy Change 30 2.7 2.7 signal
325 Salivary Hypersecretion 31 2.7 2.7 signal
326 Sleep Apnoea Syndrome 59 2.7 2.7 signal
327 Loss Of Consciousness 394 2.7 2.7 signal
328 Potentiating Drug Interaction 10 2.7 2.7 signal
329 Unresponsive To Stimuli 78 2.7 2.7 signal
330 Drug Level Decreased 31 2.7 2.7 signal
331 Gingival Pain 24 2.6 2.6 signal
332 Sexual Dysfunction 35 2.6 2.6 signal
333 Personality Change 28 2.6 2.6 signal
334 Vitamin B12 Deficiency 12 2.6 2.6 signal
335 Enuresis 12 2.6 2.6 signal
336 Spinal Disorder 28 2.6 2.6 signal
337 Endometriosis 14 2.6 2.6 signal
338 Fear 79 2.6 2.6 signal
339 Panic Reaction 21 2.6 2.6 signal
340 Tremor 484 2.5 2.6 signal
341 Amnesia 190 2.5 2.6 signal
342 Drug Ineffective For Unapproved Indication 162 2.5 2.6 signal
343 Joint Injury 62 2.5 2.5 signal
344 Malabsorption 15 2.5 2.5 signal
345 Disturbance In Attention 156 2.5 2.5 signal
346 Priapism 10 2.5 2.5 signal
347 Vomiting 1,344 2.5 2.6 signal
348 Exposure During Pregnancy 178 2.5 2.5 signal
349 Mood Swings 91 2.5 2.5 signal
350 Sleep Terror 12 2.5 2.5 signal
351 Gallbladder Disorder 51 2.5 2.5 signal
352 Adverse Event 261 2.5 2.5 signal
353 Hand Fracture 20 2.5 2.5 signal
354 Muscle Contractions Involuntary 10 2.5 2.5 signal
355 Injury 199 2.5 2.5 signal
356 Inadequate Analgesia 24 2.4 2.5 signal
357 Limb Injury 75 2.4 2.4 signal
358 Faecaloma 15 2.4 2.4 signal
359 Migraine 261 2.4 2.4 signal
360 Psychological Trauma 24 2.4 2.4 signal
361 Dysphemia 12 2.4 2.4 signal
362 Rotator Cuff Syndrome 35 2.4 2.4 signal
363 Psychiatric Symptom 20 2.4 2.4 signal
364 Iron Deficiency 12 2.4 2.4 signal
365 Somnolence 542 2.4 2.4 signal
366 Physical Disability 12 2.4 2.4 signal
367 Nervousness 141 2.4 2.4 signal
368 Plantar Fasciitis 9 2.3 2.3 signal
369 Feeling Jittery 51 2.3 2.3 signal
370 Pregnancy 54 2.3 2.3 signal
371 Economic Problem 41 2.3 2.3 signal
372 Toxicity To Various Agents 446 2.3 2.4 signal
373 Agitation 195 2.3 2.3 signal
374 Ankle Fracture 41 2.3 2.3 signal
375 Carpal Tunnel Syndrome 37 2.3 2.3 signal
376 Face Injury 10 2.3 2.3 signal
377 Head Injury 83 2.3 2.3 signal
378 Aphthous Ulcer 20 2.3 2.3 signal
379 Dysuria 96 2.3 2.3 signal
380 Hyperreflexia 9 2.3 2.3 signal
381 Tooth Extraction 32 2.2 2.3 signal
382 Mouth Ulceration 54 2.2 2.3 signal
383 Joint Dislocation 27 2.2 2.2 signal
384 Nightmare 89 2.2 2.2 signal
385 Upper Limb Fracture 51 2.2 2.2 signal
386 Lethargy 146 2.2 2.2 signal
387 Sedation 66 2.2 2.2 signal
388 Foot Fracture 48 2.2 2.2 signal
389 Accidental Overdose 92 2.2 2.2 signal
390 Nerve Injury 28 2.2 2.2 signal
391 Wrist Fracture 30 2.2 2.2 signal
392 Screaming 16 2.2 2.2 signal
393 Abnormal Behaviour 99 2.2 2.2 signal
394 Apparent Death 9 2.2 2.2 signal
395 Prescription Drug Used Without A Prescription 15 2.2 2.2 signal
396 Emotional Disorder 76 2.1 2.1 signal
397 Loss Of Libido 22 2.1 2.1 signal
398 Erectile Dysfunction 63 2.1 2.1 signal
399 Laceration 23 2.1 2.1 signal
400 Off Label Use 2,075 2.1 2.2 signal
401 Delusion 37 2.1 2.1 signal
402 Nerve Compression 22 2.1 2.1 signal
403 Ovarian Cyst 24 2.1 2.1 signal
404 Snoring 9 2.1 2.1 signal
405 Seizure 273 2.1 2.1 signal
406 Mental Status Changes 66 2.1 2.1 signal
407 Underdose 173 2.1 2.1 signal
408 Dysphoria 12 2.1 2.1 signal
409 Lower Limb Fracture 45 2.1 2.1 signal
410 Loss Of Personal Independence In Daily Activities 111 2.0 2.0 signal
411 Sciatica 37 2.0 2.0 signal
412 Oesophageal Disorder 9 2.0 2.0 no signal
413 Oedema Peripheral 285 2.0 2.1 signal
414 Hypersomnia 66 2.0 2.0 signal
415 Prostatomegaly 9 2.0 2.0 no signal
416 Cervix Carcinoma 9 2.0 2.0 no signal
417 Dysarthria 86 2.0 2.0 signal
418 Product Substitution Issue 131 2.0 2.0 no signal
419 Sluggishness 23 2.0 2.0 no signal
420 Fibromyalgia 55 2.0 2.0 no signal
421 Mydriasis 29 2.0 2.0 no signal
422 Scoliosis 14 2.0 2.0 no signal
423 Appendicectomy 8 2.0 2.0 no signal
424 Spinal Fusion Surgery 9 2.0 2.0 no signal
425 Hiccups 18 1.9 1.9 no signal
426 Abnormal Dreams 61 1.9 1.9 no signal
427 Urinary Retention 73 1.9 1.9 no signal
428 Self-medication 9 1.9 1.9 no signal
429 Leg Amputation 9 1.9 1.9 no signal
430 Schizophrenia 26 1.9 1.9 no signal
431 Skin Laceration 23 1.9 1.9 no signal
432 Trismus 11 1.9 1.9 no signal
433 Gestational Diabetes 10 1.9 1.9 no signal
