Reaction
Substance Dependence reporting signals
As of the last recalculation, Substance Dependence appears in 661 FAERS reports alongside 22 co-occurring drug terms. The strongest observed disproportionality signal is ETHYL ALCOHOL (PRR 109.9).
Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.
| Drug | Co-reports | PRR | ROR |
|---|---|---|---|
| Ethyl Alcohol | 83 | 109.9 | 110.2 |
| Fentanyl Citrate | 47 | 89.1 | 89.3 |
| Isopropyl Alcohol | 83 | 88.3 | 88.5 |
| Alcohol | 85 | 79.0 | 79.2 |
| Nicotine Polacrilex Mini | 25 | 54.5 | 54.6 |
| Nicotine Polarilex | 25 | 54.5 | 54.6 |
| Methadone Hydrochloride | 15 | 44.6 | 44.7 |
| Hydromorphone Hydrochloride | 103 | 41.6 | 41.6 |
| Oxycodone Hydrochloride | 201 | 41.4 | 41.5 |
| Morphine Sulfate | 113 | 35.2 | 35.2 |
| Amphetamine | 8 | 30.8 | 30.8 |
| Methadone | 36 | 28.0 | 28.0 |
| Aripiprazole Oral | 28 | 22.2 | 22.2 |
| Aripiprazole Orally Disintegrating | 28 | 22.2 | 22.2 |
| Nicotine Polacrilex | 25 | 21.3 | 21.4 |
| Nicotine | 25 | 20.2 | 20.2 |
| Oxycodone | 91 | 17.6 | 17.6 |
| Buprenorphine Hydrochloride, Naloxone Hydrochloride | 13 | 17.3 | 17.3 |
| Rocuronium Bromide | 6 | 16.2 | 16.2 |
| Desvenlafaxine Succinate | 12 | 14.2 | 14.2 |
| Naltrexone | 12 | 12.5 | 12.5 |
| Buprenorphine | 27 | 9.5 | 9.5 |