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Hypernatraemia reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,899 reports · 323 co-occurring drugs

As of the last recalculation, Hypernatraemia appears in 4,899 FAERS reports alongside 323 co-occurring drug terms. The strongest observed disproportionality signal is TOLVAPTAN (PRR 114.9).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Tolvaptan	364	114.9	117.8
Lithium	180	31.5	31.7
Lithium Bromatum	180	31.5	31.7
Lithium Carbonate	97	24.7	24.9
Valproic Acid	148	20.5	20.6
Sevoflurane	38	19.6	19.7
Dextrose Monohydrate	58	18.6	18.7
Dextrose	56	18.3	18.3
Valproate Sodium	81	16.9	17.0
Piperacillin Sodium And Tazobactam Sodium	76	16.7	16.8
Memantine	49	15.4	15.4
Memantine Hydrochloride	49	15.4	15.4
Piperacillin And Tazobactam	45	15.1	15.1
Sodium Bicarbonate	80	14.8	14.9
Sodium Bicarbonate Injection,	80	14.8	14.9
Magnesium Sulfate In Water For	42	14.1	14.1
Magnesium Sulfate Heptahydrate	42	13.8	13.8
Magnesium Sulfate	42	13.8	13.8
Piperacillin Sodium,Tazobactam Sodium	80	13.0	13.0
Sodium Chloride	224	12.6	12.6
Midazolam	73	12.5	12.5
Calcium Gluconate	35	12.4	12.5
Sodium Chloride Tablets	203	12.2	12.2
Sodium Chloride Tablet	202	12.1	12.2
Midazolam Hydrochloride	75	12.0	12.0
Meropenem	85	11.4	11.5
Norepinephrine Bitartrate	38	11.3	11.3
Micafungin Sodium	22	11.1	11.1
Norepinephrine	27	10.8	10.8
Phytonadione	21	10.6	10.6
Lactulose	91	10.3	10.3
Haloperidol	58	10.3	10.3
Haloperidol Lactate	58	10.1	10.1
Propofol	85	10.0	10.1
Dapagliflozin	71	9.7	9.7
Vancomycin Hydrochloride	139	9.2	9.2
Lacosamide	79	9.2	9.2
Phenobarbital	31	9.1	9.2
Mesna	18	9.1	9.1
Vancomycin	121	9.1	9.1
Cefepime Hydrochloride	34	9.0	9.0
Dexamethasone Sodium Phosphate	21	8.8	8.8
Gentamicin	27	8.8	8.8
Mesna Injection	17	8.8	8.8
Cefepime	29	8.6	8.7
Thiamine Hydrochloride	25	8.6	8.6
Aripiprazole Oral	79	8.2	8.2
Aripiprazole Orally Disintegrating	79	8.2	8.2
Ampicillin	16	8.2	8.2
Ampicillin Sodium	16	8.2	8.2
Hydrocortisone 1%	126	8.2	8.2
Hydrocortisone Cream	126	8.1	8.1
Anti-Itch	125	8.1	8.1
Anti-Pruritic	125	8.1	8.1
Antipruritic (Anti-Itch)	125	8.1	8.1
Cool Relief Gel With Aloe	125	8.1	8.1
Drs. Hydrocortisone	125	8.1	8.1
Hydrocortisone Continuous Spray	125	8.1	8.1
Hydrocortisone Spray	125	8.1	8.1
Anti-Itch Cream	125	8.1	8.1
Hydrocortisone Lotion	125	8.1	8.1
Hydrocortisone Cream 1%	125	8.1	8.1
Hydrocortisone Cream 1/2%	125	8.1	8.1
Donepezil Hydrochloride	69	8.1	8.1
Divalproex Sodium	87	8.1	8.1
