OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Tolvaptan

1,015 flagged reaction(s) · 44,798 total co-reports · max PRR 6,212.1
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Rapid Correction Of Hyponatraemia 204 6,212.1 6,301.1 signal
2 Renal Cyst Ruptured 26 361.3 361.9 signal
3 Urine Osmolarity Decreased 17 238.5 238.8 signal
4 Polycystic Liver Disease 15 235.9 236.2 signal
5 Renal Cyst Haemorrhage 27 203.4 203.8 signal
6 Pulmonary Vein Occlusion 9 181.4 181.5 signal
7 Renal Cyst Infection 16 161.3 161.4 signal
8 Low Cardiac Output Syndrome 30 143.1 143.4 signal
9 Hypernatraemia 364 114.9 117.8 signal
10 Urine Osmolarity Increased 10 100.1 100.2 signal
11 Drug Monitoring Procedure Incorrectly Performed 43 99.9 100.2 signal
12 Fluid Intake Restriction 7 98.2 98.3 signal
13 Blood Sodium Increased 162 92.3 93.3 signal
14 Investigation Noncompliance 6 85.9 85.9 signal
15 Polyuria 448 83.9 86.6 signal
16 Thirst 954 82.0 87.8 signal
17 Bilirubin Urine Present 6 81.0 81.0 signal
18 Osmotic Demyelination Syndrome 39 80.8 81.0 signal
19 Polydipsia 208 80.5 81.6 signal
20 Hepatic Cyst Infection 5 78.6 78.7 signal
21 Blood Urea Nitrogen/creatinine Ratio Decreased 7 75.3 75.4 signal
22 Procedural Failure 8 69.8 69.9 signal
23 Defect Conduction Intraventricular 14 65.3 65.3 signal
24 Pulmonary Arterial Wedge Pressure Increased 7 61.8 61.9 signal
25 Cyst Rupture 26 58.0 58.1 signal
26 Cardiac Failure Chronic 158 55.9 56.6 signal
27 Liver Carcinoma Ruptured 8 47.5 47.5 signal
28 Haemorrhagic Cyst 12 46.2 46.2 signal
29 Renal Transplant 107 44.3 44.6 signal
30 Immobilisation Syndrome 6 42.5 42.5 signal
31 Blood Sodium Abnormal 28 39.3 39.4 signal
32 Glomerular Filtration Rate Decreased 284 34.8 35.5 signal
33 Nocturia 281 34.5 35.1 signal
34 Aspartate Aminotransferase Decreased 12 33.9 33.9 signal
35 Uraemic Encephalopathy 7 33.6 33.6 signal
36 Congestive Hepatopathy 10 33.4 33.4 signal
37 Protein-losing Gastroenteropathy 11 33.3 33.3 signal
38 Alanine Aminotransferase Decreased 16 32.9 33.0 signal
39 Blood Sodium Decreased 367 28.9 29.6 signal
40 Brain Natriuretic Peptide Increased 60 28.8 28.9 signal
41 Carbon Dioxide Decreased 22 28.5 28.6 signal
42 Marasmus 29 28.5 28.6 signal
43 Pulmonary Veno-occlusive Disease 13 27.6 27.6 signal
44 N-terminal Prohormone Brain Natriuretic Peptide Increased 26 27.4 27.4 signal
45 Rhythm Idioventricular 6 27.3 27.3 signal
46 Hyperuricaemia 74 26.7 26.8 signal
47 Transplant 42 26.1 26.2 signal
48 Urine Output Increased 46 25.9 25.9 signal
49 Blood Urea Increased 291 25.5 26.0 signal
50 Urine Albumin/creatinine Ratio Increased 9 25.1 25.1 signal
51 Blood Chloride Increased 29 24.8 24.9 signal
52 Bronchial Carcinoma 13 24.2 24.2 signal
53 Congenital Cystic Kidney Disease 13 22.4 22.4 signal
54 Dialysis 216 22.4 22.7 signal
55 Blood Osmolarity Increased 5 22.2 22.2 signal
56 Right Ventricular Failure 106 22.1 22.3 signal
57 Upper Respiratory Tract Inflammation 18 22.0 22.0 signal
58 Kidney Enlargement 16 21.6 21.6 signal
59 Hepatic Encephalopathy 134 21.1 21.3 signal
60 Prerenal Failure 20 21.1 21.1 signal
61 Oesophageal Varices Haemorrhage 30 20.3 20.3 signal
62 Hepatorenal Syndrome 23 19.9 20.0 signal
63 Pollakiuria 552 19.5 20.2 signal
64 Cardiac Amyloidosis 14 18.9 18.9 signal
65 Cardiorenal Syndrome 7 18.0 18.0 signal
66 Jugular Vein Distension 7 17.9 17.9 signal
67 Concomitant Disease Progression 24 17.8 17.9 signal
68 Blood Alkaline Phosphatase Decreased 11 16.9 16.9 signal
69 Colonoscopy 25 16.6 16.7 signal
70 Thirst Decreased 7 16.6 16.6 signal
71 Renal Ischaemia 6 16.2 16.2 signal
72 Hyperchloraemia 7 16.0 16.0 signal
73 Peritoneal Dialysis 9 15.8 15.9 signal
74 Blood Phosphorus Abnormal 5 15.8 15.8 signal
75 Concomitant Disease Aggravated 66 15.7 15.7 signal
76 Drug Monitoring Procedure Not Performed 19 15.6 15.7 signal
77 Aortic Valve Stenosis 19 15.6 15.6 signal
78 Atrial Tachycardia 22 15.3 15.3 signal
79 Hepatic Congestion 10 15.3 15.3 signal
80 Cardiac Failure Acute 69 15.2 15.3 signal
81 Renal Impairment 856 15.0 15.9 signal
82 Blood Uric Acid Increased 59 15.0 15.0 signal
83 Cardiac Failure 814 14.8 15.7 signal
84 Drug Titration Error 26 14.7 14.7 signal
85 Hyperglycaemic Hyperosmolar Nonketotic Syndrome 11 14.6 14.6 signal
86 Glomerular Filtration Rate Increased 8 14.4 14.4 signal
87 Small Cell Lung Cancer 14 14.0 14.0 signal
88 Blood Osmolarity Decreased 6 13.9 13.9 signal
89 Hepatic Function Abnormal 351 13.9 14.2 signal
90 Hepatic Cyst 32 13.8 13.8 signal
91 Liver Transplant 33 13.3 13.4 signal
92 Haemorrhagic Infarction 5 13.3 13.3 signal
93 Urine Protein/creatinine Ratio Increased 8 13.1 13.2 signal
94 Pulmonary Arterial Hypertension 130 13.1 13.2 signal
95 Fluid Intake Reduced 44 13.0 13.1 signal
96 Urine Output Decreased 75 12.5 12.6 signal
97 Glomerular Filtration Rate Abnormal 12 12.5 12.5 signal
98 Chylothorax 6 12.3 12.3 signal
99 Ischaemic Hepatitis 11 11.9 11.9 signal
100 Blood Urea Nitrogen/creatinine Ratio Increased 5 11.4 11.4 signal
101 Gallbladder Polyp 6 11.2 11.2 signal
102 Infected Cyst 9 11.0 11.0 signal
103 Cytomegalovirus Test Positive 13 10.7 10.7 signal
104 Incorrect Drug Administration Rate 31 10.7 10.7 signal
105 Medical Procedure 12 10.7 10.7 signal
106 Incorrect Product Administration Duration 148 10.7 10.8 signal
107 Dactylitis 7 10.4 10.4 signal
108 Fluid Imbalance 5 10.3 10.3 signal
109 Inability To Afford Medication 69 10.2 10.3 signal
110 Blood Chloride Decreased 18 10.1 10.1 signal
111 Pulmonary Congestion 91 10.0 10.1 signal
112 Incorrect Drug Administration Duration 196 10.0 10.2 signal
