Reaction

Cardiac Failure Acute reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,560 reports · 410 co-occurring drugs

As of the last recalculation, Cardiac Failure Acute appears in 6,560 FAERS reports alongside 410 co-occurring drug terms. The strongest observed disproportionality signal is EPLERENONE (PRR 28.7).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Eplerenone	114	28.7	29.0
Metolazone	73	20.8	21.0
Febuxostat Tablets 40 Mg	62	19.5	19.6
Febuxostat Tablets 80 Mg	62	19.5	19.6
Torsemide	165	16.2	16.3
Bumetanide	130	15.9	16.0
Tolvaptan	69	15.2	15.3
Amiodarone Hydrochloride	45	12.8	12.9
Febuxostat	66	12.6	12.7
Tafamidis	41	11.1	11.1
Spironolactone	445	10.7	10.7
Pitavastatin Calcium	31	9.7	9.7
Captopril	29	9.6	9.6
Isosorbide Mononitrate	61	9.4	9.4
Furosemide	952	8.6	8.7
Sildenafil Powder,	95	8.6	8.6
Digoxin	188	8.5	8.5
Mesna Injection	22	8.5	8.5
Norepinephrine	28	8.3	8.4
Mesna	22	8.3	8.3
Bisoprolol Fumarate	338	8.3	8.3
Selexipag	66	8.2	8.2
Carfilzomib	72	8.2	8.2
Norepinephrine Bitartrate	36	8.0	8.0
Riociguat	80	7.9	7.9
Epoprostenol	32	7.8	7.8
Macitentan	166	7.8	7.8
Dapagliflozin	76	7.7	7.8
0Xygen	116	7.6	7.6
Oxygen	116	7.6	7.6
Sildenafil	135	7.5	7.5
Sacubitril And Valsartan	254	7.2	7.2
Meropenem	67	6.7	6.7
Carvedilol	274	6.7	6.7
Magnesium Oxide	86	6.6	6.6
Sodium Bicarbonate	48	6.6	6.6
Sodium Bicarbonate Injection,	48	6.6	6.6
Isosorbide Dinitrate	39	6.4	6.4
Enalapril	110	6.4	6.4
Enalapril Maleate	48	6.2	6.2
Lubiprostone	18	6.1	6.1
Micafungin Sodium	16	6.0	6.0
Sevoflurane	15	5.7	5.7
Warfarin	223	5.7	5.7
Entecavir	21	5.7	5.7
Hydrocortisone Sodium Succinate	16	5.4	5.4
Doxorubicin	149	5.4	5.4
Candesartan	59	5.3	5.3
Potassium Chloride, Dextrose Monohydrate	151	5.3	5.3
Potassium Chloride Oral	151	5.3	5.3
Potassium Chloride Extended-Release	151	5.3	5.3
Sildenafil Citrate	205	5.2	5.2
Posaconazole Delayed-Release	18	5.2	5.2
Nebivolol	26	5.2	5.2
Telmisartan	29	5.2	5.2
Bosentan	80	5.1	5.1
Dextrose	21	5.1	5.1
Ferrous Sulfate	79	5.0	5.0
Empagliflozin	105	5.0	5.0
Atropine Sulfate	17	5.0	5.0
Dextrose Monohydrate	21	5.0	5.0
Atropine	13	5.0	5.0
Testosterone Cypionate	14	5.0	5.0
Valsartan Oral	84	5.0	5.0
Valsartan	160	4.9	4.9
Potassium Chloride	173	4.9	4.9
Mycophenolic Acid	49	4.9	4.9
Piperacillin Sodium And Tazobactam Sodium	30	4.9	4.9
Methimazole	12	4.9	4.9
Melphalan Hydrochloride	38	4.8	4.8
Melphalan	34	4.8	4.8
Treprostinil	183	4.7	4.7
