OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Methadone Hydrochloride

1,017 flagged reaction(s) · 35,247 total co-reports · max PRR 3,076.2
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Malignant Cranial Nerve Neoplasm 16 3,076.2 3,080.8 signal
2 Ivth Nerve Disorder 6 961.3 961.9 signal
3 Antemortem Blood Drug Level Abnormal 4 854.5 854.8 signal
4 Retro-orbital Neoplasm 16 831.4 832.7 signal
5 Vision Abnormal Neonatal 112 703.7 711.1 signal
6 Neonatal Hypoacusis 41 412.7 414.3 signal
7 Postmortem Blood Drug Level Abnormal 18 272.5 273.0 signal
8 Phyllodes Tumour 10 270.8 271.0 signal
9 Congenital Nystagmus 24 249.4 250.0 signal
10 Hepatitis C Rna 5 234.5 234.6 signal
11 Brachial Artery Entrapment Syndrome 4 226.2 226.3 signal
12 Strabismus Congenital 15 225.3 225.6 signal
13 Drug Dependence, Antepartum 5 209.0 209.1 signal
14 Drug Withdrawal Syndrome Neonatal 1,431 206.4 237.9 signal
15 Substance Abuser 20 204.5 204.9 signal
16 Learning Disability 465 184.0 192.2 signal
17 Neuroblastoma Recurrent 16 168.1 168.3 signal
18 Developmental Delay 508 115.3 121.0 signal
19 Anti-erythropoietin Antibody Negative 5 111.8 111.8 signal
20 Optic Nerve Hypoplasia 5 110.5 110.5 signal
21 Radiation Associated Pain 10 97.1 97.2 signal
22 Muscle Tone Disorder 14 90.6 90.7 signal
23 Diabetic Wound 4 89.4 89.5 signal
24 Substance Use 64 84.5 85.0 signal
25 Accidental Poisoning 55 82.7 83.2 signal
26 Sudden Infant Death Syndrome 19 77.4 77.5 signal
27 Pierre Robin Syndrome 8 74.3 74.4 signal
28 Hyperinsulinaemic Hypoglycaemia 7 65.7 65.7 signal
29 Multiple Drug Overdose Accidental 14 60.6 60.7 signal
30 Myocardial Fibrosis 25 59.7 59.8 signal
31 Toxicologic Test Abnormal 18 59.0 59.1 signal
32 Substance Use Disorder 89 58.1 58.5 signal
33 Bradypnoea 71 52.9 53.3 signal
34 Visceral Congestion 13 52.6 52.7 signal
35 Drug Diversion 148 51.7 52.4 signal
36 Weight Decrease Neonatal 5 51.1 51.2 signal
37 Holoprosencephaly 4 49.0 49.0 signal
38 Victim Of Child Abuse 6 48.5 48.5 signal
39 Narcotic Intoxication 6 45.8 45.8 signal
40 Substance Dependence 15 44.6 44.7 signal
41 Hepatitis C Antibody Positive 6 44.5 44.6 signal
42 Chemical Submission 5 40.2 40.2 signal
43 Premature Labour 111 38.7 39.1 signal
44 Toxic Leukoencephalopathy 14 38.3 38.4 signal
45 Myocardial Oedema 7 35.9 35.9 signal
46 Brachial Plexopathy 4 35.8 35.8 signal
47 Foetal Exposure During Pregnancy 1,455 35.5 40.9 signal
48 Congenital Diaphragmatic Hernia 7 35.2 35.3 signal
49 Miosis 131 32.6 33.0 signal
50 Child Abuse 4 31.6 31.7 signal
51 Multiple Drug Overdose Intentional 49 29.7 29.8 signal
52 Torsade De Pointes 115 28.9 29.2 signal
53 Epidural Lipomatosis 5 28.4 28.4 signal
54 Adnexa Uteri Mass 4 28.3 28.3 signal
55 Thyroxine Increased 10 28.0 28.1 signal
56 Respiratory Depression 167 26.9 27.3 signal
57 Multiple Drug Overdose 65 25.5 25.6 signal
58 Electrocardiogram Qt Corrected Interval Prolonged 10 24.8 24.8 signal
59 Drug Use Disorder 100 23.8 24.0 signal
60 Substance-induced Psychotic Disorder 26 23.2 23.2 signal
61 Substance Abuse 93 22.5 22.7 signal
62 Cardiopulmonary Failure 44 22.1 22.2 signal
63 Hypertonia Neonatal 6 22.1 22.2 signal
64 Respiratory Acidosis 44 22.1 22.2 signal
65 Premature Delivery 179 22.0 22.4 signal
66 Accidental Death 20 21.3 21.3 signal
67 Leukoencephalopathy 39 20.5 20.6 signal
68 Faecal Volume Decreased 5 20.4 20.4 signal
69 Intentional Misuse 20 20.3 20.4 signal
70 Ductus Arteriosus Premature Closure 4 19.1 19.1 signal
71 Victim Of Sexual Abuse 5 19.0 19.0 signal
72 Biopsy Liver 4 19.0 19.0 signal
73 Dependence 534 18.9 19.8 signal
74 Drug Abuse 791 18.6 20.0 signal
75 Polysubstance Abuse 6 18.3 18.3 signal
76 White Coat Hypertension 5 18.2 18.2 signal
77 Diabetic Hyperosmolar Coma 4 18.0 18.0 signal
78 Homeless 4 17.5 17.5 signal
79 Cerebral Hypoperfusion 4 17.1 17.1 signal
80 Chloasma 4 17.0 17.0 signal
81 Poisoning 106 16.5 16.7 signal
82 Bone Marrow Disorder 24 15.7 15.7 signal
83 Executive Dysfunction 4 15.3 15.3 signal
84 Anoxic Encephalopathy 5 15.1 15.1 signal
85 Hypoxic-ischaemic Encephalopathy 19 14.2 14.2 signal
86 Asphyxia 58 13.9 14.0 signal
87 Hypercapnia 21 13.8 13.8 signal
88 Toxicity To Various Agents 1,144 13.4 14.8 signal
89 Electrocardiogram Qt Prolonged 242 13.2 13.5 signal
90 Sudden Cardiac Death 23 13.2 13.2 signal
91 Premature Baby 198 12.9 13.1 signal
92 Suspected Transmission Of An Infectious Agent Via Product 8 12.7 12.7 signal
93 Sopor 85 12.5 12.6 signal
94 Drug Dependence 1,027 12.4 13.6 signal
95 Exposure During Pregnancy 392 12.4 12.8 signal
96 Foetal Growth Retardation 5 12.4 12.4 signal
97 Metastases To Spine 21 12.3 12.3 signal
98 Cardio-respiratory Arrest 263 12.3 12.5 signal
99 Hepatic Fibrosis 21 12.0 12.1 signal
100 Product Tampering 11 12.0 12.0 signal
101 Toxic Encephalopathy 30 11.9 11.9 signal
102 Maternal Exposure During Pregnancy 532 11.8 12.4 signal
103 Brain Hypoxia 6 11.7 11.7 signal
104 Stoma Complication 6 11.5 11.5 signal
105 Abscess Neck 4 11.5 11.5 signal
106 Drug Abuser 36 11.3 11.4 signal
107 Strabismus 17 11.3 11.3 signal
108 Accidental Overdose 210 11.3 11.5 signal
109 Ventricular Arrhythmia 21 11.3 11.3 signal
110 Labelled Drug-drug Interaction Issue 8 11.2 11.2 signal
111 Blood Pressure Diastolic Increased 26 11.0 11.0 signal
112 Congenital Anomaly 43 10.8 10.8 signal
113 Piloerection 6 10.8 10.8 signal
114 Multiple Congenital Abnormalities 8 10.8 10.8 signal
115 Eschar 4 10.6 10.6 signal
