OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Tiotropium Bromide Inhalation Spray

1,025 flagged reaction(s) · 44,216 total co-reports · max PRR 9,280.9
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Amniotic Fluid Index Increased 15 9,280.9 9,293.4 signal
2 Genital Infection Viral 11 1,701.5 1,703.2 signal
3 Broncholithiasis 9 759.3 760.0 signal
4 Heart Sounds 20 488.5 489.3 signal
5 Occupational Asthma 8 297.0 297.2 signal
6 Fev1/fvc Ratio Abnormal 5 290.0 290.2 signal
7 Hyperkaliuria 6 232.0 232.1 signal
8 Total Lung Capacity Increased 24 181.1 181.5 signal
9 Prolonged Expiration 21 162.4 162.7 signal
10 Congenital Megaureter 12 123.7 123.9 signal
11 Asthma-chronic Obstructive Pulmonary Disease Overlap Syndrome 31 119.1 119.5 signal
12 Atheroembolism 8 117.9 117.9 signal
13 Fev1/fvc Ratio Decreased 7 116.0 116.1 signal
14 Foetal Macrosomia 15 109.2 109.3 signal
15 Lung Diffusion Disorder 8 100.3 100.4 signal
16 Kidney Duplex 12 100.3 100.4 signal
17 Left-to-right Cardiac Shunt 15 100.2 100.3 signal
18 Respiratory Gas Exchange Disorder 18 96.0 96.2 signal
19 Lymph Node Calcification 9 90.8 90.9 signal
20 Breath Sounds 6 85.7 85.7 signal
21 Dose Calculation Error 25 83.6 83.8 signal
22 Mucosal Hypertrophy 6 81.9 81.9 signal
23 Bronchomalacia 5 73.7 73.7 signal
24 Reversible Airways Obstruction 15 56.5 56.6 signal
25 Sleep Disorder Due To A General Medical Condition 438 52.4 54.5 signal
26 Vital Capacity Decreased 11 47.0 47.1 signal
27 Bronchial Obstruction 34 46.6 46.7 signal
28 Heart Rate 8 44.3 44.4 signal
29 Acquired Diaphragmatic Eventration 8 43.7 43.7 signal
30 Device Programming Error 7 42.7 42.8 signal
31 Bronchial Wall Thickening 16 42.4 42.5 signal
32 Motor Developmental Delay 12 40.0 40.0 signal
33 Obstructive Airways Disorder 226 38.9 39.7 signal
34 Lung Hyperinflation 17 37.7 37.8 signal
35 Spirometry Abnormal 11 35.9 35.9 signal
36 Intensive Care Unit Acquired Weakness 7 35.1 35.1 signal
37 Peak Expiratory Flow Rate Decreased 8 34.7 34.7 signal
38 Sputum Purulent 12 34.7 34.7 signal
39 Congenital Hydronephrosis 12 32.0 32.0 signal
40 Asthmatic Crisis 60 31.4 31.5 signal
41 Oesophageal Dilatation 7 30.6 30.7 signal
42 Vocal Cord Dysfunction 8 30.6 30.6 signal
43 Blood Immunoglobulin E Increased 39 30.6 30.7 signal
44 Allergy To Plants 7 29.3 29.3 signal
45 Product Delivery Mechanism Issue 74 29.1 29.3 signal
46 Dependence On Oxygen Therapy 7 27.8 27.8 signal
47 Wheezing 840 27.1 29.2 signal
48 Full Blood Count Abnormal 145 26.2 26.6 signal
49 Female Sterilisation 7 25.9 26.0 signal
50 Asthma 1,473 25.0 28.7 signal
51 Total Lung Capacity Decreased 21 25.0 25.0 signal
52 Infusion Site Discharge 22 24.5 24.6 signal
53 Blood Count Abnormal 195 24.2 24.6 signal
54 Eosinophil Count Increased 102 23.4 23.6 signal
55 Vulval Disorder 8 23.0 23.0 signal
56 Bronchial Secretion Retention 15 22.6 22.6 signal
57 Pneumonia Streptococcal 13 22.5 22.6 signal
58 Sputum Discoloured 110 22.1 22.4 signal
59 Bronchial Hyperreactivity 14 22.1 22.2 signal
60 Bronchiectasis 75 21.4 21.6 signal
61 Stress Urinary Incontinence 12 21.0 21.0 signal
62 Loss Of Personal Independence In Daily Activities 520 20.8 21.8 signal
63 Chronic Obstructive Pulmonary Disease 561 20.5 21.5 signal
64 Oxygen Consumption Decreased 6 18.7 18.7 signal
65 Multiple Allergies 77 18.6 18.8 signal
66 Post-acute Covid-19 Syndrome 12 18.4 18.5 signal
67 Adrenal Suppression 8 18.0 18.0 signal
68 Eosinophil Count Abnormal 7 17.8 17.8 signal
69 Obstructive Sleep Apnoea Syndrome 13 17.7 17.7 signal
70 Clostridium Test Positive 20 17.4 17.4 signal
71 Breath Sounds Abnormal 45 17.3 17.4 signal
72 Erosive Duodenitis 7 16.6 16.6 signal
73 Rhinitis Allergic 38 16.2 16.3 signal
74 Genital Herpes 13 16.0 16.1 signal
75 Respiration Abnormal 57 15.8 15.9 signal
76 Pulmonary Function Test Abnormal 13 15.8 15.8 signal
77 Dust Allergy 8 15.7 15.7 signal
78 Nasal Polyps 40 15.7 15.8 signal
79 Therapeutic Product Effect Incomplete 580 15.6 16.4 signal
80 Infusion Site Bruising 17 15.2 15.2 signal
81 Nocturnal Dyspnoea 10 14.9 14.9 signal
82 Pulmonary Function Test Decreased 34 14.6 14.7 signal
83 Respiratory Tract Irritation 8 14.6 14.6 signal
84 Bronchopulmonary Aspergillosis Allergic 7 14.5 14.5 signal
85 Emphysema 76 14.2 14.3 signal
86 Drug Delivery System Issue 14 14.1 14.1 signal
87 Rhonchi 10 13.7 13.7 signal
88 Oxygen Saturation Abnormal 20 13.5 13.5 signal
89 Productive Cough 330 13.2 13.6 signal
90 Spontaneous Haemorrhage 7 13.2 13.2 signal
91 Hypochromic Anaemia 7 13.1 13.1 signal
92 Rales 40 13.0 13.1 signal
93 Upper-airway Cough Syndrome 56 12.9 13.0 signal
94 Respiratory Symptom 19 12.8 12.9 signal
95 Cholangiocarcinoma 10 12.8 12.8 signal
96 Sputum Increased 14 12.5 12.5 signal
97 Lung Opacity 17 12.5 12.5 signal
98 Vocal Cord Disorder 13 12.4 12.5 signal
99 Infusion Site Mass 7 12.4 12.4 signal
100 Seasonal Allergy 90 12.1 12.2 signal
101 Painful Respiration 15 11.8 11.8 signal
102 Throat Clearing 23 11.7 11.7 signal
103 Dyspnoea Exertional 226 11.4 11.6 signal
104 Mean Cell Haemoglobin Concentration Decreased 10 11.4 11.4 signal
105 Restrictive Pulmonary Disease 7 11.3 11.3 signal
106 Sense Of Oppression 7 11.3 11.3 signal
107 Pneumonia Pseudomonal 9 11.2 11.2 signal
108 Infusion Site Rash 8 11.1 11.1 signal
109 Snoring 22 11.0 11.1 signal
110 Hilar Lymphadenopathy 5 10.8 10.8 signal
111 Device Infusion Issue 14 10.8 10.8 signal
112 Bronchitis Chronic 14 10.8 10.8 signal
113 Secretion Discharge 70 10.7 10.8 signal