Propofol	54	4.7	4.7
Linezolid	44	4.7	4.7
Cytarabine	88	4.7	4.7
Prasugrel Hydrochloride	15	4.7	4.7
Lenvatinib	48	4.7	4.7
Itraconazole	17	4.6	4.6
Baricitinib	14	4.6	4.6
Anastrozole Tablets	31	4.6	4.6
Sotalol Hydrochloride	24	4.6	4.6
Piperacillin Sodium,Tazobactam Sodium	38	4.6	4.6
Cefepime Hydrochloride	23	4.5	4.5
Nitroglycerin	76	4.5	4.5
Tamsulosin Hydrochloride	29	4.5	4.5
Metoprolol Succinate Er Tablets	88	4.5	4.5
Clopidogrel Bisulfate	142	4.5	4.5
Oxazepam	30	4.4	4.4
Azacitidine	41	4.4	4.4
Metoprolol Succinate	117	4.3	4.3
Posaconazole	22	4.3	4.3
Dutasteride	11	4.3	4.3
Piperacillin And Tazobactam	17	4.2	4.2
Gemcitabine	52	4.2	4.2
Azacitidine For	24	4.2	4.2
Allopurinol	202	4.2	4.2
Haloperidol	32	4.2	4.2
Apixaban	87	4.2	4.2
Fluorouracil Cream, 0.5%	99	4.2	4.2
Fluorouracil	100	4.1	4.2
Fludarabine Phosphate	51	4.1	4.1
Haloperidol Lactate	32	4.1	4.1
Colchicine	34	4.1	4.1
Bendamustine Hcl	20	4.1	4.1
Doxorubicin Hydrochloride	42	4.1	4.1
Voriconazole	39	4.1	4.1
Insulin Glargine-Yfgn	28	4.1	4.1
Moxifloxacin	18	4.1	4.1
Methoxy Polyethylene Glycol-Epoetin Beta	14	4.0	4.0
Bicalutamide	19	4.0	4.0
Granisetron Hydrochloride	13	4.0	4.0
Heparin Sodium	17	3.9	3.9
Fondaparinux Sodium	10	3.9	3.9
Dalteparin Sodium	13	3.9	3.9
Rabeprazole	27	3.9	3.9
Osimertinib	39	3.9	3.9
Ampicillin	10	3.8	3.8
Ampicillin Sodium	10	3.8	3.8
Cyclophosphamide Injection, Solution	208	3.8	3.8
Cyclophosphamide	208	3.8	3.8
Cyclophosphamide For Injection	208	3.8	3.8
Calcitriol Capsules 0.25 Mcg	24	3.8	3.8
Calcitriol Capsules 0.5 Mcg	24	3.8	3.8
Ursodiol	26	3.8	3.8
Calcitriol	24	3.8	3.8
Venlafaxine	84	3.8	3.8
Epoetin Alfa	14	3.8	3.8
Dexamethasone Sodium Phosphate	12	3.8	3.8
Phytonadione	10	3.7	3.7
Magnesium Sulfate In Water For	15	3.7	3.7
Warfarin Sodium	54	3.7	3.7
Ticagrelor	37	3.7	3.7
Diltiazem Hydrochloride	40	3.7	3.7
Trastuzumab	79	3.7	3.7
Suvorexant	15	3.7	3.7
Testosterone	27	3.7	3.7
Gemcitabine Hydrochloride	61	3.7	3.7
Magnesium Sulfate Heptahydrate	15	3.7	3.7
Magnesium Sulfate	15	3.7	3.7
Oseltamivir Phosphate	28	3.6	3.7
Ketoprofen	15	3.6	3.6
Guanfacine	9	3.6	3.6
Diltiazem Hydrochloride Extended-Release Tablets	13	3.6	3.6
Ursosiol	22	3.6	3.6
Chlorthalidone	13	3.6	3.6
Darbepoetin Alfa	59	3.5	3.5
Clopidogrel	213	3.5	3.5
Mycophenolate Mofetil	146	3.5	3.5
Mycophenolate Mofetil Hydrochloride	146	3.5	3.5
Pembrolizumab	113	3.5	3.5
Calcium Gluconate	13	3.4	3.4
Oxaliplatin	79	3.4	3.4