434 Tibia Fracture 10 1.9 1.9 no signal
435 Constipation 458 1.9 1.9 no signal
436 Hyperthermia 16 1.9 1.9 no signal
437 Meniscus Injury 13 1.8 1.8 no signal
438 Nausea 1,649 1.8 1.9 no signal
439 Product Taste Abnormal 28 1.8 1.8 no signal
440 Breast Mass 14 1.8 1.8 no signal
441 Ocular Icterus 9 1.8 1.8 no signal
442 Hyperventilation 12 1.8 1.8 no signal
443 Food Poisoning 11 1.8 1.8 no signal
444 Poor Quality Sleep 44 1.8 1.8 no signal
445 Caesarean Section 24 1.8 1.8 no signal
446 Drooling 14 1.8 1.8 no signal
447 Renal Tubular Necrosis 20 1.8 1.8 no signal
448 Mood Altered 55 1.8 1.8 no signal
449 Chills 237 1.8 1.8 no signal
450 Ulcer 32 1.8 1.8 no signal
451 Autoimmune Disorder 19 1.7 1.7 no signal
452 Inguinal Hernia 12 1.7 1.7 no signal
453 Affect Lability 19 1.7 1.7 no signal
454 Aggression 98 1.7 1.7 no signal
455 Lacrimation Increased 58 1.7 1.7 no signal
456 Weight Fluctuation 20 1.7 1.7 no signal
457 Skin Tightness 9 1.7 1.7 no signal
458 Musculoskeletal Discomfort 33 1.7 1.7 no signal
459 Decreased Appetite 442 1.7 1.7 no signal
460 Nicotine Dependence 15 1.7 1.7 no signal
461 Arthropod Bite 14 1.7 1.7 no signal
462 Renal Pain 20 1.7 1.7 no signal
463 Mania 31 1.7 1.7 no signal
464 Kidney Infection 37 1.7 1.7 no signal
465 Back Pain 438 1.6 1.7 no signal
466 Pharyngeal Swelling 18 1.6 1.6 no signal
467 Subcutaneous Abscess 9 1.6 1.6 no signal
468 Hernia 36 1.6 1.6 no signal
469 Frustration Tolerance Decreased 15 1.6 1.6 no signal
470 Dry Mouth 151 1.6 1.6 no signal
471 Depressed Mood 98 1.6 1.6 no signal
472 Throat Tightness 50 1.6 1.6 no signal
473 Rhinorrhoea 119 1.6 1.6 no signal
474 Faecal Incontinence 9 1.6 1.6 no signal
475 Aphagia 9 1.6 1.6 no signal
476 Appetite Disorder 12 1.6 1.6 no signal
477 Application Site Vesicles 12 1.6 1.6 no signal
478 Arthropathy 102 1.6 1.6 no signal
479 Hepatomegaly 18 1.6 1.6 no signal
480 Brain Oedema 23 1.6 1.6 no signal
481 Grand Mal Convulsion 17 1.6 1.6 no signal
482 Speech Disorder 95 1.6 1.6 no signal
483 Dyskinesia 73 1.6 1.6 no signal
484 Aneurysm 9 1.6 1.6 no signal
485 Delirium 62 1.6 1.6 no signal
486 Headache 1,122 1.6 1.6 no signal
487 Hospitalisation 273 1.6 1.6 no signal
488 Eating Disorder 38 1.6 1.6 no signal
489 Mouth Haemorrhage 13 1.6 1.6 no signal
490 Stress 126 1.5 1.5 no signal
491 Nephrolithiasis 80 1.5 1.5 no signal
492 Parkinsonism 17 1.5 1.5 no signal
493 Cellulitis 87 1.5 1.5 no signal
494 Contraindicated Product Administered 52 1.5 1.5 no signal
495 Cyanosis 27 1.5 1.5 no signal
496 Flank Pain 16 1.5 1.5 no signal
497 Neck Pain 95 1.5 1.5 no signal
498 Product Administration Interrupted 13 1.5 1.5 no signal
499 Localised Infection 41 1.5 1.5 no signal
500 Disorientation 67 1.5 1.5 no signal
501 Emphysema 17 1.5 1.5 no signal
502 Muscle Atrophy 21 1.5 1.5 no signal
503 Poisoning 21 1.5 1.5 no signal
504 Staphylococcal Infection 55 1.5 1.5 no signal
505 Gastroenteritis Viral 30 1.4 1.4 no signal
506 Malaise 728 1.4 1.5 no signal
507 Feeding Disorder 33 1.4 1.4 no signal
508 Neuralgia 40 1.4 1.4 no signal
509 Drug Level Below Therapeutic 9 1.4 1.4 no signal
510 Renal Cyst 13 1.4 1.4 no signal
511 Scar 28 1.4 1.4 no signal
512 Respiratory Distress 45 1.4 1.4 no signal
513 Product Prescribing Issue 33 1.4 1.4 no signal
514 Muscle Strain 14 1.4 1.4 no signal
515 Appendicitis 15 1.4 1.4 no signal
516 Intentional Self-injury 32 1.4 1.4 no signal
517 Hyperaesthesia 13 1.4 1.4 no signal
518 Oedema 85 1.4 1.4 no signal
519 Spinal Operation 19 1.4 1.4 no signal
520 Sleep Disorder 109 1.4 1.4 no signal
521 Photophobia 29 1.4 1.4 no signal
522 Small Intestinal Obstruction 19 1.4 1.4 no signal
523 Anhedonia 41 1.4 1.4 no signal
524 Drug Effect Incomplete 57 1.4 1.4 no signal
525 Skin Warm 9 1.4 1.4 no signal
526 Therapeutic Response Decreased 93 1.3 1.4 no signal
527 Weight Decreased 427 1.3 1.3 no signal
528 Hot Flush 115 1.3 1.3 no signal
529 Bedridden 20 1.3 1.3 no signal
530 Product Dispensing Error 33 1.3 1.3 no signal
531 Dysgeusia 113 1.3 1.3 no signal
532 Coordination Abnormal 21 1.3 1.3 no signal
533 Illness 150 1.3 1.3 no signal
534 Abdominal Discomfort 249 1.3 1.3 no signal
535 Coma 71 1.3 1.3 no signal
536 Confusional State 241 1.3 1.3 no signal
537 Discomfort 90 1.3 1.3 no signal
538 Drug Dispensing Error 23 1.3 1.3 no signal
