Reaction

Cardiac Failure Chronic reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,200 reports · 177 co-occurring drugs

As of the last recalculation, Cardiac Failure Chronic appears in 4,200 FAERS reports alongside 177 co-occurring drug terms. The strongest observed disproportionality signal is EPLERENONE (PRR 112.5).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Eplerenone	272	112.5	114.9
Tolvaptan	158	55.9	56.6
Tafamidis	118	51.1	51.6
Torsemide	199	31.2	31.4
Febuxostat Tablets 40 Mg	63	31.2	31.3
Febuxostat Tablets 80 Mg	63	31.2	31.3
Sacubitril And Valsartan	606	30.1	30.2
Dapagliflozin	162	26.5	26.6
Spironolactone	585	23.8	23.9
Amiodarone Hydrochloride	48	21.5	21.6
Bisoprolol Fumarate	514	21.2	21.3
Febuxostat	66	19.8	19.9
Furosemide	996	15.8	15.9
Bumetanide	71	13.5	13.6
Carvedilol	338	13.4	13.4
Isosorbide Mononitrate	55	13.3	13.3
Valsartan Oral	141	13.3	13.3
Nebivolol	40	12.6	12.6
Digoxin	165	11.8	11.8
Metolazone	26	11.5	11.6
Telmisartan	40	11.2	11.2
Ramipril	258	10.9	11.0
Empagliflozin	139	10.5	10.6
Pitavastatin Calcium	21	10.2	10.2
Isosorbide Dinitrate	37	9.5	9.5
Enalapril	103	9.4	9.4
Apixaban	121	9.2	9.2
Lubiprostone	17	8.9	9.0
Valsartan	176	8.6	8.6
Ranolazine	18	8.6	8.6
Rabeprazole	37	8.3	8.4
Candesartan	58	8.2	8.2
Norepinephrine Bitartrate	23	8.0	8.0
Warfarin	190	7.7	7.7
Clopidogrel Bisulfate	154	7.7	7.7
Epoprostenol	20	7.6	7.6
Bicalutamide	22	7.2	7.2
Sildenafil Powder,	50	7.0	7.0
Norepinephrine	15	7.0	7.0
Selexipag	35	6.8	6.8
Methoxy Polyethylene Glycol-Epoetin Beta	15	6.8	6.8
Nebivolol Hydrochloride	44	6.5	6.5
Riociguat	42	6.4	6.4
Prasugrel Hydrochloride	13	6.4	6.4
Allopurinol	189	6.2	6.2
Rosuvastatin	243	6.2	6.2
Magnesium Oxide	51	6.1	6.1
Rosuvastatin Calcium	34	6.0	6.0
Trastuzumab	82	6.0	6.0
Human Insulin	15	6.0	6.0
Agalsidase Beta	11	5.9	5.9
Tamsulosin Hydrochloride	24	5.9	5.9
Sildenafil	67	5.8	5.8
Warfarin Sodium	51	5.5	5.5
Dutasteride	9	5.5	5.5
Esomeprazole Magnesium Capsule, Delayed Release	16	5.5	5.5
Esomeprazole Magnesium Delayed Release Capsules	16	5.5	5.5
Esomeprazole Magnesium Dihydrate	16	5.5	5.5
Metoroprolol Tartrate	69	5.3	5.3
Atorvastatin Calcium, Film Coated	73	5.2	5.2
Enalapril Maleate	26	5.2	5.2
Linagliptin	19	5.2	5.2
Potassium Chloride, Dextrose Monohydrate	95	5.2	5.2
Potassium Chloride Oral	95	5.2	5.2
Potassium Chloride Extended-Release	95	5.2	5.2
Bosentan	52	5.2	5.2
Metoprolol	252	5.2	5.2
Clopidogrel	198	5.1	5.2
Metoprolol Tartrate Injection	189	5.1	5.1
Macitentan	70	5.1	5.1
Potassium Chloride	114	5.1	5.1
Human Immunoglobulin G	21	5.1	5.1
Epoetin Alfa	12	5.0	5.0
Ticagrelor	32	5.0	5.0
Rivaroxaban	202	5.0	5.0
Suvorexant	13	5.0	5.0
Metoprolol Tartrate	259	4.9	4.9
Ursosiol	19	4.9	4.9
Rabeprazole Sodium	26	4.7	4.8
Indapamide	17	4.7	4.7
Icosapent Ethyl	8	4.7	4.7
Metoprolol Succinate Er Tablets	57	4.6	4.6