116 Respiratory Arrest 150 10.6 10.7 signal
117 Drug Level Increased 89 10.5 10.6 signal
118 Coma Hepatic 4 10.4 10.5 signal
119 Maternal Drugs Affecting Foetus 41 10.3 10.4 signal
120 Intervertebral Discitis 10 10.3 10.4 signal
121 Radiation Pneumonitis 11 10.0 10.1 signal
122 Self-medication 21 10.0 10.0 signal
123 Exposure Via Breast Milk 20 10.0 10.0 signal
124 Drug Toxicity 70 9.9 10.0 signal
125 Brain Herniation 15 9.8 9.8 signal
126 Foetal Growth Restriction 30 9.7 9.7 signal
127 Hypogonadism 5 9.6 9.6 signal
128 Menopausal Symptoms 11 9.4 9.4 signal
129 Drug Exposure During Pregnancy 165 9.4 9.5 signal
130 Respiratory Rate Decreased 15 9.3 9.3 signal
131 Drug Tolerance 24 9.2 9.3 signal
132 Cleft Palate 9 9.1 9.1 signal
133 Aspiration 50 9.0 9.1 signal
134 Bladder Dilatation 5 9.0 9.0 signal
135 Completed Suicide 384 8.9 9.2 signal
136 Accidental Exposure To Product By Child 31 8.9 8.9 signal
137 Drug Screen Negative 8 8.9 8.9 signal
138 Stress Cardiomyopathy 26 8.8 8.8 signal
139 Immune Thrombocytopenia 20 8.7 8.8 signal
140 Complex Partial Seizures 5 8.7 8.7 signal
141 Overdose 941 8.5 9.2 signal
142 Pupils Unequal 5 8.4 8.4 signal
143 Disability 84 8.3 8.4 signal
144 Coma Scale Abnormal 12 8.2 8.2 signal
145 Mutism 6 8.1 8.1 signal
146 Long Qt Syndrome 10 8.1 8.1 signal
147 Coma 196 8.0 8.2 signal
148 Cardiac Death 5 8.0 8.0 signal
149 Nystagmus 21 7.7 7.8 signal
150 Hypoventilation 13 7.7 7.7 signal
151 Left Atrial Dilatation 5 7.6 7.6 signal
152 Pulmonary Haemorrhage 30 7.5 7.5 signal
153 Drug Screen Positive 30 7.4 7.5 signal
154 Poisoning Deliberate 35 7.4 7.4 signal
155 Post-traumatic Stress Disorder 25 7.3 7.3 signal
156 Incoherent 24 7.2 7.2 signal
157 Bone Neoplasm 4 7.2 7.2 signal
158 Trismus 19 7.2 7.2 signal
159 Unresponsive To Stimuli 94 7.1 7.2 signal
160 Nerve Injury 40 7.0 7.0 signal
161 Psychiatric Decompensation 7 7.0 7.0 signal
162 Alcohol Use 13 6.8 6.8 signal
163 Hypopnoea 12 6.8 6.8 signal
164 Suicide Attempt 209 6.7 6.8 signal
165 Pupil Fixed 6 6.7 6.7 signal
166 Ischaemic Cerebral Infarction 4 6.7 6.7 signal
167 Drug Withdrawal Syndrome 304 6.7 6.9 signal
168 Heat Stroke 5 6.6 6.6 signal
169 Hyperparathyroidism 7 6.6 6.6 signal
170 Brain Injury 34 6.6 6.6 signal
171 Biliary Dilatation 5 6.6 6.6 signal
172 Imprisonment 6 6.5 6.5 signal
173 Maternal Exposure During Breast Feeding 13 6.5 6.5 signal
174 Iritis 10 6.4 6.4 signal
175 Prescription Drug Used Without A Prescription 20 6.4 6.4 signal
176 Pneumonia Aspiration 81 6.4 6.4 signal
177 Persecutory Delusion 8 6.3 6.3 signal
178 Electrocardiogram T Wave Abnormal 5 6.3 6.3 signal
179 Small For Dates Baby 16 6.3 6.3 signal
180 Arteriosclerosis Coronary Artery 21 6.2 6.2 signal
181 Emotional Distress 384 6.2 6.4 signal
182 Hepatitis C 38 6.1 6.1 signal
183 Sudden Death 33 6.0 6.0 signal
184 Heart Disease Congenital 11 6.0 6.0 signal
185 Accidental Exposure 13 6.0 6.0 signal
186 Compartment Syndrome 8 6.0 6.0 signal
187 Deafness Neurosensory 10 6.0 6.0 signal
188 Myoclonus 36 5.9 5.9 signal
189 Brain Oedema 38 5.9 5.9 signal
190 Cerebellar Infarction 5 5.8 5.8 signal
191 Pulmonary Congestion 39 5.8 5.8 signal
192 Depressed Level Of Consciousness 116 5.7 5.8 signal
193 Snoring 11 5.7 5.7 signal
194 Wound Infection Staphylococcal 5 5.6 5.6 signal
195 Disorganised Speech 5 5.4 5.4 signal
196 Generalised Anxiety Disorder 4 5.3 5.3 signal
197 Impatience 5 5.2 5.2 signal
198 Cyanosis 42 5.2 5.2 signal
199 Withdrawal Syndrome 111 5.1 5.2 signal
200 Encephalitis 18 5.1 5.1 signal
201 Alcohol Abuse 7 5.1 5.1 signal
202 Escherichia Bacteraemia 6 5.1 5.1 signal
203 Accidental Drug Intake By Child 4 5.0 5.0 signal
204 Apnoea 20 5.0 5.0 signal
205 Neonatal Respiratory Distress Syndrome 9 4.9 5.0 signal
206 Oxygen Saturation Abnormal 7 4.9 4.9 signal
207 Gastrointestinal Motility Disorder 13 4.8 4.8 signal
208 Listless 8 4.8 4.8 signal
209 Injection Site Abscess 6 4.7 4.7 signal
210 Left Ventricular Dysfunction 16 4.7 4.7 signal
211 Cardiac Arrest 195 4.6 4.7 signal
212 Essential Hypertension 6 4.5 4.5 signal
213 Caesarean Section 27 4.5 4.5 signal
214 Hypopituitarism 4 4.5 4.5 signal
215 Psychomotor Skills Impaired 6 4.5 4.5 signal
216 Behaviour Disorder 12 4.4 4.4 signal
217 Electrocardiogram T Wave Inversion 5 4.4 4.4 signal
218 Idiopathic Intracranial Hypertension 5 4.3 4.3 signal
219 Serotonin Syndrome 42 4.3 4.3 signal
220 Ventricular Tachycardia 36 4.2 4.3 signal
221 Pulmonary Oedema 97 4.2 4.3 signal
222 Psychomotor Retardation 6 4.2 4.2 signal
223 Endotracheal Intubation 6 4.2 4.2 signal
224 Rhabdomyolysis 89 4.2 4.2 signal
225 Delirium 73 4.1 4.1 signal
226 Electrocardiogram St Segment Elevation 7 4.1 4.1 signal
227 Exposure During Breast Feeding 7 4.1 4.1 signal
228 Escherichia Sepsis 6 4.0 4.1 signal
229 Radius Fracture 5 4.0 4.0 signal
230 Diabetes Insipidus 5 4.0 4.0 signal
231 Left Ventricular Failure 7 4.0 4.0 signal
232 Juvenile Idiopathic Arthritis 5 4.0 4.0 signal
233 Hydrocephalus 11 3.9 4.0 signal
234 Petechiae 21 3.9 3.9 signal
235 Body Temperature Decreased 20 3.9 3.9 signal
236 Hyperreflexia 7 3.9 3.9 signal
237 Sedation Complication 5 3.9 3.9 signal
238 Sedation 52 3.9 3.9 signal
239 Foaming At Mouth 4 3.9 3.9 signal
240 Drug Interaction 312 3.8 3.9 signal
241 Encephalopathy 48 3.8 3.8 signal
242 Nerve Compression 18 3.8 3.8 signal
243 Brain Death 6 3.8 3.8 signal
244 Alcohol Poisoning 5 3.7 3.7 signal
245 Left Ventricular Hypertrophy 8 3.6 3.6 signal
246 Hypoxia 65 3.6 3.6 signal
