OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Lidocaine Hydrochloride And Epinephrine

1,193 flagged reaction(s) · 217,432 total co-reports · max PRR 620.8
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Local Anaesthetic Systemic Toxicity 608 620.8 628.6 signal
2 Inspiratory Capacity Decreased 84 189.3 189.7 signal
3 Sleep Disorder Therapy 55 180.7 180.9 signal
4 Appendicolith 81 116.7 116.9 signal
5 Analgesic Therapy 55 94.0 94.1 signal
6 Drug Therapy 55 89.3 89.4 signal
7 Maternal Exposure During Delivery 153 80.4 80.7 signal
8 Toxic Anterior Segment Syndrome 168 78.5 78.8 signal
9 Infusion Site Discharge 217 62.5 62.8 signal
10 Methaemoglobinaemia 245 51.2 51.5 signal
11 Lagophthalmos 43 50.3 50.4 signal
12 Infusion Site Mass 95 42.0 42.1 signal
13 Infusion Site Urticaria 58 41.5 41.6 signal
14 Infusion Site Bruising 176 38.8 38.9 signal
15 Infusion Site Pruritus 252 37.8 38.0 signal
16 Infusion Site Haemorrhage 238 34.1 34.2 signal
17 Cauda Equina Syndrome 49 29.1 29.1 signal
18 Procedural Hypotension 52 27.8 27.8 signal
19 Infusion Site Rash 82 27.5 27.6 signal
20 Infusion Site Swelling 367 27.2 27.4 signal
21 Chronic Kidney Disease-mineral And Bone Disorder 62 26.3 26.3 signal
22 Foetal Exposure During Delivery 39 25.9 26.0 signal
23 Infusion Site Discomfort 58 25.8 25.9 signal
24 Anaesthetic Complication Neurological 50 24.9 24.9 signal
25 Infusion Site Nodule 49 24.7 24.7 signal
26 Anaesthetic Complication 143 24.3 24.4 signal
27 Infusion Site Warmth 58 21.8 21.8 signal
28 Kounis Syndrome 108 21.6 21.6 signal
29 Infusion Site Irritation 57 20.6 20.7 signal
30 Infusion Site Discolouration 39 20.4 20.4 signal
31 Nephrogenic Anaemia 209 20.1 20.2 signal
32 Hyperparathyroidism Secondary 110 19.5 19.6 signal
33 Infusion Site Erythema 357 19.3 19.5 signal
34 Device Infusion Issue 105 19.2 19.3 signal
35 Infusion Site Pain 538 18.9 19.1 signal
36 Incorrect Drug Administration Rate 176 18.7 18.7 signal
37 Hyperphosphataemia 87 18.4 18.4 signal
38 Infusion Site Extravasation 245 17.6 17.7 signal
39 Administration Site Pain 43 16.9 16.9 signal
40 Vasoplegia Syndrome 60 16.6 16.6 signal
41 Retinal Vasculitis 44 16.5 16.6 signal
42 Multiple Allergies 288 16.4 16.5 signal
43 Hyperthermia Malignant 54 16.3 16.3 signal
44 Insurance Issue 504 15.1 15.2 signal
45 Blood Phosphorus Increased 84 13.7 13.7 signal
46 Infusion Site Reaction 89 13.6 13.6 signal
47 Seasonal Allergy 417 13.1 13.2 signal
48 Extradural Haematoma 39 13.0 13.0 signal
49 Pulseless Electrical Activity 119 12.6 12.6 signal
50 Corneal Oedema 62 12.2 12.2 signal
51 Infusion Site Induration 39 12.1 12.1 signal
52 Total Lung Capacity Decreased 40 11.0 11.0 signal
53 Ophthalmoplegia 39 10.9 10.9 signal
54 Rebound Acid Hypersecretion 75 10.8 10.8 signal
55 Ventricular Fibrillation 266 10.5 10.6 signal
56 Dermatitis Contact 271 10.5 10.6 signal
57 Electrocardiogram St Segment Elevation 77 10.2 10.2 signal
58 Respiratory Tract Infection Viral 53 10.0 10.1 signal
59 Obstruction 90 9.9 9.9 signal
60 Stress Cardiomyopathy 127 9.6 9.7 signal
61 Ventricular Tachycardia 346 9.2 9.2 signal
62 Paraplegia 60 9.1 9.1 signal
63 Iron Deficiency 90 8.9 8.9 signal
64 End Stage Renal Disease 370 8.8 8.9 signal
65 Pulse Absent 95 8.7 8.7 signal
66 Lung Opacity 51 8.7 8.7 signal
67 Anaphylactic Shock 503 8.6 8.7 signal
68 Poor Venous Access 200 8.5 8.5 signal
69 Ear Infection 513 8.5 8.5 signal
70 Respiratory Tract Infection 500 8.4 8.5 signal
71 Sinusitis 1,939 8.3 8.6 signal
72 Chronic Sinusitis 70 8.2 8.2 signal
73 Type I Hypersensitivity 62 7.8 7.8 signal
74 Product Distribution Issue 156 7.7 7.7 signal
75 Generalised Tonic-clonic Seizure 288 7.7 7.7 signal
76 Ventricular Hypokinesia 56 7.6 7.6 signal
77 Ingrowing Nail 41 7.6 7.6 signal
78 Animal Bite 44 7.3 7.3 signal
79 Upper Respiratory Tract Infection 759 7.2 7.3 signal
80 Status Epilepticus 185 7.1 7.2 signal
81 Otitis Media 54 7.1 7.1 signal
82 Aortic Stenosis 56 7.0 7.0 signal
83 Skin Abrasion 75 7.0 7.0 signal
84 Cardiogenic Shock 228 7.0 7.0 signal
85 Vascular Device Infection 72 7.0 7.0 signal
86 Hypophosphataemia 117 7.0 7.0 signal
87 Apnoea 124 6.9 6.9 signal
88 Catheter Site Pain 40 6.9 6.9 signal
89 Product Adhesion Issue 558 6.9 6.9 signal
90 Lumbar Spinal Stenosis 46 6.8 6.8 signal
91 Myasthenia Gravis 121 6.7 6.7 signal
92 Rhinovirus Infection 58 6.7 6.7 signal
93 Streptococcal Infection 85 6.7 6.7 signal
94 Electrocardiogram Qrs Complex Prolonged 78 6.6 6.7 signal
95 Haemodynamic Instability 113 6.6 6.6 signal
96 Deafness Neurosensory 49 6.5 6.5 signal
97 Anhedonia 393 6.5 6.5 signal
98 Ventricular Arrhythmia 54 6.4 6.4 signal
99 Bundle Branch Block Left 63 6.4 6.4 signal
100 Hypercapnia 44 6.4 6.4 signal
101 Skin Infection 164 6.4 6.4 signal
102 Renal Injury 428 6.2 6.3 signal
103 Sinus Tachycardia 201 6.2 6.2 signal
104 Anaphylactic Reaction 776 6.2 6.2 signal
105 Stridor 41 6.1 6.1 signal
106 Blood Uric Acid Increased 80 6.0 6.0 signal
107 Gastroenteritis Viral 247 5.9 6.0 signal
108 Multi-organ Failure 237 5.9 5.9 signal
109 Paradoxical Drug Reaction 49 5.8 5.8 signal
110 Atelectasis 129 5.8 5.8 signal
111 Proctalgia 85 5.8 5.8 signal
112 Arthritis Bacterial 54 5.8 5.8 signal
113 Meningitis Aseptic 59 5.7 5.7 signal
114 Tenderness 137 5.7 5.7 signal
115 Pharyngitis Streptococcal 142 5.7 5.7 signal
116 Fear 355 5.7 5.7 signal
117 Bronchiectasis 87 5.7 5.7 signal
118 Brain Herniation 39 5.7 5.7 signal
119 Spinal Cord Compression 51 5.7 5.7 signal
120 Appendicitis 119 5.6 5.6 signal
121 Ventricular Extrasystoles 131 5.5 5.5 signal
122 Skin Laceration 136 5.5 5.5 signal
123 Spinal Osteoarthritis 111 5.5 5.5 signal
124 Respiratory Depression 153 5.4 5.4 signal
125 Intervertebral Disc Degeneration 114 5.3 5.3 signal
126 Respiratory Acidosis 48 5.3 5.3 signal
127 Tooth Infection 161 5.3 5.3 signal
128 Endophthalmitis 73 5.3 5.3 signal
129 Product Administration Interrupted 93 5.3 5.3 signal
130 Gastrointestinal Infection 108 5.3 5.3 signal
131 Lyme Disease 40 5.2 5.2 signal
132 Cardiac Arrest 980 5.1 5.2 signal
133 Activated Partial Thromboplastin Time Prolonged 60 5.1 5.1 signal
134 Nystagmus 62 5.1 5.1 signal
135 Live Birth 97 5.1 5.1 signal
136 Unresponsive To Stimuli 299 5.0 5.1 signal
137 Bacterial Infection 215 5.0 5.0 signal
138 Sinus Bradycardia 112 5.0 5.0 signal
139 Hypoxia 402 5.0 5.0 signal
140 Bronchitis 849 5.0 5.0 signal
141 Hordeolum 48 5.0 5.0 signal
142 Bradycardia 592 4.8 4.9 signal
143 Respiratory Syncytial Virus Infection 96 4.8 4.8 signal