Ceftriaxone Sodium	71	8.0	8.0
Rocuronium Bromide	22	8.0	8.0
Gentamicin Sulfate	29	7.8	7.9
Hydrocortisone Acetate	128	7.7	7.7
Brivaracetam	16	7.6	7.6
Olanzapine	182	7.4	7.4
Phenytoin	34	7.0	7.0
Zonisamide	24	6.9	6.9
Heparin Sodium	22	6.8	6.8
Bumetanide	42	6.8	6.8
Hydrocortisone Sodium Succinate	15	6.8	6.8
Furosemide	575	6.8	6.8
Sennosides 8.6 Mg Tablets	33	6.7	6.7
Remdesivir	21	6.7	6.7
Senna	33	6.7	6.7
Senna Leaf	36	6.7	6.7
Ceftriaxone	51	6.7	6.7
Amantadine	24	6.6	6.6
Dolutegravir Sodium	14	6.6	6.6
Rivastigmine	29	6.6	6.6
Levetiracetam In Sodium Chloride	117	6.5	6.6
Levetiracetam Oral	117	6.5	6.6
Levetiracetam Injection	117	6.5	6.6
Acetylcysteine	14	6.3	6.3
Sennosides	44	6.3	6.3
Hydrocortisone	129	6.3	6.3
Potassium Chloride, Dextrose Monohydrate	132	6.2	6.2
Potassium Chloride Oral	132	6.2	6.2
Potassium Chloride Extended-Release	132	6.2	6.2
Granisetron Hydrochloride	15	6.1	6.1
Indapamide	25	6.0	6.0
Bisacodyl Suppositories	18	5.9	5.9
Biscodyl	18	5.9	5.9
Aprepitant	25	5.8	5.8
Voriconazole Injection	29	5.7	5.7
Empagliflozin	88	5.6	5.6
Olanzapine Pamoate	53	5.6	5.6
Lamotirigine	92	5.5	5.5
Lamotrigine Extended-Release	92	5.5	5.5
Lamotrigine Chewable Dispersible	92	5.5	5.5
Polyethylene Glycol	14	5.5	5.5
Levetiracetam	168	5.5	5.5
Bisacodyl	18	5.4	5.5
Febuxostat Tablets 40 Mg	13	5.4	5.4
Febuxostat Tablets 80 Mg	13	5.4	5.4
Miconazole Nitrate	11	5.4	5.4
Potassium Chloride	139	5.3	5.3
Pegaspargase	15	5.2	5.2
Voriconazole	37	5.2	5.2
Cytarabine	72	5.2	5.2
Exemestane	25	5.0	5.0
Acetaminophen And Codeine	14	4.9	4.9
Valganciclovir Hydrochloride Powder,	14	4.9	4.9
Lorazepam	200	4.9	4.9
Insulin	63	4.8	4.9
Cortisone Acetate	14	4.8	4.8
Oseltamivir	9	4.8	4.8
Mirtazapine	101	4.8	4.8
Amphotericin B	14	4.8	4.8
Magnesium Oxide	46	4.7	4.7
Temozolomide	23	4.7	4.7
Lamotrigine	141	4.7	4.7
Escitslopram	63	4.6	4.7
Metronidazole	69	4.6	4.6
Linezolid	32	4.6	4.6
Ganciclovir	11	4.6	4.6
Amiodarone Hydrochloride	12	4.6	4.6
Ursodiol	23	4.5	4.5
Labetalol	14	4.5	4.5
Granisetron	11	4.5	4.5
Ganciclovir Sodium	11	4.4	4.4
Ifosfamide	22	4.4	4.4
Ferrous Sulfate	51	4.3	4.4
Risperidone	131	4.3	4.3
Etoposide	73	4.3	4.3
Spironolactone	138	4.3	4.3
Alteplase	15	4.3	4.3
Tobramycin Solution	12	4.3	4.3
Nystatin Ointment	26	4.2	4.2
Nystatin Cream	26	4.2	4.2
Metronidazole Topical	47	4.2	4.2
Doxepin	10	4.2	4.2
Chlorhexidine Gluconate	9	4.2	4.2
Enoxaparin Sodium	56	4.2	4.2
Fluconazole	68	4.2	4.2
Oxazepam	21	4.2	4.2
Tobramycin Sulfate	12	4.1	4.1