114 Pruritus Genital 13 10.6 10.6 signal
115 Oxygen Consumption Increased 13 10.4 10.4 signal
116 Oesophageal Spasm 10 10.3 10.3 signal
117 Depressive Symptom 19 10.2 10.2 signal
118 Infusion Site Swelling 33 10.1 10.2 signal
119 Lip Injury 7 10.1 10.1 signal
120 Chronic Sinusitis 20 10.1 10.1 signal
121 Lung Consolidation 15 10.1 10.1 signal
122 Halo Vision 6 10.0 10.0 signal
123 Infusion Site Haemorrhage 17 9.9 9.9 signal
124 Mycobacterial Infection 9 9.9 9.9 signal
125 Pneumonia Fungal 20 9.7 9.8 signal
126 Carbon Dioxide Increased 7 9.7 9.7 signal
127 Mitral Valve Disease 9 9.6 9.6 signal
128 Infusion Site Warmth 6 9.4 9.4 signal
129 Eosinophilic Granulomatosis With Polyangiitis 10 9.4 9.4 signal
130 Pulmonary Pain 14 9.2 9.2 signal
131 Nasal Obstruction 9 9.2 9.2 signal
132 Infusion Site Erythema 39 8.9 8.9 signal
133 Increased Bronchial Secretion 12 8.8 8.8 signal
134 Respiratory Tract Congestion 74 8.8 8.8 signal
135 Rhinitis 37 8.7 8.7 signal
136 Mast Cell Activation Syndrome 6 8.6 8.6 signal
137 Pulmonary Mass 67 8.5 8.6 signal
138 Cardiac Murmur 39 8.5 8.5 signal
139 Sarcoidosis 21 8.4 8.4 signal
140 Monocyte Count Increased 16 8.3 8.3 signal
141 Crepitations 13 8.2 8.2 signal
142 Haematological Infection 10 8.1 8.1 signal
143 Oxygen Therapy 7 8.1 8.1 signal
144 Obstruction 17 8.0 8.0 signal
145 Forced Expiratory Volume Decreased 12 8.0 8.0 signal
146 Chronic Respiratory Failure 5 7.9 7.9 signal
147 Respiratory Tract Infection 109 7.9 8.0 signal
148 Infusion Site Pruritus 13 7.9 7.9 signal
149 Speech Disorder Developmental 12 7.9 7.9 signal
150 Choking 80 7.8 7.8 signal
151 Middle Ear Effusion 9 7.7 7.7 signal
152 Blood Immunoglobulin G Increased 5 7.7 7.7 signal
153 Dyspnoea 2,291 7.7 9.4 signal
154 Glossitis 14 7.4 7.4 signal
155 Respiratory Tract Infection Viral 9 7.3 7.3 signal
156 Renal Mass 8 7.3 7.3 signal
157 Cough 1,068 7.2 7.9 signal
158 Mean Cell Haemoglobin Decreased 7 7.2 7.2 signal
159 Hypervolaemia 18 7.1 7.1 signal
160 Lower Respiratory Tract Infection 168 7.0 7.1 signal
161 Blood Immunoglobulin G Decreased 9 7.0 7.0 signal
162 Appetite Disorder 24 7.0 7.0 signal
163 Aphonia 51 6.9 6.9 signal
164 Sleep Apnoea Syndrome 68 6.7 6.7 signal
165 Oesophageal Pain 14 6.7 6.7 signal
166 Infusion Site Pain 45 6.7 6.7 signal
167 Exercise Tolerance Decreased 20 6.6 6.6 signal
168 Essential Hypertension 9 6.6 6.6 signal
169 Dry Throat 35 6.5 6.5 signal
170 Ear Pruritus 12 6.5 6.5 signal
171 Chest Discomfort 350 6.5 6.7 signal
172 Polyp 22 6.3 6.3 signal
173 Nasal Oedema 6 6.3 6.3 signal
174 Candida Infection 54 6.1 6.1 signal
175 Chest X-ray Abnormal 10 6.1 6.1 signal
176 Polymyalgia Rheumatica 10 6.1 6.1 signal
177 Pneumonia Bacterial 29 6.0 6.0 signal
178 Nasal Congestion 183 5.9 6.0 signal
179 Respiratory Syncytial Virus Infection 27 5.9 5.9 signal
180 Dyspnoea At Rest 9 5.9 5.9 signal
181 Hyperventilation 18 5.9 5.9 signal
182 Gingival Disorder 12 5.9 5.9 signal
183 Choking Sensation 17 5.8 5.8 signal
184 Stridor 9 5.8 5.8 signal
185 Insurance Issue 45 5.7 5.7 signal
186 Lung Neoplasm Malignant 125 5.7 5.8 signal
187 Rib Fracture 62 5.7 5.7 signal
188 Urine Flow Decreased 7 5.5 5.6 signal
189 Oxygen Saturation Decreased 163 5.5 5.6 signal
190 Upper Respiratory Tract Infection 134 5.5 5.5 signal
191 Bronchitis 216 5.5 5.6 signal
192 Lung Disorder 140 5.4 5.4 signal
193 Bronchiolitis 10 5.3 5.3 signal
194 Oral Discomfort 39 5.3 5.3 signal
195 Eosinophilia 48 5.2 5.2 signal
196 Infusion Site Extravasation 17 5.2 5.2 signal
197 Pneumonia 883 5.2 5.5 signal
198 Bronchospasm 39 5.1 5.2 signal
199 Body Temperature Abnormal 5 5.1 5.1 signal
200 Iron Deficiency 12 5.1 5.1 signal
201 Haemoptysis 75 5.1 5.1 signal
202 Rhinovirus Infection 10 5.0 5.0 signal
203 Haematocrit Increased 6 5.0 5.0 signal
204 Arterial Disorder 5 4.9 4.9 signal
205 Oesophageal Disorder 10 4.9 4.9 signal
206 Product Quality Issue 349 4.9 5.0 signal
207 Dysphonia 151 4.9 4.9 signal
208 Middle Insomnia 48 4.9 4.9 signal
209 Eosinophil Count Decreased 6 4.9 4.9 signal
210 Throat Irritation 115 4.9 4.9 signal
211 Abdominal Wall Haematoma 5 4.8 4.8 signal
212 Red Blood Cell Count Increased 7 4.8 4.8 signal
213 Acute Respiratory Failure 48 4.7 4.7 signal
214 Urinary Hesitation 6 4.7 4.7 signal
215 Respiratory Disorder 75 4.7 4.7 signal
216 Frustration Tolerance Decreased 20 4.7 4.7 signal
217 Extra Dose Administered 99 4.7 4.7 signal
218 Wrong Dose 6 4.7 4.7 signal
219 Intentional Device Misuse 11 4.6 4.7 signal
220 Lymphoedema 17 4.6 4.6 signal
221 Conjunctivitis 45 4.6 4.6 signal
222 Spinal Stenosis 10 4.6 4.6 signal
223 Sinusitis 250 4.6 4.7 signal
224 Suffocation Feeling 6 4.6 4.6 signal
225 Skin Laceration 26 4.5 4.5 signal
226 Laryngitis 26 4.5 4.5 signal
227 Tongue Discomfort 10 4.5 4.5 signal
228 Drug Delivery System Malfunction 12 4.5 4.5 signal
229 Oropharyngeal Pain 217 4.4 4.5 signal
230 Idiopathic Pulmonary Fibrosis 9 4.4 4.4 signal
231 Sinus Congestion 31 4.3 4.3 signal
232 Oesophageal Candidiasis 9 4.3 4.3 signal
233 Atelectasis 22 4.3 4.3 signal
234 Mycobacterium Avium Complex Infection 6 4.2 4.3 signal
235 Flank Pain 21 4.2 4.2 signal
236 Blood Loss Anaemia 5 4.2 4.2 signal
237 Haemoglobin Increased 10 4.2 4.2 signal
238 Influenza 246 4.1 4.2 signal
239 Pharyngeal Swelling 21 4.1 4.1 signal
240 Ear Disorder 10 4.1 4.1 signal
241 Sinus Disorder 43 4.1 4.1 signal
242 Oral Candidiasis 28 4.1 4.1 signal
243 Pneumonitis 58 4.0 4.1 signal
244 Near Death Experience 7 4.0 4.0 signal
245 Incorrect Drug Administration Rate 9 4.0 4.0 signal