247 Intentional Drug Misuse 39 3.6 3.6 signal
248 Potentiating Drug Interaction 6 3.6 3.6 signal
249 Bipolar I Disorder 4 3.6 3.6 signal
250 Exposed Bone In Jaw 4 3.6 3.6 signal
251 Clonus 5 3.6 3.6 signal
252 Altered State Of Consciousness 39 3.5 3.5 signal
253 Accident At Work 4 3.5 3.5 signal
254 Hyperammonaemia 9 3.5 3.5 signal
255 Paranoia 31 3.5 3.5 signal
256 Drug Level Above Therapeutic 8 3.4 3.4 signal
257 Endocarditis 9 3.4 3.4 signal
258 Computerised Tomogram Abnormal 4 3.4 3.4 signal
259 Intentional Product Misuse 148 3.3 3.4 signal
260 Hyperaesthesia 14 3.3 3.3 signal
261 Cardiomyopathy 25 3.3 3.3 signal
262 Somnambulism 11 3.3 3.3 signal
263 Mydriasis 21 3.2 3.2 signal
264 Intervertebral Disc Degeneration 15 3.1 3.1 signal
265 Infusion Site Pruritus 5 3.1 3.1 signal
266 Blood Creatinine Decreased 5 3.1 3.1 signal
267 Arteriosclerosis 15 3.1 3.1 signal
268 Stupor 5 3.0 3.0 signal
269 Affective Disorder 12 3.0 3.0 signal
270 Impaired Quality Of Life 22 3.0 3.0 signal
271 Prostatomegaly 6 3.0 3.0 signal
272 Anxiety 435 3.0 3.1 signal
273 Nephrogenic Anaemia 7 2.9 2.9 signal
274 Leukocytosis 27 2.9 2.9 signal
275 Areflexia 4 2.9 2.9 no signal
276 Intentional Self-injury 30 2.9 2.9 signal
277 Emphysema 15 2.9 2.9 signal
278 Hypothermia 15 2.9 2.9 signal
279 Intentional Overdose 94 2.9 2.9 signal
280 Hepatic Cyst 5 2.9 2.9 signal
281 Somnolence 296 2.9 2.9 signal
282 Pulse Absent 7 2.9 2.9 signal
283 Respiration Abnormal 10 2.9 2.9 signal
284 Regurgitation 5 2.9 2.9 signal
285 Hypervolaemia 7 2.8 2.8 signal
286 Dental Caries 16 2.8 2.8 signal
287 Ventricular Extrasystoles 15 2.8 2.8 signal
288 Faecal Incontinence 7 2.8 2.8 signal
289 Product Administration Interrupted 11 2.8 2.8 signal
290 Drug Screen False Positive 4 2.8 2.8 no signal
291 Hepatomegaly 14 2.8 2.8 signal
292 Hemiparesis 24 2.7 2.8 signal
293 Abscess Limb 6 2.7 2.7 signal
294 Diabetic Neuropathy 7 2.7 2.7 signal
295 Agitation 103 2.7 2.7 signal
296 Lung Neoplasm 6 2.7 2.7 signal
297 Biliary Colic 4 2.7 2.7 no signal
298 Fibromyalgia 33 2.7 2.7 signal
299 Catatonia 7 2.6 2.6 signal
300 Metabolic Encephalopathy 4 2.6 2.6 no signal
301 Craniocerebral Injury 4 2.6 2.6 no signal
302 Vascular Device Infection 6 2.6 2.6 signal
303 Metastases To Liver 23 2.6 2.6 signal
304 Blood Thyroid Stimulating Hormone Increased 12 2.5 2.5 signal
305 Economic Problem 20 2.5 2.5 signal
306 Spinal Cord Compression 5 2.5 2.5 no signal
307 Joint Range Of Motion Decreased 17 2.5 2.5 signal
308 Euphoric Mood 13 2.5 2.5 signal
309 Candida Infection 21 2.5 2.5 signal
310 Ventricular Fibrillation 14 2.5 2.5 signal
311 Trigeminal Neuralgia 5 2.4 2.4 no signal
312 Candidiasis 5 2.4 2.4 no signal
313 Homicidal Ideation 5 2.4 2.4 no signal
314 Hypertonia 7 2.4 2.4 signal
315 Hyperpyrexia 5 2.4 2.4 no signal
316 Mental Status Changes 33 2.3 2.3 signal
317 Hypoacusis 51 2.3 2.3 signal
318 Hypoalbuminaemia 9 2.3 2.3 signal
319 Phlebitis 6 2.3 2.3 no signal
320 Purulent Discharge 5 2.3 2.3 no signal
321 Drug-induced Liver Injury 36 2.3 2.3 signal
322 Loss Of Personal Independence In Daily Activities 55 2.3 2.3 signal
323 Granuloma 4 2.3 2.3 no signal
324 Bronchopneumonia 4 2.2 2.2 no signal
325 Neurotoxicity 20 2.2 2.2 signal
326 Extrasystoles 8 2.2 2.2 signal
327 Carotid Artery Stenosis 4 2.2 2.2 no signal
328 Sinus Bradycardia 11 2.2 2.2 signal
329 Hypokalaemia 52 2.2 2.2 signal
330 Spinal Osteoarthritis 10 2.2 2.2 signal
331 Sinus Tachycardia 16 2.2 2.2 signal
332 Iron Deficiency 5 2.2 2.2 no signal
333 Respiratory Distress 31 2.2 2.2 signal
334 Dysarthria 42 2.2 2.2 signal
335 Hiccups 9 2.2 2.2 signal
336 Faecaloma 6 2.2 2.2 no signal
337 Therapy Non-responder 49 2.1 2.1 signal
338 Blood Phosphorus Decreased 4 2.1 2.1 no signal
339 Cardiac Disorder 103 2.1 2.2 signal
340 Hypoglycaemia 53 2.1 2.1 signal
341 Hypophosphataemia 8 2.1 2.1 no signal
342 Renal Function Test Abnormal 5 2.1 2.1 no signal
343 Disease Complication 5 2.1 2.1 no signal
344 Adrenal Insufficiency 13 2.1 2.1 signal
345 Prostatic Disorder 6 2.1 2.1 no signal
346 Loss Of Consciousness 139 2.1 2.1 signal
347 Hyperacusis 4 2.1 2.1 no signal
348 Angiopathy 6 2.1 2.1 no signal
349 Aggression 53 2.1 2.1 signal
350 Tooth Loss 22 2.1 2.1 signal
351 Posterior Reversible Encephalopathy Syndrome 10 2.0 2.0 signal
352 Libido Decreased 13 2.0 2.0 signal
353 Erectile Dysfunction 27 2.0 2.0 signal
354 Hypercholesterolaemia 10 2.0 2.0 signal
355 Spinal Column Stenosis 5 2.0 2.0 no signal
356 Electrolyte Imbalance 12 2.0 2.0 signal
357 Colitis Ischaemic 7 2.0 2.0 no signal
358 Respiratory Failure 75 2.0 2.0 signal
359 Nervous System Disorder 32 2.0 2.0 no signal
360 Bipolar Disorder 11 2.0 2.0 no signal
361 Hyperlipidaemia 12 2.0 2.0 no signal
362 Fungal Skin Infection 4 1.9 1.9 no signal
363 Gallbladder Operation 4 1.9 1.9 no signal
364 Sleep Apnoea Syndrome 19 1.9 1.9 no signal
365 Coronary Artery Stenosis 5 1.9 1.9 no signal
366 Pallor 27 1.9 1.9 no signal
367 Pathological Fracture 5 1.9 1.9 no signal
368 Hepatic Cytolysis 12 1.9 1.9 no signal
369 Ammonia Increased 5 1.9 1.9 no signal
370 Body Temperature Increased 20 1.9 1.9 no signal
371 Cachexia 5 1.9 1.9 no signal
372 Abnormal Faeces 8 1.9 1.9 no signal
373 Cholecystectomy 11 1.9 1.9 no signal
374 Multiple Organ Dysfunction Syndrome 27 1.9 1.9 no signal
375 Cardiomegaly 12 1.9 1.9 no signal
376 Grand Mal Convulsion 9 1.9 1.9 no signal
377 Suicidal Ideation 88 1.9 1.9 no signal
378 Failure To Thrive 5 1.9 1.9 no signal