Instalax Polyethylene Glycol 3350	12	4.1	4.1
Diazepam Oral Solution (Concentrate)	85	4.1	4.1
Diazepam Oral	85	4.1	4.1
Esomeprazole Magnesium Capsule, Delayed Release	14	4.1	4.1
Esomeprazole Magnesium Delayed Release Capsules	14	4.1	4.1
Paroxetine Hydrochloride Hemihydrate	32	4.1	4.1
Esomeprazole Magnesium Dihydrate	14	4.1	4.1
Trazodone Hydrochloride	15	4.1	4.1
Venlafaxine	68	4.1	4.1
Escitalopram Oxalate	69	4.1	4.1
Nystatin	26	4.1	4.1
Polyethylene Glycol 400	12	4.0	4.0
Paroxetine	32	4.0	4.0
Clobazam	23	4.0	4.0
Esomeprazole	58	4.0	4.0
Aripiprazole	113	4.0	4.0
Ursosiol	18	3.9	3.9
Posaconazole	15	3.9	3.9
Brinzolamide	8	3.9	3.9
Carbamazepine	61	3.9	3.9
Posaconazole Delayed-Release	10	3.9	3.9
Quetiapine	171	3.9	3.9
Filgrastim	34	3.9	3.9
Melatonin	49	3.9	3.9
Anakinra	15	3.9	3.9
Metformin Hydrochloride	53	3.8	3.8
Cetuximab	28	3.8	3.8
Metformin Hydrochloride Tablets	51	3.8	3.8
Metformin Hydrochloride Extended-Release Tablets	51	3.8	3.8
Metformin Hydrochloride Tablet	51	3.8	3.8
Magnesium Hydroxide	12	3.8	3.8
Leucovorin Calcium	17	3.8	3.8
Enalapril Maleate	22	3.8	3.8
Diazepam	106	3.8	3.8
Quetiapine Fumarate	26	3.8	3.8
Methocarbamol	20	3.8	3.8
Pitavastatin Calcium	9	3.7	3.7
Nebivolol	14	3.7	3.7
Levothyroxine Sodium Anhydrous	87	3.7	3.7
Felodipine Extended-Release Tablets	10	3.7	3.7
Felodipine	10	3.7	3.7
Bisoprolol Fumarate	114	3.6	3.6
Torsemide	28	3.6	3.6
Sucralfate Oral	12	3.6	3.6
Sucralfate Oral Suspension	12	3.6	3.6
Melphalan Hydrochloride	21	3.6	3.6
Docusate Sodium 100Mg	20	3.6	3.6
Extended Phenytoin Sodium	14	3.6	3.6
Melphalan	19	3.6	3.6
Axicabtagene Ciloleucel	8	3.4	3.5
Valganciclovir	15	3.4	3.4
Valganciclovir Hydrochloride	15	3.4	3.4
Ondansetron	86	3.4	3.4
Ondansetron Tablets	86	3.4	3.4
Fluorouracil Cream, 0.5%	60	3.4	3.4
Doxepin Hydrochloride	10	3.4	3.4
Cisplatin	61	3.3	3.3
Insulin Glulisine	8	3.3	3.3
Digoxin	56	3.3	3.3
Sertraline	91	3.3	3.3
Clozapine	97	3.3	3.3
Fluorouracil	60	3.3	3.3
Allopurinol	120	3.3	3.3
Methocarbamol Tablets	13	3.3	3.3
Febuxostat	13	3.3	3.3
Sulfamethoxazole And Trimethoprim	64	3.3	3.3
Fenofibrate	27	3.2	3.2
Dronabinol	6	3.2	3.2
Mupirocin	10	3.2	3.2
Warfarin Sodium	34	3.1	3.1
Ondansetron Hydrochloride	89	3.1	3.1
Thiotepa	7	3.1	3.1
Insulin Human	29	3.1	3.1
Erythropoietin	15	3.1	3.1
Fentanyl Citrate	13	3.1	3.1
Mupirocin Calcium	10	3.1	3.1
Venlafaxine Hydrochloride	95	3.1	3.1
Clonidine	37	3.1	3.1
Enalapril	40	3.1	3.1
Bicalutamide	11	3.1	3.1
Hydrochlorothiazide	103	3.1	3.1
Isosorbide Dinitrate	14	3.1	3.1
