Reaction

Device Maintenance Issue reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 557 reports · 36 co-occurring drugs

As of the last recalculation, Device Maintenance Issue appears in 557 FAERS reports alongside 36 co-occurring drug terms. The strongest observed disproportionality signal is TREPROSTINIL (PRR 718.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Treprostinil	453	718.1	720.7
Ketoprofen	94	321.9	324.2
Amitriptyline Hydrochloride	80	198.8	199.7
0Xygen	157	165.5	166.0
Oxygen	157	165.5	166.0
Macitentan	161	121.8	122.1
Sildenafil Powder,	89	111.0	111.3
Sildenafil	122	100.5	100.7
Clonidine	93	81.2	81.4
Riociguat	62	79.8	80.0
Lidocaine Hydrochloride	102	77.2	77.3
Sodium Chloride Tablet	119	76.6	76.7
Sodium Chloride Tablets	119	76.6	76.7
Sodium Chloride	120	72.1	72.2
Amikacin	31	71.9	72.0
Tadalafil	142	70.8	70.9
Bumetanide	34	51.2	51.2
Cetirizine Hcl	12	49.9	50.0
Sildenafil Citrate	128	48.5	48.5
Hydroxyzine Hydrochloride	14	40.8	40.8
Hydroxyzine Hydrochloride Oral	14	40.8	40.8
Metolazone	12	40.8	40.8
Potassium Chloride, Dextrose Monohydrate	84	39.7	39.8
Potassium Chloride Oral	84	39.7	39.8
Potassium Chloride Extended-Release	84	39.7	39.7
Selexipag	26	39.4	39.4
Ambrisentan	103	37.6	37.6
Potassium Chloride	93	36.4	36.4
Budesonide, Glycopyrrolate, And Formoterol Fumarate	9	32.7	32.7
Torsemide	27	32.0	32.0
Spironolactone	97	31.0	31.0
Methocarbamol Tablets	13	29.7	29.7
Cyclobenzaprine Hydrochloride	7	29.5	29.5
Amiodarone Hydrochloride	8	27.1	27.1
Prochlorperazine Maleate	6	24.6	24.6
Acetaminophen And Codeine	6	18.6	18.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.