539 Muscle Tightness 24 1.3 1.3 no signal
540 Muscle Spasms 272 1.3 1.3 no signal
541 Abdominal Pain Upper 303 1.3 1.3 no signal
542 Cardiac Disorder 138 1.3 1.3 no signal
543 Hypersensitivity 272 1.3 1.3 no signal
544 Spinal Fracture 29 1.3 1.3 no signal
545 Heart Rate Increased 144 1.3 1.3 no signal
546 Memory Impairment 200 1.3 1.3 no signal
547 Hypokinesia 21 1.3 1.3 no signal
548 Bowel Movement Irregularity 11 1.3 1.3 no signal
549 Abscess 23 1.3 1.3 no signal
550 Candida Infection 24 1.3 1.3 no signal
551 Osteomyelitis 26 1.3 1.3 no signal
552 Cholecystitis 17 1.3 1.3 no signal
553 Thyroid Disorder 22 1.2 1.2 no signal
554 Condition Aggravated 430 1.2 1.2 no signal
555 Gastrooesophageal Reflux Disease 114 1.2 1.2 no signal
556 Ligament Sprain 14 1.2 1.2 no signal
557 Chromaturia 32 1.2 1.2 no signal
558 Influenza Like Illness 117 1.2 1.2 no signal
559 Jaundice 38 1.2 1.2 no signal
560 Post Procedural Complication 27 1.2 1.2 no signal
561 Palpitations 164 1.2 1.2 no signal
562 Drug Interaction 220 1.2 1.2 no signal
563 Oral Candidiasis 18 1.2 1.2 no signal
564 Bone Loss 21 1.2 1.2 no signal
565 Drug Intolerance 133 1.2 1.2 no signal
566 Extra Dose Administered 55 1.2 1.2 no signal
567 Cardiomegaly 17 1.2 1.2 no signal
568 Uterine Leiomyoma 10 1.2 1.2 no signal
569 Pulmonary Congestion 18 1.2 1.2 no signal
570 Anal Incontinence 12 1.2 1.2 no signal
571 Facial Pain 12 1.2 1.2 no signal
572 Respiratory Arrest 37 1.2 1.2 no signal
573 Parosmia 10 1.2 1.2 no signal
574 Incorrect Route Of Drug Administration 48 1.2 1.2 no signal
575 Hypoaesthesia 198 1.2 1.2 no signal
576 Adverse Drug Reaction 118 1.2 1.2 no signal
577 Exostosis 12 1.1 1.1 no signal
578 Night Sweats 42 1.1 1.1 no signal
579 Pancreatitis 69 1.1 1.1 no signal
580 Generalised Oedema 16 1.1 1.1 no signal
581 Fall 430 1.1 1.1 no signal
582 Middle Insomnia 24 1.1 1.1 no signal
583 Feeling Hot 79 1.1 1.1 no signal
584 Pelvic Fracture 10 1.1 1.1 no signal
585 Mass 18 1.1 1.1 no signal
586 Hepatic Cirrhosis 24 1.1 1.1 no signal
587 Generalised Tonic-clonic Seizure 21 1.1 1.1 no signal
588 Insurance Issue 19 1.1 1.1 no signal
589 Treatment Noncompliance 69 1.1 1.1 no signal
590 Obstructive Airways Disorder 14 1.1 1.1 no signal
591 Paraesthesia Oral 18 1.1 1.1 no signal
592 Chest Pain 232 1.1 1.1 no signal
593 Incorrect Route Of Product Administration 21 1.1 1.1 no signal
594 Atrial Flutter 10 1.1 1.1 no signal
595 Bone Pain 73 1.1 1.1 no signal
596 Liver Disorder 55 1.1 1.1 no signal
597 Drug Administered To Patient Of Inappropriate Age 9 1.1 1.1 no signal
598 Choking 24 1.1 1.1 no signal
599 Drug Toxicity 17 1.1 1.1 no signal
600 Inappropriate Schedule Of Drug Administration 87 1.1 1.1 no signal
601 Product Administration Error 24 1.1 1.1 no signal
602 Live Birth 10 1.0 1.0 no signal
603 Amenorrhoea 20 1.0 1.0 no signal
604 Cholelithiasis 39 1.0 1.0 no signal
605 Local Swelling 21 1.0 1.0 no signal
606 Asthenia 446 1.0 1.0 no signal
607 Urticaria 195 1.0 1.0 no signal
608 Swelling Face 76 1.0 1.0 no signal
609 Liver Injury 28 1.0 1.0 no signal
610 Injection Site Induration 15 1.0 1.0 no signal
611 Pain In Extremity 341 1.0 1.0 no signal
612 Rhabdomyolysis 48 1.0 1.0 no signal
613 Tinnitus 53 1.0 1.0 no signal
614 Chronic Obstructive Pulmonary Disease 60 1.0 1.0 no signal
615 Cardiac Murmur 10 1.0 1.0 no signal
616 Swelling 107 1.0 1.0 no signal
617 Haematemesis 29 1.0 1.0 no signal
618 Cognitive Disorder 53 1.0 1.0 no signal
619 Hepatic Enzyme Increased 77 1.0 1.0 no signal
620 Incontinence 12 1.0 1.0 no signal
621 Spinal Osteoarthritis 10 1.0 1.0 no signal
622 Pain In Jaw 32 1.0 1.0 no signal
623 Injection Site Extravasation 14 1.0 1.0 no signal
624 Gastrointestinal Disorder 99 1.0 1.0 no signal
625 Depressed Level Of Consciousness 44 1.0 1.0 no signal
626 Intentional Overdose 71 1.0 1.0 no signal
627 Vision Blurred 152 1.0 1.0 no signal
628 Dehydration 148 1.0 1.0 no signal
629 Pharyngitis Streptococcal 12 1.0 1.0 no signal
630 Body Temperature Decreased 11 1.0 1.0 no signal
631 Shock Haemorrhagic 9 1.0 1.0 no signal
632 Muscle Disorder 9 1.0 1.0 no signal
633 Heart Rate Decreased 39 1.0 1.0 no signal
634 Acute Hepatic Failure 15 1.0 1.0 no signal
635 Heart Rate Irregular 25 1.0 1.0 no signal
636 Hepatic Failure 33 1.0 1.0 no signal
