Reaction

Hypervolaemia reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,736 reports · 354 co-occurring drugs

As of the last recalculation, Hypervolaemia appears in 4,736 FAERS reports alongside 354 co-occurring drug terms. The strongest observed disproportionality signal is DEXTROSE MONOHYDRATE, SODIUM CHLORIDE, SODIUM LACTATE, CALCIUM CHLORIDE, MAGNESIUM CHLORIDE (PRR 94.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Dextrose Monohydrate, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	182	94.0	95.9
Metolazone	99	39.5	39.9
Bumetanide	177	30.6	30.8
Teduglutide	90	29.9	30.1
Treprostinil	723	29.7	29.9
0Xygen	309	29.4	29.6
Oxygen	309	29.4	29.6
Macitentan	402	27.8	27.9
Riociguat	193	27.1	27.2
Sildenafil	307	24.8	25.0
Torsemide	177	24.4	24.5
Selexipag	123	21.5	21.6
Sevelamer Carbonate	44	17.0	17.0
Sildenafil Powder,	125	15.8	15.9
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	107	15.5	15.5
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	27	14.6	14.6
Ambrisentan	382	14.5	14.6
Norepinephrine	35	14.5	14.5
Tadalafil	300	14.0	14.0
Epoprostenol	41	13.9	13.9
Amiodarone Hydrochloride	35	13.8	13.9
Dextrose	41	13.8	13.8
Dextrose Monohydrate	41	13.6	13.6
Ketoprofen	39	13.2	13.2
Sildenafil Citrate	353	13.1	13.1
Sodium Bicarbonate	65	12.4	12.5
Sodium Bicarbonate Injection,	65	12.4	12.5
Norepinephrine Bitartrate	40	12.3	12.3
Human Immunoglobulin G	57	12.3	12.3
Potassium Chloride, Dextrose Monohydrate	245	12.2	12.2
Potassium Chloride Oral	245	12.2	12.2
Potassium Chloride Extended-Release	245	12.2	12.2
Sirolimus	36	11.8	11.9
Tafamidis	31	11.6	11.7
Sodium Chloride Tablet	187	11.6	11.6
Sodium Chloride Tablets	187	11.6	11.6
Sodium Chloride	198	11.5	11.5
Potassium Chloride	279	11.4	11.4
Spironolactone	325	10.8	10.9
Eplerenone	30	10.4	10.4
Valganciclovir Hydrochloride Powder,	27	9.8	9.8
Cholestyramine	25	9.1	9.1
Methoxy Polyethylene Glycol-Epoetin Beta	22	8.8	8.8
Basiliximab	23	8.6	8.6
Axicabtagene Ciloleucel	19	8.5	8.5
Valganciclovir	36	8.4	8.5
Valganciclovir Hydrochloride	36	8.4	8.5
Cyclobenzaprine Hydrochloride	17	8.3	8.4
Mycophenilic Acid	39	8.3	8.3
Rifaximin	39	8.2	8.3
Furosemide	656	8.2	8.2
Voclosporin	16	8.1	8.1
Amitriptyline Hydrochloride	32	8.1	8.1
Ferrous Sulfate	87	7.7	7.7
Calcitriol Capsules 0.25 Mcg	35	7.7	7.7
Calcitriol Capsules 0.5 Mcg	35	7.7	7.7
Hydroxyzine Hydrochloride	23	7.7	7.7
Hydroxyzine Hydrochloride Oral	23	7.7	7.7
Calcitriol	35	7.6	7.6
Doxyclycline Hyclate	29	7.5	7.5
Rocuronium Bromide	20	7.5	7.5
Mesna Injection	14	7.5	7.5
Mesna	14	7.3	7.3
Buspirone Hydrochloride	18	7.2	7.2
Atovaquone	13	7.1	7.1
Tiotropium Bromide Inhalation Spray	18	7.1	7.1
Epoetin Alfa	19	7.1	7.1
Mycophenolic Acid	51	7.1	7.1
Empagliflozin	105	7.0	7.0
Ganciclovir	16	6.9	6.9
Melatonin	84	6.9	6.9
Cefepime	22	6.8	6.8
Cefazolin	14	6.8	6.8
Ganciclovir Sodium	16	6.7	6.7
