Reaction

Orthopnoea reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,150 reports · 193 co-occurring drugs

As of the last recalculation, Orthopnoea appears in 3,150 FAERS reports alongside 193 co-occurring drug terms. The strongest observed disproportionality signal is METOLAZONE (PRR 39.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Metolazone	65	39.0	39.2
Eplerenone	59	31.0	31.1
Digoxin	276	27.8	27.9
Bumetanide	81	20.8	20.8
Spironolactone	384	20.4	20.5
Captopril	29	20.1	20.2
Isosorbide Dinitrate	51	17.5	17.6
Amiodarone Hydrochloride	29	17.3	17.3
Furosemide	751	15.9	16.0
Torsemide	78	15.9	16.0
Nitroglycerin	124	15.9	15.9
Epoprostenol	29	14.8	14.8
Carvedilol	271	14.4	14.4
Standardized Senna Concentrate	26	13.8	13.8
Febuxostat	33	13.1	13.2
Sacubitril And Valsartan	212	12.9	12.9
Potassium Chloride, Dextrose Monohydrate	169	12.7	12.7
Potassium Chloride Oral	169	12.7	12.7
Potassium Chloride Extended-Release	169	12.7	12.7
0Xygen	90	12.4	12.4
Oxygen	90	12.4	12.4
Potassium Chloride	198	12.2	12.2
Bisoprolol Fumarate	231	12.0	12.1
Dronedarone	17	11.1	11.1
Macitentan	112	11.0	11.1
Norepinephrine Bitartrate	23	10.6	10.6
Ipratropium Bromide	56	10.5	10.6
Glyburide	38	10.5	10.5
Selexipag	40	10.3	10.4
Tafamidis	18	10.1	10.2
Doxazosin	42	10.0	10.1
Enalapril Maleate	37	10.0	10.0
Promethazine Hydrochloride	27	9.7	9.7
Sotalol Hydrochloride	24	9.6	9.6
Warfarin Sodium	65	9.4	9.4
Sildenafil Powder,	50	9.4	9.4
Doxazosin Mesylate	50	9.3	9.3
Ciclesonide	19	9.3	9.3
Gemfibrozil	21	9.2	9.2
Acetylcysteine	13	9.1	9.2
Niacin	16	9.1	9.2
Warfarin	167	9.1	9.1
Diltiazem Hydrochloride	47	9.1	9.1
Ramipril	162	9.1	9.1
Sildenafil	75	8.7	8.7
Enalapril	72	8.7	8.7
Docusate Sodium - Sennosides	42	8.7	8.7
Norepinephrine	14	8.7	8.7
Meperidine Hydrochloride	12	8.6	8.6
Ticagrelor	41	8.6	8.6
Quinapril Hydrochloride	10	8.4	8.4
Colchicine	33	8.4	8.4
Cephalexin	27	8.3	8.3
Meclizine Hcl 12.5Mg	17	8.3	8.3
Meclizine Hcl 25Mg	17	8.3	8.3
Meclizine Hcl 12.5 Mg	17	8.3	8.3
Meclizine Hcl 25 Mg	17	8.3	8.3
Bosentan	60	8.0	8.0
Iohexol	10	8.0	8.0
Insulin	66	8.0	8.0
Indapamide	21	7.8	7.8
Meclizine	19	7.7	7.7
Indomethacin	15	7.5	7.5
Human Insulin	14	7.4	7.4
Ezetimibe And Simvastatin	17	7.4	7.4
Dapagliflozin	35	7.4	7.4
Metformin Hcl	61	7.4	7.4
Tolterodine Tartrate	10	7.4	7.4
Hyoscyamine Sulfate	10	7.2	7.2
Ampicillin	9	7.2	7.2
Ampicillin Sodium	9	7.2	7.2
Atropine	9	7.2	7.2
Febuxostat Tablets 40 Mg	11	7.2	7.2
Febuxostat Tablets 80 Mg	11	7.2	7.2
Meclizine Hydrochloride	21	7.1	7.1
Paricalcitol	15	7.0	7.1
Guaifenesin	32	7.0	7.0
Albuterol	122	6.9	7.0
Metoroprolol Tartrate	68	6.9	6.9
Ascorbic Acid	24	6.9	6.9
Tolvaptan	15	6.8	6.9
Clopidogrel Bisulfate	103	6.8	6.9
Exemestane	22	6.8	6.8
Nifedipine	48	6.8	6.8
Erythropoietin	21	6.8	6.8
Riociguat	33	6.7	6.8
Epoetin Alfa	12	6.7	6.7
Valsartan Oral	54	6.7	6.7
Enoxaparin Sodium	57	6.6	6.7
Temazepam	37	6.5	6.6
Chlorhexidine Gluconate	9	6.5	6.5
Docusate Sodium	56	6.5	6.5
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	20	6.5	6.5