637 Gastric Disorder 38 1.0 1.0 no signal
638 Abdominal Pain 253 1.0 1.0 no signal
639 Nervous System Disorder 34 0.9 0.9 no signal
640 Blood Thyroid Stimulating Hormone Increased 10 0.9 0.9 no signal
641 Blister 60 0.9 0.9 no signal
642 Thirst 19 0.9 0.9 no signal
643 Increased Appetite 20 0.9 0.9 no signal
644 Micturition Urgency 12 0.9 0.9 no signal
645 Fracture 20 0.9 0.9 no signal
646 Adverse Reaction 14 0.9 0.9 no signal
647 Cyst 13 0.9 0.9 no signal
648 Hysterectomy 9 0.9 0.9 no signal
649 Weight Increased 232 0.9 0.9 no signal
650 Hunger 14 0.9 0.9 no signal
651 Intestinal Obstruction 39 0.9 0.9 no signal
652 Haemoptysis 29 0.9 0.9 no signal
653 Therapeutic Response Shortened 33 0.9 0.9 no signal
654 Completed Suicide 87 0.9 0.9 no signal
655 Bone Disorder 19 0.9 0.9 no signal
656 Renal Disorder 48 0.9 0.9 no signal
657 Vitamin D Deficiency 10 0.9 0.9 no signal
658 Musculoskeletal Pain 54 0.9 0.9 no signal
659 Impaired Gastric Emptying 13 0.9 0.9 no signal
660 Inability To Afford Medication 10 0.9 0.9 no signal
661 Peripheral Swelling 156 0.9 0.9 no signal
662 Urinary Incontinence 30 0.9 0.9 no signal
663 Dizziness 503 0.9 0.9 no signal
664 Gastrointestinal Infection 9 0.9 0.9 no signal
665 Fatigue 782 0.9 0.9 no signal
666 Gastrointestinal Pain 11 0.9 0.9 no signal
667 Ageusia 25 0.9 0.9 no signal
668 Hypertension 210 0.9 0.9 no signal
669 Arthritis 78 0.9 0.9 no signal
670 Diarrhoea 635 0.9 0.9 no signal
671 Intestinal Perforation 11 0.9 0.9 no signal
672 Asphyxia 8 0.9 0.9 no signal
673 Abnormal Faeces 8 0.9 0.9 no signal
674 Paralysis 14 0.9 0.9 no signal
675 Burning Sensation 68 0.8 0.8 no signal
676 Dermatitis Contact 11 0.8 0.8 no signal
677 Cholecystectomy 11 0.8 0.8 no signal
678 Product Dose Omission In Error 26 0.8 0.8 no signal
679 Rash Pruritic 52 0.8 0.8 no signal
680 Hepatic Encephalopathy 9 0.8 0.8 no signal
681 Brain Fog 14 0.8 0.8 no signal
682 Lymphadenopathy 34 0.8 0.8 no signal
683 Blood Pressure Abnormal 19 0.8 0.8 no signal
684 Pruritus Generalised 21 0.8 0.8 no signal
685 Electrolyte Imbalance 11 0.8 0.8 no signal
686 Visual Impairment 117 0.8 0.8 no signal
687 Gingival Bleeding 13 0.8 0.8 no signal
688 Dizziness Postural 9 0.8 0.8 no signal
689 Irritable Bowel Syndrome 20 0.8 0.8 no signal
690 Vertigo 57 0.8 0.8 no signal
691 Blood Iron Decreased 11 0.8 0.8 no signal
692 Drug Administration Error 29 0.8 0.8 no signal
693 Gait Disturbance 178 0.8 0.8 no signal
694 Dystonia 18 0.8 0.8 no signal
695 Aspiration 10 0.8 0.8 no signal
696 Laryngitis 10 0.8 0.8 no signal
697 Ankylosing Spondylitis 12 0.8 0.8 no signal
698 Osteoarthritis 39 0.8 0.8 no signal
699 Pallor 25 0.8 0.8 no signal
700 Pulmonary Thrombosis 10 0.8 0.8 no signal
701 Surgery 53 0.8 0.8 no signal
702 Intentional Dose Omission 25 0.8 0.8 no signal
703 Gastritis 24 0.8 0.8 no signal
704 Musculoskeletal Stiffness 80 0.8 0.8 no signal
705 Blood Pressure Increased 139 0.8 0.8 no signal
706 Dyspnoea 512 0.8 0.8 no signal
707 Product Physical Issue 18 0.8 0.8 no signal
708 Lip Swelling 30 0.8 0.8 no signal
709 Pneumonia 291 0.8 0.8 no signal
710 Wound 25 0.8 0.8 no signal
711 Frequent Bowel Movements 24 0.8 0.8 no signal
712 Motor Dysfunction 9 0.8 0.8 no signal
713 Fistula 10 0.8 0.8 no signal
714 Application Site Irritation 11 0.8 0.8 no signal
715 Initial Insomnia 9 0.8 0.8 no signal
716 Body Temperature Increased 18 0.8 0.8 no signal
717 Akathisia 12 0.8 0.8 no signal
718 Lung Disorder 43 0.8 0.8 no signal
719 Gait Inability 29 0.8 0.8 no signal
720 Pulmonary Mass 13 0.8 0.8 no signal
721 Movement Disorder 28 0.8 0.8 no signal
722 Blood Pressure Systolic Increased 17 0.8 0.8 no signal
723 Dysphagia 82 0.8 0.8 no signal
724 Menstruation Delayed 9 0.8 0.8 no signal
725 Blood Potassium Decreased 26 0.8 0.8 no signal
726 Diabetes Mellitus 66 0.8 0.8 no signal
727 Aphasia 26 0.8 0.8 no signal
728 Cardiac Arrest 71 0.7 0.7 no signal
729 Arteriosclerosis 8 0.7 0.7 no signal
730 General Physical Health Deterioration 97 0.7 0.7 no signal
731 Gastric Ulcer 16 0.7 0.7 no signal
732 Decreased Activity 9 0.7 0.7 no signal
733 Hypoacusis 36 0.7 0.7 no signal
734 Supraventricular Tachycardia 8 0.7 0.7 no signal
735 Musculoskeletal Disorder 16 0.7 0.7 no signal
736 Immune System Disorder 11 0.7 0.7 no signal