246 Gastrointestinal Infection 19 4.0 4.0 signal
247 Throat Cancer 9 4.0 4.0 signal
248 Pulmonary Congestion 28 4.0 4.0 signal
249 Thyroid Mass 8 4.0 4.0 signal
250 Suspected Covid-19 7 4.0 4.0 signal
251 Macular Degeneration 25 4.0 4.0 signal
252 Device Power Source Issue 6 4.0 4.0 signal
253 Adrenal Insufficiency 25 3.9 3.9 signal
254 Biliary Colic 6 3.9 3.9 signal
255 Wrist Fracture 25 3.9 3.9 signal
256 Viral Infection 69 3.9 3.9 signal
257 Abnormal Loss Of Weight 14 3.9 3.9 signal
258 Infusion Site Reaction 6 3.9 3.9 signal
259 Rhinorrhoea 133 3.9 3.9 signal
260 Decreased Activity 22 3.9 3.9 signal
261 Left Ventricular Failure 7 3.9 3.9 signal
262 Product Distribution Issue 18 3.8 3.8 signal
263 Illness 203 3.8 3.9 signal
264 Pseudomonas Infection 17 3.8 3.8 signal
265 Blood Test Abnormal 28 3.8 3.8 signal
266 Intracranial Aneurysm 8 3.8 3.8 signal
267 Food Allergy 15 3.7 3.7 signal
268 Cystic Fibrosis 11 3.7 3.7 signal
269 Haemorrhage Urinary Tract 5 3.7 3.7 signal
270 Muscle Strain 17 3.7 3.7 signal
271 Pneumothorax 31 3.7 3.7 signal
272 Gastrooesophageal Reflux Disease 156 3.7 3.7 signal
273 Kidney Infection 38 3.7 3.7 signal
274 Covid-19 Pneumonia 23 3.6 3.7 signal
275 Increased Upper Airway Secretion 10 3.6 3.6 signal
276 Social Problem 8 3.6 3.6 signal
277 Pelvic Fracture 15 3.6 3.6 signal
278 Retching 41 3.6 3.6 signal
279 Covid-19 340 3.6 3.7 signal
280 Glaucoma 37 3.6 3.6 signal
281 Nasal Dryness 12 3.6 3.6 signal
282 Carotid Artery Occlusion 7 3.6 3.6 signal
283 Hordeolum 8 3.6 3.6 signal
284 Pneumonia Viral 6 3.5 3.6 signal
285 Skin Erosion 6 3.5 3.5 signal
286 Left Ventricular Hypertrophy 8 3.5 3.5 signal
287 Eye Disorder 61 3.5 3.5 signal
288 Hepatic Lesion 8 3.5 3.5 signal
289 Pleurisy 11 3.5 3.5 signal
290 Pulmonary Thrombosis 20 3.5 3.5 signal
291 Product Administration Interrupted 14 3.4 3.4 signal
292 Concussion 14 3.4 3.4 signal
293 Heart Rate Abnormal 10 3.4 3.4 signal
294 Upper Limb Fracture 36 3.4 3.4 signal
295 Oropharyngeal Discomfort 16 3.4 3.4 signal
296 Sneezing 40 3.4 3.4 signal
297 Hypoxia 62 3.3 3.3 signal
298 Renal Cyst 14 3.3 3.3 signal
299 Poor Venous Access 18 3.3 3.3 signal
300 Tooth Infection 23 3.3 3.3 signal
301 Hypopnoea 6 3.3 3.3 signal
302 Compression Fracture 9 3.3 3.3 signal
303 Skin Abrasion 8 3.2 3.2 signal
304 Aortic Aneurysm 13 3.2 3.2 signal
305 Craniocerebral Injury 5 3.1 3.1 signal
306 Ear Discomfort 17 3.1 3.1 signal
307 Cystitis 53 3.1 3.1 signal
308 Product Prescribing Error 39 3.1 3.1 signal
309 Scleroderma 6 3.1 3.1 signal
310 Brain Fog 24 3.1 3.1 signal
311 Lung Neoplasm 7 3.1 3.1 signal
312 Brain Natriuretic Peptide Increased 5 3.1 3.1 signal
313 Diastolic Dysfunction 5 3.0 3.0 signal
314 Blood Blister 5 3.0 3.0 signal
315 Ear Infection 42 3.0 3.0 signal
316 Pulmonary Hypertension 33 3.0 3.0 signal
317 Sars-cov-2 Test Positive 21 3.0 3.0 signal
318 Skin Atrophy 9 3.0 3.0 signal
319 Dry Mouth 127 3.0 3.0 signal
320 Haemoglobin Abnormal 10 2.9 2.9 signal
321 Paranasal Sinus Hypersecretion 6 2.9 2.9 signal
322 Incorrect Route Of Product Administration 26 2.9 2.9 signal
323 Cataract 91 2.9 2.9 signal
324 Abdominal Hernia 7 2.9 2.9 signal
325 Deafness Neurosensory 5 2.9 2.9 signal
326 Wrong Product Administered 10 2.8 2.8 signal
327 Device Malfunction 101 2.8 2.8 signal
328 Food Poisoning 8 2.8 2.8 signal
329 Dermatitis Contact 17 2.8 2.8 signal
330 Foetal Growth Restriction 9 2.8 2.8 signal
331 Anxiety Disorder 5 2.8 2.8 signal
332 Trigger Finger 6 2.8 2.8 signal
333 Fluid Retention 75 2.8 2.8 signal
334 Hypovolaemic Shock 7 2.8 2.8 signal
335 Product Packaging Quantity Issue 16 2.8 2.8 signal
336 Anal Incontinence 13 2.8 2.8 signal
337 Infective Pulmonary Exacerbation Of Cystic Fibrosis 8 2.7 2.7 signal
338 Spinal Fracture 29 2.7 2.7 signal
339 Hyperpyrexia 6 2.7 2.7 signal
340 Attention Deficit Hyperactivity Disorder 6 2.7 2.7 signal
341 Obesity 23 2.7 2.7 signal
342 Nasopharyngitis 265 2.7 2.7 signal
343 Exposure Via Skin Contact 32 2.7 2.7 signal
344 Quality Of Life Decreased 19 2.7 2.7 signal
345 Blood Pressure Abnormal 28 2.7 2.7 signal
346 Escherichia Urinary Tract Infection 6 2.7 2.7 signal
347 Hand Fracture 10 2.7 2.7 signal
348 Bladder Disorder 14 2.7 2.7 signal
349 Joint Injury 30 2.6 2.6 signal
350 Limb Injury 38 2.6 2.6 signal
351 Immobile 6 2.6 2.6 signal
352 Device Delivery System Issue 36 2.6 2.6 signal
353 Respiratory Distress 38 2.6 2.6 signal
354 Somnambulism 9 2.6 2.6 signal
355 Glucose Tolerance Impaired 8 2.6 2.6 signal
356 Hypercholesterolaemia 13 2.6 2.6 signal
357 Physical Disability 6 2.5 2.5 signal
358 Inappropriate Schedule Of Product Administration 238 2.5 2.6 signal
359 Sinus Headache 8 2.5 2.5 signal
360 Eye Operation 6 2.5 2.5 no signal
361 Angina Pectoris 38 2.5 2.5 signal
362 Intentional Dose Omission 36 2.5 2.5 signal
363 Atrial Fibrillation 128 2.5 2.5 signal
364 Hernia 25 2.4 2.4 signal
365 Arthritis Infective 6 2.4 2.4 no signal
366 Musculoskeletal Chest Pain 20 2.4 2.4 signal
367 Pharyngitis 16 2.4 2.4 signal
368 Right Ventricular Failure 9 2.4 2.4 signal
369 Gastroenteritis Viral 23 2.4 2.4 signal
370 Product Dose Omission Issue 361 2.4 2.4 signal
371 Foot Fracture 24 2.4 2.4 signal
372 Pulmonary Fibrosis 24 2.4 2.4 signal
373 Infection 181 2.4 2.4 signal
374 Nasal Discomfort 10 2.4 2.4 signal
375 Intentional Product Use Issue 110 2.4 2.4 signal
376 Humerus Fracture 6 2.3 2.3 no signal
377 Post Procedural Infection 10 2.3 2.3 signal
378 Vitamin D Deficiency 12 2.3 2.3 signal
379 Asphyxia 10 2.3 2.3 signal