113 Cholangitis Acute 5 10.0 10.0 signal
114 Blood Creatinine Increased 445 9.9 10.2 signal
115 Disseminated Cryptococcosis 5 9.9 9.9 signal
116 Physical Deconditioning 17 9.9 9.9 signal
117 Anion Gap Increased 9 9.8 9.8 signal
118 Catheter Management 6 9.7 9.7 signal
119 Nephrogenic Anaemia 31 9.7 9.7 signal
120 Diabetes Insipidus 16 9.6 9.7 signal
121 Underdose 480 9.6 9.9 signal
122 Cerebral Artery Embolism 8 9.5 9.5 signal
123 Critical Illness 5 9.5 9.5 signal
124 Blood Potassium Increased 104 9.4 9.4 signal
125 Hypercapnia 18 8.8 8.8 signal
126 Hypochloraemia 7 8.8 8.8 signal
127 Prescribed Underdose 119 8.7 8.8 signal
128 Renal Pain 61 8.4 8.5 signal
129 Cardiac Dysfunction 21 8.4 8.4 signal
130 Cardiac Output Decreased 5 8.3 8.3 signal
131 Liver Injury 137 8.3 8.3 signal
132 Cardiac Ablation 10 8.2 8.2 signal
133 Metabolic Alkalosis 9 8.2 8.2 signal
134 Altered State Of Consciousness 120 8.1 8.2 signal
135 Left Ventricular Failure 19 8.1 8.1 signal
136 Hyponatraemia 308 8.0 8.1 signal
137 Sinus Node Dysfunction 10 8.0 8.0 signal
138 Hypoproteinaemia 10 7.9 7.9 signal
139 Blood Urea Abnormal 5 7.8 7.8 signal
140 Metabolic Surgery 6 7.8 7.8 signal
141 Hyperkalaemia 186 7.8 7.9 signal
142 Insurance Issue 79 7.8 7.8 signal
143 Drug Dose Titration Not Performed 9 7.6 7.6 signal
144 Aortic Aneurysm Rupture 5 7.4 7.4 signal
145 Biliary Tract Disorder 7 7.4 7.4 signal
146 Occult Blood Positive 10 7.3 7.3 signal
147 Hyperammonaemia 25 7.3 7.3 signal
148 Cerebral Infarction 122 7.3 7.3 signal
149 Hepatocellular Carcinoma 38 7.3 7.3 signal
150 Alanine Aminotransferase Increased 304 7.2 7.3 signal
151 Flank Pain 46 7.2 7.2 signal
152 Pseudomembranous Colitis 11 7.1 7.1 signal
153 Gastric Polyps 11 7.1 7.1 signal
154 Aspartate Aminotransferase Increased 258 7.1 7.2 signal
155 Blood Parathyroid Hormone Increased 14 7.0 7.0 signal
156 Cardiac Ventricular Thrombosis 6 6.9 6.9 signal
157 Liver Function Test Increased 101 6.9 6.9 signal
158 Hepatitis Fulminant 14 6.9 6.9 signal
159 Hepatic Cirrhosis 88 6.9 6.9 signal
160 Orthopnoea 15 6.8 6.9 signal
161 Platelet Transfusion 6 6.8 6.8 signal
162 Ascites 135 6.7 6.7 signal
163 Pulmonary Hypertension 95 6.6 6.7 signal
164 Gastrointestinal Oedema 8 6.6 6.6 signal
165 Azotaemia 18 6.5 6.5 signal
166 Product Prescribing Issue 91 6.5 6.5 signal
167 Nephrogenic Diabetes Insipidus 5 6.3 6.3 signal
168 Po2 Decreased 5 6.3 6.3 signal
169 Hypoalbuminaemia 33 6.3 6.3 signal
170 Pulmonary Alveolar Haemorrhage 24 6.2 6.2 signal
171 Pulmonary Arterial Pressure Increased 7 6.2 6.2 signal
172 Intracranial Aneurysm 17 6.2 6.2 signal
173 Portal Hypertension 13 6.1 6.1 signal
174 Inappropriate Antidiuretic Hormone Secretion 42 6.0 6.0 signal
175 Cardiac Death 5 6.0 6.0 signal
176 Biliary Dilatation 6 5.9 5.9 signal
177 Nephrectomy 6 5.9 5.9 signal
178 Iron Deficiency Anaemia 37 5.9 5.9 signal
179 Hypopituitarism 7 5.8 5.9 signal
180 Blood Urea Decreased 5 5.8 5.8 signal
181 Aortic Valve Incompetence 17 5.8 5.8 signal
182 Aspartate Aminotransferase Abnormal 6 5.8 5.8 signal
183 Glucose Urine Present 5 5.7 5.7 signal
184 Hepatic Failure 119 5.7 5.8 signal
185 Renal Cyst 31 5.7 5.7 signal
186 Blood Bilirubin Increased 105 5.6 5.7 signal
187 Ventricular Tachycardia 64 5.6 5.6 signal
188 Tumour Haemorrhage 11 5.6 5.6 signal
189 Conduction Disorder 7 5.6 5.6 signal
190 Blood Creatinine Abnormal 13 5.5 5.5 signal
191 Intentional Dose Omission 103 5.5 5.5 signal
192 Blood Pressure Systolic Decreased 17 5.5 5.5 signal
193 Micturition Disorder 13 5.5 5.5 signal
194 Ventricular Hypokinesia 12 5.4 5.4 signal
195 Liver Disorder 165 5.4 5.5 signal
196 Transfusion 39 5.4 5.4 signal
197 Embolic Stroke 13 5.4 5.4 signal
198 Blood Phosphorus Increased 10 5.3 5.3 signal
199 Blood Bicarbonate Decreased 7 5.3 5.3 signal
200 Carbon Dioxide Increased 5 5.3 5.3 signal
201 Gamma-glutamyltransferase Increased 81 5.3 5.3 signal
202 Mean Cell Haemoglobin Increased 6 5.3 5.3 signal
203 Hypovolaemia 21 5.2 5.2 signal
204 Oliguria 22 5.2 5.2 signal
205 Dehydration 472 5.2 5.3 signal
206 Pneumonia Aspiration 88 5.1 5.2 signal
207 Enteritis Infectious 6 5.1 5.1 signal
208 Ventricular Fibrillation 39 5.1 5.1 signal
209 Lung Opacity 9 5.1 5.1 signal
210 Disseminated Intravascular Coagulation 49 5.1 5.1 signal
211 Dyspnoea At Rest 10 5.0 5.0 signal
212 Protein Total Decreased 13 5.0 5.0 signal
213 Mitral Valve Incompetence 39 5.0 5.0 signal
214 Renal Haemorrhage 7 5.0 5.0 signal
215 Protein Urine Present 17 5.0 5.0 signal
216 Pyelonephritis 29 4.9 4.9 signal
217 Atrial Thrombosis 7 4.9 4.9 signal
218 Aortic Dissection 14 4.9 4.9 signal
219 Blood Alkaline Phosphatase Increased 83 4.9 4.9 signal
220 Ammonia Increased 17 4.8 4.9 signal
221 Neurogenic Bladder 7 4.8 4.8 signal
222 Hyperphosphataemia 7 4.8 4.8 signal
223 Amylase Increased 12 4.8 4.8 signal
224 Mean Cell Haemoglobin Decreased 6 4.8 4.8 signal
225 Generalised Oedema 40 4.7 4.7 signal
226 Catheter Site Infection 12 4.7 4.7 signal
227 Hyperparathyroidism Secondary 8 4.6 4.6 signal
228 Gastrointestinal Perforation 13 4.6 4.6 signal
229 Cystitis Interstitial 5 4.5 4.5 signal
230 Portal Vein Thrombosis 10 4.5 4.5 signal
231 Large Intestinal Haemorrhage 7 4.5 4.5 signal
232 Hernia Repair 8 4.5 4.5 signal
233 Bradyarrhythmia 5 4.4 4.4 signal
234 Blood Pressure Decreased 201 4.4 4.5 signal
235 Eosinophil Count Increased 25 4.4 4.4 signal
236 Blood Potassium Abnormal 8 4.4 4.4 signal
237 Anuria 26 4.4 4.4 signal
238 Mean Cell Haemoglobin Concentration Decreased 5 4.4 4.4 signal
239 Contraindicated Product Prescribed 5 4.4 4.4 signal