737 Throat Irritation 37 0.7 0.7 no signal
738 Knee Operation 8 0.7 0.7 no signal
739 Ear Pain 16 0.7 0.7 no signal
740 Chronic Kidney Disease 63 0.7 0.7 no signal
741 Dysstasia 24 0.7 0.7 no signal
742 Epilepsy 25 0.7 0.7 no signal
743 Myalgia 138 0.7 0.7 no signal
744 Bradycardia 43 0.7 0.7 no signal
745 Fluid Retention 41 0.7 0.7 no signal
746 Oxygen Saturation Decreased 45 0.7 0.7 no signal
747 Paraesthesia 127 0.7 0.7 no signal
748 Bladder Disorder 8 0.7 0.7 no signal
749 Pulmonary Oedema 36 0.7 0.7 no signal
750 Pneumonia Aspiration 20 0.7 0.7 no signal
751 Rash Generalised 21 0.7 0.7 no signal
752 Peripheral Coldness 11 0.7 0.7 no signal
753 Balance Disorder 69 0.7 0.7 no signal
754 Eye Disorder 26 0.7 0.7 no signal
755 Tachycardia 70 0.7 0.7 no signal
756 Influenza 88 0.7 0.7 no signal
757 Drug Level Increased 13 0.7 0.7 no signal
758 Eye Swelling 29 0.7 0.7 no signal
759 Subarachnoid Haemorrhage 8 0.7 0.7 no signal
760 Neoplasm 9 0.7 0.7 no signal
761 Hip Fracture 25 0.7 0.7 no signal
762 Oropharyngeal Pain 72 0.7 0.7 no signal
763 Encephalopathy 19 0.7 0.7 no signal
764 Rash Macular 27 0.7 0.7 no signal
765 Skin Ulcer 20 0.7 0.7 no signal
766 Tardive Dyskinesia 22 0.7 0.7 no signal
767 Application Site Pain 17 0.7 0.7 no signal
768 Myocardial Infarction 135 0.7 0.7 no signal
769 Systemic Lupus Erythematosus 27 0.7 0.7 no signal
770 Skin Discolouration 35 0.7 0.7 no signal
771 Neuropathy Peripheral 72 0.7 0.7 no signal
772 Brain Neoplasm 7 0.7 0.7 no signal
773 Contusion 73 0.7 0.7 no signal
774 Syncope 76 0.7 0.7 no signal
775 Ataxia 9 0.7 0.7 no signal
776 Myoclonus 9 0.7 0.7 no signal
777 Gastroenteritis 11 0.7 0.7 no signal
778 Bacterial Infection 14 0.7 0.7 no signal
779 Arthralgia 312 0.7 0.7 no signal
780 Muscle Rigidity 9 0.7 0.7 no signal
781 Menorrhagia 15 0.7 0.7 no signal
782 Rash 326 0.7 0.7 no signal
783 Cystitis 24 0.7 0.7 no signal
784 Hyperglycaemia 27 0.6 0.6 no signal
785 Hepatitis 19 0.6 0.6 no signal
786 Head Discomfort 13 0.6 0.6 no signal
787 Colon Cancer 11 0.6 0.6 no signal
788 Skin Lesion 20 0.6 0.6 no signal
789 Dyspepsia 72 0.6 0.6 no signal
790 Respiratory Disorder 22 0.6 0.6 no signal
791 No Therapeutic Response 9 0.6 0.6 no signal
792 Tendon Rupture 9 0.6 0.6 no signal
793 Inflammation 37 0.6 0.6 no signal
794 Pollakiuria 30 0.6 0.6 no signal
795 Malnutrition 8 0.6 0.6 no signal
796 Skin Infection 8 0.6 0.6 no signal
797 Respiratory Failure 52 0.6 0.6 no signal
798 Limb Discomfort 22 0.6 0.6 no signal
799 Hypophagia 18 0.6 0.6 no signal
800 Face Oedema 12 0.6 0.6 no signal
801 Blood Pressure Fluctuation 17 0.6 0.6 no signal
802 Asthma 79 0.6 0.6 no signal
803 Renal Failure 94 0.6 0.6 no signal
804 Taste Disorder 14 0.6 0.6 no signal
805 Hypotonia 7 0.6 0.6 no signal
806 Blindness 28 0.6 0.6 no signal
807 Vasculitis 8 0.6 0.6 no signal
808 Dysphonia 40 0.6 0.6 no signal
809 Spinal Pain 8 0.6 0.6 no signal
810 Nasopharyngitis 126 0.6 0.6 no signal
811 Vaginal Haemorrhage 29 0.6 0.6 no signal
812 Sepsis 76 0.6 0.6 no signal
813 Anaphylactic Reaction 37 0.6 0.6 no signal
814 Joint Swelling 81 0.6 0.6 no signal
815 Malignant Melanoma 9 0.6 0.6 no signal
816 Tenderness 7 0.6 0.6 no signal
817 Impaired Healing 22 0.6 0.6 no signal
818 Haemorrhoids 13 0.6 0.6 no signal
819 Therapeutic Product Effect Incomplete 47 0.6 0.6 no signal
820 Abdominal Distension 69 0.6 0.6 no signal
821 Viral Infection 22 0.6 0.6 no signal
822 Pelvic Pain 12 0.6 0.6 no signal
823 Diplopia 17 0.6 0.6 no signal
824 Retinal Detachment 6 0.6 0.6 no signal
825 Ileus 8 0.6 0.6 no signal
826 White Blood Cell Count Increased 25 0.6 0.6 no signal
827 Clostridium Difficile Infection 14 0.6 0.6 no signal
828 Aphonia 9 0.6 0.6 no signal
829 Hepatic Steatosis 12 0.6 0.6 no signal
830 Acute Kidney Injury 98 0.6 0.6 no signal
831 Herpes Zoster 37 0.6 0.6 no signal
832 Pharyngitis 8 0.6 0.6 no signal
833 Abasia 16 0.6 0.6 no signal
834 Disseminated Intravascular Coagulation 9 0.6 0.6 no signal
835 Blood Glucose Fluctuation 7 0.6 0.6 no signal
836 Sinus Tachycardia 9 0.6 0.6 no signal
837 Skin Disorder 21 0.6 0.6 no signal
838 Pneumothorax 10 0.6 0.6 no signal
839 Chest Discomfort 64 0.5 0.5 no signal
840 Muscular Weakness 71 0.5 0.5 no signal
841 Rash Papular 14 0.5 0.5 no signal
842 Tuberculosis 8 0.5 0.5 no signal