Ceftriaxone	35	3.4	3.4
Ado-Trastuzumab Emtansine	9	3.4	3.4
Paclitaxel (Aibumin-Bound)	87	3.4	3.4
Docetaxel Anhydrous	71	3.4	3.4
Docetaxel	71	3.4	3.4
Cefuroxime	12	3.3	3.3
Tadalafil	104	3.3	3.3
Granisetron	11	3.3	3.3
Dofetilide	11	3.3	3.3
Cefepime	15	3.3	3.3
Ceftriaxone Sodium	40	3.3	3.3
Thiamine Hydrochloride	13	3.3	3.3
Linagliptin	19	3.3	3.3
Hydroxyurea	22	3.3	3.3
Travoprost	9	3.3	3.3
Paclitaxel	102	3.3	3.3
Nebivolol Hydrochloride	35	3.3	3.3
Amphotericin B	13	3.3	3.3
Dabigatran Etexilate	80	3.3	3.3
Pazopanib Hydrochloride	28	3.3	3.3
Fluconazole	72	3.3	3.3
Liothyronine Sodium	9	3.3	3.3
Daratumumab	41	3.3	3.3
Ifosfamide	22	3.3	3.3
Pioglitazone	44	3.2	3.2
Everolimus Tablets	17	3.2	3.2
Mycophenilic Acid	21	3.2	3.2
Gentamicin Sulfate	16	3.2	3.2
Metoprolol Tartrate Injection	188	3.2	3.2
Glimepiride	39	3.2	3.2
Methylprednisolone	136	3.2	3.2
Gefitinib	9	3.2	3.2
Pertuzumab	27	3.2	3.2
Bortezomib	88	3.2	3.2
Metoprolol	246	3.1	3.2
Metoprolol Tartrate	263	3.1	3.1
Moxifloxacin Hydrochloride	20	3.1	3.1
Sucralfate Oral	14	3.1	3.1
Sucralfate Oral Suspension	14	3.1	3.1
Enoxaparin Sodium	56	3.1	3.1
Agalsidase Beta	9	3.1	3.1
Insulin	54	3.1	3.1
Theophylline Anhydrous	12	3.1	3.1
Bleomycin Sulfate	10	3.1	3.1
Doxazosin	27	3.1	3.1
Romosozumab-Aqqg	13	3.0	3.0
Theophylline	11	3.0	3.0
Anastrozole	35	3.0	3.0
Midazolam	24	3.0	3.0
Aspirin 325 Mg	462	3.0	3.0
Aspirin 81 Mg	462	3.0	3.0
Aspirin	483	3.0	3.0
Glipizide	57	3.0	3.0
Amlodipine	247	3.0	3.0
Sennosides	28	3.0	3.0
Nifedipine	44	3.0	3.0
Midazolam Hydrochloride	25	3.0	3.0
Metoroprolol Tartrate	61	3.0	3.0
Polyethylene Glycol	10	2.9	2.9
Bendamustine Hydrochloride	11	2.9	2.9
Gentamicin	12	2.9	2.9
Doxazosin Mesylate	33	2.9	2.9
Prednisolone	162	2.9	2.9
Prednisolone Oral	162	2.9	2.9
Prednisolone Oral Solution	162	2.9	2.9
Atorvastatin Calcium, Film Coated	63	2.9	2.9
Cisplatin	70	2.9	2.9
Pantoprazole	223	2.9	2.9
Phenobarbital	13	2.8	2.9
Indapamide	16	2.8	2.8
Umeclidinium	8	2.8	2.8
Tacrolimus	138	2.8	2.8
Ramipril	109	2.8	2.8
Doxepin	9	2.8	2.8
Levofloxacin	53	2.8	2.8
Levofloxacin In 5% Dextrose	53	2.8	2.8
Amikacin	15	2.8	2.8
Etoposide	64	2.8	2.8
Ambrisentan	108	2.8	2.8
Fosaprepitant Dimeglumine	12	2.8	2.8
Inclisiran	7	2.8	2.8
Doxepin Hydrochloride	11	2.8	2.8
Anti-Thymocyte Globulin (Rabbit)	7	2.8	2.8
Fexofenadine Hcl	8	2.7	2.7
Rivaroxaban	177	2.7	2.7
Olmesartan Medoxomil	31	2.7	2.7
Simvastatin	210	2.7	2.7