240 Small Intestinal Haemorrhage 6 4.4 4.4 signal
241 Cardiomegaly 37 4.3 4.3 signal
242 Hepatotoxicity 66 4.3 4.3 signal
243 Transaminases Increased 66 4.3 4.3 signal
244 Endocarditis 15 4.3 4.3 signal
245 Urinary Hesitation 7 4.2 4.2 signal
246 Tricuspid Valve Incompetence 23 4.2 4.2 signal
247 Faeces Soft 21 4.2 4.2 signal
248 Amyloidosis 5 4.2 4.2 signal
249 Blood Creatinine Decreased 9 4.2 4.2 signal
250 Alanine Aminotransferase Abnormal 6 4.2 4.2 signal
251 Pleural Effusion 174 4.2 4.2 signal
252 End Stage Renal Disease 52 4.1 4.1 signal
253 Prothrombin Time Prolonged 17 4.1 4.1 signal
254 Haemorrhagic Diathesis 10 4.1 4.1 signal
255 Blood Albumin Decreased 22 4.0 4.1 signal
256 Lung Cancer Metastatic 8 4.0 4.0 signal
257 Haemothorax 8 4.0 4.0 signal
258 Oedema 149 4.0 4.0 signal
259 Atrial Flutter 22 4.0 4.0 signal
260 Micturition Urgency 31 4.0 4.0 signal
261 Cancer Pain 7 4.0 4.0 signal
262 Mean Cell Volume Increased 7 4.0 4.0 signal
263 Faeces Pale 6 3.9 3.9 signal
264 Hypokalaemia 124 3.9 4.0 signal
265 Blood Creatine Increased 12 3.9 3.9 signal
266 Ileus Paralytic 12 3.9 3.9 signal
267 High Density Lipoprotein Decreased 9 3.9 3.9 signal
268 Thyroiditis 8 3.9 3.9 signal
269 Urine Analysis Abnormal 8 3.9 3.9 signal
270 Tongue Ulceration 9 3.9 3.9 signal
271 Dry Mouth 213 3.8 3.9 signal
272 Haematocrit Increased 6 3.8 3.8 signal
273 Hepatitis Acute 17 3.8 3.8 signal
274 No Adverse Event 462 3.8 3.9 signal
275 Blood Potassium Decreased 77 3.7 3.7 signal
276 Wrong Technique In Product Usage Process 515 3.7 3.8 signal
277 Product Dose Omission Issue 723 3.7 3.8 signal
278 Subdural Haematoma 36 3.6 3.7 signal
279 Endotracheal Intubation 7 3.6 3.6 signal
280 Inappropriate Schedule Of Product Administration 440 3.6 3.7 signal
281 Cardiac Operation 21 3.6 3.6 signal
282 Organising Pneumonia 12 3.6 3.6 signal
283 Injection Site Infection 8 3.6 3.6 signal
284 Inappropriate Schedule Of Drug Administration 176 3.5 3.6 signal
285 Vascular Device Infection 11 3.5 3.5 signal
286 Neutrophil Count Increased 25 3.5 3.5 signal
287 Therapy Cessation 124 3.5 3.6 signal
288 Tachyarrhythmia 6 3.5 3.5 signal
289 Product Dose Omission In Error 64 3.5 3.5 signal
290 Intestinal Ischaemia 13 3.4 3.5 signal
291 Varices Oesophageal 7 3.4 3.4 signal
292 Cardiac Tamponade 11 3.4 3.4 signal
293 Large Intestine Polyp 16 3.4 3.4 signal
294 Staphylococcal Bacteraemia 10 3.4 3.4 signal
295 Pneumonia Bacterial 21 3.3 3.3 signal
296 Infusion Site Erythema 19 3.3 3.3 signal
297 Hepatitis Toxic 6 3.3 3.3 signal
298 Enterocolitis 13 3.3 3.3 signal
299 Cholangitis 14 3.3 3.3 signal
300 Diabetic Nephropathy 5 3.3 3.3 signal
301 Haemorrhage Subcutaneous 8 3.3 3.3 signal
302 Sudden Death 24 3.3 3.3 signal
303 Bacterial Test Positive 5 3.3 3.3 signal
304 Hospice Care 22 3.2 3.2 signal
305 Renal Disorder 104 3.2 3.3 signal
306 Multiple Organ Dysfunction Syndrome 62 3.2 3.2 signal
307 Hepatic Enzyme Increased 150 3.2 3.2 signal
308 Diverticulum Intestinal Haemorrhagic 5 3.2 3.2 signal
309 Scleroderma 8 3.2 3.2 signal
310 Nephrotic Syndrome 15 3.2 3.2 signal
311 Electrolyte Imbalance 25 3.2 3.2 signal
312 Cardiac Failure Congestive 176 3.2 3.2 signal
313 Product Use Issue 404 3.1 3.2 signal
314 Drug Eruption 38 3.1 3.1 signal
315 Haematocrit Decreased 43 3.1 3.1 signal
316 Listless 7 3.1 3.1 signal
317 Circulatory Collapse 36 3.1 3.1 signal
318 Duodenal Ulcer Haemorrhage 6 3.0 3.0 signal
319 Hypervolaemia 10 3.0 3.0 signal
320 Septic Shock 90 3.0 3.0 signal
321 Device Related Infection 32 3.0 3.0 signal
322 Platelet Count Decreased 218 3.0 3.0 signal
323 Product Use In Unapproved Indication 499 3.0 3.0 signal
324 Sudden Cardiac Death 7 3.0 3.0 signal
325 Product Distribution Issue 18 3.0 3.0 signal
326 Ventricular Extrasystoles 21 2.9 2.9 signal
327 Urine Abnormality 9 2.9 2.9 signal
328 Haemoglobin Increased 9 2.9 2.9 signal
329 Lymphocyte Count Decreased 35 2.9 2.9 signal
330 Dizziness Postural 19 2.9 2.9 signal
331 Interstitial Lung Disease 95 2.9 2.9 signal
332 Fibrin D Dimer Increased 7 2.9 2.9 signal
333 Renal Function Test Abnormal 9 2.8 2.8 signal
334 Bundle Branch Block Right 9 2.8 2.8 signal
335 Infusion Site Swelling 12 2.8 2.8 signal
336 Gout 35 2.8 2.8 signal
337 Drug-induced Liver Injury 60 2.8 2.8 signal
338 Colon Cancer 29 2.8 2.8 signal
339 Kidney Infection 38 2.8 2.8 signal
340 Lipoma 5 2.8 2.8 signal
341 Essential Hypertension 5 2.8 2.8 signal
342 Monocyte Count Increased 7 2.8 2.8 signal
343 Red Cell Distribution Width Increased 8 2.8 2.8 signal
344 Compression Fracture 10 2.8 2.8 signal
345 Spinal Compression Fracture 16 2.8 2.8 signal
346 Shoulder Operation 8 2.8 2.8 signal
347 Congestive Cardiomyopathy 8 2.7 2.8 signal
348 Face Oedema 32 2.7 2.7 signal
349 Supraventricular Tachycardia 18 2.7 2.7 signal
350 Skin Erosion 6 2.7 2.7 signal
351 Mycobacterium Avium Complex Infection 5 2.7 2.7 no signal
352 Acute Kidney Injury 282 2.7 2.7 signal
353 Blood Creatine Phosphokinase Increased 54 2.7 2.7 signal
354 Adrenal Insufficiency 22 2.7 2.7 signal
355 Hypoxia 64 2.7 2.7 signal
356 Pneumonia Fungal 7 2.6 2.6 signal
357 Wrong Technique In Drug Usage Process 66 2.6 2.6 signal
358 Immune Thrombocytopenia 8 2.6 2.6 signal
359 Anal Haemorrhage 5 2.6 2.6 no signal
360 Haematuria 61 2.6 2.6 signal
361 Activated Partial Thromboplastin Time Prolonged 9 2.6 2.6 signal
362 Oesophageal Candidiasis 7 2.6 2.6 signal
363 Lung Carcinoma Cell Type Unspecified Stage Iv 6 2.6 2.6 signal
364 Eye Operation 8 2.6 2.6 signal
365 Abdominal Hernia 8 2.5 2.5 signal
366 Red Blood Cell Count Decreased 50 2.5 2.5 signal