843 Acute Respiratory Distress Syndrome 11 0.5 0.5 no signal
844 Rash Erythematous 29 0.5 0.5 no signal
845 Pulmonary Embolism 59 0.5 0.5 no signal
846 Scab 7 0.5 0.5 no signal
847 Pruritus 233 0.5 0.5 no signal
848 Vitreous Floaters 6 0.5 0.5 no signal
849 Nodule 8 0.5 0.5 no signal
850 Arrhythmia 29 0.5 0.5 no signal
851 Osteoporosis 25 0.5 0.5 no signal
852 Bronchitis 45 0.5 0.5 no signal
853 Multiple Fractures 10 0.5 0.5 no signal
854 Menstruation Irregular 16 0.5 0.5 no signal
855 Ear Infection 16 0.5 0.5 no signal
856 Expired Product Administered 20 0.5 0.5 no signal
857 Drug Hypersensitivity 117 0.5 0.5 no signal
858 Septic Shock 26 0.5 0.5 no signal
859 Cerebrovascular Accident 102 0.5 0.5 no signal
860 Hypoxia 21 0.5 0.5 no signal
861 Eyelid Oedema 7 0.5 0.5 no signal
862 End Stage Renal Disease 11 0.5 0.5 no signal
863 Hypothyroidism 19 0.5 0.5 no signal
864 Erythema 122 0.5 0.5 no signal
865 Device Failure 9 0.5 0.5 no signal
866 Abdominal Pain Lower 15 0.5 0.5 no signal
867 Sinus Congestion 8 0.5 0.5 no signal
868 Dry Throat 6 0.5 0.5 no signal
869 Mobility Decreased 42 0.5 0.5 no signal
870 Ear Discomfort 6 0.5 0.5 no signal
871 Drug Effect Decreased 32 0.5 0.5 no signal
872 Product Use Complaint 9 0.5 0.5 no signal
873 Bursitis 7 0.5 0.5 no signal
874 Scratch 6 0.5 0.5 no signal
875 Blood Urine Present 11 0.5 0.5 no signal
876 Skeletal Injury 6 0.5 0.5 no signal
877 Blindness Unilateral 8 0.5 0.5 no signal
878 Flatulence 32 0.5 0.5 no signal
879 Pyrexia 193 0.5 0.5 no signal
880 Body Height Decreased 6 0.5 0.5 no signal
881 Sinus Disorder 11 0.5 0.5 no signal
882 Deep Vein Thrombosis 36 0.5 0.5 no signal
883 Drug Dose Omission 92 0.5 0.5 no signal
884 Infusion Site Pain 7 0.5 0.5 no signal
885 Liver Function Test Abnormal 16 0.5 0.5 no signal
886 Haematochezia 30 0.5 0.5 no signal
887 Incorrect Product Administration Duration 11 0.5 0.5 no signal
888 Acute Myocardial Infarction 16 0.5 0.5 no signal
889 Hiatus Hernia 7 0.5 0.5 no signal
890 Product Packaging Issue 5 0.5 0.5 no signal
891 Ventricular Fibrillation 6 0.5 0.5 no signal
892 Haematoma 14 0.5 0.5 no signal
893 Ocular Hyperaemia 25 0.5 0.5 no signal
894 Thrombosis 43 0.5 0.5 no signal
895 Product Dose Omission 35 0.5 0.5 no signal
896 Knee Arthroplasty 11 0.5 0.5 no signal
897 Hip Arthroplasty 8 0.5 0.5 no signal
898 Pulmonary Hypertension 11 0.5 0.5 no signal
899 Shock 12 0.5 0.5 no signal
900 Eructation 10 0.5 0.5 no signal
901 Eye Pain 29 0.5 0.5 no signal
902 Internal Haemorrhage 6 0.5 0.5 no signal
903 Glaucoma 10 0.5 0.5 no signal
904 Alopecia 102 0.5 0.5 no signal
905 Musculoskeletal Chest Pain 8 0.5 0.5 no signal
906 Injection Site Mass 19 0.5 0.4 no signal
907 Infection 74 0.4 0.4 no signal
908 Blood Pressure Decreased 34 0.4 0.4 no signal
909 Nasal Congestion 30 0.4 0.4 no signal
910 Madarosis 6 0.4 0.4 no signal
911 Splenomegaly 6 0.4 0.4 no signal
912 Fungal Infection 17 0.4 0.4 no signal
913 Rectal Haemorrhage 22 0.4 0.4 no signal
914 Coeliac Disease 5 0.4 0.4 no signal
915 Coronary Artery Occlusion 7 0.4 0.4 no signal
916 Application Site Rash 7 0.4 0.4 no signal
917 Colitis 19 0.4 0.4 no signal
918 Type 2 Diabetes Mellitus 17 0.4 0.4 no signal
919 Respiratory Tract Congestion 8 0.4 0.4 no signal
920 Drug Ineffective 659 0.4 0.4 no signal
921 Product Administered At Inappropriate Site 9 0.4 0.4 no signal
922 Nocturia 6 0.4 0.4 no signal
923 Hepatocellular Injury 7 0.4 0.4 no signal
924 Wheezing 29 0.4 0.4 no signal
925 Temperature Intolerance 5 0.4 0.4 no signal
926 Product Quality Issue 66 0.4 0.4 no signal
927 Eye Discharge 5 0.4 0.4 no signal
928 Hyperkalaemia 17 0.4 0.4 no signal
929 Acne 37 0.4 0.4 no signal
930 Injection Site Discomfort 5 0.4 0.4 no signal
931 Femur Fracture 15 0.4 0.4 no signal
932 Urinary Tract Infection 82 0.4 0.4 no signal
933 Product Odour Abnormal 5 0.4 0.4 no signal
934 Product Complaint 12 0.4 0.4 no signal
935 Blood Creatine Phosphokinase Increased 14 0.4 0.4 no signal
936 Multiple Sclerosis 23 0.4 0.4 no signal
937 Extrapyramidal Disorder 12 0.4 0.4 no signal
938 Unintended Pregnancy 5 0.4 0.4 no signal
939 Hair Colour Changes 6 0.4 0.4 no signal
940 Upper Respiratory Tract Infection 22 0.4 0.4 no signal
941 Hypotension 95 0.4 0.4 no signal
942 Transient Ischaemic Attack 16 0.4 0.4 no signal