Calcium Gluconate	18	6.6	6.6
Benzonatate	24	6.4	6.4
Fluticasone Propionate Nasal	43	6.3	6.3
Cetirizine Hcl	13	6.2	6.3
Micafungin Sodium	12	6.2	6.2
Atorvastatin Calcium, Film Coated	97	6.2	6.2
Lidocaine Hydrochloride	82	6.1	6.1
Cefepime Hydrochloride	22	6.0	6.0
Iron Sucrose	13	6.0	6.0
Adrenalinum	56	6.0	6.0
Mycophenolate Mofetil	178	5.9	6.0
Magnesium Oxide	56	5.9	5.9
Mycophenolate Mofetil Hydrochloride	178	5.9	5.9
Ursosiol	26	5.9	5.9
Nystatin Ointment	35	5.9	5.9
Pantoprazole Sodium In 0.9% Sodium Chloride	82	5.9	5.9
Pantoprazole Sodium Injection	82	5.9	5.9
Nystatin Cream	35	5.9	5.9
Piperacillin Sodium,Tazobactam Sodium	35	5.8	5.8
Nystatin	36	5.8	5.8
Colchicine	34	5.7	5.7
Ursodiol	28	5.7	5.7
Cariprazine	12	5.7	5.7
Insulin Glargine-Yfgn	28	5.7	5.7
Melphalan Hydrochloride	32	5.6	5.6
Melphalan	29	5.6	5.6
Piperacillin Sodium And Tazobactam Sodium	25	5.6	5.6
Posaconazole Delayed-Release	14	5.6	5.6
Lactulose	48	5.5	5.6
Piperacillin And Tazobactam	16	5.5	5.5
Famotidine	143	5.5	5.5
Terazosin Hydrochloride	11	5.4	5.5
Umeclidinium	11	5.4	5.4
Erythropoietin	25	5.4	5.4
Chlorthalidone	14	5.3	5.3
Thiamine Hydrochloride	15	5.3	5.3
Fludarabine Phosphate	47	5.3	5.3
Guaifenesin	36	5.2	5.2
Tacrolimus Ointment 0.1%	144	5.2	5.2
Clonidine	60	5.2	5.2
Tacrolimus Extended-Release Capsules	144	5.2	5.2
Rosuvastatin Calcium	33	5.2	5.2
Docusate Sodium 100Mg	28	5.2	5.2
Acetylcysteine	11	5.1	5.1
Cefazolin Sodium	14	5.1	5.1
Sacubitril And Valsartan	132	5.1	5.1
Dapagliflozin	36	5.1	5.1
Metoprolol Succinate Er Tablets	71	5.1	5.1
Nitroglycerin	60	5.0	5.0
Labetalol	15	5.0	5.0
Diphenhydramine Hydrochloride Capsule, Liquid Filled	24	5.0	5.0
Anti-Thymocyte Globulin (Rabbit)	9	4.9	4.9
Hydroxyzine	52	4.8	4.8
Heparin Sodium	15	4.8	4.8
Ampicillin	9	4.8	4.8
Ampicillin Sodium	9	4.8	4.8
Warfarin Sodium	50	4.8	4.8
Promethazine Hydrochloride	20	4.7	4.8
Magnesium Sulfate Heptahydrate	14	4.7	4.7
Magnesium Sulfate	14	4.7	4.7
Tacrolimus	163	4.7	4.7
Allopurinol	162	4.7	4.7
Phytonadione	9	4.7	4.7
Digoxin	75	4.7	4.7
Tizanidine Hydrochloride	19	4.6	4.6
Posaconazole	17	4.6	4.6
Thiotepa	10	4.6	4.6
Pantoprazole Sodium	151	4.6	4.6
Carvedilol	138	4.6	4.6
Vancomycin Hydrochloride	68	4.6	4.6
Sennosides	31	4.6	4.6
Cyanocobalamin	34	4.6	4.6
Vancomycin	59	4.5	4.5
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	21	4.5	4.5
Diphenoxylate Hydrochloride And Atropine Sulfate	14	4.5	4.5
Bisoprolol Fumarate	136	4.5	4.5
Naproxen Sodium, Pseudoephedrine Hydrochloride	21	4.5	4.5
Fluticasone Propionate	130	4.5	4.5
Methimazole	8	4.5	4.5
Magnesium Sulfate In Water For	13	4.5	4.5
Octreotide Acetate	31	4.5	4.5
Lidocaine, Menthol	50	4.5	4.5
Ondansetron Hydrochloride	122	4.5	4.5
Psyllium Husk	10	4.5	4.5
Lidicaine	49	4.4	4.4
Burn Relief	49	4.4	4.4
Lidocaine Hydrochloride And Epinephrine	49	4.4	4.4
Bisacodyl Suppositories	13	4.4	4.4
Biscodyl	13	4.4	4.4