367 Adenovirus Infection 5 2.5 2.5 no signal
368 Disease Complication 8 2.5 2.5 signal
369 Hysterectomy 15 2.5 2.5 signal
370 Creatinine Renal Clearance Decreased 7 2.5 2.5 signal
371 Therapy Interrupted 119 2.5 2.5 signal
372 Shock Haemorrhagic 14 2.5 2.5 signal
373 Rales 10 2.5 2.5 signal
374 Haemoglobin Abnormal 11 2.5 2.5 signal
375 Umbilical Hernia 8 2.5 2.5 signal
376 Ileus 21 2.5 2.5 signal
377 Peripheral Arterial Occlusive Disease 7 2.5 2.5 signal
378 Bacteraemia 20 2.5 2.5 signal
379 Blood Calcium Decreased 19 2.4 2.4 signal
380 Conjunctival Hyperaemia 6 2.4 2.4 no signal
381 Shock 38 2.4 2.4 signal
382 Dyschezia 5 2.4 2.4 no signal
383 Lung Adenocarcinoma 5 2.4 2.4 no signal
384 Haemodialysis 14 2.4 2.4 signal
385 Depressed Level Of Consciousness 65 2.4 2.4 signal
386 Atrioventricular Block Second Degree 5 2.4 2.4 no signal
387 Ventricular Arrhythmia 6 2.4 2.4 no signal
388 Melaena 36 2.4 2.4 signal
389 Blood Lactate Dehydrogenase Increased 26 2.4 2.4 signal
390 Dyspnoea Exertional 61 2.4 2.4 signal
391 Surgery 94 2.4 2.4 signal
392 Hepatic Steatosis 30 2.3 2.3 signal
393 Pericardial Effusion 37 2.3 2.3 signal
394 Diverticulum Intestinal 7 2.3 2.3 signal
395 Hepatic Enzyme Abnormal 8 2.3 2.3 signal
396 Cholecystitis Acute 9 2.3 2.3 signal
397 Gastroenteritis 23 2.3 2.3 signal
398 Fluid Retention 80 2.3 2.3 signal
399 Liver Function Test Abnormal 46 2.3 2.3 signal
400 Tongue Oedema 6 2.3 2.3 no signal
401 Subarachnoid Haemorrhage 16 2.3 2.3 signal
402 Haemolytic Anaemia 14 2.3 2.3 signal
403 Haemoptysis 43 2.2 2.2 signal
404 Nephropathy Toxic 17 2.2 2.2 signal
405 Cholecystitis 18 2.2 2.2 signal
406 Product Administered To Patient Of Inappropriate Age 9 2.2 2.2 signal
407 Gastroenteritis Viral 27 2.2 2.2 signal
408 Haemoglobin Decreased 153 2.2 2.2 signal
409 Lower Gastrointestinal Haemorrhage 11 2.2 2.2 signal
410 Respiratory Failure 108 2.1 2.2 signal
411 Hyperbilirubinaemia 15 2.1 2.1 signal
412 Oropharyngeal Discomfort 13 2.1 2.1 signal
413 Cervical Vertebral Fracture 5 2.1 2.1 no signal
414 Pancytopenia 81 2.1 2.1 signal
415 Sepsis 162 2.1 2.1 signal
416 Sleep Disorder 101 2.1 2.1 signal
417 Lipase Increased 11 2.1 2.1 signal
418 Decreased Appetite 334 2.1 2.1 signal
419 Urinary Retention 48 2.1 2.1 signal
420 Acidosis 11 2.1 2.1 signal
421 Gastric Ulcer Haemorrhage 8 2.1 2.1 no signal
422 Pulmonary Oedema 64 2.1 2.1 signal
423 Foot Operation 7 2.1 2.1 no signal
424 Venoocclusive Liver Disease 7 2.1 2.1 no signal
425 Haemorrhoidal Haemorrhage 7 2.1 2.1 no signal
426 Treatment Noncompliance 77 2.1 2.1 signal
427 Blood Urine Present 27 2.1 2.1 signal
428 Staphylococcal Sepsis 7 2.1 2.1 no signal
429 Diverticulitis 39 2.0 2.1 signal
430 Renal Failure 188 2.0 2.1 signal
431 Bundle Branch Block Left 6 2.0 2.0 no signal
432 Atrial Fibrillation 137 2.0 2.1 signal
433 White Blood Cell Count Increased 54 2.0 2.0 signal
434 Aneurysm 7 2.0 2.0 no signal
435 Internal Haemorrhage 16 2.0 2.0 signal
436 Acute Hepatic Failure 19 2.0 2.0 signal
437 Arterial Occlusive Disease 11 2.0 2.0 signal
438 Hepatic Lesion 6 2.0 2.0 no signal
439 Coronary Arterial Stent Insertion 7 2.0 2.0 no signal
440 Oedema Peripheral 169 2.0 2.0 signal
441 Refusal Of Treatment By Patient 9 2.0 2.0 no signal
442 Orthostatic Hypotension 24 2.0 2.0 no signal
443 Anaemia 262 2.0 2.0 no signal
444 Hypertriglyceridaemia 8 2.0 2.0 no signal
445 Cytomegalovirus Viraemia 6 2.0 2.0 no signal
446 Blood Calcium Increased 12 2.0 2.0 no signal
447 Hydronephrosis 10 1.9 1.9 no signal
448 Faeces Discoloured 29 1.9 1.9 no signal
449 Haemodynamic Instability 10 1.9 1.9 no signal
450 Cardiogenic Shock 19 1.9 1.9 no signal
451 Pneumothorax 21 1.9 1.9 no signal
452 Renal Tubular Necrosis 13 1.9 1.9 no signal
453 Cholecystectomy 15 1.9 1.9 no signal
454 Hepatomegaly 13 1.9 1.9 no signal
455 Muscle Rupture 5 1.9 1.9 no signal
456 Hypothyroidism 41 1.9 1.9 no signal
457 Faeces Hard 5 1.9 1.9 no signal
458 Nephropathy 12 1.9 1.9 no signal
459 Duodenal Ulcer 9 1.9 1.9 no signal
460 Delirium 44 1.8 1.9 no signal
461 Cardio-respiratory Arrest 53 1.8 1.8 no signal
462 Feeding Disorder 25 1.8 1.8 no signal
463 Therapy Change 12 1.8 1.8 no signal
464 Abdominal Distension 129 1.8 1.8 no signal
465 Hospitalisation 189 1.8 1.8 no signal
466 Humerus Fracture 6 1.8 1.8 no signal
467 Thrombotic Microangiopathy 12 1.8 1.8 no signal
468 Syncope 124 1.8 1.8 no signal
469 Drug Administered To Patient Of Inappropriate Age 9 1.8 1.8 no signal
470 Atelectasis 12 1.8 1.8 no signal
471 Chronic Kidney Disease 94 1.8 1.8 no signal
472 Bradycardia 65 1.8 1.8 no signal
473 Breath Sounds Abnormal 6 1.8 1.8 no signal
474 Hypotension 243 1.8 1.8 no signal
475 Food Craving 6 1.8 1.8 no signal
476 Stress Cardiomyopathy 7 1.8 1.8 no signal
477 Abdominal Tenderness 6 1.8 1.8 no signal
478 Gastrointestinal Haemorrhage 101 1.7 1.7 no signal
479 Atrioventricular Block Complete 8 1.7 1.7 no signal
480 Chromaturia 27 1.7 1.7 no signal
481 Adverse Event 110 1.7 1.7 no signal
482 Toxic Skin Eruption 12 1.7 1.7 no signal
483 Illness 119 1.7 1.7 no signal
484 Product Prescribing Error 28 1.7 1.7 no signal
485 Death 1,018 1.7 1.8 no signal
486 Dyslipidaemia 6 1.7 1.7 no signal
487 Haematemesis 30 1.7 1.7 no signal
488 Infusion Site Pain 15 1.7 1.7 no signal
489 Hypertransaminasaemia 8 1.7 1.7 no signal
490 Electrocardiogram Qrs Complex Prolonged 6 1.7 1.7 no signal
491 Pneumonia 379 1.7 1.7 no signal
492 Femoral Neck Fracture 6 1.7 1.7 no signal
493 Dysuria 43 1.7 1.7 no signal
494 Left Ventricular Hypertrophy 5 1.7 1.7 no signal