144 Kidney Infection 216 4.8 4.8 signal
145 Arthritis Infective 51 4.8 4.8 signal
146 Neurotoxicity 191 4.8 4.8 signal
147 Sinus Disorder 217 4.8 4.8 signal
148 Hyperlipidaemia 131 4.7 4.8 signal
149 Decubitus Ulcer 89 4.7 4.7 signal
150 Labelled Drug-drug Interaction Medication Error 97 4.7 4.7 signal
151 Brain Oedema 137 4.7 4.7 signal
152 Pneumonia Fungal 42 4.7 4.7 signal
153 Chronic Kidney Disease 826 4.7 4.7 signal
154 Pseudomonas Infection 91 4.7 4.7 signal
155 Breath Sounds Abnormal 53 4.7 4.7 signal
156 Viral Infection 357 4.7 4.7 signal
157 Torsade De Pointes 84 4.6 4.6 signal
158 Neuralgia 258 4.6 4.6 signal
159 Eye Infection 119 4.6 4.6 signal
160 Troponin Increased 80 4.6 4.6 signal
161 Post Procedural Infection 85 4.5 4.6 signal
162 Peripheral Vascular Disorder 54 4.5 4.5 signal
163 Sensory Loss 84 4.5 4.5 signal
164 Glucose Tolerance Impaired 61 4.5 4.5 signal
165 Weight Fluctuation 108 4.5 4.5 signal
166 Paranasal Sinus Discomfort 39 4.5 4.5 signal
167 Immune Thrombocytopenia 46 4.5 4.5 signal
168 Mental Status Changes 285 4.4 4.5 signal
169 Hypervolaemia 49 4.4 4.4 signal
170 Incorrect Route Of Product Administration 171 4.4 4.4 signal
171 Normal Newborn 55 4.4 4.4 signal
172 Tooth Abscess 103 4.4 4.4 signal
173 Bronchospasm 144 4.4 4.4 signal
174 Mydriasis 128 4.3 4.3 signal
175 Pre-existing Condition Improved 63 4.3 4.3 signal
176 Candida Infection 166 4.3 4.3 signal
177 Trigeminal Neuralgia 40 4.3 4.3 signal
178 Infusion Related Reaction 655 4.3 4.3 signal
179 Heparin-induced Thrombocytopenia 49 4.3 4.3 signal
180 Post Procedural Complication 190 4.3 4.3 signal
181 Pharyngitis 123 4.3 4.3 signal
182 Food Poisoning 52 4.2 4.2 signal
183 Circulatory Collapse 167 4.2 4.2 signal
184 Staphylococcal Infection 323 4.2 4.3 signal
185 Myoclonus 115 4.2 4.2 signal
186 Hypoaesthesia Oral 144 4.1 4.2 signal
187 Concussion 74 4.1 4.1 signal
188 Localised Infection 229 4.1 4.1 signal
189 Left Ventricular Dysfunction 63 4.1 4.1 signal
190 Varicose Vein 49 4.1 4.1 signal
191 Meningitis 63 4.1 4.1 signal
192 Diverticulum Intestinal 41 4.1 4.1 signal
193 Cardiotoxicity 83 4.1 4.1 signal
194 Procedural Complication 72 4.0 4.0 signal
195 Rales 54 4.0 4.0 signal
196 Cystitis 295 4.0 4.0 signal
197 Rhinitis Allergic 41 4.0 4.0 signal
198 Arthropod Bite 67 4.0 4.0 signal
199 Drug Ineffective For Unapproved Indication 505 3.9 4.0 signal
200 Escherichia Infection 74 3.9 3.9 signal
201 Food Allergy 68 3.9 3.9 signal
202 Monoplegia 39 3.9 3.9 signal
203 Rib Fracture 183 3.9 3.9 signal
204 Skin Necrosis 46 3.8 3.8 signal
205 Renal Failure 1,181 3.8 3.9 signal
206 Urinary Tract Infection 1,493 3.8 3.9 signal
207 Spinal Column Stenosis 42 3.8 3.8 signal
208 Injury 618 3.8 3.8 signal
209 Renal Tubular Necrosis 86 3.8 3.8 signal
210 Economic Problem 134 3.8 3.8 signal
211 Staphylococcal Sepsis 43 3.8 3.8 signal
212 Nerve Injury 96 3.7 3.7 signal
213 Hyperaesthesia 71 3.7 3.7 signal
214 Cellulitis 432 3.7 3.7 signal
215 Atrioventricular Block Complete 57 3.7 3.7 signal
216 Miosis 67 3.6 3.6 signal
217 Acute Respiratory Failure 161 3.6 3.7 signal
218 Haemorrhoids 164 3.6 3.6 signal
219 Sciatica 133 3.6 3.6 signal
220 Rotator Cuff Syndrome 108 3.6 3.6 signal
221 Acute Pulmonary Oedema 47 3.6 3.6 signal
222 Nerve Compression 77 3.6 3.6 signal
223 Covid-19 Pneumonia 99 3.6 3.6 signal
224 Ligament Sprain 82 3.6 3.6 signal
225 Behaviour Disorder 44 3.6 3.6 signal
226 Stress 593 3.6 3.6 signal
227 Productive Cough 388 3.5 3.6 signal
228 Facial Pain 73 3.5 3.5 signal
229 Gingivitis 44 3.5 3.5 signal
230 Limb Injury 220 3.5 3.5 signal
231 Illness 816 3.5 3.6 signal
232 Lymphoedema 56 3.5 3.5 signal
233 Impaired Gastric Emptying 103 3.5 3.5 signal
234 Fibromyalgia 196 3.5 3.5 signal
235 Infective Pulmonary Exacerbation Of Cystic Fibrosis 44 3.5 3.5 signal
236 Grand Mal Convulsion 75 3.5 3.5 signal
237 Scar 137 3.5 3.5 signal
238 Hypotension 1,594 3.4 3.5 signal
239 Oral Candidiasis 103 3.4 3.4 signal
240 Facial Paralysis 67 3.4 3.4 signal
241 Musculoskeletal Chest Pain 122 3.4 3.4 signal
242 Postoperative Wound Infection 53 3.4 3.4 signal
243 Ecchymosis 54 3.4 3.4 signal
244 Injection Site Discharge 40 3.4 3.4 signal
245 Supraventricular Tachycardia 75 3.4 3.4 signal
246 Iron Deficiency Anaemia 72 3.4 3.4 signal
247 Therapy Partial Responder 118 3.4 3.4 signal
248 Tachypnoea 106 3.4 3.4 signal
249 Upper-airway Cough Syndrome 64 3.4 3.4 signal
250 Renal Cyst 62 3.4 3.4 signal
251 Covid-19 1,377 3.4 3.4 signal
252 Respiratory Tract Congestion 123 3.3 3.4 signal
253 Foot Fracture 147 3.3 3.4 signal
254 Drug Level Increased 128 3.3 3.4 signal
255 Vitreous Floaters 75 3.3 3.3 signal
256 Spinal Pain 90 3.3 3.3 signal
257 Compression Fracture 40 3.3 3.3 signal
258 Exostosis 70 3.3 3.3 signal
259 Muscle Strain 66 3.3 3.3 signal
260 Hiatus Hernia 99 3.3 3.3 signal
261 Clostridium Difficile Colitis 81 3.3 3.3 signal
262 Osteomyelitis 138 3.3 3.3 signal
263 Hyperkeratosis 42 3.3 3.3 signal
264 Autoimmune Disorder 72 3.3 3.3 signal
265 Febrile Neutropenia 497 3.2 3.3 signal
266 Tachycardia 665 3.2 3.3 signal
267 Sleep Apnoea Syndrome 142 3.2 3.2 signal
268 Chronic Obstructive Pulmonary Disease 387 3.2 3.2 signal
269 Skin Warm 43 3.2 3.2 signal
270 Multiple Organ Dysfunction Syndrome 206 3.2 3.2 signal
271 Hand Fracture 52 3.2 3.2 signal
272 Toxicity To Various Agents 1,226 3.2 3.2 signal
273 Osteopenia 111 3.1 3.2 signal
274 Sinus Congestion 98 3.1 3.1 signal
275 Joint Effusion 50 3.1 3.1 signal
276 Anal Incontinence 64 3.1 3.1 signal
277 Sensitive Skin 52 3.1 3.1 signal
278 Retinal Haemorrhage 51 3.1 3.1 signal
279 Cyanosis 113 3.1 3.1 signal
280 Hereditary Angioedema 75 3.1 3.1 signal
281 Pneumothorax 113 3.1 3.1 signal
282 Carpal Tunnel Syndrome 100 3.1 3.1 signal
283 Eyelid Ptosis 72 3.1 3.1 signal
284 Vitamin D Deficiency 69 3.1 3.1 signal
285 Obstructive Airways Disorder 79 3.1 3.1 signal
286 Unevaluable Event 534 3.1 3.1 signal
287 Flank Pain 66 3.1 3.1 signal
288 Respiratory Distress 194 3.0 3.0 signal
289 Cardiomegaly 87 3.0 3.0 signal
290 Laryngitis 76 3.0 3.0 signal
291 Post-traumatic Stress Disorder 47 3.0 3.0 signal
292 Body Temperature Increased 143 3.0 3.0 signal
293 Oxygen Saturation Decreased 389 3.0 3.0 signal
294 Paraesthesia Oral 100 3.0 3.0 signal
295 Diplopia 180 3.0 3.0 signal
296 Brain Fog 101 3.0 3.0 signal
297 Spinal Compression Fracture 58 3.0 3.0 signal
298 Encephalopathy 168 3.0 3.0 signal
299 Incontinence 72 2.9 2.9 signal
300 Bursitis 82 2.9 2.9 signal