Naproxen Sodium, Pseudoephedrine Hydrochloride	20	6.5	6.5
Sildenafil Citrate	120	6.4	6.4
Benzonatate	16	6.4	6.4
Clopidogrel	183	6.4	6.4
Isosorbide Mononitrate	20	6.4	6.4
Magnesium Hydroxide	13	6.4	6.4
Fenofibrate	34	6.4	6.4
Valsartan	99	6.4	6.4
Vitamin E	30	6.4	6.4
Azithromycin	38	6.3	6.3
Aspirin 325 Mg	431	6.3	6.3
Aspirin 81 Mg	431	6.3	6.3
Aspirin	448	6.3	6.3
Itraconazole	11	6.2	6.2
Atropine Sulfate	10	6.1	6.1
Amoxicillin And Clavulanate Potassium	25	6.1	6.1
Piperacillin Sodium And Tazobactam Sodium	18	6.1	6.1
Azithromycin Monohydrate	38	6.1	6.1
Calcitriol Capsules 0.25 Mcg	18	6.0	6.0
Calcitriol Capsules 0.5 Mcg	18	6.0	6.0
Azithromycin Dihydrate	52	5.9	5.9
Fluticasone Propionate Nasal	27	5.9	5.9
Tiotropium Bromide	119	5.9	5.9
Lisinopril And Hydrochlorothiazide Tablets	7	5.9	5.9
Calcitriol	18	5.9	5.9
Metoprolol Tartrate	229	5.9	5.9
Insulin Human	35	5.9	5.9
Allopurinol	134	5.9	5.9
Budesonide	51	5.8	5.8
Theophylline	10	5.8	5.8
Ranolazine	9	5.7	5.7
Tadalafil	84	5.7	5.7
Rabeprazole Sodium	23	5.6	5.6
Letrozole Tablets	40	5.6	5.6
Letrozole	51	5.5	5.5
Metoprolol	202	5.5	5.5
Losartan Potassium	65	5.5	5.5
Tamsulosin Hydrochloride	17	5.5	5.5
Everolimus	42	5.5	5.5
Apixaban	55	5.5	5.5
Midazolam Hydrochloride	22	5.4	5.4
Simvastatin	194	5.4	5.4
Salmeterol Xinafoate	7	5.4	5.4
Theophylline Anhydrous	10	5.3	5.3
Atorvastatin Calcium	189	5.3	5.3
Mepolizumab	39	5.2	5.2
Terazosin Hydrochloride	7	5.2	5.2
Lisinopril And Hydrochlorothiazide	8	5.2	5.2
Irbesartan	34	5.1	5.1
Trastuzumab	52	5.1	5.1
Methimazole	6	5.1	5.1
Dofetilide	8	5.0	5.0
Haloperidol	18	4.9	4.9
Desoximetasone	14	4.9	4.9
Metoprolol Tartrate Injection	135	4.9	4.9
Treprostinil	90	4.8	4.9
Glipizide	44	4.8	4.8
Haloperidol Lactate	18	4.8	4.8
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	36	4.8	4.8
Metoclopramide Hydrochloride	54	4.7	4.7
Pioglitazone	30	4.6	4.6
Budesonide And Formoterol Fumarate Dihydrate	66	4.6	4.6
Atenolol	89	4.5	4.5
Lapatinib	10	4.3	4.3
Ambrisentan	78	4.2	4.2
Pazopanib Hydrochloride	17	4.2	4.2
Metoprolol Succinate Er Tablets	39	4.2	4.2
Lovastatin	16	4.1	4.1
Doxorubicin Hydrochloride	20	4.1	4.1
Nilotinib	18	4.1	4.1
Sevoflurane	5	4.0	4.0
Everolimus Tablets	10	4.0	4.0
Pertuzumab	16	3.9	3.9
Pitavastatin Calcium	6	3.9	3.9
Budesonide, Glycopyrrolate, And Formoterol Fumarate	6	3.8	3.8
Sitagliptin	40	3.7	3.7
Amlodipine Besylate And Valsartan	6	3.6	3.6
Insulin Aspart	35	3.5	3.5
Pyrazinamide	5	3.5	3.5
Deferasirox	14	3.5	3.5
Empagliflozin	35	3.5	3.5
Docetaxel Anhydrous	35	3.5	3.5
Docetaxel	35	3.5	3.5
Hydromorphone Hydrochloride	46	3.3	3.3
Rivaroxaban	100	3.2	3.2
Pegaspargase	6	3.2	3.2
Imatinib Mesylate	13	3.1	3.1
Rucaparib	4	3.0	3.0
Dabigatran Etexilate	34	2.9	2.9
Regorafenib	5	2.8	2.8
Doxorubicin	37	2.8	2.8
Darbepoetin Alfa	22	2.7	2.7
Bortezomib	34	2.5	2.5
Gemcitabine Hydrochloride	20	2.5	2.5
Ravulizumab	5	2.4	2.4
Hydrocodone Bitartrate	15	2.3	2.3
Alpelisib	3	2.3	2.3
Carfilzomib	9	2.1	2.1
Benralizumab	6	2.0	2.0
Dasatinib	10	1.8	1.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.