Fentanyl	70	3.0	3.1
Topiramate	66	3.0	3.0
Bendamustine Hcl	11	3.0	3.0
Tobramycin	17	3.0	3.0
Encorafenib	7	3.0	3.0
Amikacin	12	3.0	3.0
Asenapine Maleate	6	2.9	2.9
Primidone	7	2.9	2.9
Levofloxacin	41	2.9	2.9
Levofloxacin In 5% Dextrose	41	2.9	2.9
Oxcarbazepine	22	2.9	2.9
Terazosin Hydrochloride	6	2.9	2.9
Amlodipine Besylate	97	2.8	2.8
Olmesartan Medoxomil	24	2.8	2.8
Duloxetine	46	2.8	2.8
Trametinib	16	2.8	2.8
Hydroxyurea	14	2.8	2.8
Levodopa	8	2.8	2.8
Fosaprepitant Dimeglumine	9	2.8	2.8
Insulin Aspart	43	2.8	2.8
Doxazosin	18	2.7	2.7
Insulin Glargine-Yfgn	14	2.7	2.7
Human Insulin	8	2.7	2.7
Metoclopramide Hydrochloride	49	2.7	2.7
Canagliflozin	19	2.7	2.7
Amlodipine Besylate And Valsartan	7	2.7	2.7
Ziprasidone	11	2.7	2.7
Vigabatrin	9	2.6	2.6
Sitagliptin	44	2.6	2.6
Pravastatin Sodium	12	2.6	2.6
Warfarin	76	2.6	2.6
Dexamethasone 1.5 Mg	172	2.5	2.5
Everolimus Tablets	10	2.5	2.5
Dexamethasone	172	2.5	2.5
Brentuximab Vedotin	6	2.5	2.5
Doxorubicin	51	2.4	2.4
Azacitidine	17	2.4	2.4
Busulfan	9	2.4	2.4
Acyclovir	63	2.4	2.4
Pertuzumab	15	2.3	2.3
Doxorubicin Hydrochloride	18	2.3	2.3
Linagliptin	10	2.3	2.3
Trastuzumab	37	2.3	2.3
Cariprazine	5	2.3	2.3
Glimepiride	20	2.2	2.2
Entecavir	6	2.2	2.2
Panitumumab	8	2.2	2.2
Carbidopa And Levodopa	24	2.2	2.2
Oseltamivir Phosphate	12	2.1	2.1
Amphetamine	4	2.1	2.1
Iohexol	4	2.1	2.1
Vincristine Sulfate	14	2.0	2.0
Carboplatin	60	2.0	2.0
Vortioxetine	8	2.0	2.0
Tenofovir Disoproxil Fumarate Tablets	4	2.0	2.0
Capecitabine	42	2.0	2.0
Oxaliplatin	34	2.0	2.0
Ixazomib	13	1.9	1.9
Rasagiline Mesylate	5	1.9	1.9
Azacitidine For	8	1.9	1.9
Daptomycin	4	1.8	1.8
Ipilimumab	18	1.8	1.8
Paclitaxel	41	1.8	1.8
Paclitaxel (Aibumin-Bound)	34	1.8	1.8
Erlotinib	4	1.8	1.8
Polatuzumab Vedotin	4	1.7	1.7
Erlotinib Hydrochloride	5	1.7	1.7
Pemetrexed Disodium	15	1.7	1.7
Bortezomib	35	1.7	1.7
Palivizumab	6	1.7	1.7
Irinotecan Hydrochloride	5	1.7	1.7
Suvorexant	5	1.6	1.6
Cannabidiol	9	1.6	1.6
Bimatoprost	11	1.6	1.6
Somatropin	28	1.6	1.6
Abiraterone	5	1.6	1.6
Gemcitabine Hydrochloride	19	1.5	1.5
Lumacaftor And Ivacaftor	3	1.5	1.5
Paliperidone	8	1.5	1.5
Nivolumab	33	1.5	1.5
Bendamustine Hydrochloride	4	1.4	1.4
Eltrombopag Olamine	7	1.3	1.3
Romosozumab-Aqqg	4	1.3	1.3
Ethyl Alcohol	8	1.3	1.3
Abiraterone Acetate	12	1.2	1.2
Sacubitril And Valsartan	33	1.2	1.2
Methoxy Polyethylene Glycol-Epoetin Beta	3	1.2	1.2
Cinacalcet Hydrochloride	8	0.7	0.7
Droxidopa	3	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.