301 Ulcer 108 2.9 2.9 signal
302 Small Intestinal Obstruction 83 2.9 2.9 signal
303 Inadequate Analgesia 58 2.9 2.9 signal
304 Acute Generalised Exanthematous Pustulosis 52 2.9 2.9 signal
305 Neck Pain 376 2.9 2.9 signal
306 Wound Infection 73 2.9 2.9 signal
307 Mass 94 2.9 2.9 signal
308 Intervertebral Disc Protrusion 147 2.9 2.9 signal
309 Premature Delivery 107 2.9 2.9 signal
310 Pneumonia Bacterial 61 2.9 2.9 signal
311 Joint Dislocation 70 2.9 2.9 signal
312 Dysarthria 250 2.9 2.9 signal
313 Spinal Disorder 63 2.9 2.9 signal
314 Fungal Infection 221 2.9 2.9 signal
315 Wrong Product Administered 44 2.9 2.9 signal
316 Malnutrition 73 2.8 2.8 signal
317 Aspiration 71 2.8 2.8 signal
318 Serotonin Syndrome 125 2.8 2.8 signal
319 Impaired Quality Of Life 94 2.8 2.8 signal
320 Sepsis 724 2.8 2.8 signal
321 Gout 116 2.8 2.8 signal
322 Tricuspid Valve Incompetence 51 2.8 2.8 signal
323 Drug Toxicity 89 2.8 2.8 signal
324 Hypoalbuminaemia 49 2.8 2.8 signal
325 Oral Disorder 47 2.8 2.8 signal
326 Musculoskeletal Discomfort 110 2.8 2.8 signal
327 Nephropathy 60 2.8 2.8 signal
328 Diverticulum 46 2.8 2.8 signal
329 Pneumonia Aspiration 159 2.8 2.8 signal
330 Blood Calcium Increased 56 2.8 2.8 signal
331 Hypercholesterolaemia 61 2.8 2.8 signal
332 Bacteraemia 75 2.8 2.8 signal
333 Pulmonary Oedema 285 2.7 2.8 signal
334 Cytokine Release Syndrome 121 2.7 2.7 signal
335 Therapy Non-responder 283 2.7 2.8 signal
336 Herpes Zoster 365 2.7 2.8 signal
337 Laryngeal Oedema 39 2.7 2.7 signal
338 Blood Pressure Abnormal 125 2.7 2.7 signal
339 Oedema 341 2.7 2.7 signal
340 Influenza 704 2.7 2.7 signal
341 Body Height Decreased 68 2.7 2.7 signal
342 Clostridium Difficile Infection 136 2.7 2.7 signal
343 Pulmonary Congestion 83 2.7 2.7 signal
344 Pharyngeal Swelling 60 2.7 2.7 signal
345 Pulmonary Mass 93 2.7 2.7 signal
346 Migraine 593 2.7 2.7 signal
347 Motor Dysfunction 63 2.7 2.7 signal
348 Rhinitis 50 2.7 2.7 signal
349 Pneumonia 2,001 2.7 2.7 signal
350 Diverticulitis 171 2.7 2.7 signal
351 Brain Injury 62 2.7 2.7 signal
352 Poor Quality Sleep 132 2.7 2.7 signal
353 Respiration Abnormal 42 2.7 2.7 signal
354 Haematocrit Decreased 122 2.6 2.6 signal
355 Delirium 211 2.6 2.6 signal
356 Oral Pain 137 2.6 2.6 signal
357 Inappropriate Schedule Of Product Administration 1,078 2.6 2.7 signal
358 Respiratory Failure 445 2.6 2.6 signal
359 Pleural Effusion 371 2.6 2.6 signal
360 Urosepsis 56 2.6 2.6 signal
361 Lung Infiltration 54 2.6 2.6 signal
362 Shock 138 2.6 2.6 signal
363 Accident 72 2.6 2.6 signal
364 Contusion 581 2.6 2.6 signal
365 Papule 42 2.6 2.6 signal
366 Walking Aid User 40 2.6 2.6 signal
367 Product Dose Omission Issue 1,718 2.6 2.7 signal
368 Spinal Operation 73 2.6 2.6 signal
369 Sputum Discoloured 57 2.6 2.6 signal
370 Ear Pain 117 2.6 2.6 signal
371 Blood Pressure Decreased 399 2.6 2.6 signal
372 Aphthous Ulcer 46 2.6 2.6 signal
373 Paralysis 86 2.6 2.6 signal
374 Eye Movement Disorder 41 2.6 2.6 signal
375 Respiratory Arrest 166 2.6 2.6 signal
376 Blood Albumin Decreased 47 2.6 2.6 signal
377 Cardio-respiratory Arrest 250 2.6 2.6 signal
378 Emphysema 60 2.6 2.6 signal
379 Pelvic Fracture 46 2.6 2.6 signal
380 Mitral Valve Incompetence 67 2.6 2.6 signal
381 Back Injury 64 2.6 2.6 signal
382 Nephrolithiasis 270 2.5 2.6 signal
383 Acute Kidney Injury 899 2.5 2.6 signal
384 Ataxia 70 2.5 2.5 signal
385 Extrasystoles 41 2.5 2.5 signal
386 Joint Injury 125 2.5 2.5 signal
387 Nasopharyngitis 1,075 2.5 2.5 signal
388 Back Disorder 95 2.5 2.5 signal
389 Leukocytosis 105 2.5 2.5 signal
390 Right Ventricular Failure 41 2.5 2.5 signal
391 Inability To Afford Medication 57 2.5 2.5 signal
392 Low Birth Weight Baby 46 2.5 2.5 signal
393 Metabolic Acidosis 183 2.5 2.5 signal
394 Back Pain 1,337 2.5 2.5 signal
395 Skin Ulcer 148 2.5 2.5 signal
396 Electrocardiogram Qt Prolonged 206 2.5 2.5 signal
397 Ascites 168 2.5 2.5 signal
398 Joint Range Of Motion Decreased 76 2.5 2.5 signal
399 Hospice Care 56 2.5 2.5 signal
400 Procedural Pain 157 2.5 2.5 signal
401 Osteoarthritis 241 2.5 2.5 signal
402 Seizure 651 2.4 2.5 signal
403 Nodule 74 2.4 2.5 signal
404 Infection 817 2.4 2.5 signal
405 Conjunctivitis 104 2.4 2.4 signal
406 Bladder Disorder 56 2.4 2.4 signal
407 Dyspnoea Exertional 211 2.4 2.4 signal
408 Ankle Fracture 87 2.4 2.4 signal
409 Major Depression 41 2.4 2.4 signal
410 Blindness Transient 41 2.4 2.4 signal
411 Spinal Fracture 111 2.4 2.4 signal
412 Osteoporosis 229 2.4 2.4 signal
413 Micturition Urgency 63 2.4 2.4 signal
414 Depressed Level Of Consciousness 219 2.4 2.4 signal
415 Pulmonary Hypertension 116 2.4 2.4 signal
416 Blood Pressure Diastolic Decreased 41 2.4 2.4 signal
417 Aphonia 77 2.4 2.4 signal
418 Disability 109 2.4 2.4 signal
419 Toothache 99 2.4 2.4 signal
420 Chills 642 2.4 2.4 signal
421 Premature Baby 165 2.4 2.4 signal
422 Oral Herpes 106 2.4 2.4 signal
423 Groin Pain 48 2.4 2.4 signal
424 Device Related Infection 84 2.4 2.4 signal
425 Hyperthermia 41 2.3 2.3 signal
426 Atrioventricular Block 42 2.3 2.3 signal
427 Arteriosclerosis 51 2.3 2.3 signal
428 Renal Failure Chronic 42 2.3 2.3 signal
429 Respiratory Disorder 161 2.3 2.3 signal
430 Hydronephrosis 40 2.3 2.3 signal
431 Blood Iron Decreased 63 2.3 2.3 signal
432 Dental Caries 59 2.3 2.3 signal
433 Tubulointerstitial Nephritis 100 2.3 2.3 signal
434 Swelling 498 2.3 2.3 signal
435 Atrial Fibrillation 520 2.3 2.3 signal
436 Ejection Fraction Decreased 83 2.3 2.3 signal
437 Purpura 47 2.3 2.3 signal
438 Pain In Jaw 150 2.3 2.3 signal
439 Head Injury 167 2.3 2.3 signal
440 Acute Coronary Syndrome 44 2.3 2.3 signal
441 Substance Abuse 43 2.3 2.3 signal
442 Muscle Rigidity 63 2.3 2.3 signal
443 Abscess 84 2.3 2.3 signal
444 Wrist Fracture 63 2.3 2.3 signal
445 Renal Failure Acute 226 2.3 2.3 signal
446 Atrial Flutter 42 2.3 2.3 signal
447 Tooth Disorder 117 2.3 2.3 signal
448 Lower Respiratory Tract Infection 237 2.3 2.3 signal
449 Retinal Detachment 48 2.3 2.3 signal
450 Gastrooesophageal Reflux Disease 418 2.3 2.3 signal
451 Blood Urea Increased 87 2.2 2.2 signal
452 Hypokalaemia 237 2.2 2.2 signal
453 Fall 1,713 2.2 2.3 signal
454 Pain 3,170 2.2 2.3 signal
455 Myocardial Ischaemia 59 2.2 2.2 signal
456 Oropharyngeal Pain 476 2.2 2.2 signal
457 Dizziness Postural 49 2.2 2.2 signal
458 Anxiety 1,451 2.2 2.2 signal
459 Blood Potassium Decreased 153 2.2 2.2 signal
460 Loss Of Consciousness 651 2.2 2.2 signal
461 Heart Rate Decreased 179 2.2 2.2 signal
462 Muscle Tightness 82 2.2 2.2 signal