379 Major Depression 7 1.9 1.9 no signal
380 Pre-existing Condition Improved 6 1.9 1.9 no signal
381 Sickle Cell Anaemia With Crisis 15 1.9 1.9 no signal
382 Congestive Cardiomyopathy 4 1.8 1.8 no signal
383 Aortic Valve Incompetence 4 1.8 1.8 no signal
384 Bundle Branch Block Left 4 1.8 1.8 no signal
385 Inadequate Analgesia 8 1.8 1.8 no signal
386 Blood Magnesium Decreased 8 1.8 1.8 no signal
387 Hepatic Lesion 4 1.8 1.8 no signal
388 Hyperthermia 7 1.8 1.8 no signal
389 Muscle Rigidity 11 1.8 1.8 no signal
390 Psychotic Disorder 27 1.8 1.8 no signal
391 Cardiogenic Shock 13 1.8 1.8 no signal
392 Hallucination 68 1.8 1.8 no signal
393 Crying 33 1.8 1.8 no signal
394 Purpura 8 1.8 1.8 no signal
395 Wrong Product Administered 6 1.8 1.8 no signal
396 Restlessness 33 1.8 1.8 no signal
397 Pain 552 1.7 1.8 no signal
398 Confusional State 143 1.7 1.7 no signal
399 Acute Myocardial Infarction 26 1.7 1.7 no signal
400 Joint Effusion 6 1.7 1.7 no signal
401 Herpes Virus Infection 5 1.7 1.7 no signal
402 Ischaemia 4 1.7 1.7 no signal
403 Decubitus Ulcer 7 1.7 1.7 no signal
404 Hereditary Angioedema 9 1.7 1.7 no signal
405 Urine Odour Abnormal 5 1.7 1.7 no signal
406 Decreased Interest 5 1.7 1.7 no signal
407 Psychomotor Hyperactivity 14 1.6 1.6 no signal
408 Acute Respiratory Failure 16 1.6 1.6 no signal
409 Tachycardia 74 1.6 1.6 no signal
410 Osteomyelitis 15 1.6 1.6 no signal
411 Oesophagitis 9 1.6 1.6 no signal
412 Obesity 13 1.6 1.6 no signal
413 Renal Tubular Necrosis 8 1.6 1.6 no signal
414 Infusion Site Swelling 5 1.6 1.6 no signal
415 Hepatic Steatosis 15 1.6 1.6 no signal
416 Hypersomnia 23 1.6 1.6 no signal
417 Haemodynamic Instability 6 1.6 1.6 no signal
418 Status Epilepticus 9 1.6 1.6 no signal
419 Mitral Valve Incompetence 9 1.6 1.6 no signal
420 Motor Dysfunction 8 1.5 1.5 no signal
421 Multiple Injuries 5 1.5 1.5 no signal
422 Visual Impairment 96 1.5 1.5 no signal
423 Hyperbilirubinaemia 8 1.5 1.5 no signal
424 Convulsion 45 1.5 1.5 no signal
425 Poor Venous Access 8 1.5 1.5 no signal
426 Foetal Death 4 1.5 1.5 no signal
427 Appetite Disorder 5 1.5 1.5 no signal
428 Aplastic Anaemia 4 1.5 1.5 no signal
429 Tricuspid Valve Incompetence 6 1.5 1.5 no signal
430 Pneumothorax 12 1.5 1.5 no signal
431 Neuroleptic Malignant Syndrome 9 1.5 1.5 no signal
432 Brain Fog 11 1.5 1.5 no signal
433 Clostridium Difficile Colitis 8 1.5 1.5 no signal
434 Hepatic Encephalopathy 7 1.5 1.5 no signal
435 Hepatic Cirrhosis 14 1.5 1.5 no signal
436 Small Intestinal Obstruction 9 1.4 1.4 no signal
437 Blood Potassium Decreased 22 1.4 1.4 no signal
438 Lethargy 42 1.4 1.4 no signal
439 Constipation 158 1.4 1.4 no signal
440 Intestinal Ischaemia 4 1.4 1.4 no signal
441 Intervertebral Disc Protrusion 16 1.4 1.4 no signal
442 Hypercalcaemia 9 1.4 1.4 no signal
443 Toxic Epidermal Necrolysis 11 1.4 1.4 no signal
444 No Therapeutic Response 9 1.4 1.4 no signal
445 Metabolic Acidosis 23 1.4 1.4 no signal
446 Lymphoedema 5 1.4 1.4 no signal
447 Ill-defined Disorder 44 1.4 1.4 no signal
448 Live Birth 6 1.4 1.4 no signal
449 Coordination Abnormal 10 1.4 1.4 no signal
450 Myocarditis 8 1.4 1.4 no signal
451 Menorrhagia 14 1.4 1.4 no signal
452 Mental Impairment 17 1.4 1.4 no signal
453 Scar 12 1.4 1.4 no signal
454 Hyperhidrosis 90 1.4 1.4 no signal
455 Urinary Retention 23 1.3 1.3 no signal
456 Mood Swings 22 1.3 1.3 no signal
457 Orthostatic Hypotension 12 1.3 1.3 no signal
458 Bradykinesia 4 1.3 1.3 no signal
459 Disorientation 27 1.3 1.3 no signal
460 Cerebral Disorder 5 1.3 1.3 no signal
461 Abnormal Behaviour 27 1.3 1.3 no signal
462 Cardiotoxicity 6 1.3 1.3 no signal
463 Death 582 1.3 1.3 no signal
464 Blood Pressure Diastolic Decreased 5 1.3 1.3 no signal
465 Arrhythmia 32 1.3 1.3 no signal
466 Accident 8 1.3 1.3 no signal
467 Sleep Disorder 47 1.3 1.3 no signal
468 Ataxia 8 1.3 1.3 no signal
469 Depression 153 1.3 1.3 no signal
470 Ketoacidosis 5 1.3 1.3 no signal
471 Hepatitis Cholestatic 4 1.3 1.3 no signal
472 Mental Disorder 29 1.3 1.3 no signal
473 Tachypnoea 9 1.3 1.3 no signal
474 Pneumonia Bacterial 6 1.3 1.3 no signal
475 Hepatocellular Carcinoma 5 1.3 1.3 no signal
476 Blood Urea Increased 11 1.3 1.3 no signal
477 Hypomagnesaemia 9 1.3 1.3 no signal
478 Musculoskeletal Chest Pain 10 1.3 1.3 no signal
479 Oxygen Saturation Decreased 36 1.3 1.3 no signal
480 Road Traffic Accident 27 1.3 1.3 no signal
481 Ejection Fraction Decreased 10 1.3 1.3 no signal
482 Mass 9 1.3 1.3 no signal
483 Product Prescribing Issue 13 1.2 1.2 no signal
484 Electrocardiogram Abnormal 5 1.2 1.2 no signal
485 Foot Fracture 12 1.2 1.2 no signal
486 Malnutrition 7 1.2 1.2 no signal
487 Renal Failure Acute 27 1.2 1.2 no signal
488 Abscess 10 1.2 1.2 no signal
489 Tooth Disorder 14 1.2 1.2 no signal
490 Blood Calcium Decreased 7 1.2 1.2 no signal
491 Atelectasis 6 1.2 1.2 no signal
492 Muscle Tightness 10 1.2 1.2 no signal
493 Pancytopenia 34 1.2 1.2 no signal
494 Myocardial Ischaemia 7 1.2 1.2 no signal
495 Bradyphrenia 4 1.2 1.2 no signal
496 Poor Quality Sleep 13 1.2 1.2 no signal
497 Pneumonia 196 1.2 1.2 no signal
498 Restless Legs Syndrome 11 1.2 1.2 no signal
499 Infusion Site Erythema 5 1.2 1.2 no signal
500 Rectal Haemorrhage 26 1.2 1.2 no signal
501 Bradycardia 32 1.2 1.2 no signal
502 Seizure 69 1.2 1.2 no signal
503 Acute Coronary Syndrome 5 1.2 1.2 no signal
504 Splenomegaly 7 1.2 1.2 no signal
505 Hepatic Failure 18 1.2 1.2 no signal
506 Spinal Compression Fracture 5 1.2 1.2 no signal
