Reaction

Which drugs are most reported with Developmental delay?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,980 reports · 99 co-occurring drugs

As of the last recalculation, Developmental Delay appears in 8,980 FAERS reports alongside 99 co-occurring drug terms. The strongest observed disproportionality signal is HYDROCODONE BITARTRATE AND ACETAMINOPHEN (PRR 122.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Hydrocodone Bitartrate And Acetaminophen	2,240	122.4	127.5
Methadone Hydrochloride	508	115.3	121.0
Oxycodone And Acetaminophen Tablets	346	69.9	72.0
Methadone	724	42.6	43.3
Hydromorphone Hydrochloride	1,388	41.2	41.8
Oxycodone Hydrochloride	2,714	41.1	41.6
Oxycodone And Acetaminophen	391	40.6	41.3
Oxymorphone Hydrochloride	174	35.2	35.8
Valproate Sodium	286	33.1	33.5
Meperidine Hydrochloride	111	28.3	28.6
Buprenorphine Hydrochloride, Naloxone Hydrochloride	280	27.7	28.1
Nevirapine	97	25.2	25.4
Morphine Sulfate	1,141	24.8	25.1
Oxycodone Hydrochloride And Acetaminophen	900	23.3	23.6
Tramadol Hydrochloride	352	22.5	22.7
Fentanyl Citrate	146	19.2	19.4
Hydrocodone Bitartrate	320	17.7	17.8
Acetaminophen And Codeine	81	15.5	15.6
Zidovudine	74	12.9	13.0
Clobazam	128	12.3	12.4
Phenobarbital	71	11.4	11.5
Buprenorphine	385	10.0	10.1
Valproic Acid	132	9.8	9.9
Zonisamide	57	9.0	9.0
Oxycodone	638	8.4	8.5
Misoprostol	35	8.4	8.4
Primidone	32	7.3	7.3
Paroxetine Hydrochloride	254	6.6	6.6
Divalproex Sodium	125	6.3	6.3
Fentanyl	258	6.2	6.2
Vigabatrin	38	6.1	6.1
Lopinavir And Ritonavir	33	5.7	5.7
Oxcarbazepine	75	5.4	5.4
Ampicillin	19	5.3	5.3
Ampicillin Sodium	19	5.3	5.3
Levetiracetam In Sodium Chloride	168	5.1	5.1
Levetiracetam Oral	168	5.1	5.1
Levetiracetam Injection	168	5.1	5.1
Lamotirigine	147	4.8	4.8
Lamotrigine Extended-Release	147	4.8	4.8
Lamotrigine Chewable Dispersible	147	4.8	4.8
Levetiracetam	265	4.7	4.7
Topiramate	164	4.1	4.1
Diazepam Oral Solution (Concentrate)	154	4.1	4.1
Diazepam Oral	154	4.1	4.1
Carisoprodol	32	3.9	3.9
Phytonadione	14	3.8	3.8
Diazepam	196	3.8	3.8
Morphine	117	3.7	3.7
Lamivudine	48	3.6	3.6
Lamotrigine	200	3.6	3.6
Carbamazepine	94	3.3	3.3
Palivizumab	20	3.0	3.0
Emtricitabine And Tenofovir Disoproxil Fumarate	58	3.0	3.0
Phenytoin	26	2.9	2.9
Promethazine Hydrochloride	22	2.7	2.8
Sertraline Hydrochloride	125	2.5	2.5
Lamivudine Oral	26	2.4	2.4
Atazanavir	14	2.3	2.3
Lacosamide	35	2.2	2.2
Abacavir Sulfate	9	2.1	2.1
Ethyl Alcohol	25	2.1	2.1
Efavirenz	10	2.1	2.1
Lithium	22	2.0	2.0
Lithium Bromatum	22	2.0	2.0
Magnesium Sulfate In Water For	11	2.0	2.0
Amphetamine	7	2.0	2.0
Magnesium Sulfate Heptahydrate	11	2.0	2.0
Magnesium Sulfate	11	2.0	2.0
Fluoxetine Hydrochloride	105	1.9	1.9
Ziprasidone	14	1.8	1.8
Ritonavir	23	1.8	1.8
Isopropyl Alcohol	26	1.8	1.8
Clonazepam	121	1.8	1.8
Venlafaxine	54	1.8	1.8
Azithromycin Dihydrate	44	1.7	1.7
Labetalol	10	1.7	1.7
Ondansetron Hydrochloride	90	1.7	1.7
Nicotine Polacrilex Mini	11	1.7	1.7
Nicotine Polarilex	11	1.7	1.7
Sevoflurane	6	1.7	1.7
Alcohol	27	1.6	1.6
Fluoxetine	46	1.6	1.6
Ritonavir 100 Mg	10	1.6	1.6
Ondansetron	70	1.5	1.5
Ondansetron Tablets	70	1.5	1.5
Guanfacine	5	1.5	1.5
Progesterone	14	1.4	1.4
Ifosfamide	12	1.3	1.3
Cannabidiol	12	1.2	1.2
Asfotase Alfa	5	1.2	1.2
Atomoxetine Hydrochloride	11	1.1	1.1
Isotretinoin	21	1.0	1.0
Tapentadol Hydrochloride	14	1.0	1.0
Nicotine Polacrilex	14	0.8	0.8
Tenofovir Disoproxil Fumarate	12	0.8	0.8
Lurasidone Hydrochloride	7	0.8	0.8
Temozolomide	7	0.8	0.8
Somatropin	19	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.