463 Hepatomegaly 50 2.2 2.2 signal
464 Muscle Twitching 117 2.2 2.2 signal
465 Irritable Bowel Syndrome 108 2.2 2.2 signal
466 Hemiparesis 86 2.2 2.2 signal
467 Electrolyte Imbalance 58 2.2 2.2 signal
468 Pulmonary Thrombosis 55 2.2 2.2 signal
469 Lethargy 289 2.2 2.2 signal
470 Hypertensive Crisis 56 2.2 2.2 signal
471 Upper Limb Fracture 100 2.2 2.2 signal
472 Pyelonephritis 43 2.2 2.2 signal
473 Blood Magnesium Decreased 43 2.1 2.2 signal
474 Neutrophil Count Increased 51 2.1 2.1 signal
475 Stomatitis 301 2.1 2.1 signal
476 Ileus 61 2.1 2.1 signal
477 Cardiomyopathy 73 2.1 2.1 signal
478 Oropharyngeal Discomfort 44 2.1 2.1 signal
479 Intentional Product Use Issue 433 2.1 2.1 signal
480 Myositis 44 2.1 2.1 signal
481 Hypomagnesaemia 68 2.1 2.1 signal
482 Cataract 290 2.1 2.1 signal
483 Post Procedural Haemorrhage 57 2.1 2.1 signal
484 Eye Inflammation 46 2.1 2.1 signal
485 Blood Calcium Decreased 55 2.1 2.1 signal
486 Generalised Oedema 60 2.1 2.1 signal
487 Foot Deformity 54 2.1 2.1 signal
488 Emotional Distress 591 2.1 2.1 signal
489 Urinary Incontinence 144 2.1 2.1 signal
490 Application Site Pain 107 2.1 2.1 signal
491 Bone Disorder 89 2.1 2.1 signal
492 Drug Interaction 767 2.1 2.1 signal
493 Cyst 60 2.1 2.1 signal
494 Lymphadenopathy 171 2.1 2.1 signal
495 Neuropathy Peripheral 456 2.1 2.1 signal
496 Haematoma 125 2.1 2.1 signal
497 Psychological Trauma 42 2.1 2.1 signal
498 Pallor 131 2.1 2.1 signal
499 Accidental Overdose 175 2.1 2.1 signal
500 Coma 228 2.1 2.1 signal
501 Limb Discomfort 148 2.1 2.1 signal
502 Hyponatraemia 268 2.1 2.1 signal
503 Lymphocyte Count Decreased 84 2.0 2.1 signal
504 Scratch 49 2.0 2.0 signal
505 Restless Legs Syndrome 86 2.0 2.0 signal
506 Pyrexia 1,635 2.0 2.1 signal
507 Blood Pressure Increased 723 2.0 2.1 signal
508 Tooth Fracture 52 2.0 2.0 signal
509 Tinnitus 217 2.0 2.0 signal
510 Discomfort 285 2.0 2.0 signal
511 Hyperkalaemia 164 2.0 2.0 signal
512 Subarachnoid Haemorrhage 48 2.0 2.0 signal
513 Urinary Retention 156 2.0 2.0 signal
514 Nasal Congestion 274 2.0 2.0 signal
515 Hypertension 992 2.0 2.0 signal
516 Disseminated Intravascular Coagulation 66 2.0 2.0 signal
517 Cough 1,305 2.0 2.0 signal
518 Oesophagitis 51 2.0 2.0 signal
519 Road Traffic Accident 195 2.0 2.0 signal
520 Cold Sweat 82 2.0 2.0 signal
521 Mucosal Inflammation 121 2.0 2.0 signal
522 Coagulopathy 77 2.0 2.0 no signal
523 Blood Sodium Decreased 87 2.0 2.0 no signal
524 Haemoptysis 129 2.0 2.0 no signal
525 Photophobia 86 2.0 2.0 no signal
526 Hypotonia 46 2.0 2.0 no signal
527 Renal Impairment 382 2.0 2.0 no signal
528 Lower Limb Fracture 87 2.0 2.0 no signal
529 Wheezing 269 2.0 2.0 no signal
530 Renal Pain 48 2.0 2.0 no signal
531 Restlessness 166 2.0 2.0 no signal
532 Hernia 87 1.9 2.0 no signal
533 Exposure During Pregnancy 281 1.9 2.0 no signal
534 Blood Urine Present 86 1.9 1.9 no signal
535 Ocular Discomfort 49 1.9 1.9 no signal
536 Presyncope 109 1.9 1.9 no signal
537 Dermatitis Allergic 56 1.9 1.9 no signal
538 Cardiac Murmur 39 1.9 1.9 no signal
539 Headache 2,802 1.9 2.0 no signal
540 Chromaturia 101 1.9 1.9 no signal
541 Complication Associated With Device 59 1.9 1.9 no signal
542 Product Use In Unapproved Indication 1,088 1.9 1.9 no signal
543 Increased Tendency To Bruise 41 1.9 1.9 no signal
544 Hallucination, Visual 93 1.9 1.9 no signal
545 Basal Cell Carcinoma 69 1.9 1.9 no signal
546 Constipation 956 1.9 1.9 no signal
547 Liver Function Test Increased 94 1.9 1.9 no signal
548 Erythema Multiforme 41 1.9 1.9 no signal
549 Hypothyroidism 140 1.9 1.9 no signal
550 Quality Of Life Decreased 59 1.9 1.9 no signal
551 Dehydration 585 1.9 1.9 no signal
552 Heart Rate Increased 432 1.9 1.9 no signal
553 Full Blood Count Abnormal 46 1.9 1.9 no signal
554 Wound 121 1.9 1.9 no signal
555 Squamous Cell Carcinoma 41 1.9 1.9 no signal
556 Septic Shock 188 1.9 1.9 no signal
557 Dysuria 160 1.9 1.9 no signal
558 Angioedema 191 1.9 1.9 no signal
559 Gastrointestinal Disorder 380 1.9 1.9 no signal
560 Abdominal Distension 446 1.8 1.9 no signal
561 Fluid Retention 218 1.8 1.9 no signal
562 Peripheral Swelling 657 1.8 1.9 no signal
563 Hypoaesthesia 641 1.8 1.9 no signal
564 Blood Test Abnormal 60 1.8 1.8 no signal
565 Deformity 40 1.8 1.8 no signal
566 Thrombosis 344 1.8 1.8 no signal
567 Needle Issue 121 1.8 1.8 no signal
568 Red Blood Cell Count Decreased 121 1.8 1.8 no signal
569 Nervous System Disorder 132 1.8 1.8 no signal
570 Chest Pain 781 1.8 1.8 no signal
571 Glaucoma 81 1.8 1.8 no signal
572 Skin Discolouration 193 1.8 1.8 no signal
573 Maternal Exposure During Pregnancy 370 1.8 1.8 no signal
574 Taste Disorder 84 1.8 1.8 no signal
575 Confusional State 678 1.8 1.8 no signal
576 Transfusion 44 1.8 1.8 no signal
577 Visual Acuity Reduced 140 1.8 1.8 no signal
578 Burning Sensation 293 1.8 1.8 no signal
579 Neoplasm 48 1.8 1.8 no signal
580 Aphasia 126 1.8 1.8 no signal
581 Chest Discomfort 424 1.8 1.8 no signal
582 Influenza Like Illness 343 1.8 1.8 no signal
583 Epistaxis 311 1.8 1.8 no signal
584 Asthma 464 1.8 1.8 no signal
585 Blood Cholesterol Increased 193 1.8 1.8 no signal
586 Heart Rate Irregular 94 1.8 1.8 no signal
587 Intraocular Pressure Increased 53 1.8 1.8 no signal
588 Acute Respiratory Distress Syndrome 73 1.8 1.8 no signal
589 Somnolence 829 1.8 1.8 no signal
590 Tendon Rupture 51 1.8 1.8 no signal
591 Sars-cov-2 Test Positive 55 1.8 1.8 no signal
592 Colitis 155 1.8 1.8 no signal
593 Arthritis 324 1.8 1.8 no signal
594 Impaired Healing 135 1.8 1.8 no signal
595 Dystonia 80 1.8 1.8 no signal
596 White Blood Cell Count Increased 158 1.8 1.8 no signal
597 Anaemia 781 1.8 1.8 no signal
598 Vertigo 249 1.8 1.8 no signal
599 Eye Pain 225 1.8 1.8 no signal
600 Sleep Disorder 285 1.8 1.8 no signal
601 Speech Disorder 213 1.8 1.8 no signal
602 Application Site Rash 56 1.7 1.8 no signal
603 Arrhythmia 193 1.7 1.8 no signal
604 Muscular Weakness 461 1.7 1.8 no signal
605 Syncope 406 1.7 1.8 no signal
606 Tendonitis 63 1.7 1.7 no signal
607 Mouth Ulceration 85 1.7 1.7 no signal
608 Weight Decreased 1,125 1.7 1.8 no signal
609 Swollen Tongue 126 1.7 1.7 no signal
610 Dysphagia 381 1.7 1.7 no signal
611 Lung Disorder 197 1.7 1.7 no signal
612 Oedema Peripheral 492 1.7 1.7 no signal
613 Musculoskeletal Pain 212 1.7 1.7 no signal
614 Night Sweats 129 1.7 1.7 no signal
615 Drug Hypersensitivity 778 1.7 1.7 no signal
616 Ear Discomfort 41 1.7 1.7 no signal
617 Lip Swelling 133 1.7 1.7 no signal
618 Agitation 293 1.7 1.7 no signal