507 Pneumonitis 16 1.2 1.2 no signal
508 Blood Bilirubin Increased 16 1.2 1.2 no signal
509 Coronary Artery Disease 18 1.1 1.2 no signal
510 Subarachnoid Haemorrhage 6 1.1 1.1 no signal
511 Skin Ulcer 15 1.1 1.1 no signal
512 Ankle Fracture 9 1.1 1.1 no signal
513 Blood Testosterone Decreased 4 1.1 1.1 no signal
514 Weight Fluctuation 6 1.1 1.1 no signal
515 Blood Pressure Decreased 38 1.1 1.1 no signal
516 Head Injury 18 1.1 1.1 no signal
517 Lymphopenia 8 1.1 1.1 no signal
518 Intentional Product Use Issue 50 1.1 1.1 no signal
519 Choking 11 1.1 1.1 no signal
520 Amnesia 37 1.1 1.1 no signal
521 Haemorrhoids 11 1.1 1.1 no signal
522 Labelled Drug-drug Interaction Medication Error 5 1.1 1.1 no signal
523 Extrapyramidal Disorder 14 1.1 1.1 no signal
524 Loss Of Libido 5 1.1 1.1 no signal
525 Skin Laceration 6 1.1 1.1 no signal
526 Diverticulum 4 1.1 1.1 no signal
527 Hypotension 111 1.1 1.1 no signal
528 Haemophagocytic Lymphohistiocytosis 4 1.1 1.1 no signal
529 Generalised Tonic-clonic Seizure 9 1.1 1.1 no signal
530 Pulmonary Thrombosis 6 1.1 1.1 no signal
531 Infusion Site Pain 7 1.1 1.1 no signal
532 Bone Disorder 10 1.1 1.1 no signal
533 End Stage Renal Disease 10 1.1 1.1 no signal
534 Dyskinesia 22 1.1 1.1 no signal
535 Coagulopathy 9 1.1 1.1 no signal
536 Blood Pressure Fluctuation 13 1.1 1.1 no signal
537 Personality Change 5 1.0 1.0 no signal
538 Flank Pain 5 1.0 1.0 no signal
539 Oedema Peripheral 65 1.0 1.0 no signal
540 Chromaturia 12 1.0 1.0 no signal
541 Therapy Partial Responder 8 1.0 1.0 no signal
542 Anger 18 1.0 1.0 no signal
543 Sputum Discoloured 5 1.0 1.0 no signal
544 Dermatitis Contact 6 1.0 1.0 no signal
545 Impaired Driving Ability 6 1.0 1.0 no signal
546 Shock 12 1.0 1.0 no signal
547 Hallucination, Visual 11 1.0 1.0 no signal
548 Injury 37 1.0 1.0 no signal
549 Acidosis 4 1.0 1.0 no signal
550 Quality Of Life Decreased 7 1.0 1.0 no signal
551 Accidental Exposure To Product 52 1.0 1.0 no signal
552 Drug Ineffective For Unapproved Indication 29 1.0 1.0 no signal
553 Jaundice 14 1.0 1.0 no signal
554 Vomiting 243 1.0 1.0 no signal
555 Delusion 8 1.0 1.0 no signal
556 Drug Dispensing Error 8 1.0 1.0 no signal
557 Atrioventricular Block 4 1.0 1.0 no signal
558 Cold Sweat 9 1.0 1.0 no signal
559 Acute Respiratory Distress Syndrome 9 1.0 1.0 no signal
560 Diabetes Mellitus Inadequate Control 9 1.0 1.0 no signal
561 Visual Acuity Reduced 17 1.0 1.0 no signal
562 Faeces Discoloured 11 1.0 1.0 no signal
563 Product Prescribing Error 12 1.0 1.0 no signal
564 Dyspnoea Exertional 19 1.0 1.0 no signal
565 Blood Albumin Decreased 4 1.0 1.0 no signal
566 Cholecystitis 6 1.0 1.0 no signal
567 Wound 14 1.0 1.0 no signal
568 Type 2 Diabetes Mellitus 17 1.0 1.0 no signal
569 Low Birth Weight Baby 4 1.0 1.0 no signal
570 Product Administration Error 10 1.0 1.0 no signal
571 Haematocrit Decreased 10 1.0 1.0 no signal
572 Diabetic Ketoacidosis 12 1.0 1.0 no signal
573 Salivary Hypersecretion 5 1.0 1.0 no signal
574 Illness 50 1.0 1.0 no signal
575 Toothache 9 1.0 1.0 no signal
576 Neuralgia 12 1.0 1.0 no signal
577 Hepatocellular Injury 7 1.0 1.0 no signal
578 Nightmare 17 1.0 1.0 no signal
579 Ileus 6 1.0 1.0 no signal
580 Generalised Oedema 6 0.9 0.9 no signal
581 Paralysis 7 0.9 0.9 no signal
582 Neutrophil Count Increased 5 0.9 0.9 no signal
583 Osteoporosis 20 0.9 0.9 no signal
584 Scratch 5 0.9 0.9 no signal
585 Blood Alkaline Phosphatase Increased 12 0.9 0.9 no signal
586 Back Pain 112 0.9 0.9 no signal
587 Osteonecrosis Of Jaw 12 0.9 0.9 no signal
588 Pericarditis 8 0.9 0.9 no signal
589 Syncope 48 0.9 0.9 no signal
590 Blood Sodium Decreased 9 0.9 0.9 no signal
591 Treatment Noncompliance 26 0.9 0.9 no signal
592 Unintended Pregnancy 5 0.9 0.9 no signal
593 Skin Fissures 9 0.9 0.9 no signal
594 Cellulitis 24 0.9 0.9 no signal
595 Transfusion 5 0.9 0.9 no signal
596 Fracture 9 0.9 0.9 no signal
597 Renal Pain 5 0.9 0.9 no signal
598 Incontinence 5 0.9 0.9 no signal
599 Procedural Pain 13 0.9 0.9 no signal
600 Dry Mouth 38 0.9 0.9 no signal
601 Colon Cancer 7 0.9 0.9 no signal
602 Medication Error 26 0.9 0.9 no signal
603 Respiratory Disorder 14 0.9 0.9 no signal
604 Dystonia 9 0.9 0.9 no signal
605 Disturbance In Attention 25 0.9 0.9 no signal
606 Oedema 25 0.9 0.9 no signal
607 Chronic Obstructive Pulmonary Disease 24 0.9 0.9 no signal
608 Cardiac Murmur 4 0.9 0.9 no signal
609 Acute Kidney Injury 70 0.9 0.9 no signal
610 Osteopenia 7 0.9 0.9 no signal
611 Dyspepsia 45 0.9 0.9 no signal
612 Hyperkalaemia 16 0.9 0.9 no signal
613 Gastritis 12 0.9 0.9 no signal
614 Intestinal Obstruction 17 0.9 0.9 no signal
615 Tooth Fracture 5 0.9 0.9 no signal
616 Weight Increased 101 0.9 0.9 no signal
617 Staphylococcal Infection 15 0.9 0.9 no signal
618 Tremor 75 0.9 0.9 no signal
619 Lung Infiltration 4 0.9 0.9 no signal
620 Obstructive Airways Disorder 5 0.9 0.9 no signal
621 Gallbladder Disorder 8 0.9 0.9 no signal
622 Ascites 13 0.9 0.9 no signal
623 Chest Pain 82 0.9 0.9 no signal
624 Acute Hepatic Failure 6 0.9 0.9 no signal
625 Bone Marrow Failure 9 0.9 0.9 no signal
626 Hallucination, Auditory 7 0.9 0.9 no signal
627 Infusion Related Reaction 29 0.9 0.9 no signal
628 Urinary Incontinence 13 0.9 0.9 no signal
629 Haemoglobin Decreased 45 0.9 0.9 no signal
630 Wrong Technique In Drug Usage Process 16 0.8 0.8 no signal
631 Weight Decreased 121 0.8 0.8 no signal
632 Renal Failure 58 0.8 0.8 no signal
633 Muscle Twitching 10 0.8 0.8 no signal