495 Lymphoma 18 1.7 1.7 no signal
496 Pulmonary Haemorrhage 9 1.7 1.7 no signal
497 Jaundice 31 1.7 1.7 no signal
498 Cardiac Arrest 94 1.6 1.7 no signal
499 Product Substitution Issue 65 1.6 1.6 no signal
500 Hip Surgery 6 1.6 1.6 no signal
501 Catheterisation Cardiac 5 1.6 1.6 no signal
502 Haemorrhagic Anaemia 5 1.6 1.6 no signal
503 Clostridium Difficile Infection 24 1.6 1.6 no signal
504 Hypophagia 28 1.6 1.6 no signal
505 Lumbar Vertebral Fracture 5 1.6 1.6 no signal
506 C-reactive Protein Increased 40 1.6 1.6 no signal
507 Arrhythmia 52 1.6 1.6 no signal
508 Oxygen Saturation Decreased 61 1.6 1.6 no signal
509 Peritonitis Bacterial 11 1.6 1.6 no signal
510 Localised Oedema 5 1.6 1.6 no signal
511 Pemphigoid 8 1.6 1.6 no signal
512 Acute Coronary Syndrome 9 1.6 1.6 no signal
513 Middle Insomnia 20 1.6 1.6 no signal
514 Appetite Disorder 7 1.6 1.6 no signal
515 Acute Pulmonary Oedema 6 1.6 1.6 no signal
516 Troponin Increased 8 1.5 1.5 no signal
517 Hypocalcaemia 20 1.5 1.5 no signal
518 Urinary Tract Infection 179 1.5 1.5 no signal
519 Limb Operation 5 1.5 1.5 no signal
520 Metastases To Lymph Nodes 7 1.5 1.5 no signal
521 Blood Magnesium Decreased 9 1.5 1.5 no signal
522 Colitis Ischaemic 7 1.5 1.5 no signal
523 Bronchopulmonary Aspergillosis 8 1.5 1.5 no signal
524 Brain Fog 15 1.5 1.5 no signal
525 Ejection Fraction Decreased 16 1.5 1.5 no signal
526 Multi-organ Failure 18 1.5 1.5 no signal
527 Blood Iron Decreased 12 1.5 1.5 no signal
528 Laboratory Test Abnormal 30 1.5 1.5 no signal
529 Aspiration 11 1.5 1.5 no signal
530 Lymphoedema 7 1.5 1.5 no signal
531 Acute Myocardial Infarction 30 1.5 1.5 no signal
532 Large Intestine Perforation 7 1.5 1.5 no signal
533 International Normalised Ratio Increased 29 1.5 1.5 no signal
534 Nephrolithiasis 46 1.5 1.5 no signal
535 Oesophagitis 11 1.5 1.5 no signal
536 Off Label Use 871 1.5 1.5 no signal
537 Product Dose Omission 66 1.4 1.4 no signal
538 Acute Respiratory Failure 19 1.4 1.4 no signal
539 Hepatitis C 12 1.4 1.4 no signal
540 Haemophagocytic Lymphohistiocytosis 7 1.4 1.4 no signal
541 Dermatitis Contact 11 1.4 1.4 no signal
542 Lung Neoplasm Malignant 40 1.4 1.4 no signal
543 Hyperthyroidism 14 1.4 1.4 no signal
544 Myelodysplastic Syndrome 14 1.4 1.4 no signal
545 Erythema Multiforme 9 1.4 1.4 no signal
546 Cerebral Haemorrhage 34 1.4 1.4 no signal
547 Fracture 18 1.4 1.4 no signal
548 Splenomegaly 11 1.4 1.4 no signal
549 Food Poisoning 5 1.4 1.4 no signal
550 Neutrophil Count Decreased 38 1.4 1.4 no signal
551 Decreased Activity 10 1.4 1.4 no signal
552 Angioedema 41 1.3 1.3 no signal
553 Cardiac Flutter 6 1.3 1.3 no signal
554 Injection Site Induration 12 1.3 1.3 no signal
555 Hiatus Hernia 12 1.3 1.3 no signal
556 Agranulocytosis 17 1.3 1.3 no signal
557 Cardiac Murmur 8 1.3 1.3 no signal
558 Hyperglycaemia 33 1.3 1.3 no signal
559 Haemolysis 7 1.3 1.3 no signal
560 Purpura 8 1.3 1.3 no signal
561 Atrioventricular Block 7 1.3 1.3 no signal
562 Blood Triglycerides Increased 16 1.3 1.3 no signal
563 Proteinuria 17 1.3 1.3 no signal
564 Left Ventricular Dysfunction 6 1.3 1.3 no signal
565 Malnutrition 10 1.3 1.3 no signal
566 Coronavirus Infection 6 1.3 1.3 no signal
567 Brain Injury 9 1.3 1.3 no signal
568 Labelled Drug-drug Interaction Medication Error 8 1.3 1.3 no signal
569 Lip Dry 8 1.3 1.3 no signal
570 Eating Disorder 19 1.3 1.3 no signal
571 Constipation 191 1.3 1.3 no signal
572 Fluid Overload 13 1.3 1.3 no signal
573 Cardiac Valve Disease 5 1.3 1.3 no signal
574 Autoimmune Hepatitis 6 1.3 1.3 no signal
575 Toxic Epidermal Necrolysis 13 1.3 1.3 no signal
576 Blood Test Abnormal 12 1.2 1.2 no signal
577 Cellulitis 43 1.2 1.2 no signal
578 Product Supply Issue 6 1.2 1.2 no signal
579 Arteriosclerosis 8 1.2 1.2 no signal
580 Taste Disorder 17 1.2 1.2 no signal
581 Hemiplegia 7 1.2 1.2 no signal
582 Cardiac Pacemaker Insertion 5 1.2 1.2 no signal
583 Platelet Count Abnormal 5 1.2 1.2 no signal
584 Contraindicated Product Administered 25 1.2 1.2 no signal
585 General Physical Health Deterioration 95 1.2 1.2 no signal
586 Spinal Operation 10 1.2 1.2 no signal
587 Neoplasm Malignant 55 1.2 1.2 no signal
588 Hypoglycaemia 40 1.2 1.2 no signal
589 Drug Prescribing Error 16 1.2 1.2 no signal
590 Haemorrhoids 16 1.2 1.2 no signal
591 Rhabdomyolysis 34 1.2 1.2 no signal
592 Cystitis 26 1.2 1.2 no signal
593 Drug Interaction 129 1.2 1.2 no signal
594 Pyrexia 279 1.2 1.2 no signal
595 Intestinal Perforation 9 1.2 1.2 no signal
596 Respiratory Disorder 24 1.2 1.2 no signal
597 Peripheral Coldness 11 1.2 1.2 no signal
598 Brain Oedema 10 1.1 1.1 no signal
599 Dry Throat 8 1.1 1.1 no signal
600 Cytokine Release Syndrome 15 1.1 1.1 no signal
601 Drug Level Increased 13 1.1 1.1 no signal
602 Myocardial Ischaemia 9 1.1 1.1 no signal
603 Weight Increased 174 1.1 1.1 no signal
604 Gastric Cancer 20 1.1 1.1 no signal
605 Low Density Lipoprotein Increased 6 1.1 1.1 no signal
606 Condition Aggravated 235 1.1 1.1 no signal
607 Upper Gastrointestinal Haemorrhage 13 1.1 1.1 no signal
608 Tenderness 8 1.1 1.1 no signal
609 Torsade De Pointes 6 1.1 1.1 no signal
610 Polyp 5 1.1 1.1 no signal
611 Stevens-johnson Syndrome 17 1.1 1.1 no signal
612 Brain Neoplasm 7 1.1 1.1 no signal
613 Urosepsis 7 1.1 1.1 no signal
614 Mental Status Changes 21 1.1 1.1 no signal
615 Bacterial Infection 14 1.1 1.1 no signal
616 Loss Of Consciousness 96 1.1 1.1 no signal
617 Disease Progression 88 1.1 1.1 no signal
618 Hepatitis 19 1.1 1.1 no signal
619 Metastases To Liver 13 1.1 1.1 no signal
620 Pain In Jaw 21 1.1 1.1 no signal
