Reaction

Appendicitis Perforated reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,499 reports · 41 co-occurring drugs

As of the last recalculation, Appendicitis Perforated appears in 2,499 FAERS reports alongside 41 co-occurring drug terms. The strongest observed disproportionality signal is SEVOFLURANE (PRR 13.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Sevoflurane	13	13.1	13.1
Cefazolin	11	10.1	10.1
Cefazolin Sodium	11	7.6	7.6
Dalteparin Sodium	9	7.1	7.1
Clozapine	89	6.1	6.1
Interferon Beta-1A	127	5.7	5.7
Midazolam	17	5.6	5.7
Risankizumab-Rzaa	54	5.6	5.6
Granisetron Hydrochloride	7	5.6	5.6
Piperacillin Sodium And Tazobactam Sodium	13	5.5	5.5
Midazolam Hydrochloride	17	5.3	5.3
Granisetron	6	4.8	4.8
Ocrelizumab	34	4.6	4.6
Vedolizumab	47	4.6	4.6
Agalsidase Beta	5	4.5	4.5
Tofacitinib Citrate	7	4.5	4.5
Upadacitinib	41	4.2	4.2
Orlistat	12	3.9	3.9
Natalizumab	82	3.9	3.9
Peginterferon Beta-1A	6	3.8	3.8
Axitinib	8	3.4	3.4
Buprenorphine Hydrochloride, Naloxone Hydrochloride	9	3.1	3.1
Abiraterone	5	3.1	3.1
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	3	3.1	3.1
Atezolizumab	14	3.0	3.0
Dimethyl Fumarate	43	2.9	2.9
Vismodegib	3	2.8	2.8
Siponimod	3	2.8	2.8
Acalabrutinib	4	2.8	2.8
Umeclidinium Bromide And Vilanterol Trifenatate	5	2.5	2.5
Ranolazine	3	2.4	2.4
Tirzepatide	42	2.2	2.2
Diroximel Fumarate	3	2.1	2.1
Lenvatinib	8	2.0	2.0
Rimegepant Sulfate	3	2.0	2.0
Cabozantinib	11	1.9	1.9
Dornase Alfa	4	1.7	1.7
Bimekizumab	4	1.6	1.6
Esketamine Hydrochloride	3	1.4	1.4
Pirfenidone	6	1.2	1.2
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	4	1.1	1.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.