619 Hair Colour Changes 50 1.7 1.7 no signal
620 Acute Myocardial Infarction 117 1.7 1.7 no signal
621 Macular Degeneration 47 1.7 1.7 no signal
622 Dry Mouth 319 1.7 1.7 no signal
623 Pulmonary Embolism 375 1.7 1.7 no signal
624 Vomiting 1,841 1.7 1.7 no signal
625 Eye Discharge 40 1.7 1.7 no signal
626 Fatigue 3,040 1.7 1.7 no signal
627 Rhinorrhoea 252 1.7 1.7 no signal
628 Skin Disorder 130 1.7 1.7 no signal
629 Blood Pressure Fluctuation 94 1.7 1.7 no signal
630 Dyskinesia 158 1.7 1.7 no signal
631 Pain In Extremity 1,149 1.7 1.7 no signal
632 Scab 44 1.7 1.7 no signal
633 Product Availability Issue 87 1.7 1.7 no signal
634 Laceration 37 1.7 1.7 no signal
635 Mental Disorder 169 1.7 1.7 no signal
636 Pericardial Effusion 89 1.7 1.7 no signal
637 Dysphonia 225 1.7 1.7 no signal
638 Nausea 3,030 1.7 1.7 no signal
639 Face Oedema 65 1.7 1.7 no signal
640 Eating Disorder 82 1.7 1.7 no signal
641 Dyspnoea 2,169 1.7 1.7 no signal
642 Skin Lesion 104 1.6 1.6 no signal
643 Retching 81 1.6 1.6 no signal
644 Lung Infection 60 1.6 1.6 no signal
645 Head Discomfort 67 1.6 1.6 no signal
646 Feeling Cold 106 1.6 1.6 no signal
647 Gallbladder Disorder 68 1.6 1.6 no signal
648 Parkinsonism 37 1.6 1.6 no signal
649 Tremor 630 1.6 1.6 no signal
650 Posterior Reversible Encephalopathy Syndrome 36 1.6 1.6 no signal
651 Drug Intolerance 363 1.6 1.6 no signal
652 Pulmonary Fibrosis 72 1.6 1.6 no signal
653 Thyroid Disorder 58 1.6 1.6 no signal
654 Blood Potassium Increased 61 1.6 1.6 no signal
655 Product Use Issue 702 1.6 1.6 no signal
656 Petechiae 39 1.6 1.6 no signal
657 Blister 210 1.6 1.6 no signal
658 Device Occlusion 52 1.6 1.6 no signal
659 Breast Cancer Metastatic 40 1.6 1.6 no signal
660 Secretion Discharge 46 1.6 1.6 no signal
661 Temperature Intolerance 38 1.6 1.6 no signal
662 Hypokinesia 54 1.6 1.6 no signal
663 Toxic Epidermal Necrolysis 56 1.6 1.6 no signal
664 Red Blood Cell Sedimentation Rate Increased 41 1.6 1.6 no signal
665 Cholecystectomy 42 1.6 1.6 no signal
666 Gastritis 97 1.6 1.6 no signal
667 Cholelithiasis 121 1.6 1.6 no signal
668 Blindness 150 1.6 1.6 no signal
669 Swelling Face 239 1.6 1.6 no signal
670 Adrenal Insufficiency 44 1.6 1.6 no signal
671 Blood Pressure Systolic Increased 72 1.6 1.6 no signal
672 Balance Disorder 318 1.6 1.6 no signal
673 Urticaria 610 1.6 1.6 no signal
674 Product Quality Issue 494 1.6 1.6 no signal
675 Hepatic Steatosis 68 1.6 1.6 no signal
676 Dysstasia 107 1.6 1.6 no signal
677 Product Dose Omission In Error 98 1.6 1.6 no signal
678 Haematuria 125 1.6 1.6 no signal
679 Decreased Appetite 843 1.6 1.6 no signal
680 Product Prescribing Issue 74 1.6 1.6 no signal
681 Muscle Spasticity 45 1.6 1.6 no signal
682 Skin Reaction 51 1.6 1.6 no signal
683 Muscle Spasms 665 1.6 1.6 no signal
684 Full Blood Count Decreased 73 1.6 1.6 no signal
685 Altered State Of Consciousness 78 1.6 1.6 no signal
686 Cholecystitis 43 1.6 1.6 no signal
687 Tooth Extraction 45 1.6 1.6 no signal
688 Product Administration Error 72 1.6 1.6 no signal
689 Injection Site Extravasation 45 1.6 1.6 no signal
690 C-reactive Protein Increased 131 1.6 1.6 no signal
691 Disorientation 143 1.6 1.6 no signal
692 Deep Vein Thrombosis 235 1.6 1.6 no signal
693 Paraesthesia 566 1.5 1.6 no signal
694 Musculoskeletal Stiffness 314 1.5 1.5 no signal
695 Dermatitis 74 1.5 1.5 no signal
696 Poisoning 45 1.5 1.5 no signal
697 Hypothermia 36 1.5 1.5 no signal
698 Incorrect Product Administration Duration 72 1.5 1.5 no signal
699 Decreased Activity 38 1.5 1.5 no signal
700 Gait Inability 117 1.5 1.5 no signal
701 Application Site Erythema 93 1.5 1.5 no signal
702 Arthropathy 197 1.5 1.5 no signal
703 Sedation 92 1.5 1.5 no signal
704 Photosensitivity Reaction 58 1.5 1.5 no signal
705 Hip Fracture 113 1.5 1.5 no signal
706 Gingival Bleeding 48 1.5 1.5 no signal
707 Pulmonary Arterial Hypertension 51 1.5 1.5 no signal
708 Immune System Disorder 46 1.5 1.5 no signal
709 Medication Error 194 1.5 1.5 no signal
710 Abdominal Pain 812 1.5 1.5 no signal
711 Sneezing 78 1.5 1.5 no signal
712 Peripheral Coldness 48 1.5 1.5 no signal
713 Rash Maculo-papular 77 1.5 1.5 no signal
714 Intentional Dose Omission 95 1.5 1.5 no signal
715 Bone Density Decreased 110 1.5 1.5 no signal
716 Surgery 201 1.5 1.5 no signal
717 Metastases To Lung 40 1.5 1.5 no signal
718 Toxic Skin Eruption 35 1.5 1.5 no signal
719 Depression 791 1.5 1.5 no signal
720 Feeding Disorder 69 1.5 1.5 no signal
721 Erythema 707 1.5 1.5 no signal
722 Muscle Atrophy 43 1.5 1.5 no signal
723 Madarosis 40 1.5 1.5 no signal
724 Pregnancy 69 1.5 1.5 no signal
725 Dizziness 1,698 1.5 1.5 no signal
726 Hair Texture Abnormal 46 1.5 1.5 no signal
727 Aspartate Aminotransferase Increased 181 1.5 1.5 no signal
728 Pancytopenia 189 1.5 1.5 no signal
729 Hypersomnia 97 1.5 1.5 no signal
730 Rectal Haemorrhage 146 1.5 1.5 no signal
731 Obesity 54 1.5 1.5 no signal
732 Diabetes Mellitus 259 1.5 1.5 no signal
733 Transient Ischaemic Attack 114 1.4 1.5 no signal
734 Metastases To Bone 55 1.4 1.4 no signal
735 Hyperhidrosis 433 1.4 1.5 no signal
736 Metastases To Central Nervous System 43 1.4 1.4 no signal
737 Joint Stiffness 88 1.4 1.4 no signal
738 Bedridden 44 1.4 1.4 no signal
739 Gait Disturbance 642 1.4 1.4 no signal
740 Skin Cancer 72 1.4 1.4 no signal
741 Initial Insomnia 34 1.4 1.4 no signal
742 Product Preparation Error 69 1.4 1.4 no signal
743 Throat Tightness 90 1.4 1.4 no signal
744 Body Temperature Decreased 33 1.4 1.4 no signal
745 Amnesia 217 1.4 1.4 no signal
746 Blood Alkaline Phosphatase Increased 82 1.4 1.4 no signal
747 Fistula 37 1.4 1.4 no signal
748 Arthralgia 1,359 1.4 1.4 no signal
749 Bone Pain 192 1.4 1.4 no signal
750 Hypersensitivity 606 1.4 1.4 no signal
751 Asthenia 1,228 1.4 1.4 no signal
752 Throat Irritation 146 1.4 1.4 no signal
753 Drug Abuse 273 1.4 1.4 no signal
754 Drug Effect Less Than Expected 46 1.4 1.4 no signal
755 Rash Pruritic 176 1.4 1.4 no signal
756 Intestinal Obstruction 122 1.4 1.4 no signal
757 Mental Impairment 79 1.4 1.4 no signal
758 Blood Bilirubin Increased 88 1.4 1.4 no signal
759 Cognitive Disorder 151 1.4 1.4 no signal
760 Haemoglobin Decreased 334 1.4 1.4 no signal
761 Coronary Artery Disease 99 1.4 1.4 no signal
762 Helicobacter Infection 33 1.4 1.4 no signal
763 Pneumonitis 87 1.4 1.4 no signal
764 Gastric Ulcer 61 1.4 1.4 no signal
765 Renal Disorder 149 1.4 1.4 no signal
766 Activities Of Daily Living Impaired 64 1.4 1.4 no signal
767 Fluid Overload 47 1.4 1.4 no signal