380 Dysuria 45 2.3 2.3 signal
381 Ligament Sprain 12 2.3 2.3 signal
382 Osteoporosis 50 2.3 2.3 signal
383 Lung Infection 19 2.3 2.3 signal
384 Device Physical Property Issue 9 2.3 2.3 signal
385 Back Injury 13 2.3 2.3 signal
386 Coronavirus Infection 8 2.3 2.3 signal
387 Product Dispensing Error 26 2.3 2.3 signal
388 Spinal Compression Fracture 10 2.2 2.2 signal
389 Oral Herpes 23 2.2 2.2 signal
390 Cardiac Failure Chronic 5 2.2 2.2 no signal
391 Fall 388 2.2 2.2 signal
392 Atrioventricular Block 9 2.2 2.2 signal
393 Respiratory Failure 84 2.2 2.2 signal
394 Bone Cancer 5 2.2 2.2 no signal
395 Catheterisation Cardiac 5 2.1 2.1 no signal
396 Inability To Afford Medication 11 2.1 2.1 signal
397 Hypoacusis 48 2.1 2.1 signal
398 Gout 20 2.1 2.1 signal
399 Oral Pain 25 2.1 2.1 signal
400 Aspiration 12 2.1 2.1 signal
401 Blood Iron Decreased 13 2.1 2.1 signal
402 Back Disorder 18 2.1 2.1 signal
403 Product Administration Error 22 2.1 2.1 signal
404 Urinary Tract Infection 187 2.1 2.1 signal
405 Impaired Gastric Emptying 14 2.1 2.1 signal
406 Product Use Complaint 17 2.1 2.1 signal
407 Transient Ischaemic Attack 37 2.1 2.1 signal
408 Oral Disorder 8 2.0 2.1 no signal
409 Prostatic Disorder 6 2.0 2.0 no signal
410 Heart Rate Increased 107 2.0 2.0 signal
411 Bacterial Infection 20 2.0 2.0 signal
412 Nephrolithiasis 49 2.0 2.0 signal
413 Troponin Increased 8 2.0 2.0 no signal
414 Hip Fracture 34 2.0 2.0 no signal
415 Chest Pain 196 2.0 2.0 no signal
416 Device Issue 92 2.0 2.0 no signal
417 Hyponatraemia 59 2.0 2.0 no signal
418 Lower Limb Fracture 20 2.0 2.0 no signal
419 Electrolyte Imbalance 12 2.0 2.0 no signal
420 Impaired Quality Of Life 15 2.0 2.0 no signal
421 Breast Mass 7 2.0 2.0 no signal
422 Device Use Issue 18 2.0 2.0 no signal
423 Immunosuppression 9 2.0 2.0 no signal
424 Pulmonary Arterial Hypertension 15 1.9 1.9 no signal
425 Fibromyalgia 25 1.9 1.9 no signal
426 Post Procedural Haemorrhage 12 1.9 1.9 no signal
427 Symptom Recurrence 6 1.9 1.9 no signal
428 Cardiac Disorder 96 1.9 1.9 no signal
429 Affective Disorder 8 1.9 1.9 no signal
430 Foot Operation 5 1.9 1.9 no signal
431 Pharyngitis Streptococcal 11 1.9 1.9 no signal
432 Head Injury 32 1.9 1.9 no signal
433 Furuncle 8 1.9 1.9 no signal
434 Product Physical Issue 20 1.9 1.9 no signal
435 Hiatus Hernia 13 1.9 1.9 no signal
436 Product Complaint 25 1.9 1.9 no signal
437 Eye Pruritus 33 1.9 1.9 no signal
438 Platelet Count Increased 13 1.9 1.9 no signal
439 Toothache 18 1.9 1.9 no signal
440 Erysipelas 5 1.9 1.9 no signal
441 Neoplasm Malignant 66 1.9 1.9 no signal
442 Device Defective 16 1.9 1.9 no signal
443 Musculoskeletal Discomfort 17 1.9 1.9 no signal
444 Sleep Disorder 69 1.9 1.9 no signal
445 Poor Quality Sleep 21 1.8 1.8 no signal
446 Eye Infection 11 1.8 1.8 no signal
447 Diabetes Mellitus 75 1.8 1.8 no signal
448 Cachexia 5 1.8 1.8 no signal
449 Cardiac Failure Congestive 79 1.8 1.8 no signal
450 Thyroid Disorder 15 1.8 1.8 no signal
451 Neutrophil Count Increased 10 1.8 1.8 no signal
452 Panic Reaction 7 1.8 1.8 no signal
453 Cardiac Failure 78 1.8 1.8 no signal
454 Product Taste Abnormal 13 1.8 1.8 no signal
455 Benign Prostatic Hyperplasia 5 1.8 1.8 no signal
456 Arthritis 76 1.8 1.8 no signal
457 Foreign Body Sensation In Eyes 6 1.8 1.8 no signal
458 Intentional Underdose 7 1.8 1.8 no signal
459 Disability 19 1.8 1.8 no signal
460 Pulmonary Oedema 43 1.8 1.8 no signal
461 Intervertebral Disc Protrusion 21 1.8 1.8 no signal
462 Neoplasm 11 1.8 1.8 no signal
463 Arthropod Bite 7 1.8 1.8 no signal
464 Photopsia 6 1.8 1.8 no signal
465 Migraine 90 1.8 1.8 no signal
466 Facial Paralysis 8 1.8 1.8 no signal
467 Cardiac Operation 8 1.8 1.8 no signal
468 Post Procedural Complication 18 1.8 1.8 no signal
469 Intestinal Obstruction 35 1.8 1.8 no signal
470 Stress 67 1.8 1.8 no signal
471 Fungal Infection 31 1.8 1.8 no signal
472 Rotator Cuff Syndrome 12 1.8 1.8 no signal
473 Ear Pain 18 1.7 1.7 no signal
474 Throat Tightness 25 1.7 1.7 no signal
475 Hospitalisation 141 1.7 1.8 no signal
476 Aspergillus Infection 6 1.7 1.7 no signal
477 Body Height Decreased 10 1.7 1.7 no signal
478 Heart Rate Irregular 21 1.7 1.7 no signal
479 Accident 11 1.7 1.7 no signal
480 Device Failure 14 1.7 1.7 no signal
481 Drug Effect Less Than Expected 13 1.7 1.7 no signal
482 Wound Infection 10 1.7 1.7 no signal
483 Hospice Care 9 1.7 1.7 no signal
484 Spinal Osteoarthritis 8 1.7 1.7 no signal
485 Malaise 398 1.7 1.7 no signal
486 Lymphadenopathy 32 1.7 1.7 no signal
487 Red Blood Cell Sedimentation Rate Increased 10 1.7 1.7 no signal
488 Facial Pain 8 1.7 1.7 no signal
489 Hypertensive Crisis 10 1.7 1.7 no signal
490 Product Label Issue 6 1.7 1.7 no signal
491 Post-traumatic Stress Disorder 6 1.7 1.7 no signal
492 Pleural Effusion 54 1.7 1.7 no signal
493 Peripheral Swelling 136 1.7 1.7 no signal
494 Eye Discharge 9 1.7 1.7 no signal
495 Tooth Abscess 9 1.7 1.7 no signal
496 Deafness 23 1.7 1.7 no signal
497 Atrial Flutter 7 1.6 1.6 no signal
498 Infarction 6 1.6 1.6 no signal
499 Drug Effect Incomplete 32 1.6 1.6 no signal
500 Weight Fluctuation 9 1.6 1.6 no signal
501 Product Packaging Issue 8 1.6 1.6 no signal
502 Dementia 24 1.6 1.6 no signal
503 Blood Pressure Increased 132 1.6 1.6 no signal
504 Hyperkalaemia 30 1.6 1.6 no signal
505 Vision Blurred 117 1.6 1.6 no signal
506 Extrasystoles 6 1.6 1.6 no signal
507 Anaphylactic Reaction 47 1.6 1.6 no signal
508 Joint Dislocation 9 1.6 1.6 no signal
509 Blindness Unilateral 12 1.6 1.6 no signal