Ursodiol	20	4.6	4.6
Dabigatran Etexilate	69	4.5	4.5
Doxorubicin	79	4.5	4.5
Sildenafil Citrate	112	4.5	4.5
Pantoprazole Sodium In 0.9% Sodium Chloride	55	4.4	4.4
Pantoprazole Sodium Injection	55	4.4	4.4
Metoprolol Succinate	74	4.3	4.3
Nitroglycerin	46	4.3	4.3
Carfilzomib	24	4.2	4.2
Ipratropium Bromide	30	4.2	4.2
Candesartan Cilexetil	22	4.2	4.2
Dextrose	11	4.1	4.2
Doxorubicin Hydrochloride	27	4.1	4.1
Erlotinib	8	4.1	4.1
Dextrose Monohydrate	11	4.1	4.1
Ezetimibe	61	4.1	4.1
Irbesartan	36	4.0	4.0
Brinzolamide	7	4.0	4.0
Heparin Sodium	11	4.0	4.0
Nifedipine	37	3.9	3.9
Insulin Glargine-Yfgn	17	3.9	3.9
Bleomycin Sulfate	8	3.8	3.8
Aspirin 325 Mg	366	3.8	3.8
Aspirin 81 Mg	366	3.8	3.8
Doxazosin	21	3.7	3.7
Aspirin	377	3.7	3.7
Sitagliptin	53	3.7	3.7
Romosozumab-Aqqg	10	3.7	3.7
Docetaxel Anhydrous	49	3.6	3.6
Docetaxel	49	3.6	3.6
Amlodipine Besylate And Valsartan	8	3.6	3.6
Dabigatran Etexilate Mesylate	52	3.6	3.6
Erlotinib Hydrochloride	9	3.6	3.6
Finasteride	43	3.6	3.6
Insulin Glulisine	7	3.4	3.4
Doxazosin Mesylate	24	3.3	3.3
Dofetilide	7	3.3	3.3
Metformin Er 500 Mg	194	3.3	3.3
Metformin Er 750 Mg	194	3.3	3.3
Sotalol Hydrochloride	11	3.3	3.3
Memantine	9	3.3	3.3
Memantine Hydrochloride	9	3.3	3.3
Metformin	219	3.2	3.2
Donepezil Hydrochloride	23	3.1	3.1
Zoledronic Acid	25	3.1	3.1
Budesonide And Formoterol Fumarate Dihydrate	60	3.1	3.1
Vincristine Sulfate	18	3.1	3.1
Nilotinib	18	3.0	3.0
Sitagliptin And Metformin Hydrochloride	13	3.0	3.0
Chlorthalidone	7	3.0	3.0
Insulin Degludec	14	3.0	3.0
Cyclophosphamide Injection, Solution	104	3.0	3.0
Cyclophosphamide	104	3.0	3.0
Cyclophosphamide For Injection	104	3.0	3.0
Glimepiride	23	2.9	2.9
Dronedarone	6	2.9	2.9
Patiromer	8	2.9	2.9
Deferasirox	15	2.8	2.8
Darbepoetin Alfa	30	2.8	2.8
Insulin Human	21	2.6	2.6
Tiotropium Bromide	71	2.6	2.6
Bendamustine Hcl	8	2.6	2.6
Pioglitazone	22	2.5	2.5
Timolol	6	2.5	2.5
Levodopa	6	2.5	2.5
Azacitidine	14	2.3	2.3
Ambrisentan	58	2.3	2.3
Ifosfamide	10	2.3	2.3
Treprostinil	58	2.3	2.3
Tadalafil	46	2.3	2.3
Tiotropium Bromide Inhalation Spray	5	2.2	2.2
Bosutinib	4	2.2	2.2
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	13	2.1	2.1
Acalabrutinib	5	2.0	2.0
Enzalutamide	24	2.0	2.0
Azacitidine For	7	1.9	1.9
Olaparib	8	1.9	1.9
Osimertinib	12	1.9	1.9
Pemetrexed	8	1.9	1.9
Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride And Dextrose	3	1.8	1.8
Sevoflurane	3	1.8	1.8
Daratumumab	14	1.7	1.7
Eltrombopag Olamine	8	1.7	1.7
Bendamustine Hydrochloride	4	1.7	1.7
Gefitinib	3	1.6	1.6
Remdesivir	4	1.5	1.5
Fam-Trastuzumab Deruxtecan-Nxki	3	1.5	1.5
Durvalumab	6	1.5	1.5
Leuprolide Acetate	22	1.4	1.4
Ledipasvir And Sofosbuvir	5	1.3	1.3
Benralizumab	5	1.2	1.2
Ranibizumab	6	1.1	1.1
Aflibercept	7	1.1	1.1
Droxidopa	4	0.9	0.9
Pomalidomide	15	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.