Reaction

Heart Sounds reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 96 reports · 30 co-occurring drugs

As of the last recalculation, Heart Sounds appears in 96 FAERS reports alongside 30 co-occurring drug terms. The strongest observed disproportionality signal is QUINAPRIL HYDROCHLORIDE (PRR 4,395.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Quinapril Hydrochloride	60	4,395.6	4,429.5
Dimenhydrinate	60	3,253.7	3,272.3
Theophylline Anhydrous	61	2,924.1	2,938.7
Theophylline	59	2,886.0	2,901.0
Diltiazem Hydrochloride Extended-Release Tablets	49	1,906.1	1,914.4
Nitrofurantoin	57	1,843.2	1,849.6
Nitrofurantoin (Monohydrate/Macrocrystals)	57	1,819.2	1,825.5
Ipratropium Bromide	71	1,654.1	1,657.4
Insulin Degludec	57	1,294.6	1,297.8
Mepolizumab	63	797.8	798.8
Mometasone	38	742.7	744.3
Lactulose	53	668.0	668.9
Diltiazem Hydrochloride	49	626.2	627.1
Amitriptyline Hydrochloride	32	592.7	593.8
Nitroglycerin	54	497.8	498.3
Tiotropium Bromide Inhalation Spray	20	488.5	489.3
Fluticasone Propionate And Salmeterol Xinafoate	55	463.6	464.0
Cyanocobalamin	37	395.6	396.1
Mometasone Furoate	42	387.7	388.1
Loperamide Hydrochloride Oral	15	377.3	377.8
Azithromycin	40	368.7	369.1
Azithromycin Monohydrate	40	356.2	356.5
Loperamide Hcl	15	299.4	299.8
Fluoxetine	45	274.6	274.7
Metformin Hydrochloride Tablets	40	258.6	258.7
Metformin Hydrochloride Extended-Release Tablets	40	258.5	258.7
Metformin Hydrochloride Tablet	40	258.5	258.7
Insulin Aspart	43	254.7	254.8
Metformin Hydrochloride	40	250.5	250.7
Sildenafil	33	187.7	187.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.