Bisacodyl	12	2.7	2.7
Tacrolimus Ointment 0.1%	105	2.7	2.7
Bisacodyl Suppositories	11	2.7	2.7
Acetylcysteine	8	2.7	2.7
Rocuronium Bromide	10	2.7	2.7
Tacrolimus Extended-Release Capsules	105	2.7	2.7
Amlodipine Besylate	123	2.7	2.7
Amoxicillin And Clavulanate Potassium	23	2.7	2.7
Dabigatran Etexilate Mesylate	61	2.7	2.7
Biscodyl	11	2.7	2.7
Carboplatin	106	2.7	2.7
Sucralfate	20	2.7	2.7
Fesoterodine Fumarate	9	2.6	2.6
Panitumumab	13	2.6	2.6
Axitinib	16	2.6	2.6
Donepezil Hydrochloride	30	2.6	2.6
Octreotide Acetate	25	2.6	2.6
Quinine	7	2.6	2.6
Ethyl Alcohol	22	2.6	2.6
Selinexor	7	2.6	2.6
Sitagliptin	58	2.6	2.6
Abiraterone	11	2.6	2.6
Brinzolamide	7	2.6	2.6
Human Insulin	10	2.5	2.5
Docusate Sodium 100Mg	19	2.5	2.5
Rifampicin	8	2.5	2.5
Sodium Chloride	62	2.5	2.5
Terazosin Hydrochloride	7	2.5	2.5
Crizotinib	10	2.5	2.5
Metoclopramide	43	2.5	2.5
Lactulose	30	2.5	2.5
Voriconazole Injection	17	2.5	2.5
Ganciclovir	8	2.5	2.5
Senna Leaf	18	2.5	2.5
Brentuximab Vedotin	8	2.5	2.5
Aripiprazole Oral	32	2.5	2.5
Aripiprazole Orally Disintegrating	32	2.5	2.5
Methadone	33	2.5	2.5
Rabeprazole Sodium	21	2.4	2.4
Sorafenib	16	2.4	2.4
Sodium Chloride Tablet	56	2.4	2.4
Sodium Chloride Tablets	56	2.4	2.4
Sennosides 8.6 Mg Tablets	16	2.4	2.4
Lansoprazole	134	2.4	2.4
Senna	16	2.4	2.4
Ganciclovir Sodium	8	2.4	2.4
Oseltamivir	6	2.4	2.4
Venlafaxine Hydrochloride	98	2.4	2.4
Sirolimus	10	2.4	2.4
Rosuvastatin	150	2.4	2.4
Mupirocin	10	2.4	2.4
Losartan Potassium	58	2.3	2.3
Imatinib	13	2.3	2.3
Alteplase	11	2.3	2.3
Memantine	10	2.3	2.3
Memantine Hydrochloride	10	2.3	2.3
Nivolumab	70	2.3	2.3
Mupirocin Calcium	10	2.3	2.3
Benzonatate	12	2.3	2.3
Cyclosporine	80	2.3	2.3
Iohexol	6	2.3	2.3
Amlodipine Besylate And Valsartan	8	2.3	2.3
Vancomycin Hydrochloride	47	2.3	2.3
Vancomycin	41	2.3	2.3
Pravastatin Sodium	14	2.2	2.2
Abiraterone Acetate	29	2.2	2.2
Aprepitant	13	2.2	2.2
Famotidine	82	2.2	2.2
Mirtazapine	64	2.2	2.2
Durvalumab	14	2.2	2.2
Insulin Glulisine	7	2.2	2.2
Dronedarone	7	2.2	2.2
Loperamide Hydrochloride Oral	7	2.2	2.2
Rifampin	10	2.2	2.2
Atorvastatin Calcium	167	2.2	2.2
Isopropyl Alcohol	23	2.2	2.2
Dextrose Monohydrate, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	6	2.2	2.2
Irbesartan	30	2.1	2.1
Clarithromycin	23	2.1	2.1
Atezolizumab	26	2.1	2.1
Dexamethasone 1.5 Mg	193	2.1	2.1
Bevacizumab	82	2.1	2.1
Lopinavir And Ritonavir	9	2.1	2.1
Metoclopramide Hydrochloride	51	2.1	2.1