768 Treatment Failure 260 1.4 1.4 no signal
769 Rash 1,373 1.4 1.4 no signal
770 Impaired Driving Ability 36 1.4 1.4 no signal
771 Hypophagia 80 1.4 1.4 no signal
772 Sluggishness 32 1.4 1.4 no signal
773 Hallucination 236 1.4 1.4 no signal
774 Pollakiuria 131 1.4 1.4 no signal
775 Nocturia 38 1.4 1.4 no signal
776 Inflammation 161 1.4 1.4 no signal
777 Vision Blurred 428 1.3 1.4 no signal
778 Intentional Product Misuse 271 1.3 1.3 no signal
779 Tooth Loss 65 1.3 1.3 no signal
780 Lacrimation Increased 93 1.3 1.3 no signal
781 Malaise 1,367 1.3 1.3 no signal
782 Cardiac Failure Congestive 252 1.3 1.3 no signal
783 Convulsion 180 1.3 1.3 no signal
784 Osteonecrosis Of Jaw 77 1.3 1.3 no signal
785 Eyelid Oedema 36 1.3 1.3 no signal
786 Blood Creatinine Increased 201 1.3 1.3 no signal
787 Diarrhoea 1,969 1.3 1.3 no signal
788 Caesarean Section 36 1.3 1.3 no signal
789 Internal Haemorrhage 35 1.3 1.3 no signal
790 Dry Eye 148 1.3 1.3 no signal
791 Blood Triglycerides Increased 54 1.3 1.3 no signal
792 Palpitations 355 1.3 1.3 no signal
793 Dialysis 43 1.3 1.3 no signal
794 Weight Increased 673 1.3 1.3 no signal
795 Off Label Use 2,611 1.3 1.3 no signal
796 Loss Of Personal Independence In Daily Activities 143 1.3 1.3 no signal
797 Paranoia 52 1.3 1.3 no signal
798 No Therapeutic Response 37 1.3 1.3 no signal
799 Immunodeficiency 44 1.3 1.3 no signal
800 Ovarian Cyst 30 1.3 1.3 no signal
801 Product Use Complaint 46 1.3 1.3 no signal
802 Central Nervous System Lesion 41 1.3 1.3 no signal
803 Mobility Decreased 212 1.3 1.3 no signal
804 Cardiac Disorder 277 1.3 1.3 no signal
805 Platelet Count Decreased 314 1.3 1.3 no signal
806 Alanine Aminotransferase Increased 181 1.3 1.3 no signal
807 Deafness 77 1.3 1.3 no signal
808 Orthostatic Hypotension 51 1.3 1.3 no signal
809 Disturbance In Attention 158 1.3 1.3 no signal
810 Condition Aggravated 881 1.3 1.3 no signal
811 Stevens-johnson Syndrome 65 1.3 1.3 no signal
812 Vasculitis 34 1.3 1.3 no signal
813 Thrombocytopenia 325 1.3 1.3 no signal
814 Sensory Disturbance 47 1.3 1.3 no signal
815 Hyperbilirubinaemia 30 1.3 1.3 no signal
816 Memory Impairment 400 1.3 1.3 no signal
817 Splenomegaly 34 1.3 1.3 no signal
818 Hyperthyroidism 42 1.3 1.3 no signal
819 Hip Arthroplasty 44 1.2 1.2 no signal
820 Multiple Fractures 48 1.2 1.2 no signal
821 Glomerular Filtration Rate Decreased 35 1.2 1.2 no signal
822 Feeling Hot 177 1.2 1.2 no signal
823 Hepatic Cytolysis 35 1.2 1.2 no signal
824 General Physical Health Deterioration 329 1.2 1.2 no signal
825 Neutrophil Count Decreased 116 1.2 1.2 no signal
826 Leukaemia 27 1.2 1.2 no signal
827 Dyspepsia 280 1.2 1.2 no signal
828 Subdural Haematoma 41 1.2 1.2 no signal
829 Insomnia 761 1.2 1.2 no signal
830 Haemorrhage 297 1.2 1.2 no signal
831 Joint Swelling 342 1.2 1.2 no signal
832 Rash Erythematous 133 1.2 1.2 no signal
833 Nervousness 149 1.2 1.2 no signal
834 Hepatic Cirrhosis 53 1.2 1.2 no signal
835 Overdose 612 1.2 1.2 no signal
836 Myalgia 479 1.2 1.2 no signal
837 Pruritus 1,064 1.2 1.2 no signal
838 Plasma Cell Myeloma 110 1.2 1.2 no signal
839 Therapeutic Product Effect Incomplete 198 1.2 1.2 no signal
840 Flushing 284 1.2 1.2 no signal
841 Cardiac Failure 223 1.2 1.2 no signal
842 Osteonecrosis 92 1.2 1.2 no signal
843 Feeling Abnormal 667 1.2 1.2 no signal
844 Eye Haemorrhage 37 1.2 1.2 no signal
845 Drug Ineffective 3,637 1.2 1.2 no signal
846 Rash Papular 62 1.2 1.2 no signal
847 Psychomotor Hyperactivity 46 1.2 1.2 no signal
848 Malignant Melanoma 37 1.2 1.2 no signal
849 Coronary Artery Occlusion 38 1.2 1.2 no signal
850 Platelet Count Increased 36 1.2 1.2 no signal
851 Panic Attack 100 1.2 1.2 no signal
852 Gastrointestinal Pain 30 1.2 1.2 no signal
853 Abdominal Discomfort 456 1.2 1.2 no signal
854 Drug Administered At Inappropriate Site 29 1.2 1.2 no signal
855 Impaired Work Ability 58 1.2 1.2 no signal
856 Angina Pectoris 78 1.2 1.2 no signal
857 Skin Haemorrhage 39 1.2 1.2 no signal
858 Pericarditis 45 1.2 1.2 no signal
859 Rash Macular 94 1.2 1.2 no signal
860 Pelvic Pain 49 1.2 1.2 no signal
861 Palmar-plantar Erythrodysaesthesia Syndrome 63 1.2 1.2 no signal
862 Neutropenia 363 1.2 1.2 no signal
863 Hepatic Encephalopathy 25 1.2 1.2 no signal
864 Decreased Immune Responsiveness 26 1.1 1.1 no signal
865 Product Physical Issue 53 1.1 1.1 no signal
866 Incorrect Route Of Drug Administration 96 1.1 1.1 no signal
867 Acute Hepatic Failure 36 1.1 1.1 no signal
868 Eye Disorder 86 1.1 1.1 no signal
869 Brain Neoplasm 24 1.1 1.1 no signal
870 Transaminases Increased 58 1.1 1.1 no signal
871 Abdominal Pain Upper 535 1.1 1.1 no signal
872 Systemic Lupus Erythematosus 92 1.1 1.1 no signal
873 Ageusia 65 1.1 1.1 no signal
874 White Blood Cell Count Decreased 282 1.1 1.1 no signal
875 Flatulence 147 1.1 1.1 no signal
876 Haematemesis 66 1.1 1.1 no signal
877 Hypocalcaemia 49 1.1 1.1 no signal
878 Therapy Interrupted 179 1.1 1.1 no signal
879 Hypercalcaemia 32 1.1 1.1 no signal
880 Poisoning Deliberate 24 1.1 1.1 no signal
881 Eosinophilia 45 1.1 1.1 no signal
882 Coordination Abnormal 36 1.1 1.1 no signal
883 Cerebral Haemorrhage 91 1.1 1.1 no signal
884 Foetal Exposure During Pregnancy 206 1.1 1.1 no signal
885 Sleep Disorder Due To A General Medical Condition 41 1.1 1.1 no signal
886 Ankylosing Spondylitis 33 1.1 1.1 no signal
887 Visual Impairment 311 1.1 1.1 no signal
888 Hot Flush 190 1.1 1.1 no signal
889 Injection Site Discomfort 26 1.1 1.1 no signal
890 Delusion 39 1.1 1.1 no signal
891 Folliculitis 26 1.1 1.1 no signal
892 Oral Discomfort 35 1.1 1.1 no signal
893 Hepatic Failure 76 1.1 1.1 no signal
894 Cerebrovascular Accident 427 1.1 1.1 no signal
895 Gastric Haemorrhage 29 1.1 1.1 no signal
896 Rheumatoid Arthritis 282 1.1 1.1 no signal
897 Application Site Irritation 31 1.1 1.1 no signal
898 Adverse Drug Reaction 222 1.1 1.1 no signal
899 Movement Disorder 80 1.1 1.1 no signal
900 Gastrointestinal Haemorrhage 208 1.1 1.1 no signal
901 Bipolar Disorder 27 1.1 1.1 no signal
902 Feeling Jittery 47 1.1 1.1 no signal
903 Liver Disorder 109 1.1 1.1 no signal
904 Glossodynia 55 1.1 1.1 no signal
905 Diarrhoea Haemorrhagic 23 1.1 1.1 no signal
906 Ocular Hyperaemia 114 1.1 1.1 no signal
907 Drug Eruption 43 1.1 1.1 no signal
908 Synovitis 44 1.0 1.0 no signal
909 Polyneuropathy 29 1.0 1.0 no signal
910 Hyperglycaemia 88 1.0 1.0 no signal
911 Injection Site Discolouration 30 1.0 1.0 no signal
912 Blood Count Abnormal 37 1.0 1.0 no signal
913 Dementia 67 1.0 1.0 no signal