943 Colitis Ulcerative 21 0.4 0.4 no signal
944 Acute Respiratory Failure 9 0.4 0.4 no signal
945 Breast Pain 5 0.4 0.4 no signal
946 Anaphylactic Shock 12 0.4 0.4 no signal
947 Haemorrhage Intracranial 7 0.4 0.4 no signal
948 Haematuria 16 0.4 0.4 no signal
949 Altered State Of Consciousness 10 0.4 0.4 no signal
950 Therapy Interrupted 32 0.4 0.4 no signal
951 Lower Respiratory Tract Infection 21 0.4 0.4 no signal
952 Ocular Discomfort 5 0.4 0.4 no signal
953 Death 394 0.4 0.4 no signal
954 Joint Stiffness 12 0.4 0.4 no signal
955 Cardiac Failure Congestive 37 0.4 0.4 no signal
956 Red Blood Cell Count Decreased 13 0.4 0.4 no signal
957 Blood Triglycerides Increased 8 0.4 0.4 no signal
958 Foot Deformity 5 0.4 0.4 no signal
959 Hypertensive Crisis 5 0.4 0.4 no signal
960 Lung Infection 7 0.4 0.4 no signal
961 Ill-defined Disorder 27 0.4 0.4 no signal
962 Product Dose Omission Issue 124 0.4 0.4 no signal
963 Conjunctivitis 8 0.4 0.4 no signal
964 Sensory Disturbance 7 0.4 0.4 no signal
965 Renal Injury 13 0.4 0.4 no signal
966 Dementia 12 0.4 0.4 no signal
967 Flushing 44 0.4 0.4 no signal
968 Tubulointerstitial Nephritis 8 0.4 0.4 no signal
969 Eye Pruritus 14 0.4 0.4 no signal
970 Productive Cough 20 0.4 0.4 no signal
971 Product Prescribing Error 10 0.4 0.4 no signal
972 Injection Site Pain 127 0.4 0.4 no signal
973 Sinusitis 43 0.4 0.4 no signal
974 Visual Acuity Reduced 14 0.4 0.4 no signal
975 Diabetic Ketoacidosis 10 0.4 0.4 no signal
976 Electrocardiogram Qt Prolonged 15 0.4 0.4 no signal
977 Faeces Discoloured 9 0.4 0.4 no signal
978 Medication Error 23 0.4 0.4 no signal
979 Anosmia 6 0.4 0.4 no signal
980 Presyncope 10 0.4 0.4 no signal
981 Thyroid Cancer 5 0.4 0.4 no signal
982 Oral Herpes 8 0.4 0.4 no signal
983 Secretion Discharge 5 0.4 0.4 no signal
984 Pancreatitis Acute 9 0.4 0.4 no signal
985 Eyelid Ptosis 4 0.3 0.3 no signal
986 Pericardial Effusion 9 0.3 0.3 no signal
987 Injection Site Pruritus 26 0.3 0.3 no signal
988 Blood Count Abnormal 6 0.3 0.3 no signal
989 No Adverse Event 69 0.3 0.3 no signal
990 Hyperbilirubinaemia 4 0.3 0.3 no signal
991 Tendonitis 6 0.3 0.3 no signal
992 Dysmenorrhoea 5 0.3 0.3 no signal
993 Deafness 10 0.3 0.3 no signal
994 Angina Pectoris 11 0.3 0.3 no signal
995 Transfusion 4 0.3 0.3 no signal
996 Rheumatoid Arthritis 43 0.3 0.3 no signal
997 Skin Burning Sensation 27 0.3 0.3 no signal
998 Full Blood Count Abnormal 4 0.3 0.3 no signal
999 Injection Site Reaction 26 0.3 0.3 no signal
1000 Eye Irritation 21 0.3 0.3 no signal
1001 Neoplasm Malignant 25 0.3 0.3 no signal
1002 Sudden Death 4 0.3 0.3 no signal
1003 Blood Glucose Decreased 18 0.3 0.3 no signal
1004 Anaemia 71 0.3 0.3 no signal
1005 Skin Cancer 8 0.3 0.3 no signal
1006 Cataract 22 0.3 0.3 no signal
1007 Diverticulitis 10 0.3 0.3 no signal
1008 Red Blood Cell Sedimentation Rate Increased 4 0.3 0.3 no signal
1009 Accidental Exposure To Product 36 0.3 0.3 no signal
1010 Stevens-johnson Syndrome 8 0.3 0.3 no signal
1011 C-reactive Protein Increased 13 0.3 0.3 no signal
1012 Cough 100 0.3 0.3 no signal
1013 Product Availability Issue 8 0.3 0.3 no signal
1014 Rebound Effect 4 0.3 0.3 no signal
1015 Dry Eye 17 0.3 0.3 no signal
1016 Hypokalaemia 16 0.3 0.3 no signal
1017 Metrorrhagia 6 0.3 0.3 no signal
1018 Respiratory Tract Infection 9 0.3 0.3 no signal
1019 Gastric Haemorrhage 4 0.3 0.3 no signal
1020 Pulmonary Arterial Hypertension 5 0.3 0.3 no signal
1021 Blood Cholesterol Increased 16 0.3 0.3 no signal
1022 Lactic Acidosis 11 0.3 0.3 no signal
1023 Injection Site Haematoma 5 0.3 0.3 no signal
1024 Haemoglobin Decreased 35 0.3 0.3 no signal
1025 Injection Site Warmth 7 0.3 0.3 no signal
1026 Therapeutic Product Effect Decreased 15 0.3 0.3 no signal
1027 Macular Degeneration 4 0.3 0.3 no signal
1028 Disease Recurrence 16 0.3 0.3 no signal
1029 Injection Site Erythema 41 0.3 0.3 no signal
1030 Psoriasis 43 0.3 0.3 no signal
1031 Covid-19 58 0.3 0.3 no signal
1032 Coronary Artery Disease 10 0.3 0.3 no signal
1033 Incorrect Dose Administered 73 0.3 0.3 no signal
1034 Ovarian Cancer 3 0.3 0.3 no signal
1035 Haematotoxicity 3 0.3 0.3 no signal
1036 Lymphoma 5 0.3 0.3 no signal
1037 Diarrhoea Haemorrhagic 3 0.3 0.3 no signal
1038 Epistaxis 24 0.3 0.3 no signal
1039 Deformity 3 0.3 0.3 no signal