Dexamethasone	193	2.1	2.1
Pyrazinamide	6	2.0	2.0
Capecitabine	58	2.0	2.0
Busulfan	10	2.0	2.0
Venetoclax	39	2.0	2.0
Acyclovir	72	2.0	2.0
Erythropoietin	13	2.0	2.0
Hydroxychloroquine	47	2.0	2.0
Ipilimumab	27	2.0	2.0
Irinotecan Hydrochloride	8	2.0	2.0
Loperamide Hcl	8	2.0	2.0
Atovaquone	5	2.0	2.0
Fentanyl Citrate	11	2.0	2.0
Everolimus	31	1.9	1.9
Obinutuzumab	10	1.9	1.9
Pemetrexed	13	1.9	1.9
Raltegravir	10	1.9	1.9
Pemetrexed Disodium	23	1.9	1.9
Fentanyl	59	1.9	1.9
Zidovudine	8	1.9	1.9
Metformin Er 500 Mg	176	1.9	1.9
Metformin Er 750 Mg	176	1.9	1.9
Guaifenesin	18	1.9	1.9
Insulin Human	23	1.8	1.8
Olanzapine	62	1.8	1.8
Blinatumomab	6	1.8	1.8
Alcohol	22	1.8	1.8
Erlotinib Hydrochloride	7	1.8	1.8
Sitagliptin And Metformin Hydrochloride	12	1.8	1.8
Bosutinib	5	1.8	1.8
Losartan	94	1.7	1.7
Efavirenz	6	1.7	1.7
Rifaximin	11	1.7	1.7
Iron Sucrose	5	1.7	1.7
Sevelamer Carbonate	6	1.7	1.7
Pancrelipase	20	1.6	1.6
Thalidomide	19	1.6	1.6
Enzalutamide	30	1.6	1.6
Aripiprazole	62	1.6	1.6
Fexofenadine Hydrochloride	11	1.6	1.6
Dorzolamide Hydrochloride And Timolol Maleate	4	1.6	1.6
Tobramycin Solution	6	1.6	1.6
Paricalcitol	7	1.6	1.6
Acalabrutinib	6	1.6	1.6
Linaclotide	13	1.5	1.5
Sunitinib Malate	19	1.5	1.5
Ranolazine	5	1.5	1.5
Umeclidinium Bromide And Vilanterol Trifenatate	8	1.5	1.5
Vincristine Sulfate	14	1.5	1.5
Ibrutinib	38	1.5	1.5
Mirabegron	18	1.5	1.5
Miconazole Nitrate	4	1.5	1.5
Dasatinib	17	1.5	1.5
Remdesivir	6	1.4	1.4
Mometasone Furoate And Formoterol Fumarate Dihydrate	7	1.4	1.4
Insulin Glargine	109	1.4	1.4
Apalutamide	5	1.3	1.3
Risperidone	56	1.3	1.3
Thiotepa	4	1.3	1.3
Droxidopa	9	1.3	1.3
Rotigotine	6	1.3	1.3
Methylphenidate	12	1.3	1.3
Axicabtagene Ciloleucel	4	1.3	1.3
Encorafenib	4	1.3	1.3
Palivizumab	6	1.2	1.2
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	12	1.2	1.2
Clozapine	48	1.2	1.2
Bimatoprost	11	1.2	1.2
Deferasirox	10	1.2	1.2
Canakinumab	4	1.2	1.2
Dornase Alfa	7	1.1	1.1
Sofosbuvir	7	1.1	1.1
Nintedanib	11	1.1	1.1
Ixazomib	10	1.1	1.1
Vemurafenib	4	1.1	1.1
Romiplostim	5	1.1	1.1
Cabozantinib	15	1.0	1.0
Fam-Trastuzumab Deruxtecan-Nxki	3	0.9	0.9
Lenalidomide	124	0.9	0.9
Budesonide, Glycopyrrolate, And Formoterol Fumarate	3	0.9	0.9
Brexpiprazole	4	0.8	0.8
Aflibercept	7	0.7	0.7
Patiromer	3	0.7	0.7
Dulaglutide	19	0.7	0.7
Pomalidomide	21	0.6	0.6
Cinacalcet Hydrochloride	7	0.5	0.5
Pirfenidone	6	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.