510 Renal Pain 9 1.6 1.6 no signal
511 Leukaemia 8 1.6 1.6 no signal
512 Gait Inability 28 1.6 1.6 no signal
513 Bedridden 11 1.6 1.6 no signal
514 Gastritis 22 1.6 1.6 no signal
515 Diverticulum 6 1.6 1.6 no signal
516 Ocular Discomfort 9 1.6 1.6 no signal
517 Nocturia 10 1.6 1.6 no signal
518 Glomerular Filtration Rate Decreased 10 1.6 1.6 no signal
519 Tongue Disorder 6 1.5 1.6 no signal
520 Skin Swelling 7 1.5 1.5 no signal
521 Depressed Mood 43 1.5 1.5 no signal
522 Herpes Zoster 47 1.5 1.5 no signal
523 Tooth Fracture 9 1.5 1.5 no signal
524 Small Intestinal Obstruction 10 1.5 1.5 no signal
525 Hepatomegaly 8 1.5 1.5 no signal
526 Blood Pressure Diastolic Decreased 6 1.5 1.5 no signal
527 Weight Decreased 225 1.5 1.5 no signal
528 Cardiomegaly 10 1.5 1.5 no signal
529 Off Label Use 696 1.5 1.5 no signal
530 Intestinal Perforation 9 1.5 1.5 no signal
531 Blood Calcium Increased 7 1.5 1.5 no signal
532 Scab 9 1.5 1.5 no signal
533 Heart Rate Decreased 28 1.5 1.5 no signal
534 Thrombosis 64 1.5 1.5 no signal
535 Respiratory Arrest 22 1.5 1.5 no signal
536 Epistaxis 59 1.5 1.5 no signal
537 Localised Infection 19 1.5 1.5 no signal
538 Asthenia 295 1.5 1.5 no signal
539 Eye Swelling 29 1.5 1.5 no signal
540 Labelled Drug-drug Interaction Medication Error 7 1.5 1.5 no signal
541 Urinary Retention 26 1.5 1.5 no signal
542 Arrhythmia 37 1.5 1.5 no signal
543 Urinary Incontinence 23 1.5 1.5 no signal
544 Injection Site Discomfort 8 1.5 1.5 no signal
545 Lymphoma 12 1.5 1.5 no signal
546 Ankle Fracture 12 1.5 1.5 no signal
547 Cardiac Flutter 5 1.5 1.5 no signal
548 Exostosis 7 1.4 1.4 no signal
549 Tenderness 8 1.4 1.4 no signal
550 Bacteraemia 9 1.4 1.4 no signal
551 Speech Disorder 40 1.4 1.4 no signal
552 Hemiparesis 13 1.4 1.4 no signal
553 Pneumonia Aspiration 19 1.4 1.4 no signal
554 Brain Neoplasm 7 1.4 1.4 no signal
555 Nerve Compression 7 1.4 1.4 no signal
556 Urosepsis 7 1.4 1.4 no signal
557 Sepsis 84 1.4 1.4 no signal
558 Chromaturia 17 1.4 1.4 no signal
559 Hepatic Steatosis 14 1.4 1.4 no signal
560 Renal Disorder 35 1.4 1.4 no signal
561 Taste Disorder 15 1.4 1.4 no signal
562 Hypertension 158 1.4 1.4 no signal
563 Pollakiuria 31 1.4 1.4 no signal
564 Back Pain 173 1.4 1.4 no signal
565 Product Use Issue 139 1.4 1.4 no signal
566 Spinal Operation 9 1.4 1.4 no signal
567 Syncope 74 1.4 1.4 no signal
568 Shock Haemorrhagic 6 1.4 1.4 no signal
569 Colon Cancer 11 1.4 1.4 no signal
570 Dizziness 366 1.4 1.4 no signal
571 Escherichia Infection 6 1.4 1.4 no signal
572 Bipolar Disorder 8 1.4 1.4 no signal
573 Hypoaesthesia Oral 11 1.4 1.4 no signal
574 Gallbladder Disorder 13 1.4 1.4 no signal
575 Therapeutic Response Shortened 23 1.4 1.4 no signal
576 Lip Swelling 24 1.4 1.4 no signal
577 Inflammation 37 1.4 1.4 no signal
578 Knee Arthroplasty 15 1.4 1.4 no signal
579 Headache 450 1.4 1.4 no signal
580 Cerebrovascular Accident 122 1.4 1.4 no signal
581 Sensation Of Foreign Body 6 1.3 1.3 no signal
582 Product Container Issue 6 1.3 1.3 no signal
583 Eye Pain 39 1.3 1.3 no signal
584 Lacrimation Increased 21 1.3 1.3 no signal
585 Intraocular Pressure Increased 9 1.3 1.3 no signal
586 Palpitations 82 1.3 1.3 no signal
587 Internal Haemorrhage 8 1.3 1.3 no signal
588 Hypersomnia 20 1.3 1.3 no signal
589 Photophobia 13 1.3 1.3 no signal
590 Skin Cancer 15 1.3 1.3 no signal
591 Pericardial Effusion 16 1.3 1.3 no signal
592 Sciatica 11 1.3 1.3 no signal
593 Discomfort 42 1.3 1.3 no signal
594 Injection Site Rash 21 1.3 1.3 no signal
595 Blood Sodium Decreased 13 1.3 1.3 no signal
596 Orthostatic Hypotension 12 1.3 1.3 no signal
597 Diverticulitis 19 1.3 1.3 no signal
598 Oedema Peripheral 84 1.3 1.3 no signal
599 Contusion 66 1.3 1.3 no signal
600 Night Sweats 22 1.3 1.3 no signal
601 Rash Erythematous 32 1.3 1.3 no signal
602 Feeling Abnormal 164 1.3 1.3 no signal
603 Pyrexia 236 1.3 1.3 no signal
604 Arthropathy 38 1.3 1.3 no signal
605 Dry Eye 33 1.3 1.3 no signal
606 Pulmonary Embolism 65 1.3 1.3 no signal
607 Feeling Jittery 13 1.3 1.3 no signal
608 Respiratory Rate Increased 6 1.3 1.3 no signal
609 Product Use In Unapproved Indication 164 1.3 1.3 no signal
610 Tooth Disorder 15 1.3 1.3 no signal
611 Cerebral Haemorrhage 24 1.3 1.3 no signal
612 Pain In Jaw 19 1.3 1.3 no signal
613 Intentional Product Misuse 58 1.3 1.3 no signal
614 Visual Impairment 82 1.3 1.3 no signal
615 Therapeutic Response Unexpected 30 1.3 1.3 no signal
616 Condition Aggravated 200 1.2 1.3 no signal
617 Incontinence 7 1.2 1.2 no signal
618 Loss Of Consciousness 84 1.2 1.2 no signal
619 Hypokalaemia 30 1.2 1.2 no signal
620 Retinal Detachment 6 1.2 1.2 no signal
621 Procedural Pain 18 1.2 1.2 no signal
622 Nervousness 34 1.2 1.2 no signal
623 Limb Discomfort 20 1.2 1.2 no signal
624 Tendonitis 10 1.2 1.2 no signal
625 Pharyngeal Oedema 10 1.2 1.2 no signal
626 Oesophagitis 7 1.2 1.2 no signal
627 Swollen Tongue 20 1.2 1.2 no signal
628 Fatigue 496 1.2 1.2 no signal
629 Tremor 106 1.2 1.2 no signal
630 Arteriosclerosis 6 1.2 1.2 no signal
631 Product Dose Omission In Error 17 1.2 1.2 no signal
632 Arterial Occlusive Disease 5 1.2 1.2 no signal
633 Dialysis 9 1.2 1.2 no signal
634 Nerve Injury 7 1.2 1.2 no signal
635 Skin Infection 7 1.2 1.2 no signal
636 Paraesthesia Oral 9 1.2 1.2 no signal
637 Dizziness Postural 6 1.2 1.2 no signal
638 Dyspepsia 61 1.2 1.2 no signal
639 Chills 73 1.2 1.2 no signal
640 Prescribed Overdose 12 1.2 1.2 no signal
641 Device Mechanical Issue 8 1.2 1.2 no signal
642 Hypokinesia 9 1.2 1.2 no signal