914 Therapeutic Response Unexpected 108 1.0 1.0 no signal
915 Intentional Overdose 152 1.0 1.0 no signal
916 Skin Fissures 45 1.0 1.0 no signal
917 Suicidal Ideation 217 1.0 1.0 no signal
918 International Normalised Ratio Increased 68 1.0 1.0 no signal
919 Thirst 42 1.0 1.0 no signal
920 Alopecia 463 1.0 1.0 no signal
921 Knee Arthroplasty 49 1.0 1.0 no signal
922 Ischaemic Stroke 42 1.0 1.0 no signal
923 Poor Quality Product Administered 24 1.0 1.0 no signal
924 Cytopenia 28 1.0 1.0 no signal
925 Coeliac Disease 23 1.0 1.0 no signal
926 Neoplasm Progression 82 1.0 1.0 no signal
927 Crying 85 1.0 1.0 no signal
928 Emotional Disorder 72 1.0 1.0 no signal
929 Intestinal Perforation 26 1.0 1.0 no signal
930 Acute Myeloid Leukaemia 36 1.0 1.0 no signal
931 Upper Gastrointestinal Haemorrhage 39 1.0 1.0 no signal
932 Faeces Discoloured 50 1.0 1.0 no signal
933 Salivary Hypersecretion 23 1.0 1.0 no signal
934 Eye Swelling 85 1.0 1.0 no signal
935 Disease Progression 271 1.0 1.0 no signal
936 Myocarditis 26 1.0 1.0 no signal
937 Dysgeusia 171 1.0 1.0 no signal
938 Injection Site Swelling 173 1.0 1.0 no signal
939 Proteinuria 43 1.0 1.0 no signal
940 Prescribed Overdose 44 1.0 1.0 no signal
941 Choking 44 1.0 1.0 no signal
942 Middle Insomnia 42 1.0 1.0 no signal
943 Hospitalisation 344 1.0 1.0 no signal
944 Breast Pain 24 1.0 1.0 no signal
945 Application Site Pruritus 51 1.0 1.0 no signal
946 Musculoskeletal Disorder 43 1.0 1.0 no signal
947 Sudden Death 24 1.0 1.0 no signal
948 Malignant Neoplasm Progression 228 1.0 1.0 no signal
949 Therapeutic Product Effect Decreased 99 1.0 1.0 no signal
950 Type 2 Diabetes Mellitus 75 1.0 1.0 no signal
951 Blood Glucose Decreased 107 1.0 1.0 no signal
952 Gastric Disorder 77 1.0 1.0 no signal
953 Myelodysplastic Syndrome 32 1.0 1.0 no signal
954 Lymphoma 34 0.9 0.9 no signal
955 Pharyngeal Oedema 34 0.9 0.9 no signal
956 Withdrawal Syndrome 92 0.9 0.9 no signal
957 Libido Decreased 27 0.9 0.9 no signal
958 Eczema 109 0.9 0.9 no signal
959 Dry Throat 22 0.9 0.9 no signal
960 Epilepsy 66 0.9 0.9 no signal
961 Rhabdomyolysis 90 0.9 0.9 no signal
962 Inappropriate Antidiuretic Hormone Secretion 22 0.9 0.9 no signal
963 Injection Site Induration 28 0.9 0.9 no signal
964 Product Packaging Issue 20 0.9 0.9 no signal
965 Blood Creatine Phosphokinase Increased 63 0.9 0.9 no signal
966 Lactic Acidosis 69 0.9 0.9 no signal
967 Product Administered At Inappropriate Site 39 0.9 0.9 no signal
968 Injection Site Mass 79 0.9 0.9 no signal
969 Thinking Abnormal 40 0.9 0.9 no signal
970 Blindness Unilateral 30 0.9 0.9 no signal
971 Abdominal Pain Lower 54 0.9 0.9 no signal
972 Hypoglycaemia 103 0.9 0.9 no signal
973 Hypoacusis 91 0.9 0.9 no signal
974 Psoriatic Arthropathy 85 0.9 0.9 no signal
975 Blood Glucose Abnormal 39 0.9 0.9 no signal
976 Skin Exfoliation 175 0.9 0.9 no signal
977 Psychotic Disorder 62 0.9 0.9 no signal
978 Pemphigus 26 0.9 0.9 no signal
979 Melaena 46 0.9 0.9 no signal
980 Eye Irritation 116 0.9 0.9 no signal
981 Colon Cancer 31 0.9 0.9 no signal
982 Therapy Change 20 0.9 0.9 no signal
983 Depressed Mood 109 0.9 0.9 no signal
984 Skin Irritation 95 0.9 0.9 no signal
985 Hepatic Enzyme Increased 140 0.9 0.9 no signal
986 Gastroenteritis 30 0.9 0.9 no signal
987 Therapeutic Response Decreased 124 0.9 0.9 no signal
988 Complication Of Device Insertion 38 0.9 0.9 no signal
989 Embedded Device 20 0.9 0.9 no signal
990 Neoplasm Malignant 134 0.9 0.9 no signal
991 Haematochezia 110 0.9 0.9 no signal
992 Mood Altered 54 0.9 0.9 no signal
993 Injection Site Pruritus 132 0.9 0.9 no signal
994 Injection Site Pain 600 0.9 0.8 no signal
995 Affect Lability 19 0.8 0.8 no signal
996 Fracture 37 0.8 0.8 no signal
997 Extrapyramidal Disorder 49 0.8 0.8 no signal
998 Death 1,679 0.8 0.8 no signal
999 Device Dislocation 84 0.8 0.8 no signal
1000 Laboratory Test Abnormal 57 0.8 0.8 no signal
1001 Treatment Noncompliance 105 0.8 0.8 no signal
1002 Pancreatitis 102 0.8 0.8 no signal
1003 Nightmare 67 0.8 0.8 no signal
1004 Cerebral Infarction 47 0.8 0.8 no signal
1005 Therapeutic Response Shortened 61 0.8 0.8 no signal
1006 Injection Site Erythema 236 0.8 0.8 no signal
1007 Leukopenia 95 0.8 0.8 no signal
1008 Ill-defined Disorder 115 0.8 0.8 no signal
1009 Prostatic Specific Antigen Increased 26 0.8 0.8 no signal
1010 Cardiovascular Disorder 48 0.8 0.8 no signal
1011 Irritability 113 0.8 0.8 no signal
1012 Expired Product Administered 62 0.8 0.8 no signal
1013 Rash Generalised 49 0.8 0.8 no signal
1014 Local Swelling 33 0.8 0.8 no signal
1015 Knee Operation 18 0.8 0.8 no signal
1016 Device Failure 28 0.8 0.8 no signal
1017 Aggression 92 0.8 0.8 no signal
1018 Liver Injury 44 0.8 0.8 no signal
1019 Blood Lactate Dehydrogenase Increased 29 0.8 0.8 no signal
1020 Product Dose Omission 120 0.8 0.8 no signal
1021 Increased Appetite 34 0.8 0.8 no signal
1022 Bone Marrow Failure 37 0.8 0.8 no signal
1023 Contraindicated Product Administered 54 0.8 0.8 no signal
1024 Injection Site Bruising 141 0.8 0.8 no signal
1025 Cholestasis 34 0.8 0.8 no signal
1026 Pruritus Generalised 39 0.8 0.8 no signal
1027 Lymphopenia 25 0.8 0.8 no signal
1028 Drug Administration Error 55 0.8 0.8 no signal
1029 Wrong Technique In Drug Usage Process 65 0.8 0.8 no signal
1030 Dry Skin 230 0.8 0.8 no signal
1031 Drug Effect Incomplete 64 0.7 0.7 no signal
1032 Adverse Reaction 23 0.7 0.7 no signal
1033 Eye Pruritus 57 0.7 0.7 no signal
1034 Hepatic Function Abnormal 64 0.7 0.7 no signal
1035 No Adverse Event 306 0.7 0.7 no signal
1036 Myocardial Infarction 302 0.7 0.7 no signal
1037 Metastases To Liver 30 0.7 0.7 no signal
1038 Frequent Bowel Movements 46 0.7 0.7 no signal
1039 Multiple Sclerosis 82 0.7 0.7 no signal
1040 Nephropathy Toxic 19 0.7 0.7 no signal
1041 Injection Site Warmth 35 0.7 0.7 no signal
1042 Abortion Induced 16 0.7 0.7 no signal
1043 Injection Site Reaction 116 0.7 0.7 no signal
1044 Device Issue 147 0.7 0.7 no signal
1045 Eructation 32 0.7 0.7 no signal
1046 Vaginal Haemorrhage 71 0.7 0.7 no signal
1047 Drug Effect Decreased 91 0.7 0.7 no signal
1048 Thrombotic Microangiopathy 16 0.7 0.7 no signal
1049 Femur Fracture 51 0.7 0.7 no signal
1050 Incorrect Dose Administered 369 0.7 0.7 no signal
1051 Product Prescribing Error 38 0.7 0.7 no signal
1052 Hepatitis 41 0.7 0.7 no signal
1053 Sickle Cell Anaemia With Crisis 25 0.7 0.7 no signal
1054 Gamma-glutamyltransferase Increased 35 0.7 0.7 no signal
1055 Hunger 21 0.7 0.7 no signal
1056 Completed Suicide 131 0.7 0.7 no signal
