Reaction

Substance Abuse reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,049 reports · 151 co-occurring drugs

As of the last recalculation, Substance Abuse appears in 8,049 FAERS reports alongside 151 co-occurring drug terms. The strongest observed disproportionality signal is BUPRENORPHINE HYDROCHLORIDE, NALOXONE HYDROCHLORIDE (PRR 123.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Buprenorphine Hydrochloride, Naloxone Hydrochloride	1,008	123.4	128.7
Ethyl Alcohol	834	88.4	91.2
Isopropyl Alcohol	832	70.9	72.7
Amphetamine	210	67.4	69.1
Alcohol	887	66.3	67.8
Oxazepam	231	28.6	28.9
Nicotine Polacrilex Mini	157	27.6	27.9
Nicotine Polarilex	157	27.6	27.9
Methadone	424	27.0	27.2
Naltrexone	309	26.9	27.2
Methadone Hydrochloride	93	22.5	22.7
Diazepam Oral Solution (Concentrate)	653	20.6	20.7
Diazepam Oral	653	20.6	20.7
Oxycodone Hydrochloride	1,412	20.2	20.3
Dronabinol	58	18.8	18.9
Diazepam	776	18.1	18.3
Morphine Sulfate	735	17.1	17.2
Derma Foam Excel Hand Sanitizer	52	16.9	17.0
Ethanol	52	16.9	17.0
Hydromorphone Hydrochloride	504	15.0	15.1
Buprenorphine	493	14.6	14.7
Fentanyl Citrate	91	13.3	13.4
Meperidine Hydrochloride	44	12.4	12.5
Temazepam	166	11.6	11.7
Nicotine Polacrilex	163	11.2	11.3
Alprazolam	782	10.8	10.8
Nicotine	165	10.7	10.8
Fentanyl	390	10.7	10.7
Hydrocodone Bitartrate And Acetaminophen	200	9.4	9.4
Quetiapine Fumarate	98	8.7	8.7
Clonazepam	507	8.7	8.7
Oxycodone	570	8.4	8.4
Morphine	225	8.0	8.0
Aripiprazole Oral	117	7.4	7.4
Aripiprazole Orally Disintegrating	117	7.4	7.4
Carisoprodol	51	7.0	7.0
Quetiapine	489	6.9	6.9
Methylphenidate Hydrochloride	151	6.7	6.7
Lorazepam	442	6.7	6.7
Bupropion	113	6.6	6.7
Tramadol Hydrochloride	87	6.0	6.0
Olanzapine	244	6.0	6.0
Paroxetine Hydrochloride Hemihydrate	76	5.9	6.0
Paliperidone Palmitate	72	5.8	5.8
Paroxetine	76	5.8	5.8
Esketamine Hydrochloride	40	5.8	5.8
Oxycodone Hydrochloride And Acetaminophen	212	5.7	5.7
Olanzapine Pamoate	86	5.5	5.5
Diphenhydramine Hcl	23	5.4	5.4
Pregabalin	527	5.3	5.3
Dimenhydrinate	21	5.1	5.1
Aripiprazole	218	4.7	4.7
Lithium	45	4.6	4.6
Lithium Bromatum	45	4.6	4.6
Atropine Sulfate	19	4.6	4.6
Mirtazapine	157	4.5	4.5
Rocuronium Bromide	20	4.4	4.4
Hydrocodone Bitartrate	73	4.4	4.4
Venlafaxine	115	4.2	4.2
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	55	4.0	4.1
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	63	3.9	4.0
Ziprasidone	26	3.8	3.8
Hydroxyzine	70	3.8	3.8
Methylphenidate	42	3.8	3.8
Citalopram Hydrobromide	152	3.7	3.7
Lithium Carbonate	24	3.7	3.7
Phenobarbital	20	3.6	3.6
Diphenhydramine	85	3.5	3.5
Oxycodone And Acetaminophen	31	3.4	3.5
