Reaction

Which drugs are most reported with Intentional underdose?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,192 reports · 99 co-occurring drugs

As of the last recalculation, Intentional Underdose appears in 7,192 FAERS reports alongside 99 co-occurring drug terms. The strongest observed disproportionality signal is BUPRENORPHINE HYDROCHLORIDE, NALOXONE HYDROCHLORIDE (PRR 143.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Buprenorphine Hydrochloride, Naloxone Hydrochloride	1,027	143.6	149.9
Niraparib	658	94.3	97.2
Icosapent Ethyl	156	54.2	55.2
Levodopa	202	49.7	50.6
Fluticasone Propionate And Salmeterol	540	40.4	41.0
Droxidopa	166	22.8	22.9
Voclosporin	66	22.2	22.4
Naltrexone Hydrochloride And Bupropion Hydrochloride	57	19.5	19.6
Umeclidinium Bromide And Vilanterol Trifenatate	101	17.7	17.8
Rucaparib	50	16.5	16.6
Fluticasone Furoate And Vilanterol Trifenatate	175	14.4	14.5
Dimethyl Fumarate	550	13.9	14.0
Nemolizumab-Ilto	57	13.1	13.1
Vigabatrin	55	11.0	11.0
Rasagiline Mesylate	42	11.0	11.0
Amantadine	58	10.9	11.0
Carbidopa And Levodopa	160	10.0	10.0
Umeclidinium	29	9.4	9.4
Cenobamate	21	7.3	7.3
Nicotine Polacrilex Mini	36	7.0	7.0
Nicotine Polarilex	36	7.0	7.0
Vibegron	15	5.4	5.4
Diroximel Fumarate	22	5.4	5.4
Enzalutamide	105	5.2	5.2
Ranolazine	18	5.0	5.0
Fluticasone Propionate And Salmeterol Xinafoate	101	4.9	4.9
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	69	4.9	4.9
Salmeterol Xinafoate	13	4.4	4.4
Suvorexant	19	4.3	4.3
Pramipexole	22	4.2	4.2
Clobazam	32	3.8	3.8
Pimavanserin Tartrate	72	3.8	3.8
Fluticasone Furoate	14	3.3	3.4
Ropinirole	17	3.2	3.2
Nicotine Polacrilex	37	2.8	2.8
Docusate Sodium - Sennosides	30	2.7	2.7
Fingolimod Hcl	79	2.7	2.7
Nicotine	37	2.7	2.7
Rifaximin	19	2.6	2.6
Rotigotine	13	2.6	2.6
Atovaquone	7	2.5	2.5
Alendronate Sodium Tablet	16	2.5	2.5
Lubiprostone	8	2.4	2.5
Melatonin	45	2.4	2.4
Ethyl Alcohol	22	2.3	2.3
Cyclobenzaprine Hydrochloride	7	2.3	2.3
Clonazepam	120	2.2	2.2
Budesonide	44	2.2	2.2
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	26	2.1	2.1
Brimonidine Tartrate	13	2.1	2.1
Methocarbamol Tablets	12	2.1	2.1
Albuterol Sulfate	209	2.1	2.1
Modafinil	23	2.1	2.1
Donepezil Hydrochloride	26	2.1	2.1
Lovastatin	18	2.0	2.0
Linaclotide	18	2.0	2.0
Isopropyl Alcohol	22	1.9	1.9
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	26	1.8	1.8
Eplerenone	8	1.8	1.8
Tiotropium Bromide Inhalation Spray	7	1.8	1.8
Bupropion	27	1.8	1.8
Cannabidiol	14	1.7	1.7
Amikacin	10	1.7	1.7
Rivastigmine	11	1.7	1.7
Losartan	99	1.6	1.6
Alcohol	22	1.6	1.6
Fexofenadine Hydrochloride	12	1.6	1.6
Dalfampridine	39	1.6	1.6
Prochlorperazine Maleate	5	1.6	1.6
Polyethylene Glycol 3350	50	1.5	1.5
Armodafinil	11	1.5	1.5
Buprenorphine	48	1.5	1.5
Naltrexone	16	1.5	1.5
Methadone	22	1.5	1.5
Insulin Degludec	12	1.5	1.5
Dorzolamide Hydrochloride And Timolol Maleate	4	1.5	1.5
Mirabegron	19	1.4	1.4
Budesonide, Glycopyrrolate, And Formoterol Fumarate	5	1.4	1.4
Olaparib	10	1.4	1.4
Dofetilide	5	1.4	1.4
Vortioxetine	8	1.4	1.4
Peginterferon Beta-1A	6	1.3	1.3
Lisdexamfetamine Dimesylate	15	1.3	1.3
Liraglutide	22	1.3	1.3
Vilazodone Hydrochloride	4	1.3	1.3
Lurasidone Hydrochloride	9	1.2	1.2
Acetaminophen, Aspirin (Nsaid) And Caffeine	7	1.2	1.2
Nintedanib	12	1.1	1.1
Ivacaftor	3	1.1	1.1
Trifluridine And Tipiracil	4	1.1	1.1
Sodium Oxybate	23	1.0	1.0
Tolvaptan	5	1.0	1.0
Acetaminophen, Aspirin, And Caffeine	7	1.0	1.0
Fam-Trastuzumab Deruxtecan-Nxki	3	0.9	0.9
Abaloparatide	6	0.6	0.6
Tirzepatide	31	0.6	0.6
Tapentadol Hydrochloride	6	0.5	0.5
Voxelotor	4	0.5	0.5
Adapalene	6	0.1	0.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.