1057 Euphoric Mood 16 0.7 0.7 no signal
1058 Injury Associated With Device 31 0.7 0.7 no signal
1059 Drug Effective For Unapproved Indication 45 0.7 0.7 no signal
1060 Interstitial Lung Disease 74 0.7 0.7 no signal
1061 Adverse Event 141 0.7 0.7 no signal
1062 Anosmia 22 0.7 0.7 no signal
1063 Abnormal Behaviour 60 0.6 0.6 no signal
1064 Rebound Effect 17 0.6 0.6 no signal
1065 Device Leakage 63 0.6 0.6 no signal
1066 Accidental Exposure To Product 148 0.6 0.6 no signal
1067 Pain Of Skin 40 0.6 0.6 no signal
1068 Product Packaging Quantity Issue 16 0.6 0.6 no signal
1069 Mania 24 0.6 0.6 no signal
1070 Blood Glucose Increased 274 0.6 0.6 no signal
1071 Hallucination, Auditory 23 0.6 0.6 no signal
1072 Product Odour Abnormal 15 0.6 0.6 no signal
1073 Abasia 36 0.6 0.6 no signal
1074 Liver Function Test Abnormal 42 0.6 0.6 no signal
1075 Injection Site Irritation 18 0.6 0.6 no signal
1076 Suicide Attempt 86 0.6 0.6 no signal
1077 Jaundice 38 0.6 0.6 no signal
1078 Wrong Technique In Product Usage Process 284 0.6 0.6 no signal
1079 Abnormal Dreams 39 0.6 0.6 no signal
1080 Product Substitution Issue 79 0.6 0.6 no signal
1081 Drug Level Decreased 14 0.6 0.6 no signal
1082 Drug-induced Liver Injury 42 0.6 0.6 no signal
1083 Agranulocytosis 25 0.6 0.6 no signal
1084 Glycosylated Haemoglobin Increased 34 0.6 0.6 no signal
1085 Multiple Sclerosis Relapse 92 0.6 0.6 no signal
1086 Exposure Via Skin Contact 30 0.6 0.6 no signal
1087 Drug Resistance 34 0.6 0.6 no signal
1088 Inflammatory Bowel Disease 13 0.6 0.6 no signal
1089 Injection Site Urticaria 32 0.6 0.6 no signal
1090 Akathisia 18 0.6 0.6 no signal
1091 Drug Exposure During Pregnancy 45 0.6 0.6 no signal
1092 Prescribed Underdose 26 0.6 0.6 no signal
1093 Tardive Dyskinesia 37 0.6 0.6 no signal
1094 Sexual Dysfunction 15 0.6 0.6 no signal
1095 Hepatocellular Injury 18 0.5 0.5 no signal
1096 Drug Withdrawal Syndrome 112 0.5 0.5 no signal
1097 Uveitis 17 0.5 0.5 no signal
1098 Bone Loss 19 0.5 0.5 no signal
1099 Hepatitis C 15 0.5 0.5 no signal
1100 Mood Swings 39 0.5 0.5 no signal
1101 Erectile Dysfunction 31 0.5 0.5 no signal
1102 Cytomegalovirus Infection 20 0.5 0.5 no signal
1103 Abnormal Weight Gain 15 0.5 0.5 no signal
1104 Amenorrhoea 20 0.5 0.5 no signal
1105 Unintentional Medical Device Removal 14 0.5 0.5 no signal
1106 Device Breakage 47 0.5 0.5 no signal
1107 Vaginal Discharge 12 0.5 0.5 no signal
1108 Circumstance Or Information Capable Of Leading To Medication Error 40 0.5 0.5 no signal
1109 Blood Thyroid Stimulating Hormone Increased 11 0.5 0.5 no signal
1110 Injection Site Rash 36 0.5 0.5 no signal
1111 Injection Site Haemorrhage 94 0.5 0.5 no signal
1112 Extra Dose Administered 47 0.5 0.5 no signal
1113 Anger 40 0.5 0.5 no signal
1114 Drug Reaction With Eosinophilia And Systemic Symptoms 30 0.5 0.5 no signal
1115 Therapy Cessation 59 0.5 0.5 no signal
1116 Psoriasis 150 0.5 0.5 no signal
1117 Haemorrhage Intracranial 17 0.5 0.5 no signal
1118 Device Malfunction 76 0.5 0.5 no signal
1119 Dermatitis Atopic 56 0.5 0.5 no signal
1120 Colitis Ulcerative 49 0.5 0.5 no signal
1121 Injection Site Nodule 12 0.5 0.5 no signal
1122 Injection Site Haematoma 16 0.5 0.5 no signal
1123 Blood Glucose Fluctuation 12 0.5 0.5 no signal
1124 Disease Recurrence 52 0.5 0.5 no signal
1125 Lung Neoplasm Malignant 45 0.5 0.5 no signal
1126 Hepatotoxicity 24 0.5 0.5 no signal
1127 Pancreatitis Acute 24 0.5 0.5 no signal
1128 Gastric Cancer 27 0.5 0.5 no signal
1129 Diabetic Ketoacidosis 25 0.4 0.4 no signal
1130 Product Taste Abnormal 14 0.4 0.4 no signal
1131 Drug Dependence 169 0.4 0.4 no signal
1132 Apathy 15 0.4 0.4 no signal
1133 Drug Prescribing Error 20 0.4 0.4 no signal
1134 Incorrect Drug Administration Duration 29 0.4 0.4 no signal
1135 Diabetes Mellitus Inadequate Control 18 0.4 0.4 no signal
1136 Product Dispensing Error 22 0.4 0.4 no signal
1137 Neuroleptic Malignant Syndrome 12 0.4 0.4 no signal
1138 Genital Haemorrhage 13 0.4 0.4 no signal
1139 Device Deployment Issue 12 0.4 0.4 no signal
1140 Thyroid Cancer 12 0.4 0.4 no signal
1141 Intentional Drug Misuse 21 0.4 0.4 no signal
1142 Device Use Issue 17 0.4 0.4 no signal
1143 Syringe Issue 17 0.4 0.4 no signal
1144 Personality Change 9 0.4 0.4 no signal
1145 Skeletal Injury 10 0.4 0.4 no signal
1146 Acne 72 0.4 0.4 no signal
1147 Complication Of Device Removal 16 0.4 0.4 no signal
1148 Skin Burning Sensation 67 0.4 0.4 no signal
1149 Breast Cancer Female 25 0.4 0.4 no signal
1150 Device Defective 15 0.4 0.4 no signal
1151 Drug Dose Omission 154 0.4 0.4 no signal
1152 Breast Cancer 85 0.4 0.4 no signal
1153 Pneumocystis Jirovecii Pneumonia 9 0.4 0.4 no signal
1154 Wrong Technique In Device Usage Process 39 0.4 0.4 no signal
1155 Hand Deformity 11 0.4 0.4 no signal
1156 Device Difficult To Use 55 0.4 0.4 no signal
1157 Underdose 59 0.3 0.3 no signal
1158 Pharmaceutical Product Complaint 21 0.3 0.3 no signal
1159 Tuberculosis 10 0.3 0.3 no signal
1160 Ovarian Cancer 7 0.3 0.3 no signal
1161 Menorrhagia 15 0.3 0.3 no signal
1162 Abortion Spontaneous 30 0.3 0.3 no signal
1163 Breast Cancer Stage I 7 0.3 0.3 no signal
1164 Inappropriate Schedule Of Drug Administration 52 0.3 0.3 no signal
1165 Drug Dispensing Error 11 0.3 0.3 no signal
1166 Product Storage Error 60 0.3 0.3 no signal
1167 Product Complaint 17 0.3 0.3 no signal
1168 Peritonitis 14 0.3 0.3 no signal
1169 Incorrect Dose Administered By Device 16 0.3 0.3 no signal
1170 Anorexia 8 0.3 0.3 no signal
1171 Dysmenorrhoea 8 0.3 0.3 no signal
1172 Device Adhesion Issue 9 0.3 0.3 no signal
1173 Device Use Error 19 0.2 0.2 no signal
1174 Intentional Self-injury 11 0.2 0.2 no signal
1175 Gynaecomastia 17 0.2 0.2 no signal
1176 Myelosuppression 17 0.2 0.2 no signal
1177 Meningioma 7 0.2 0.2 no signal
1178 Drug Withdrawal Syndrome Neonatal 7 0.2 0.2 no signal
1179 Pancreatic Carcinoma 13 0.2 0.2 no signal
1180 Menstruation Irregular 11 0.2 0.2 no signal
1181 Metrorrhagia 7 0.2 0.2 no signal
1182 Incorrect Product Storage 5 0.2 0.2 no signal
1183 Prostate Cancer 29 0.2 0.2 no signal
1184 Bladder Cancer 20 0.1 0.1 no signal
1185 Hepatic Cancer 8 0.1 0.1 no signal
1186 Schizophrenia 4 0.1 0.1 no signal
1187 Device Expulsion 20 0.1 0.1 no signal
1188 Oesophageal Carcinoma 9 0.1 0.1 no signal
1189 Renal Cancer 14 0.1 0.1 no signal
1190 Accidental Underdose 4 0.1 0.1 no signal
1191 Dependence 15 0.1 0.1 no signal
1192 Device Delivery System Issue 6 0.1 0.1 no signal
1193 Drug Dose Omission By Device 15 0.1 0.1 no signal