Reaction

International Normalised Ratio Fluctuation reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,069 reports · 43 co-occurring drugs

As of the last recalculation, International Normalised Ratio Fluctuation appears in 2,069 FAERS reports alongside 43 co-occurring drug terms. The strongest observed disproportionality signal is MEPERIDINE HYDROCHLORIDE (PRR 185.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Meperidine Hydrochloride	157	185.4	188.6
Warfarin Sodium	351	91.5	92.2
Erythromycin	148	85.4	86.1
Misoprostol	73	78.1	78.7
Warfarin	595	65.7	66.0
Metronidazole Topical	146	33.1	33.2
Diclofenac Potassium, Film Coated	24	29.0	29.1
Diclofenac Potassium Tablets	24	29.0	29.1
Metronidazole	163	27.8	27.9
Levofloxacin	132	23.5	23.5
Levofloxacin In 5% Dextrose	132	23.5	23.5
Diclofenac Potassium	24	22.6	22.6
Sulfasalazine	156	21.6	21.7
Hydroxychloroquine Sulfate	146	17.3	17.3
Leflunomide	163	16.9	16.9
Bisoprolol Fumarate	186	15.0	15.1
Digoxin	101	14.8	14.9
Celecoxib	178	14.8	14.8
Phytonadione	11	13.1	13.1
Diclofenac Sodium 1%	43	12.3	12.4
Diclofenac Sodium Topical	43	12.3	12.4
Diclofenac Sodium Topical Gel, 1%	43	12.3	12.3
Adalimumab-Fkjp	52	11.6	11.6
Cortisone Acetate	14	11.5	11.5
Adalimumab-Aaty	52	11.3	11.3
Adalimumab-Adaz	57	11.1	11.2
Dofetilide	11	10.6	10.6
Insulin Glargine-Yfgn	18	8.3	8.4
Enoxaparin Sodium	45	8.0	8.0
Desoximetasone	15	8.0	8.0
Erlotinib	7	7.3	7.3
Niacin	8	7.0	7.0
Insulin Glulisine	7	6.9	6.9
Sotalol Hydrochloride	11	6.7	6.7
Pregabalin	167	6.6	6.6
Dronedarone	6	5.9	5.9
Erlotinib Hydrochloride	7	5.6	5.6
Efavirenz	6	5.4	5.4
Sarilumab	12	4.6	4.6
Isopropyl Alcohol	14	4.2	4.2
Alcohol	14	3.6	3.6
Enzalutamide	15	2.6	2.6
Pirfenidone	7	1.7	1.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.