621 Pulmonary Mass 11 1.1 1.1 no signal
622 Hypercalcaemia 9 1.1 1.1 no signal
623 Gallbladder Disorder 13 1.1 1.1 no signal
624 Haematochezia 40 1.1 1.1 no signal
625 Viral Infection 24 1.0 1.0 no signal
626 Renal Failure Acute 31 1.0 1.0 no signal
627 Muscle Atrophy 9 1.0 1.0 no signal
628 Blood Pressure Systolic Increased 14 1.0 1.0 no signal
629 Musculoskeletal Chest Pain 11 1.0 1.0 no signal
630 White Blood Cell Count Decreased 77 1.0 1.0 no signal
631 Urinary Incontinence 21 1.0 1.0 no signal
632 Bladder Disorder 7 1.0 1.0 no signal
633 Pneumocystis Jirovecii Pneumonia 7 1.0 1.0 no signal
634 Hepatic Cancer 17 1.0 1.0 no signal
635 Neutropenic Sepsis 5 1.0 1.0 no signal
636 Dysphagia 66 1.0 1.0 no signal
637 Metabolic Acidosis 22 1.0 1.0 no signal
638 Encephalopathy 17 1.0 1.0 no signal
639 Diverticulum 5 1.0 1.0 no signal
640 Panic Reaction 5 1.0 1.0 no signal
641 Graft Versus Host Disease 5 1.0 1.0 no signal
642 Platelet Count Increased 9 1.0 1.0 no signal
643 Influenza 77 1.0 1.0 no signal
644 Hypokinesia 10 1.0 1.0 no signal
645 Intentional Underdose 5 1.0 1.0 no signal
646 Gastritis 18 1.0 1.0 no signal
647 Respiratory Arrest 19 1.0 1.0 no signal
648 Groin Pain 6 1.0 1.0 no signal
649 Epistaxis 51 1.0 1.0 no signal
650 Anal Incontinence 6 1.0 1.0 no signal
651 Malaise 295 1.0 1.0 no signal
652 Dizziness 334 1.0 1.0 no signal
653 Product Availability Issue 15 1.0 1.0 no signal
654 Weight Decreased 186 1.0 1.0 no signal
655 Dry Skin 87 1.0 1.0 no signal
656 Incontinence 7 1.0 1.0 no signal
657 Angina Pectoris 19 1.0 1.0 no signal
658 Hepatic Cytolysis 8 1.0 1.0 no signal
659 No Therapeutic Response 8 0.9 0.9 no signal
660 Abdominal Pain 150 0.9 0.9 no signal
661 Injection Site Discolouration 8 0.9 0.9 no signal
662 Infection 93 0.9 0.9 no signal
663 Drug Effect Less Than Expected 9 0.9 0.9 no signal
664 Rib Fracture 13 0.9 0.9 no signal
665 Eosinophilia 11 0.9 0.9 no signal
666 Pancreatitis Acute 14 0.9 0.9 no signal
667 Knee Arthroplasty 13 0.9 0.9 no signal
668 Hernia 12 0.9 0.9 no signal
669 Acute Respiratory Distress Syndrome 11 0.9 0.9 no signal
670 Myocarditis 7 0.9 0.9 no signal
671 Dyspepsia 60 0.9 0.9 no signal
672 Gastrooesophageal Reflux Disease 49 0.9 0.9 no signal
673 Menstrual Disorder 5 0.9 0.9 no signal
674 Seizure 70 0.9 0.9 no signal
675 Cholelithiasis 20 0.9 0.9 no signal
676 Ill-defined Disorder 37 0.9 0.9 no signal
677 Hypertension 129 0.9 0.9 no signal
678 Cardiomyopathy 9 0.9 0.9 no signal
679 Staphylococcal Infection 20 0.9 0.9 no signal
680 Head Injury 19 0.9 0.9 no signal
681 Diarrhoea 387 0.9 0.9 no signal
682 Post Procedural Haemorrhage 7 0.9 0.9 no signal
683 Palpitations 70 0.9 0.9 no signal
684 Neoplasm Progression 21 0.9 0.9 no signal
685 Eyelid Oedema 7 0.9 0.9 no signal
686 Cardiac Disorder 56 0.9 0.9 no signal
687 Glycosylated Haemoglobin Increased 15 0.9 0.9 no signal
688 Dyspnoea 335 0.9 0.9 no signal
689 Blood Glucose Increased 112 0.9 0.9 no signal
690 Tachypnoea 8 0.9 0.9 no signal
691 Intestinal Obstruction 22 0.9 0.9 no signal
692 Economic Problem 9 0.8 0.8 no signal
693 Erectile Dysfunction 15 0.8 0.8 no signal
694 Drug Intolerance 56 0.8 0.8 no signal
695 Blood Pressure Increased 89 0.8 0.8 no signal
696 Femur Fracture 18 0.8 0.8 no signal
697 Disorientation 23 0.8 0.8 no signal
698 Muscle Strain 5 0.8 0.8 no signal
699 Presyncope 14 0.8 0.8 no signal
700 Foot Fracture 11 0.8 0.8 no signal
701 Respiratory Tract Infection 15 0.8 0.8 no signal
702 Vomiting 270 0.8 0.8 no signal
703 Intentional Product Use Issue 50 0.8 0.8 no signal
704 Fall 185 0.8 0.8 no signal
705 Blood Pressure Abnormal 11 0.8 0.8 no signal
706 Nausea 436 0.8 0.8 no signal
707 Impaired Gastric Emptying 7 0.8 0.8 no signal
708 Gastrointestinal Pain 6 0.8 0.8 no signal
709 Incorrect Dose Administered 122 0.8 0.8 no signal
710 Blood Thyroid Stimulating Hormone Increased 5 0.8 0.8 no signal
711 Pericarditis 9 0.8 0.8 no signal
712 Blood Glucose Decreased 26 0.8 0.8 no signal
713 Dementia 15 0.8 0.8 no signal
714 Feeling Cold 15 0.8 0.8 no signal
715 Hypertensive Crisis 6 0.8 0.8 no signal
716 Plasma Cell Myeloma 21 0.8 0.8 no signal
717 Tubulointerstitial Nephritis 10 0.8 0.8 no signal
718 Dysarthria 20 0.8 0.8 no signal
719 Dermatitis 11 0.8 0.8 no signal
720 Rebound Effect 6 0.8 0.8 no signal
721 Hip Arthroplasty 8 0.8 0.8 no signal
722 Fatigue 409 0.8 0.8 no signal
723 Abdominal Pain Upper 108 0.8 0.8 no signal
724 Gastric Ulcer 10 0.8 0.8 no signal
725 Confusional State 85 0.8 0.8 no signal
726 Pharyngeal Swelling 5 0.8 0.8 no signal
727 Lethargy 30 0.8 0.8 no signal
728 Chronic Obstructive Pulmonary Disease 27 0.8 0.8 no signal
729 Choking 10 0.7 0.7 no signal
730 Knee Operation 5 0.7 0.7 no signal
731 Nasopharyngitis 95 0.7 0.7 no signal
732 Poor Quality Sleep 11 0.7 0.7 no signal
733 Depressed Mood 27 0.7 0.7 no signal
734 Myocardial Infarction 89 0.7 0.7 no signal
735 Hypomagnesaemia 7 0.7 0.7 no signal
736 Back Pain 117 0.7 0.7 no signal
737 Myelosuppression 17 0.7 0.7 no signal
738 Ovarian Cyst 5 0.7 0.7 no signal
739 Insomnia 132 0.7 0.7 no signal
740 Hypothermia 5 0.7 0.7 no signal
741 Sluggishness 5 0.7 0.7 no signal
742 Epilepsy 15 0.7 0.7 no signal
743 Asthenia 184 0.7 0.7 no signal
744 Headache 306 0.7 0.7 no signal
745 Folliculitis 5 0.7 0.7 no signal
746 Peritonitis 10 0.7 0.7 no signal
747 Heart Rate Decreased 17 0.7 0.7 no signal
748 Coagulopathy 8 0.7 0.7 no signal
749 Cytomegalovirus Infection 8 0.7 0.7 no signal
750 Incorrect Route Of Product Administration 8 0.7 0.7 no signal
751 Muscle Spasms 87 0.7 0.7 no signal
752 Pruritus 179 0.7 0.7 no signal