Lidocaine	57	4.3	4.3
Dexamethasone Sodium Phosphate	10	4.3	4.3
Doxorubicin	86	4.3	4.3
Methocarbamol	22	4.3	4.3
Loperamide Hydrochloride	43	4.3	4.3
Sevoflurane	8	4.2	4.2
Metoprolol Succinate	82	4.2	4.2
Methocarbamol Tablets	16	4.2	4.2
Abiraterone	13	4.2	4.2
Ciclesonide	13	4.2	4.2
Standardized Senna Concentrate	12	4.2	4.2
Doxepin Hydrochloride	12	4.2	4.2
Indapamide	17	4.2	4.2
Metoroprolol Tartrate	62	4.2	4.2
Epinephrine	61	4.1	4.1
Loperamide Hydrochloride And Dimethicone	30	4.1	4.1
Linagliptin	17	4.1	4.1
Warfarin	116	4.1	4.1
Nintedanib	29	4.1	4.1
Docusate Sodium	53	4.1	4.1
Bisacodyl	13	4.1	4.1
Lidocaine Hydrochloride And Epinephrine Bitartrate	49	4.1	4.1
Lidocaine 4%	50	4.1	4.1
Magnesium	75	4.1	4.1
Carfilzomib	26	4.1	4.1
Doxorubicin Hydrochloride	30	4.1	4.1
Fluticasone Furoate, Umeclidinium Bromide And Vilanterol Trifenatate	38	4.1	4.1
Metformin Hydrochloride Tablets	52	4.0	4.0
Metformin Hydrochloride Extended-Release Tablets	52	4.0	4.0
Metformin Hydrochloride Tablet	52	4.0	4.0
Propofol	33	4.0	4.0
Acetaminophen And Codeine	11	4.0	4.0
Metformin Hydrochloride	53	4.0	4.0
Loratadine Oral	44	4.0	4.0
Doxycycline Hyclate	60	3.9	3.9
Amlodipine	233	3.9	3.9
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	27	3.9	3.9
Bosutinib	8	3.9	3.9
Mupirocin	12	3.9	3.9
Iron	59	3.9	3.9
Apixaban	59	3.9	3.9
Doxepin	9	3.9	3.9
Doxycycline	60	3.9	3.9
Cyclophosphamide Injection, Solution	153	3.9	3.9
Cyclophosphamide	153	3.9	3.9
Cyclophosphamide For Injection	153	3.9	3.9
Zinc Gluconate	23	3.9	3.9
Albuterol Sulfate	250	3.9	3.9
Cefuroxime	10	3.9	3.9
Mupirocin Calcium	12	3.8	3.8
Nifedipine	41	3.8	3.8
Isosorbide Mononitrate	18	3.8	3.8
Pantoprazole	212	3.8	3.8
Doxazosin Mesylate	31	3.8	3.8
Doxazosin	24	3.8	3.8
Zinc	21	3.8	3.8
Eculizumab	46	3.7	3.7
Zinc Chloride	21	3.7	3.7
Iohexol	7	3.7	3.7
Dicyclomine Hydrochloride	12	3.7	3.7
Levothyroxine Sodium Anhydrous	83	3.7	3.7
Senna Leaf	19	3.6	3.6
Azithromycin	33	3.6	3.6
Pegaspargase	10	3.6	3.6
Quinine	7	3.6	3.6
Ravulizumab	11	3.6	3.6
Sulfamethoxazole And Trimethoprim	68	3.6	3.6
Meropenem	26	3.6	3.6
Sennosides 8.6 Mg Tablets	17	3.6	3.6
Amoxicillin And Clavulanate Potassium	22	3.6	3.6
Senna	17	3.6	3.6
Cyclobenzaprine	40	3.5	3.5
Azithromycin Monohydrate	33	3.5	3.5
Ceftriaxone	26	3.5	3.5
Valacyclovir	33	3.5	3.5
Metoprolol	196	3.5	3.5
Vitamin C	72	3.5	3.5
Febuxostat Tablets 40 Mg	8	3.5	3.5
Febuxostat Tablets 80 Mg	8	3.5	3.5
Vincristine Sulfate	23	3.5	3.5
Tamsulosin Hydrochloride	16	3.5	3.5
Dronedarone	8	3.5	3.5
Brexpiprazole	13	3.4	3.5
Sotalol Hydrochloride	13	3.4	3.4
Metoprolol Tartrate	205	3.4	3.4
Amlodipine Besylate	111	3.4	3.4
Bosentan	38	3.3	3.3
Butalbital, Acetaminophen, And Caffeine	8	3.3	3.3
Ergocalciferol	273	3.2	3.2
Metoprolol Tartrate Injection	137	3.2	3.2
Cytarabine	44	3.2	3.2
Insulin Aspart	48	3.2	3.2
Prochlorperazine	20	3.2	3.2
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	36	3.2	3.2