1040 Multiple Sclerosis Relapse 22 0.3 0.3 no signal
1041 Leukaemia 3 0.3 0.3 no signal
1042 Skin Fissures 6 0.3 0.3 no signal
1043 Angioedema 14 0.3 0.3 no signal
1044 Sickle Cell Anaemia With Crisis 5 0.3 0.3 no signal
1045 Product Adhesion Issue 11 0.3 0.3 no signal
1046 Cardio-respiratory Arrest 13 0.3 0.3 no signal
1047 Cerebral Haemorrhage 11 0.3 0.3 no signal
1048 Anorexia 4 0.3 0.3 no signal
1049 Treatment Failure 25 0.3 0.3 no signal
1050 Application Site Erythema 8 0.3 0.3 no signal
1051 Complication Associated With Device 4 0.3 0.3 no signal
1052 Cardiac Failure 24 0.3 0.3 no signal
1053 Full Blood Count Decreased 6 0.3 0.3 no signal
1054 Injection Site Rash 9 0.3 0.3 no signal
1055 Pain Of Skin 8 0.3 0.3 no signal
1056 Blood Bilirubin Increased 8 0.3 0.3 no signal
1057 Complication Of Device Removal 5 0.3 0.3 no signal
1058 Blood Creatinine Increased 19 0.3 0.3 no signal
1059 Hypoglycaemia 14 0.3 0.3 no signal
1060 Haemorrhage 30 0.3 0.2 no signal
1061 Syringe Issue 5 0.2 0.2 no signal
1062 Incorrect Drug Administration Duration 8 0.2 0.2 no signal
1063 Renal Failure Acute 12 0.2 0.2 no signal
1064 Injection Site Swelling 21 0.2 0.2 no signal
1065 Skin Exfoliation 23 0.2 0.2 no signal
1066 Cardiovascular Disorder 7 0.2 0.2 no signal
1067 Psoriatic Arthropathy 11 0.2 0.2 no signal
1068 Injection Site Nodule 3 0.2 0.2 no signal
1069 Ascites 8 0.2 0.2 no signal
1070 Osteonecrosis 9 0.2 0.2 no signal
1071 Fluid Overload 4 0.2 0.2 no signal
1072 Blood Glucose Abnormal 5 0.2 0.2 no signal
1073 Therapy Non-responder 12 0.2 0.2 no signal
1074 Circumstance Or Information Capable Of Leading To Medication Error 9 0.2 0.2 no signal
1075 Breast Cancer 25 0.2 0.2 no signal
1076 Myocarditis 3 0.2 0.2 no signal
1077 Leukopenia 13 0.2 0.2 no signal
1078 Breast Cancer Female 7 0.2 0.2 no signal
1079 Unintentional Medical Device Removal 3 0.2 0.2 no signal
1080 Gynaecomastia 8 0.2 0.2 no signal
1081 Bone Density Decreased 8 0.2 0.2 no signal
1082 Cytopenia 3 0.2 0.2 no signal
1083 Renal Impairment 21 0.2 0.2 no signal
1084 Gastrointestinal Haemorrhage 21 0.2 0.2 no signal
1085 White Blood Cell Count Decreased 27 0.2 0.2 no signal
1086 Injection Site Urticaria 6 0.2 0.2 no signal
1087 Injection Site Discolouration 3 0.2 0.2 no signal
1088 Muscle Spasticity 3 0.2 0.2 no signal
1089 Dyspnoea Exertional 9 0.2 0.2 no signal
1090 Eczema 12 0.2 0.2 no signal
1091 Injection Site Irritation 3 0.2 0.2 no signal
1092 Intraocular Pressure Increased 3 0.2 0.2 no signal
1093 Device Dislocation 10 0.2 0.2 no signal
1094 Dry Skin 30 0.2 0.2 no signal
1095 Incorrect Product Storage 3 0.2 0.2 no signal
1096 Hair Texture Abnormal 3 0.2 0.2 no signal
1097 Application Site Pruritus 5 0.2 0.2 no signal
1098 Platelet Count Decreased 23 0.2 0.2 no signal
1099 Injection Site Bruising 17 0.2 0.2 no signal
1100 Atrial Fibrillation 21 0.2 0.2 no signal
1101 Blood Glucose Increased 40 0.2 0.2 no signal
1102 Needle Issue 6 0.2 0.2 no signal
1103 Aspartate Aminotransferase Increased 11 0.2 0.2 no signal
1104 Pancreatic Carcinoma 6 0.2 0.2 no signal
1105 Device Breakage 8 0.2 0.2 no signal
1106 Product Use In Unapproved Indication 48 0.2 0.2 no signal
1107 Alanine Aminotransferase Increased 12 0.2 0.2 no signal
1108 Lung Neoplasm Malignant 8 0.2 0.2 no signal
1109 Device Defective 3 0.2 0.2 no signal
1110 Device Use Issue 3 0.2 0.2 no signal
1111 Pleural Effusion 10 0.1 0.1 no signal
1112 Complication Of Device Insertion 3 0.1 0.1 no signal
1113 Hyponatraemia 9 0.1 0.1 no signal
1114 Prostate Cancer 13 0.1 0.1 no signal
1115 Skin Irritation 7 0.1 0.1 no signal
1116 Dermatitis Atopic 7 0.1 0.1 no signal
1117 Product Storage Error 12 0.1 0.1 no signal
1118 Oesophageal Carcinoma 4 0.1 0.1 no signal
1119 Renal Cancer 6 0.1 0.1 no signal
1120 Hepatic Cancer 3 0.1 0.1 no signal
1121 Bladder Cancer 7 0.1 0.1 no signal
1122 Thrombocytopenia 13 0.1 0.1 no signal
1123 Device Delivery System Issue 3 0.1 0.1 no signal
1124 Neutropenia 15 0.1 0.1 no signal
1125 Injection Site Haemorrhage 8 0.1 0.1 no signal
1126 Device Leakage 4 0.1 0.1 no signal
1127 Device Use Error 3 0.1 0.1 no signal
1128 Drug Dose Omission By Device 6 0.1 0.1 no signal
1129 Wrong Technique In Device Usage Process 3 0.1 0.1 no signal
1130 Device Expulsion 4 0.1 0.1 no signal