753 Lower Limb Fracture 9 0.7 0.7 no signal
754 Malignant Neoplasm Progression 48 0.7 0.7 no signal
755 Clostridium Difficile Colitis 5 0.7 0.7 no signal
756 Covid-19 83 0.7 0.7 no signal
757 Metastases To Central Nervous System 6 0.7 0.7 no signal
758 Prescribed Overdose 9 0.7 0.7 no signal
759 Peripheral Swelling 71 0.7 0.7 no signal
760 Tachycardia 41 0.7 0.7 no signal
761 Haematoma 12 0.7 0.7 no signal
762 Pulmonary Thrombosis 5 0.7 0.7 no signal
763 Blood Pressure Fluctuation 11 0.7 0.7 no signal
764 Cold Sweat 8 0.7 0.7 no signal
765 Diabetes Mellitus Inadequate Control 8 0.7 0.7 no signal
766 Eye Haemorrhage 6 0.7 0.7 no signal
767 Osteomyelitis 8 0.6 0.6 no signal
768 Swelling 41 0.6 0.6 no signal
769 Retinal Detachment 4 0.6 0.6 no signal
770 Increased Tendency To Bruise 4 0.6 0.6 no signal
771 Abdominal Pain Lower 11 0.6 0.6 no signal
772 Gastric Haemorrhage 5 0.6 0.6 no signal
773 Haemorrhage 45 0.6 0.6 no signal
774 Anaphylactic Shock 11 0.6 0.6 no signal
775 Drug Resistance 11 0.6 0.6 no signal
776 Mouth Ulceration 9 0.6 0.6 no signal
777 Seasonal Allergy 6 0.6 0.6 no signal
778 Leukaemia 4 0.6 0.6 no signal
779 Skin Fissures 8 0.6 0.6 no signal
780 Covid-19 Pneumonia 5 0.6 0.6 no signal
781 Polyneuropathy 5 0.6 0.6 no signal
782 Deafness 11 0.6 0.6 no signal
783 Candida Infection 7 0.6 0.6 no signal
784 Pulmonary Fibrosis 8 0.6 0.6 no signal
785 Diabetes Mellitus 32 0.6 0.6 no signal
786 Paralysis 6 0.6 0.6 no signal
787 Hyperlipidaemia 5 0.6 0.6 no signal
788 Impaired Quality Of Life 6 0.6 0.6 no signal
789 Pancreatitis 22 0.6 0.6 no signal
790 Glaucoma 8 0.6 0.6 no signal
791 Restlessness 15 0.6 0.6 no signal
792 Musculoskeletal Discomfort 7 0.6 0.6 no signal
793 Abdominal Discomfort 68 0.6 0.6 no signal
794 Rash Maculo-papular 9 0.6 0.6 no signal
795 Limb Injury 11 0.6 0.6 no signal
796 Product Administration Error 8 0.6 0.6 no signal
797 Upper Limb Fracture 8 0.6 0.6 no signal
798 Loss Of Personal Independence In Daily Activities 19 0.6 0.6 no signal
799 Chest Pain 74 0.6 0.6 no signal
800 Deep Vein Thrombosis 26 0.6 0.6 no signal
801 Muscular Weakness 45 0.6 0.6 no signal
802 Contusion 38 0.6 0.6 no signal
803 Feeling Abnormal 95 0.6 0.6 no signal
804 Cough 110 0.6 0.6 no signal
805 Bone Marrow Failure 8 0.6 0.6 no signal
806 Cerebrovascular Accident 66 0.6 0.6 no signal
807 Road Traffic Accident 16 0.6 0.6 no signal
808 Herpes Zoster 22 0.6 0.6 no signal
809 Drug Effect Incomplete 14 0.6 0.6 no signal
810 Sciatica 6 0.5 0.5 no signal
811 Coma 18 0.5 0.5 no signal
812 Sars-cov-2 Test Positive 5 0.5 0.5 no signal
813 Gastrointestinal Disorder 33 0.5 0.5 no signal
814 Impaired Work Ability 8 0.5 0.5 no signal
815 Thrombosis 30 0.5 0.5 no signal
816 Cataract 22 0.5 0.5 no signal
817 Mental Disorder 16 0.5 0.5 no signal
818 Lymphadenopathy 13 0.5 0.5 no signal
819 Metastases To Bone 6 0.5 0.5 no signal
820 Cholestasis 7 0.5 0.5 no signal
821 Blood Glucose Fluctuation 4 0.5 0.5 no signal
822 Drug Dose Omission 61 0.5 0.5 no signal
823 Bronchitis 27 0.5 0.5 no signal
824 Vertigo 22 0.5 0.5 no signal
825 Coronary Artery Disease 11 0.5 0.5 no signal
826 Thrombocytopenia 40 0.5 0.5 no signal
827 Aphonia 5 0.5 0.5 no signal
828 Somnolence 72 0.5 0.5 no signal
829 Therapeutic Product Effect Incomplete 25 0.5 0.5 no signal
830 Impaired Driving Ability 4 0.5 0.5 no signal
831 Skin Ulcer 9 0.5 0.5 no signal
832 Febrile Neutropenia 23 0.5 0.5 no signal
833 Lung Disorder 17 0.5 0.5 no signal
834 Pancreatic Carcinoma 10 0.5 0.5 no signal
835 Heart Rate Increased 34 0.5 0.5 no signal
836 Rash Generalised 9 0.5 0.5 no signal
837 Immunodeficiency 5 0.5 0.5 no signal
838 Productive Cough 16 0.5 0.5 no signal
839 Neuroleptic Malignant Syndrome 4 0.5 0.5 no signal
840 Fungal Infection 11 0.5 0.5 no signal
841 Rhinorrhoea 21 0.5 0.5 no signal
842 Adverse Drug Reaction 29 0.5 0.5 no signal
843 Blood Cholesterol Increased 15 0.5 0.5 no signal
844 Drug Administration Error 10 0.5 0.5 no signal
845 Acute Myeloid Leukaemia 5 0.5 0.5 no signal
846 Cyanosis 5 0.5 0.5 no signal
847 Migraine 30 0.5 0.5 no signal
848 Sleep Apnoea Syndrome 6 0.5 0.5 no signal
849 Post Procedural Complication 6 0.5 0.5 no signal
850 Inflammation 16 0.5 0.5 no signal
851 Convulsion 18 0.5 0.4 no signal
852 Parkinsonism 3 0.4 0.4 no signal
853 Electrocardiogram Qt Prolonged 11 0.4 0.4 no signal
854 Sinusitis 31 0.4 0.4 no signal
855 Product Physical Issue 6 0.4 0.4 no signal
856 Therapeutic Response Decreased 18 0.4 0.4 no signal
857 Abortion Spontaneous 12 0.4 0.4 no signal
858 Stomatitis 18 0.4 0.4 no signal
859 Pain Of Skin 8 0.4 0.4 no signal
860 Pneumonitis 8 0.4 0.4 no signal
861 Maternal Exposure During Pregnancy 26 0.4 0.4 no signal
862 Chest Discomfort 30 0.4 0.4 no signal
863 Pulmonary Embolism 28 0.4 0.4 no signal
864 Depression 67 0.4 0.4 no signal
865 Coronary Artery Occlusion 4 0.4 0.4 no signal
866 Device Occlusion 4 0.4 0.4 no signal
867 Wheezing 17 0.4 0.4 no signal
868 Musculoskeletal Pain 15 0.4 0.4 no signal
869 Head Discomfort 5 0.4 0.4 no signal
870 Skin Discolouration 13 0.4 0.4 no signal
871 Upper Respiratory Tract Infection 13 0.4 0.4 no signal
872 Dysgeusia 21 0.4 0.4 no signal
873 Joint Injury 6 0.4 0.4 no signal
874 Hot Flush 21 0.4 0.4 no signal
875 Accidental Overdose 10 0.4 0.4 no signal
876 Skin Disorder 9 0.4 0.4 no signal
877 Drug Ineffective For Unapproved Indication 15 0.4 0.4 no signal
878 Dry Eye 13 0.4 0.4 no signal
879 Speech Disorder 14 0.4 0.4 no signal
880 Osteoporosis 11 0.4 0.4 no signal
881 Increased Appetite 5 0.4 0.4 no signal