Abacavir Sulfate	7	3.2	3.2
Pramipexole	11	3.2	3.2
Everolimus Tablets	12	3.2	3.2
Etoposide	52	3.1	3.1
Ondansetron	77	3.1	3.1
Ondansetron Tablets	77	3.1	3.1
Gemcitabine Hydrochloride	37	3.1	3.1
Acyclovir	79	3.1	3.1
Tolvaptan	10	3.0	3.0
Gemcitabine	27	3.0	3.0
Minocycline	8	3.0	3.0
Loperamide Hydrochloride Oral	7	3.0	3.0
Triamcinolone Acetonide Ointment Usp, 0.05%	16	3.0	3.0
Gabapentin	240	3.0	3.0
Ceftriaxone Sodium	26	3.0	3.0
Clobetasol Propionate Ointment Usp, 0.05%	7	3.0	3.0
Clobetasol Propionate	7	3.0	3.0
Midazolam	17	3.0	3.0
Terbinafine Hydrochloride	6	3.0	3.0
Budesonide, Glycopyrrolate, And Formoterol Fumarate	7	2.9	2.9
Aspirin 325 Mg	326	2.9	2.9
Aspirin 81 Mg	326	2.9	2.9
Dofetilide	7	2.9	2.9
Azacitidine For	12	2.9	2.9
Febuxostat	11	2.9	2.9
Daptomycin	6	2.9	2.9
Methadone Hydrochloride	7	2.8	2.8
Amphotericin B	8	2.8	2.8
Atorvastatin Calcium	154	2.8	2.8
Darbepoetin Alfa	34	2.8	2.8
Midazolam Hydrochloride	17	2.8	2.8
Cisplatin	49	2.8	2.8
Vibegron	5	2.7	2.7
Ifosfamide	13	2.7	2.7
Loratadine	64	2.6	2.6
Icosapent Ethyl	5	2.6	2.6
Dexamethasone 1.5 Mg	166	2.5	2.5
Acalabrutinib	7	2.5	2.5
Dexlansoprazole	24	2.5	2.5
Dexamethasone	167	2.5	2.5
Dasatinib	21	2.5	2.5
Oxazepam	12	2.5	2.5
Insulin Human	22	2.4	2.4
Triamcinolone Acetonide	17	2.4	2.4
Azacitidine	16	2.4	2.4
Everolimus	27	2.3	2.3
Bortezomib	47	2.3	2.3
Polyethylene Glycol 3350	50	2.3	2.3
Lanreotide Acetate	4	2.2	2.2
Patiromer	7	2.2	2.2
Fam-Trastuzumab Deruxtecan-Nxki	5	2.2	2.2
Diclofenac Potassium, Film Coated	4	2.1	2.1
Diclofenac Potassium Tablets	4	2.1	2.1
Venetoclax	29	2.1	2.1
Rasagiline Mesylate	5	2.0	2.0
Voxelotor	10	2.0	2.0
Pomalidomide	45	1.9	1.9
Agalsidase Beta	4	1.9	1.9
Cinacalcet Hydrochloride	20	1.9	1.9
Rivaroxaban	87	1.9	1.9
Umeclidinium Bromide And Vilanterol Trifenatate	7	1.8	1.8
Insulin Lispro	57	1.8	1.8
Abiraterone Acetate	17	1.8	1.8
Oral Semaglutide	29	1.7	1.7
Irinotecan Hydrochloride	5	1.7	1.7
Mometasone Furoate And Formoterol Fumarate Dihydrate	6	1.7	1.7
Olaparib	8	1.7	1.7
Inclisiran	3	1.6	1.6
Diclofenac Potassium	4	1.6	1.6
Pirfenidone	15	1.6	1.6
Obinutuzumab	6	1.6	1.6
Sofosbuvir	7	1.6	1.6
Paricalcitol	5	1.6	1.6
Lumacaftor And Ivacaftor	3	1.5	1.5
Ixazomib	10	1.5	1.5
Alteplase	5	1.5	1.5
Ethyl Alcohol	9	1.5	1.5
Avapritinib	4	1.5	1.5
Belimumab	10	1.4	1.4
Polatuzumab Vedotin	3	1.4	1.4
Dornase Alfa	6	1.3	1.3
Encorafenib	3	1.3	1.3
Daratumumab	12	1.3	1.3
Remdesivir	4	1.3	1.3
Atezolizumab	11	1.2	1.2
Axitinib	5	1.1	1.1
Elexacaftor, Tezacaftor, And Ivacaftor	3	1.1	1.1
Rimegepant Sulfate	3	1.0	1.0
Enzalutamide	13	1.0	1.0
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	4	1.0	1.0
Dulaglutide	19	0.9	0.9
Valbenazine	5	0.9	0.9
Lifitegrast	3	0.8	0.8
Minoxidil Foam 5% (Womens)	6	0.8	0.8
Droxidopa	3	0.6	0.6
Minoxidil	6	0.6	0.6
Tirzepatide	17	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.