Furosemide vs Bumetanide: side effects in FDA adverse event reports
At a glance
| Furosemide | Bumetanide | |
|---|---|---|
| Drug class | Loop Diuretic | Loop Diuretic |
| Brand names | – | – |
| FAERS reports | 398,182 | 26,224 |
| Serious | 81% | 77% |
| Death outcome | 61,850 | 4,122 |
| Boxed warning | No | Yes Bumetanide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful m |
Signals both drugs share
| Reaction | Furosemide | Bumetanide | Label screen (A / B) |
|---|---|---|---|
| End stage renal disease | 3,380 · PRR 11.6 | 422 · PRR 18.7 | Labeled (related wording) / Not in label — unassessed |
| Right ventricular failure | 1,267 · PRR 11.3 | 198 · PRR 23.0 | Not in label — unassessed / Labeled (related wording) |
| Nephrogenic anaemia | 1,661 · PRR 28.7 | 228 · PRR 40.9 | Likely indication confounding / Likely indication confounding |
| Cardiac failure acute | 952 · PRR 8.6 | 130 · PRR 15.9 | Not in label — unassessed / Not in label — unassessed |
| Hyperparathyroidism secondary | 895 · PRR 28.4 | 112 · PRR 36.9 | Not in label — unassessed / Not in label — unassessed |
| Hypervolaemia | 656 · PRR 8.2 | 177 · PRR 30.6 | Not in label — unassessed / Not in label — unassessed |
| Orthopnoea | 751 · PRR 15.9 | 81 · PRR 20.8 | Not in label — unassessed / Not in label — unassessed |
| Rebound acid hypersecretion | 701 · PRR 15.4 | 71 · PRR 18.9 | Not in label — unassessed / Not in label — unassessed |
| Chronic kidney disease-mineral and bone disorder | 367 · PRR 26.9 | 29 · PRR 22.1 | Not in label — unassessed / Not in label — unassessed |
| Left atrial dilatation | 264 · PRR 13.4 | 25 · PRR 15.8 | Not in label — unassessed / Not in label — unassessed |
Labeled signals distinctive to Furosemide
- Orthostatic hypotension — n=2,320, PRR 7.9 Labeled adverse reaction
- Metabolic alkalosis — n=428, PRR 19.0 Labeled (related wording)
Labeled signals distinctive to Bumetanide
- Chronic left ventricular failure — n=27, PRR 66.0 Labeled (related wording)
- Acute left ventricular failure — n=19, PRR 23.0 Labeled (related wording)
Common questions
Which has more reported side effects, Furosemide or Bumetanide?
Furosemide has 398,182 FAERS reports and Bumetanide 26,224. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (81% vs 77%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Furosemide and Bumetanide share?
Both drugs carry disproportionality signals for end stage renal disease, right ventricular failure, nephrogenic anaemia, cardiac failure acute, hyperparathyroidism secondary. Shared signals often reflect a shared drug class or the condition both are used for.
Is Furosemide or Bumetanide safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.