882 Balance Disorder 23 0.4 0.4 no signal
883 Transient Ischaemic Attack 9 0.4 0.4 no signal
884 Flatulence 15 0.4 0.4 no signal
885 Lower Respiratory Tract Infection 12 0.4 0.4 no signal
886 Heart Rate Irregular 6 0.4 0.4 no signal
887 Discomfort 16 0.4 0.4 no signal
888 Menstruation Irregular 7 0.4 0.4 no signal
889 Oropharyngeal Pain 24 0.4 0.4 no signal
890 Rash Macular 9 0.4 0.4 no signal
891 Eczema 13 0.4 0.4 no signal
892 Rash 112 0.4 0.4 no signal
893 Oral Herpes 5 0.4 0.4 no signal
894 Nasal Congestion 15 0.4 0.4 no signal
895 Hypoacusis 11 0.4 0.4 no signal
896 Gynaecomastia 8 0.4 0.4 no signal
897 Nervous System Disorder 8 0.4 0.4 no signal
898 Medication Error 14 0.4 0.4 no signal
899 Extra Dose Administered 10 0.4 0.4 no signal
900 Full Blood Count Decreased 5 0.4 0.4 no signal
901 Mental Impairment 6 0.4 0.4 no signal
902 Schizophrenia 3 0.4 0.4 no signal
903 Injection Site Warmth 5 0.4 0.4 no signal
904 Leukopenia 12 0.3 0.3 no signal
905 Hallucination 18 0.3 0.3 no signal
906 Memory Impairment 33 0.3 0.3 no signal
907 Tinnitus 11 0.3 0.3 no signal
908 Visual Acuity Reduced 8 0.3 0.3 no signal
909 Circumstance Or Information Capable Of Leading To Medication Error 8 0.3 0.3 no signal
910 Cardiovascular Disorder 6 0.3 0.3 no signal
911 Irritable Bowel Syndrome 5 0.3 0.3 no signal
912 Tuberculosis 3 0.3 0.3 no signal
913 Unresponsive To Stimuli 6 0.3 0.3 no signal
914 Joint Swelling 28 0.3 0.3 no signal
915 Genital Haemorrhage 3 0.3 0.3 no signal
916 Aphasia 7 0.3 0.3 no signal
917 Swelling Face 15 0.3 0.3 no signal
918 Disease Recurrence 11 0.3 0.3 no signal
919 Dysmenorrhoea 3 0.3 0.3 no signal
920 Skin Exfoliation 19 0.3 0.3 no signal
921 Tremor 38 0.3 0.3 no signal
922 Feeling Hot 14 0.3 0.3 no signal
923 Intervertebral Disc Protrusion 5 0.3 0.3 no signal
924 Hypoaesthesia 34 0.3 0.3 no signal
925 Limb Discomfort 7 0.3 0.3 no signal
926 Swollen Tongue 7 0.3 0.3 no signal
927 Pain In Extremity 66 0.3 0.3 no signal
928 Frequent Bowel Movements 6 0.3 0.3 no signal
929 Dysphonia 13 0.3 0.3 no signal
930 Rash Pruritic 12 0.3 0.3 no signal
931 Lactic Acidosis 7 0.3 0.3 no signal
932 Myalgia 37 0.3 0.3 no signal
933 Night Sweats 7 0.3 0.3 no signal
934 Abnormal Dreams 6 0.3 0.3 no signal
935 Wound 6 0.3 0.3 no signal
936 Chills 25 0.3 0.3 no signal
937 Overdose 46 0.3 0.3 no signal
938 Lip Swelling 7 0.3 0.3 no signal
939 Hypersomnia 6 0.3 0.3 no signal
940 Stress 15 0.3 0.3 no signal
941 Type 2 Diabetes Mellitus 7 0.3 0.3 no signal
942 Intentional Product Misuse 18 0.3 0.3 no signal
943 Neutropenia 28 0.3 0.3 no signal
944 Neuralgia 5 0.3 0.3 no signal
945 Dysstasia 6 0.3 0.3 no signal
946 Erythema 42 0.3 0.3 no signal
947 Gait Disturbance 39 0.3 0.3 no signal
948 Therapeutic Product Effect Decreased 9 0.3 0.3 no signal
949 Throat Irritation 9 0.3 0.3 no signal
950 Unevaluable Event 15 0.3 0.3 no signal
951 Dyskinesia 8 0.3 0.3 no signal
952 Emotional Disorder 6 0.3 0.3 no signal
953 Diplopia 5 0.3 0.3 no signal
954 Mucosal Inflammation 5 0.3 0.3 no signal
955 Agitation 14 0.3 0.3 no signal
956 Drug Ineffective 249 0.3 0.3 no signal
957 Ear Infection 5 0.3 0.3 no signal
958 Asthma 21 0.3 0.3 no signal
959 Hip Fracture 6 0.3 0.3 no signal
960 Arthralgia 77 0.3 0.3 no signal
961 Rectal Haemorrhage 8 0.3 0.3 no signal
962 Amnesia 12 0.3 0.3 no signal
963 Neck Pain 10 0.3 0.3 no signal
964 Hyperhidrosis 23 0.3 0.3 no signal
965 Hypersensitivity 32 0.3 0.2 no signal
966 Pain 106 0.2 0.2 no signal
967 Rash Erythematous 8 0.2 0.2 no signal
968 Infusion Related Reaction 11 0.2 0.2 no signal
969 Oesophageal Carcinoma 5 0.2 0.2 no signal
970 Incorrect Route Of Drug Administration 6 0.2 0.2 no signal
971 Arthritis 13 0.2 0.2 no signal
972 Therapeutic Response Unexpected 7 0.2 0.2 no signal
973 Movement Disorder 5 0.2 0.2 no signal
974 Gait Inability 5 0.2 0.2 no signal
975 Expired Product Administered 5 0.2 0.2 no signal
976 Cognitive Disorder 7 0.2 0.2 no signal
977 Intentional Self-injury 3 0.2 0.2 no signal
978 Suicide Attempt 9 0.2 0.2 no signal
979 Alopecia 29 0.2 0.2 no signal
980 Anxiety 42 0.2 0.2 no signal
981 Injection Site Swelling 11 0.2 0.2 no signal
982 Eye Pain 8 0.2 0.2 no signal
983 Mobility Decreased 10 0.2 0.2 no signal
984 Breast Cancer 13 0.2 0.2 no signal
985 Urticaria 23 0.2 0.2 no signal
986 Therapy Non-responder 6 0.2 0.2 no signal
987 Influenza Like Illness 11 0.2 0.2 no signal
988 Colitis 5 0.2 0.2 no signal
989 Vision Blurred 18 0.2 0.2 no signal
990 Injection Site Erythema 16 0.2 0.2 no signal
991 Injury 9 0.2 0.2 no signal
992 Paraesthesia 20 0.2 0.2 no signal
993 Arthropathy 7 0.2 0.2 no signal
994 Drug Hypersensitivity 24 0.2 0.2 no signal
995 Visual Impairment 15 0.2 0.2 no signal
996 Osteoarthritis 5 0.2 0.2 no signal
997 Neuropathy Peripheral 11 0.2 0.2 no signal
998 Prostate Cancer 9 0.2 0.2 no signal
999 Renal Cancer 5 0.2 0.2 no signal
1000 Burning Sensation 7 0.1 0.1 no signal
1001 Suicidal Ideation 9 0.1 0.1 no signal
1002 Exposure During Pregnancy 6 0.1 0.1 no signal
1003 Disturbance In Attention 5 0.1 0.1 no signal
1004 Anaphylactic Reaction 5 0.1 0.1 no signal
1005 Irritability 5 0.1 0.1 no signal
1006 Injection Site Pain 25 0.1 0.1 no signal
1007 Acne 6 0.1 0.1 no signal
1008 Toxicity To Various Agents 13 0.1 0.1 no signal
1009 Injection Site Haemorrhage 6 0.1 0.1 no signal
1010 Injection Site Pruritus 5 0.1 0.1 no signal
1011 Treatment Failure 6 0.1 0.1 no signal
1012 Completed Suicide 6 0.1 0.1 no signal
1013 Flushing 7 0.1 0.1 no signal
1014 Musculoskeletal Stiffness 5 0.1 0.1 no signal
1015 Rheumatoid Arthritis 6 0.1 0.1 no signal