Acetaminophen Tablet Extended Release	325	3.4	3.4
Pain Reliever	325	3.4	3.4
Acetaminophen 500Mg	325	3.4	3.4
Lisdexamfetamine Dimesylate	43	3.4	3.4
Citalopram	173	3.3	3.3
Valproate Sodium	26	3.3	3.3
Haloperidol	30	3.2	3.2
Paroxetine Hydrochloride	111	3.2	3.2
Venlafaxine Hydrochloride	160	3.2	3.2
Haloperidol Lactate	30	3.1	3.1
Doxepin	12	3.1	3.1
Zolpidem Tartrate	154	3.0	3.0
Atropine	9	2.8	2.8
Risperidone	142	2.8	2.8
Paliperidone	25	2.8	2.8
Acetaminophen And Codeine	13	2.8	2.8
Butalbital, Acetaminophen, And Caffeine	11	2.7	2.7
Guanfacine	8	2.6	2.6
Oxycodone And Acetaminophen Tablets	12	2.6	2.6
Tapentadol Hydrochloride	33	2.6	2.6
Clozapine	122	2.5	2.5
Clonidine	50	2.5	2.5
Divalproex Sodium	45	2.5	2.5
Amitriptyline Hydrochloride	17	2.5	2.5
Valproic Acid	30	2.5	2.5
Doxepin Hydrochloride	12	2.5	2.5
Cyclobenzaprine	47	2.4	2.4
Sertraline	107	2.4	2.4
Escitslopram	53	2.4	2.4
Oxybutynin Chloride	8	2.4	2.4
Duloxetine	63	2.3	2.3
Lidocaine Hydrochloride	54	2.3	2.3
Ibuprofen 200Mg	175	2.3	2.3
Lidicaine	43	2.3	2.3
Burn Relief	43	2.3	2.3
Lidocaine Hydrochloride And Epinephrine	43	2.3	2.3
Ibuprofen Capsule	173	2.3	2.3
Ibuprofen Tablet, Film Coated	173	2.3	2.3
Ibupfrofen	173	2.3	2.3
Ibuprofen Tablets Usp, 200Mg	173	2.3	2.3
Ibuprofen Oral	173	2.3	2.3
Ibuprofen Capsules 200 Mg	173	2.3	2.3
Ibuprofen 200 Mg	173	2.3	2.3
Lidocaine, Menthol	43	2.2	2.2
Bupropion Hydrochloride	83	2.2	2.2
Gabapentin	301	2.2	2.2
Diphenhydramine Hydrochloride	138	2.2	2.2
Acetaminophen	365	2.2	2.2
Fluoxetine	55	2.1	2.1
Escitalopram Oxalate	60	2.1	2.1
Asenapine Maleate	7	2.1	2.1
Lidocaine 4%	43	2.0	2.0
Lamotrigine	103	2.0	2.0
Oxymorphone Hydrochloride	9	2.0	2.0
Sildenafil Powder,	27	2.0	2.0
Fluoxetine Hydrochloride	96	2.0	2.0
Midazolam Hydrochloride	20	1.9	1.9
Desvenlafaxine Succinate	20	1.9	1.9
Lidocaine	43	1.9	1.9
Buspirone Hydrochloride	8	1.9	1.9
Lurasidone Hydrochloride	15	1.9	1.9
Trazodone Hydrochloride	11	1.8	1.8
Sertraline Hydrochloride	83	1.8	1.8
Ziprasidone Mesylate	10	1.8	1.8
Calcium, Magnesium, Potassium, And Sodium Oxybates	6	1.8	1.8
Ibuprofen	187	1.8	1.8
Lamotirigine	46	1.7	1.7
Lamotrigine Extended-Release	46	1.7	1.7
Lamotrigine Chewable Dispersible	46	1.7	1.7
Sodium Oxybate	40	1.6	1.6
Modafinil	19	1.5	1.5
Sildenafil	34	1.5	1.5
Etonogestrel And Ethinyl Estradiol	13	1.5	1.5
Propofol	21	1.5	1.5
Atomoxetine Hydrochloride	13	1.4	1.4
Cariprazine	4	1.1	1.1
Brexpiprazole	7	1.1	1.1
Orlistat	10	1.0	1.0
Velpatasvir And Sofosbuvir	4	0.8	0.8
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	3	0.8	0.8
Emtricitabine And Tenofovir Alafenamide	3	0.7	0.7
Valbenazine	6	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.