643 Micturition Urgency 7 1.2 1.2 no signal
644 Vitreous Floaters 6 1.2 1.2 no signal
645 Diplopia 16 1.2 1.2 no signal
646 Cellulitis 31 1.2 1.2 no signal
647 Immunodeficiency 9 1.1 1.2 no signal
648 Swelling 57 1.1 1.1 no signal
649 Feeling Cold 17 1.1 1.1 no signal
650 Therapy Interrupted 42 1.1 1.1 no signal
651 Therapy Non-responder 27 1.1 1.1 no signal
652 Hypersensitivity 112 1.1 1.1 no signal
653 Anxiety 172 1.1 1.1 no signal
654 Acute Coronary Syndrome 5 1.1 1.1 no signal
655 Ocular Hyperaemia 28 1.1 1.1 no signal
656 Weight Increased 133 1.1 1.1 no signal
657 Motor Dysfunction 6 1.1 1.1 no signal
658 Lethargy 34 1.1 1.1 no signal
659 Face Oedema 10 1.1 1.1 no signal
660 Osteopenia 9 1.1 1.1 no signal
661 Product Prescribing Issue 12 1.1 1.1 no signal
662 Angioedema 26 1.1 1.1 no signal
663 Initial Insomnia 6 1.1 1.1 no signal
664 Tinnitus 27 1.1 1.1 no signal
665 Body Temperature Increased 12 1.1 1.1 no signal
666 Tachycardia 52 1.1 1.1 no signal
667 Hypotension 117 1.1 1.1 no signal
668 Skin Fissures 11 1.1 1.1 no signal
669 Blood Pressure Fluctuation 14 1.1 1.1 no signal
670 Scratch 6 1.1 1.1 no signal
671 Product Preparation Error 12 1.1 1.1 no signal
672 Urticaria 96 1.1 1.1 no signal
673 Eczema 29 1.1 1.1 no signal
674 Drug Ineffective 757 1.1 1.1 no signal
675 Myocardial Infarction 101 1.1 1.1 no signal
676 Acute Myocardial Infarction 17 1.1 1.1 no signal
677 Insomnia 153 1.1 1.1 no signal
678 Blood Pressure Decreased 38 1.1 1.1 no signal
679 Skin Disorder 19 1.1 1.1 no signal
680 Feeling Hot 35 1.1 1.1 no signal
681 Carpal Tunnel Syndrome 8 1.1 1.1 no signal
682 Surgery 33 1.1 1.1 no signal
683 Metabolic Acidosis 18 1.1 1.1 no signal
684 Gait Disturbance 109 1.1 1.1 no signal
685 Tendon Rupture 7 1.1 1.1 no signal
686 Hypothyroidism 18 1.1 1.1 no signal
687 Osteoarthritis 24 1.1 1.1 no signal
688 Blood Potassium Decreased 17 1.1 1.1 no signal
689 Clostridium Difficile Colitis 6 1.1 1.1 no signal
690 Cyst 7 1.1 1.1 no signal
691 Cardiogenic Shock 8 1.1 1.1 no signal
692 Infusion Related Reaction 37 1.1 1.1 no signal
693 Memory Impairment 77 1.1 1.1 no signal
694 Vertigo 34 1.0 1.0 no signal
695 Oedema 30 1.0 1.0 no signal
696 Anosmia 8 1.0 1.0 no signal
697 Prescribed Underdose 11 1.0 1.0 no signal
698 Skin Lesion 15 1.0 1.0 no signal
699 Drug Intolerance 53 1.0 1.0 no signal
700 Road Traffic Accident 23 1.0 1.0 no signal
701 Abdominal Pain Upper 112 1.0 1.0 no signal
702 Bone Disorder 10 1.0 1.0 no signal
703 Dental Caries 6 1.0 1.0 no signal
704 Increased Tendency To Bruise 5 1.0 1.0 no signal
705 Medication Error 30 1.0 1.0 no signal
706 Injury 38 1.0 1.0 no signal
707 Neck Pain 30 1.0 1.0 no signal
708 Blood Cholesterol Increased 25 1.0 1.0 no signal
709 Blood Urea Increased 9 1.0 1.0 no signal
710 Dehydration 71 1.0 1.0 no signal
711 Complication Associated With Device 7 1.0 1.0 no signal
712 Hip Arthroplasty 8 1.0 1.0 no signal
713 Ill-defined Disorder 32 1.0 1.0 no signal
714 Pain In Extremity 155 1.0 1.0 no signal
715 Blood Urine Present 10 1.0 1.0 no signal
716 Needle Issue 15 1.0 1.0 no signal
717 Autoimmune Disorder 5 1.0 1.0 no signal
718 Panic Attack 19 1.0 1.0 no signal
719 Accidental Exposure To Product 52 1.0 1.0 no signal
720 Abdominal Pain 121 1.0 1.0 no signal
721 Amnesia 34 1.0 1.0 no signal
722 Muscular Weakness 59 1.0 1.0 no signal
723 Pruritus 196 1.0 1.0 no signal
724 Device Related Infection 8 1.0 1.0 no signal
725 Femur Fracture 16 1.0 1.0 no signal
726 Vasculitis 6 1.0 1.0 no signal
727 Renal Impairment 43 1.0 1.0 no signal
728 General Physical Health Deterioration 59 1.0 1.0 no signal
729 Staphylococcal Infection 17 1.0 1.0 no signal
730 Abdominal Pain Lower 13 1.0 1.0 no signal
731 Head Discomfort 9 1.0 1.0 no signal
732 Cold Sweat 9 1.0 1.0 no signal
733 Coronary Artery Occlusion 7 1.0 1.0 no signal
734 Arthralgia 210 1.0 1.0 no signal
735 Colitis 19 0.9 0.9 no signal
736 Type 2 Diabetes Mellitus 17 0.9 0.9 no signal
737 Device Occlusion 7 0.9 0.9 no signal
738 Disease Recurrence 24 0.9 0.9 no signal
739 Haematocrit Decreased 10 0.9 0.9 no signal
740 Salivary Hypersecretion 5 0.9 0.9 no signal
741 Gastrointestinal Haemorrhage 42 0.9 0.9 no signal
742 Device Use Error 17 0.9 0.9 no signal
743 Pain 306 0.9 0.9 no signal
744 Dysgeusia 37 0.9 0.9 no signal
745 Restless Legs Syndrome 9 0.9 0.9 no signal
746 Sluggishness 5 0.9 0.9 no signal
747 Product Availability Issue 11 0.9 0.9 no signal
748 Generalised Tonic-clonic Seizure 8 0.9 0.9 no signal
749 Rash Macular 17 0.9 0.9 no signal
750 Subdural Haematoma 7 0.9 0.9 no signal
751 Impaired Healing 16 0.9 0.9 no signal
752 Constipation 105 0.9 0.9 no signal
753 Hyperthyroidism 7 0.9 0.9 no signal
754 Chronic Kidney Disease 37 0.9 0.9 no signal
755 Thinking Abnormal 9 0.9 0.9 no signal
756 Dermatitis Atopic 24 0.9 0.9 no signal
757 Ageusia 12 0.9 0.9 no signal
758 Death 413 0.9 0.9 no signal
759 Stomatitis 29 0.9 0.9 no signal
760 Flatulence 27 0.9 0.9 no signal
761 Pallor 13 0.9 0.9 no signal
762 Liver Disorder 21 0.9 0.9 no signal
763 Upper Gastrointestinal Haemorrhage 8 0.9 0.9 no signal
764 Rash 205 0.9 0.9 no signal
765 Gastric Ulcer 9 0.9 0.9 no signal
766 Burning Sensation 33 0.9 0.9 no signal
767 Wrong Technique In Product Usage Process 95 0.9 0.9 no signal
768 Metastases To Central Nervous System 6 0.9 0.9 no signal
769 Irritable Bowel Syndrome 10 0.9 0.9 no signal
770 Eating Disorder 10 0.9 0.9 no signal
771 White Blood Cell Count Increased 18 0.9 0.9 no signal
772 Gastrointestinal Disorder 41 0.9 0.9 no signal