634 Gastric Haemorrhage 5 0.8 0.8 no signal
635 Lung Disorder 21 0.8 0.8 no signal
636 Neck Pain 24 0.8 0.8 no signal
637 Vasculitis 5 0.8 0.8 no signal
638 Sexual Dysfunction 5 0.8 0.8 no signal
639 Carpal Tunnel Syndrome 6 0.8 0.8 no signal
640 Pleural Effusion 26 0.8 0.8 no signal
641 Anaemia 81 0.8 0.8 no signal
642 Hypocalcaemia 8 0.8 0.8 no signal
643 Gastric Ulcer 8 0.8 0.8 no signal
644 Red Blood Cell Count Decreased 12 0.8 0.8 no signal
645 Blood Pressure Increased 64 0.8 0.8 no signal
646 Chronic Kidney Disease 32 0.8 0.8 no signal
647 Post Procedural Complication 8 0.8 0.8 no signal
648 White Blood Cell Count Increased 16 0.8 0.8 no signal
649 Affect Lability 4 0.8 0.8 no signal
650 Liver Injury 10 0.8 0.8 no signal
651 Prescribed Overdose 8 0.8 0.8 no signal
652 Nocturia 5 0.8 0.8 no signal
653 Gastroenteritis 6 0.8 0.8 no signal
654 Drug Prescribing Error 8 0.8 0.8 no signal
655 Hypertension 87 0.8 0.8 no signal
656 Blood Creatine Phosphokinase Increased 12 0.8 0.8 no signal
657 Hypothyroidism 13 0.8 0.8 no signal
658 Renal Disorder 19 0.8 0.8 no signal
659 Stevens-johnson Syndrome 9 0.8 0.8 no signal
660 Insurance Issue 6 0.8 0.8 no signal
661 Sinus Disorder 8 0.8 0.8 no signal
662 Cyst 5 0.8 0.8 no signal
663 Intentional Dose Omission 11 0.8 0.8 no signal
664 Pharyngitis 5 0.8 0.8 no signal
665 Migraine 38 0.8 0.8 no signal
666 Osteoarthritis 17 0.8 0.8 no signal
667 Taste Disorder 8 0.8 0.8 no signal
668 Irritability 24 0.8 0.8 no signal
669 Hypoaesthesia Oral 6 0.8 0.8 no signal
670 Cholelithiasis 13 0.8 0.8 no signal
671 Abnormal Dreams 11 0.8 0.8 no signal
672 Blood Triglycerides Increased 7 0.8 0.8 no signal
673 Nasal Congestion 23 0.8 0.8 no signal
674 Diabetes Mellitus 30 0.8 0.8 no signal
675 Thyroid Disorder 6 0.8 0.8 no signal
676 Device Related Infection 6 0.8 0.8 no signal
677 Wheezing 23 0.8 0.8 no signal
678 Pain In Jaw 11 0.8 0.8 no signal
679 Limb Discomfort 12 0.8 0.8 no signal
680 Pulmonary Embolism 37 0.8 0.8 no signal
681 Gastrooesophageal Reflux Disease 31 0.8 0.8 no signal
682 Femur Fracture 12 0.8 0.8 no signal
683 Thrombocytopenia 43 0.8 0.8 no signal
684 Hyperglycaemia 14 0.8 0.8 no signal
685 Diplopia 10 0.8 0.8 no signal
686 Panic Attack 14 0.7 0.7 no signal
687 Pulmonary Hypertension 8 0.7 0.7 no signal
688 Tooth Infection 5 0.7 0.7 no signal
689 Ulcer 6 0.7 0.7 no signal
690 Nausea 296 0.7 0.7 no signal
691 Eating Disorder 8 0.7 0.7 no signal
692 Abdominal Pain 87 0.7 0.7 no signal
693 Movement Disorder 12 0.7 0.7 no signal
694 Nephrolithiasis 17 0.7 0.7 no signal
695 Heart Rate Decreased 13 0.7 0.7 no signal
696 Product Dispensing Error 8 0.7 0.7 no signal
697 Back Disorder 6 0.7 0.7 no signal
698 Blood Urine Present 7 0.7 0.7 no signal
699 Metastases To Bone 6 0.7 0.7 no signal
700 Cholestasis 7 0.7 0.7 no signal
701 Mania 6 0.7 0.7 no signal
702 Blood Glucose Fluctuation 4 0.7 0.7 no signal
703 Aphasia 11 0.7 0.7 no signal
704 Decreased Appetite 84 0.7 0.7 no signal
705 Inappropriate Schedule Of Product Administration 64 0.7 0.7 no signal
706 Amenorrhoea 6 0.7 0.7 no signal
707 Dementia 10 0.7 0.7 no signal
708 Blood Pressure Systolic Increased 7 0.7 0.7 no signal
709 Gastrointestinal Haemorrhage 30 0.7 0.7 no signal
710 Oral Pain 8 0.7 0.7 no signal
711 Intestinal Perforation 4 0.7 0.7 no signal
712 Upper Gastrointestinal Haemorrhage 6 0.7 0.7 no signal
713 Fatigue 276 0.7 0.7 no signal
714 Seasonal Allergy 5 0.7 0.7 no signal
715 Drug Intolerance 34 0.7 0.7 no signal
716 Dysuria 13 0.7 0.7 no signal
717 Upper Limb Fracture 7 0.7 0.7 no signal
718 Bronchospasm 5 0.7 0.7 no signal
719 Fall 116 0.7 0.7 no signal
720 Abortion Spontaneous 14 0.7 0.7 no signal
721 Neoplasm 4 0.7 0.7 no signal
722 Epistaxis 26 0.7 0.7 no signal
723 Metastases To Lung 4 0.7 0.7 no signal
724 Apathy 5 0.7 0.7 no signal
725 Depressed Mood 18 0.7 0.7 no signal
726 Multi-organ Failure 6 0.7 0.7 no signal
727 Neoplasm Progression 12 0.7 0.7 no signal
728 Eyelid Oedema 4 0.7 0.7 no signal
729 Night Sweats 11 0.7 0.7 no signal
730 Sepsis 38 0.7 0.7 no signal
731 Bronchitis 25 0.7 0.7 no signal
732 Balance Disorder 29 0.7 0.7 no signal
733 Haemorrhage 35 0.7 0.7 no signal
734 General Physical Health Deterioration 38 0.6 0.6 no signal
735 Glomerular Filtration Rate Decreased 4 0.6 0.6 no signal
736 Drug Effect Decreased 18 0.6 0.6 no signal
737 Retching 7 0.6 0.6 no signal
738 Gastrointestinal Disorder 29 0.6 0.6 no signal
739 Memory Impairment 45 0.6 0.6 no signal
740 Conjunctivitis 6 0.6 0.6 no signal
741 Impaired Work Ability 7 0.6 0.6 no signal
742 Eye Pain 18 0.6 0.6 no signal
743 Drug Administration Error 10 0.6 0.6 no signal
744 Headache 201 0.6 0.6 no signal
745 Thinking Abnormal 6 0.6 0.6 no signal
746 Deformity 3 0.6 0.6 no signal
747 Proteinuria 6 0.6 0.6 no signal
748 Gamma-glutamyltransferase Increased 7 0.6 0.6 no signal
749 Hypophagia 8 0.6 0.6 no signal
750 Dehydration 42 0.6 0.6 no signal
751 Haematemesis 8 0.6 0.6 no signal
752 Feeling Jittery 6 0.6 0.6 no signal
753 Hepatitis 8 0.6 0.6 no signal
754 Urinary Tract Infection 53 0.6 0.6 no signal
755 Insomnia 83 0.6 0.6 no signal
756 Thrombotic Microangiopathy 3 0.6 0.6 no signal
757 Alanine Aminotransferase Increased 19 0.6 0.6 no signal
758 Sleep Disorder Due To A General Medical Condition 5 0.6 0.6 no signal
759 Knee Operation 3 0.6 0.6 no signal
760 Hiatus Hernia 4 0.6 0.6 no signal
761 Mobility Decreased 22 0.6 0.6 no signal
762 Mucosal Inflammation 8 0.6 0.6 no signal
763 Dysphagia 29 0.6 0.6 no signal