773 Rash Pruritic 25 0.9 0.9 no signal
774 Somnolence 93 0.9 0.9 no signal
775 Agitation 34 0.9 0.9 no signal
776 Nodule 6 0.9 0.9 no signal
777 Myalgia 78 0.9 0.9 no signal
778 Pruritus Generalised 10 0.9 0.9 no signal
779 Presyncope 11 0.9 0.9 no signal
780 Hypoaesthesia 68 0.9 0.9 no signal
781 Injection Site Urticaria 11 0.9 0.9 no signal
782 Dysarthria 17 0.9 0.9 no signal
783 Hyperhidrosis 58 0.8 0.8 no signal
784 Eye Haemorrhage 6 0.8 0.8 no signal
785 Thirst 8 0.8 0.8 no signal
786 Eye Irritation 25 0.8 0.8 no signal
787 Vomiting 210 0.8 0.8 no signal
788 Muscle Spasms 82 0.8 0.8 no signal
789 Injection Site Bruising 35 0.8 0.8 no signal
790 Drug Hypersensitivity 86 0.8 0.8 no signal
791 Osteomyelitis 8 0.8 0.8 no signal
792 Myocarditis 5 0.8 0.8 no signal
793 Joint Swelling 53 0.8 0.8 no signal
794 Hallucination, Auditory 7 0.8 0.8 no signal
795 Intentional Overdose 28 0.8 0.8 no signal
796 Premature Delivery 7 0.8 0.8 no signal
797 Injection Site Erythema 54 0.8 0.8 no signal
798 Wrong Technique In Device Usage Process 20 0.8 0.8 no signal
799 Abdominal Discomfort 73 0.8 0.8 no signal
800 Injection Site Pruritus 29 0.8 0.8 no signal
801 Anaemia 83 0.8 0.8 no signal
802 Dermatitis 9 0.8 0.8 no signal
803 Dysphagia 41 0.8 0.8 no signal
804 Mobility Decreased 31 0.8 0.8 no signal
805 Abdominal Distension 45 0.8 0.8 no signal
806 Muscle Tightness 7 0.8 0.8 no signal
807 Rhabdomyolysis 18 0.8 0.8 no signal
808 Swelling Face 28 0.8 0.8 no signal
809 Haemorrhage 45 0.8 0.8 no signal
810 Decreased Appetite 99 0.8 0.8 no signal
811 Balance Disorder 37 0.8 0.8 no signal
812 Acute Kidney Injury 65 0.8 0.8 no signal
813 Skin Ulcer 11 0.8 0.8 no signal
814 Squamous Cell Carcinoma 4 0.8 0.8 no signal
815 Influenza Like Illness 35 0.8 0.8 no signal
816 Treatment Noncompliance 23 0.8 0.8 no signal
817 Haematoma 11 0.8 0.8 no signal
818 Injection Site Swelling 32 0.8 0.8 no signal
819 Eructation 8 0.8 0.8 no signal
820 Depression 96 0.8 0.8 no signal
821 Cytopenia 5 0.8 0.8 no signal
822 Diarrhoea 268 0.8 0.8 no signal
823 Clostridium Difficile Infection 9 0.8 0.8 no signal
824 Therapy Change 4 0.8 0.8 no signal
825 Bradycardia 22 0.8 0.8 no signal
826 Mental Disorder 18 0.8 0.8 no signal
827 Neuralgia 10 0.8 0.8 no signal
828 Knee Operation 4 0.8 0.8 no signal
829 Gastroenteritis 6 0.8 0.8 no signal
830 Renal Failure 55 0.8 0.8 no signal
831 Nausea 324 0.8 0.8 no signal
832 Haemorrhoids 8 0.8 0.8 no signal
833 Cognitive Disorder 19 0.8 0.8 no signal
834 Haematuria 14 0.8 0.8 no signal
835 Scar 7 0.8 0.8 no signal
836 Injection Site Mass 15 0.8 0.8 no signal
837 Glossodynia 9 0.8 0.8 no signal
838 Injection Site Pain 122 0.8 0.8 no signal
839 Tooth Extraction 5 0.8 0.8 no signal
840 Feeding Disorder 8 0.8 0.8 no signal
841 Haematochezia 22 0.8 0.8 no signal
842 Therapy Partial Responder 6 0.7 0.7 no signal
843 Cardiac Arrest 33 0.7 0.7 no signal
844 Musculoskeletal Pain 21 0.7 0.7 no signal
845 Blood Creatinine Increased 26 0.7 0.7 no signal
846 Confusional State 64 0.7 0.7 no signal
847 Injection Site Irritation 5 0.7 0.7 no signal
848 Haematemesis 10 0.7 0.7 no signal
849 Inappropriate Antidiuretic Hormone Secretion 4 0.7 0.7 no signal
850 Product Dose Omission 26 0.7 0.7 no signal
851 Helicobacter Infection 4 0.7 0.7 no signal
852 Skin Discolouration 18 0.7 0.7 no signal
853 Drug Dispensing Error 6 0.7 0.7 no signal
854 Hallucination 29 0.7 0.7 no signal
855 Basal Cell Carcinoma 6 0.7 0.7 no signal
856 Ulcer 6 0.7 0.7 no signal
857 Delirium 13 0.7 0.7 no signal
858 Bone Pain 22 0.7 0.7 no signal
859 Maternal Exposure During Pregnancy 33 0.7 0.7 no signal
860 Interstitial Lung Disease 18 0.7 0.7 no signal
861 Increased Appetite 7 0.7 0.7 no signal
862 Movement Disorder 12 0.7 0.7 no signal
863 Skin Irritation 17 0.7 0.7 no signal
864 Blood Potassium Increased 6 0.7 0.7 no signal
865 Systemic Lupus Erythematosus 13 0.7 0.7 no signal
866 Cholelithiasis 12 0.7 0.7 no signal
867 Erythema 75 0.7 0.7 no signal
868 Therapeutic Response Decreased 22 0.7 0.7 no signal
869 Aphasia 11 0.7 0.7 no signal
870 Mental Status Changes 10 0.7 0.7 no signal
871 Haemoglobin Decreased 37 0.7 0.7 no signal
872 Foetal Exposure During Pregnancy 29 0.7 0.7 no signal
873 Accidental Overdose 13 0.7 0.7 no signal
874 Hypophagia 9 0.7 0.7 no signal
875 Cholecystectomy 4 0.7 0.7 no signal
876 Anaphylactic Shock 9 0.7 0.7 no signal
877 International Normalised Ratio Increased 10 0.7 0.7 no signal
878 Septic Shock 15 0.7 0.7 no signal
879 Metastases To Lung 4 0.7 0.7 no signal
880 Hot Flush 26 0.6 0.6 no signal
881 Dysstasia 10 0.6 0.6 no signal
882 Anhedonia 9 0.6 0.6 no signal
883 Fluid Overload 5 0.6 0.6 no signal
884 Incorrect Dose Administered 75 0.6 0.6 no signal
885 Mouth Ulceration 7 0.6 0.6 no signal
886 Therapy Cessation 17 0.6 0.6 no signal
887 Premature Baby 10 0.6 0.6 no signal
888 Circumstance Or Information Capable Of Leading To Medication Error 11 0.6 0.6 no signal
889 Disorientation 13 0.6 0.6 no signal
890 Economic Problem 5 0.6 0.6 no signal
891 Hepatic Cirrhosis 6 0.6 0.6 no signal
892 Rheumatoid Arthritis 36 0.6 0.6 no signal
893 Eye Inflammation 3 0.6 0.6 no signal
894 Hair Colour Changes 4 0.6 0.6 no signal
895 Unevaluable Event 24 0.6 0.6 no signal
896 Fracture 6 0.6 0.6 no signal
897 Nightmare 11 0.6 0.6 no signal
898 Rash Papular 7 0.6 0.6 no signal
899 Affect Lability 3 0.6 0.6 no signal
900 Injection Site Induration 4 0.6 0.6 no signal
901 Drug Prescribing Error 6 0.6 0.6 no signal
902 Ankylosing Spondylitis 4 0.6 0.6 no signal
903 Blood Pressure Systolic Increased 6 0.6 0.6 no signal
904 Injection Site Reaction 21 0.6 0.6 no signal
905 Coeliac Disease 3 0.6 0.6 no signal
906 Exposure During Pregnancy 19 0.6 0.6 no signal
907 Pancytopenia 17 0.6 0.6 no signal
908 Overdose 66 0.6 0.6 no signal
909 Psychotic Disorder 9 0.6 0.6 no signal
910 Blister 17 0.6 0.6 no signal
911 Expired Product Administered 10 0.6 0.6 no signal
912 Sopor 4 0.6 0.6 no signal
913 Neuropathy Peripheral 28 0.6 0.6 no signal
914 Fear 8 0.6 0.6 no signal
915 Coronary Artery Disease 9 0.6 0.6 no signal
916 Blindness 12 0.6 0.6 no signal
917 Mood Altered 8 0.6 0.6 no signal
918 Coma 14 0.6 0.6 no signal
919 Therapeutic Product Effect Decreased 13 0.6 0.6 no signal
920 Circulatory Collapse 5 0.5 0.5 no signal
921 Paraesthesia 46 0.5 0.5 no signal
922 Mental Impairment 7 0.5 0.5 no signal
923 Wound 8 0.5 0.5 no signal
924 Multiple Organ Dysfunction Syndrome 8 0.5 0.5 no signal
925 Hereditary Angioedema 3 0.5 0.5 no signal
926 Cardio-respiratory Arrest 12 0.5 0.5 no signal
927 Flushing 29 0.5 0.5 no signal
928 Altered State Of Consciousness 6 0.5 0.5 no signal
929 Rectal Haemorrhage 12 0.5 0.5 no signal
930 Disturbance In Attention 15 0.5 0.5 no signal
931 Hyperglycaemia 10 0.5 0.5 no signal
932 Pancreatic Carcinoma 8 0.5 0.5 no signal
933 Musculoskeletal Stiffness 24 0.5 0.5 no signal
934 Gastric Cancer 7 0.5 0.5 no signal
935 Unresponsive To Stimuli 7 0.5 0.5 no signal
936 Seizure 31 0.5 0.5 no signal
937 Blood Glucose Abnormal 5 0.5 0.5 no signal
938 Adverse Drug Reaction 24 0.5 0.5 no signal
939 Joint Stiffness 7 0.5 0.5 no signal
940 Skin Exfoliation 22 0.5 0.5 no signal
941 Rebound Effect 3 0.5 0.5 no signal
942 Shock 6 0.5 0.5 no signal
943 Deep Vein Thrombosis 17 0.5 0.5 no signal
944 Breast Cancer Female 7 0.5 0.5 no signal
945 Pain Of Skin 7 0.5 0.5 no signal
946 Gastric Disorder 9 0.5 0.5 no signal
947 Dry Skin 33 0.5 0.5 no signal
948 Hepatic Enzyme Increased 17 0.5 0.5 no signal
949 Blood Glucose Decreased 12 0.5 0.5 no signal
950 Liver Injury 6 0.5 0.5 no signal
951 Thyroid Cancer 3 0.5 0.5 no signal
952 Breast Cancer 23 0.5 0.5 no signal
953 Injection Site Warmth 5 0.5 0.5 no signal
954 Tooth Loss 5 0.5 0.5 no signal
955 Glycosylated Haemoglobin Increased 6 0.4 0.4 no signal
956 Ascites 7 0.4 0.4 no signal
957 Laboratory Test Abnormal 7 0.4 0.4 no signal
958 Faeces Discoloured 5 0.4 0.4 no signal
959 Alopecia 45 0.4 0.4 no signal
960 Rash Generalised 6 0.4 0.4 no signal
961 Depressed Level Of Consciousness 9 0.4 0.4 no signal
962 Drug Interaction 36 0.4 0.4 no signal
963 Pancreatitis 12 0.4 0.4 no signal
964 Emotional Disorder 7 0.4 0.4 no signal
965 Frequent Bowel Movements 6 0.4 0.4 no signal
966 Hair Texture Abnormal 3 0.4 0.4 no signal
967 Aggression 11 0.4 0.4 no signal
968 Underdose 16 0.4 0.4 no signal
969 Suicidal Ideation 20 0.4 0.4 no signal
970 Device Difficult To Use 14 0.4 0.4 no signal
971 Prostate Cancer 17 0.4 0.4 no signal
972 Product Substitution Issue 12 0.4 0.4 no signal
973 Anger 7 0.4 0.4 no signal
974 Hypoglycaemia 10 0.4 0.4 no signal
975 Accidental Underdose 3 0.4 0.4 no signal
976 Hepatic Cancer 5 0.4 0.4 no signal
977 Renal Injury 6 0.4 0.4 no signal
978 Contraindicated Product Administered 6 0.4 0.4 no signal
979 Blood Glucose Increased 37 0.4 0.4 no signal
980 C-reactive Protein Increased 7 0.4 0.4 no signal
981 Crying 7 0.4 0.4 no signal
982 Nervous System Disorder 6 0.4 0.4 no signal
983 Psoriasis 25 0.4 0.4 no signal
984 White Blood Cell Count Decreased 20 0.3 0.3 no signal
985 Osteonecrosis 6 0.3 0.3 no signal
986 Visual Acuity Reduced 6 0.3 0.3 no signal
987 Plasma Cell Myeloma 7 0.3 0.3 no signal
988 Device Breakage 7 0.3 0.3 no signal
989 No Adverse Event 30 0.3 0.3 no signal
990 Bladder Cancer 10 0.3 0.3 no signal
991 Multiple Sclerosis 8 0.3 0.3 no signal
992 Renal Cancer 8 0.3 0.3 no signal
993 Incorrect Route Of Drug Administration 6 0.3 0.3 no signal
994 Device Leakage 7 0.3 0.3 no signal
995 Product Administered At Inappropriate Site 3 0.3 0.3 no signal
996 Neutropenia 22 0.3 0.3 no signal
997 Drug Administration Error 5 0.3 0.3 no signal
998 Multiple Sclerosis Relapse 11 0.3 0.3 no signal
999 Incorrect Dose Administered By Device 4 0.3 0.3 no signal
1000 Colitis Ulcerative 7 0.3 0.3 no signal
1001 Thrombocytopenia 17 0.3 0.3 no signal
1002 Inappropriate Schedule Of Drug Administration 11 0.3 0.3 no signal
1003 Febrile Neutropenia 10 0.3 0.3 no signal
1004 Abortion Spontaneous 6 0.3 0.3 no signal
1005 Drug Dependence 24 0.3 0.3 no signal
1006 Drug Ineffective For Unapproved Indication 8 0.3 0.3 no signal
1007 Withdrawal Syndrome 6 0.3 0.3 no signal
1008 Platelet Count Decreased 15 0.3 0.3 no signal
1009 Product Storage Error 12 0.3 0.3 no signal
1010 Malignant Neoplasm Progression 14 0.3 0.3 no signal
1011 Disease Progression 16 0.3 0.3 no signal
1012 Irritability 8 0.2 0.2 no signal
1013 Aspartate Aminotransferase Increased 7 0.2 0.2 no signal
1014 Emotional Distress 16 0.2 0.2 no signal
1015 Acne 10 0.2 0.2 no signal
1016 Drug Dose Omission By Device 9 0.2 0.2 no signal
1017 Alanine Aminotransferase Increased 7 0.2 0.2 no signal
1018 Skin Burning Sensation 8 0.2 0.2 no signal
1019 Adverse Event 10 0.2 0.2 no signal
1020 Drug Abuse 9 0.2 0.2 no signal
1021 Injection Site Haemorrhage 8 0.2 0.2 no signal
1022 Oesophageal Carcinoma 3 0.2 0.2 no signal
1023 Treatment Failure 8 0.2 0.2 no signal
1024 Drug Dose Omission 12 0.1 0.1 no signal
1025 Toxicity To Various Agents 10 0.1 0.1 no signal