764 Dyspnoea 173 0.6 0.6 no signal
765 Speech Disorder 16 0.6 0.6 no signal
766 Inflammatory Bowel Disease 3 0.6 0.6 no signal
767 Nervousness 16 0.6 0.6 no signal
768 Bedridden 4 0.6 0.6 no signal
769 Adverse Event 28 0.6 0.6 no signal
770 Pharmaceutical Product Complaint 8 0.6 0.6 no signal
771 Incorrect Route Of Drug Administration 11 0.6 0.6 no signal
772 Gait Inability 10 0.6 0.6 no signal
773 Feeding Disorder 6 0.6 0.6 no signal
774 Cognitive Disorder 14 0.6 0.6 no signal
775 Muscular Weakness 34 0.6 0.6 no signal
776 Vaginal Discharge 3 0.6 0.6 no signal
777 Product Dose Omission Issue 85 0.6 0.6 no signal
778 Incorrect Route Of Product Administration 5 0.6 0.6 no signal
779 Neuropathy Peripheral 28 0.6 0.6 no signal
780 Productive Cough 14 0.6 0.6 no signal
781 Feeling Abnormal 71 0.6 0.6 no signal
782 Transient Ischaemic Attack 10 0.6 0.6 no signal
783 Hypoaesthesia 44 0.6 0.6 no signal
784 Drug Level Decreased 3 0.6 0.6 no signal
785 Akathisia 4 0.6 0.6 no signal
786 Rib Fracture 6 0.6 0.6 no signal
787 Unevaluable Event 22 0.6 0.6 no signal
788 Musculoskeletal Discomfort 5 0.6 0.6 no signal
789 Palpitations 34 0.6 0.6 no signal
790 Pollakiuria 12 0.6 0.6 no signal
791 Feeling Cold 8 0.6 0.6 no signal
792 Mouth Ulceration 6 0.6 0.6 no signal
793 Pain In Extremity 84 0.6 0.6 no signal
794 Drug Effect Less Than Expected 4 0.6 0.6 no signal
795 Pancreatitis 15 0.6 0.6 no signal
796 Disseminated Intravascular Coagulation 4 0.6 0.6 no signal
797 Lymphadenopathy 10 0.5 0.5 no signal
798 Breast Pain 3 0.5 0.5 no signal
799 Abasia 7 0.5 0.5 no signal
800 Blood Cholesterol Increased 13 0.5 0.5 no signal
801 Septic Shock 12 0.5 0.5 no signal
802 Angina Pectoris 8 0.5 0.5 no signal
803 Gastroenteritis Viral 5 0.5 0.5 no signal
804 C-reactive Protein Increased 10 0.5 0.5 no signal
805 Renal Impairment 23 0.5 0.5 no signal
806 Cardiovascular Disorder 7 0.5 0.5 no signal
807 Myocardial Infarction 48 0.5 0.5 no signal
808 Product Use Issue 51 0.5 0.5 no signal
809 Inflammation 14 0.5 0.5 no signal
810 Fungal Infection 9 0.5 0.5 no signal
811 Blood Glucose Abnormal 5 0.5 0.5 no signal
812 Neoplasm Malignant 18 0.5 0.5 no signal
813 Bacterial Infection 5 0.5 0.5 no signal
814 Arthropathy 15 0.5 0.5 no signal
815 Photophobia 5 0.5 0.5 no signal
816 White Blood Cell Count Decreased 29 0.5 0.5 no signal
817 Arthritis 21 0.5 0.5 no signal
818 Fistula 3 0.5 0.5 no signal
819 Increased Appetite 5 0.5 0.5 no signal
820 Asthenia 100 0.5 0.5 no signal
821 Pyrexia 92 0.5 0.5 no signal
822 Flushing 27 0.5 0.5 no signal
823 Anhedonia 7 0.5 0.5 no signal
824 Heart Rate Irregular 6 0.5 0.5 no signal
825 Aspartate Aminotransferase Increased 14 0.5 0.5 no signal
826 Malaise 115 0.5 0.5 no signal
827 Pulmonary Fibrosis 5 0.5 0.5 no signal
828 Cardiac Failure 21 0.5 0.5 no signal
829 Pericardial Effusion 6 0.5 0.5 no signal
830 Product Dose Omission In Error 7 0.5 0.5 no signal
831 Blood Count Abnormal 4 0.5 0.5 no signal
832 Rash Pruritic 14 0.5 0.5 no signal
833 Glaucoma 5 0.5 0.5 no signal
834 Gastric Disorder 9 0.5 0.5 no signal
835 Product Use In Unapproved Indication 63 0.5 0.5 no signal
836 Mood Altered 7 0.5 0.5 no signal
837 Abdominal Discomfort 43 0.5 0.5 no signal
838 Skin Lesion 7 0.5 0.5 no signal
839 Swelling 24 0.5 0.5 no signal
840 Dysphonia 15 0.5 0.5 no signal
841 Bone Pain 15 0.5 0.5 no signal
842 Abdominal Pain Upper 52 0.5 0.5 no signal
843 Contusion 24 0.5 0.5 no signal
844 Localised Infection 6 0.5 0.5 no signal
845 Chills 29 0.5 0.5 no signal
846 Cerebral Infarction 6 0.5 0.5 no signal
847 Gait Disturbance 47 0.5 0.5 no signal
848 Needle Issue 7 0.5 0.5 no signal
849 Blood Creatinine Increased 16 0.5 0.5 no signal
850 Therapeutic Response Unexpected 11 0.5 0.5 no signal
851 Influenza 27 0.5 0.5 no signal
852 Myalgia 41 0.5 0.5 no signal
853 Abdominal Distension 25 0.5 0.5 no signal
854 Dysstasia 7 0.5 0.5 no signal
855 Hot Flush 18 0.5 0.5 no signal
856 Ocular Hyperaemia 11 0.5 0.5 no signal
857 Rash Erythematous 11 0.5 0.5 no signal
858 Platelet Count Decreased 25 0.5 0.5 no signal
859 Lacrimation Increased 7 0.5 0.5 no signal
860 Irritable Bowel Syndrome 5 0.5 0.5 no signal
861 Renal Injury 7 0.5 0.5 no signal
862 Heart Rate Increased 23 0.5 0.5 no signal
863 Blister 13 0.5 0.5 no signal
864 Injection Site Induration 3 0.5 0.5 no signal
865 Hyponatraemia 13 0.5 0.5 no signal
866 Off Label Use 200 0.4 0.4 no signal
867 Ankylosing Spondylitis 3 0.4 0.4 no signal
868 Flatulence 13 0.4 0.4 no signal
869 Deep Vein Thrombosis 15 0.4 0.4 no signal
870 Dysmenorrhoea 3 0.4 0.4 no signal
871 Epilepsy 7 0.4 0.4 no signal
872 Deafness 6 0.4 0.4 no signal
873 Muscle Spasms 42 0.4 0.4 no signal
874 Dry Eye 11 0.4 0.4 no signal
875 Febrile Neutropenia 15 0.4 0.4 no signal
876 Ear Infection 6 0.4 0.4 no signal
877 Liver Disorder 10 0.4 0.4 no signal
878 Incorrect Product Storage 3 0.4 0.4 no signal
879 Surgery 13 0.4 0.4 no signal
880 Swollen Tongue 7 0.4 0.4 no signal
881 Sneezing 5 0.4 0.4 no signal
882 Hospitalisation 34 0.4 0.4 no signal
883 Product Taste Abnormal 3 0.4 0.4 no signal
884 Limb Injury 6 0.4 0.4 no signal
885 Diarrhoea 142 0.4 0.4 no signal
886 Cystitis 7 0.4 0.4 no signal
887 Hip Fracture 7 0.4 0.4 no signal
888 Influenza Like Illness 18 0.4 0.4 no signal
889 Cerebrovascular Accident 37 0.4 0.4 no signal
890 Rhinorrhoea 14 0.4 0.4 no signal
891 Upper Respiratory Tract Infection 10 0.4 0.4 no signal
892 Agranulocytosis 4 0.4 0.4 no signal
893 Malignant Neoplasm Progression 22 0.4 0.4 no signal
894 Condition Aggravated 65 0.4 0.4 no signal
895 Infection 31 0.4 0.4 no signal
896 Impaired Healing 7 0.4 0.4 no signal
897 Dizziness 106 0.4 0.4 no signal
898 Therapeutic Product Effect Incomplete 15 0.4 0.4 no signal
899 Osteonecrosis 7 0.4 0.4 no signal
900 Viral Infection 7 0.4 0.4 no signal
901 Cytokine Release Syndrome 4 0.4 0.4 no signal
902 Stress 15 0.4 0.4 no signal
903 International Normalised Ratio Increased 6 0.4 0.4 no signal
904 Hepatic Enzyme Increased 14 0.4 0.4 no signal
905 Asthma 23 0.4 0.4 no signal
906 Kidney Infection 4 0.4 0.4 no signal
907 Therapeutic Product Effect Decreased 9 0.4 0.4 no signal
908 Burning Sensation 14 0.4 0.4 no signal
909 Activities Of Daily Living Impaired 4 0.4 0.4 no signal
910 Full Blood Count Decreased 4 0.4 0.4 no signal
911 Arthralgia 82 0.4 0.4 no signal
912 Systemic Lupus Erythematosus 7 0.4 0.4 no signal
913 Stomatitis 12 0.4 0.4 no signal
914 Bone Loss 3 0.4 0.4 no signal
915 Neutrophil Count Decreased 8 0.4 0.4 no signal
916 Feeling Hot 12 0.4 0.4 no signal
917 Disease Progression 23 0.4 0.4 no signal
918 Emotional Disorder 6 0.4 0.4 no signal
919 Respiratory Tract Infection 5 0.4 0.4 no signal
920 Haematoma 5 0.4 0.4 no signal
921 Gynaecomastia 6 0.4 0.4 no signal
922 Drug Ineffective 251 0.4 0.4 no signal
923 Joint Stiffness 5 0.4 0.4 no signal
924 Musculoskeletal Pain 10 0.4 0.4 no signal
925 Colitis 7 0.4 0.4 no signal
926 Frequent Bowel Movements 5 0.4 0.4 no signal
927 Musculoskeletal Stiffness 16 0.4 0.4 no signal
928 Peripheral Swelling 28 0.4 0.4 no signal
929 Rash 79 0.4 0.4 no signal
930 Discomfort 11 0.4 0.4 no signal
931 Leukopenia 9 0.4 0.4 no signal
932 Skin Disorder 6 0.4 0.4 no signal
933 Haemoptysis 5 0.3 0.3 no signal
934 Circumstance Or Information Capable Of Leading To Medication Error 6 0.3 0.3 no signal
935 Nasopharyngitis 33 0.3 0.3 no signal
936 Incorrect Dose Administered 40 0.3 0.3 no signal
937 Paraesthesia 28 0.3 0.3 no signal
938 Lower Respiratory Tract Infection 8 0.3 0.3 no signal
939 Chest Discomfort 18 0.3 0.3 no signal
940 Incorrect Drug Administration Duration 5 0.3 0.3 no signal
941 Tinnitus 8 0.3 0.3 no signal
942 Liver Function Test Abnormal 5 0.3 0.3 no signal
943 Laboratory Test Abnormal 5 0.3 0.3 no signal
944 Skin Exfoliation 14 0.3 0.3 no signal
945 Pruritus 63 0.3 0.3 no signal
946 Blood Glucose Decreased 8 0.3 0.3 no signal
947 Contraindicated Product Administered 5 0.3 0.3 no signal
948 Underdose 12 0.3 0.3 no signal
949 Covid-19 29 0.3 0.3 no signal
950 Blood Glucose Increased 31 0.3 0.3 no signal
951 Haematochezia 9 0.3 0.3 no signal
952 Eye Swelling 6 0.3 0.3 no signal
953 Oropharyngeal Pain 15 0.3 0.3 no signal
954 Cough 45 0.3 0.3 no signal
955 Cardiac Failure Congestive 13 0.3 0.3 no signal
956 Multiple Sclerosis Relapse 11 0.3 0.3 no signal
957 Therapeutic Response Shortened 5 0.3 0.3 no signal
958 Throat Irritation 7 0.3 0.3 no signal
959 Lactic Acidosis 5 0.3 0.3 no signal
960 Drug Resistance 4 0.3 0.3 no signal
961 Eye Disorder 5 0.3 0.3 no signal
962 Skin Discolouration 7 0.3 0.3 no signal
963 Joint Swelling 18 0.3 0.3 no signal
964 Vision Blurred 20 0.3 0.3 no signal
965 Haematuria 5 0.3 0.3 no signal
966 Rash Macular 5 0.3 0.3 no signal
967 Atrial Fibrillation 14 0.3 0.3 no signal
968 Cerebral Haemorrhage 5 0.3 0.3 no signal
969 Product Substitution Issue 8 0.3 0.3 no signal
970 Fluid Retention 7 0.3 0.3 no signal
971 Thrombosis 11 0.3 0.3 no signal
972 Dysgeusia 10 0.3 0.3 no signal
973 Interstitial Lung Disease 6 0.2 0.2 no signal
974 Hypersensitivity 23 0.2 0.2 no signal
975 Swelling Face 8 0.2 0.2 no signal
976 Adverse Drug Reaction 11 0.2 0.2 no signal
977 Alopecia 24 0.2 0.2 no signal
978 Treatment Failure 10 0.2 0.2 no signal
979 Injection Site Erythema 15 0.2 0.2 no signal
980 Product Dose Omission 8 0.2 0.2 no signal
981 Eczema 6 0.2 0.2 no signal
982 Gastric Cancer 3 0.2 0.2 no signal
983 Therapeutic Response Decreased 7 0.2 0.2 no signal
984 Vertigo 7 0.2 0.2 no signal
985 Device Issue 10 0.2 0.2 no signal
986 Colitis Ulcerative 5 0.2 0.2 no signal
987 Neutropenia 15 0.2 0.2 no signal
988 Injection Site Pain 33 0.2 0.2 no signal
989 Injection Site Mass 4 0.2 0.2 no signal
990 Drug Hypersensitivity 21 0.2 0.2 no signal
991 Hepatic Function Abnormal 4 0.2 0.2 no signal
992 Eye Irritation 6 0.2 0.2 no signal
993 Erythema 22 0.2 0.2 no signal
994 Sinusitis 11 0.2 0.2 no signal
995 Herpes Zoster 6 0.2 0.2 no signal
996 Device Breakage 4 0.2 0.2 no signal
997 Therapy Interrupted 7 0.2 0.2 no signal
998 Cataract 6 0.2 0.2 no signal
999 Dry Skin 13 0.2 0.2 no signal
1000 Inappropriate Schedule Of Drug Administration 7 0.2 0.2 no signal
1001 Drug Dose Omission 16 0.2 0.2 no signal
1002 Wrong Technique In Product Usage Process 19 0.2 0.2 no signal
1003 Injection Site Swelling 7 0.2 0.2 no signal
1004 Device Dislocation 4 0.2 0.2 no signal
1005 Urticaria 15 0.2 0.2 no signal
1006 Device Use Error 3 0.2 0.2 no signal
1007 Product Adhesion Issue 3 0.2 0.2 no signal
1008 Product Quality Issue 11 0.2 0.2 no signal
1009 No Adverse Event 14 0.2 0.2 no signal
1010 Device Malfunction 5 0.1 0.1 no signal
1011 Anaphylactic Reaction 4 0.1 0.1 no signal
1012 Breast Cancer 6 0.1 0.1 no signal
1013 Injection Site Bruising 5 0.1 0.1 no signal
1014 Rheumatoid Arthritis 7 0.1 0.1 no signal
1015 Injection Site Pruritus 4 0.1 0.1 no signal
1016 Product Storage Error 5 0.1 0.1 no signal
1017 Psoriasis 5 0.1 0.1 no signal