Drug

Leflunomide

1,269 flagged reaction(s) · 1,095,210 total co-reports · max PRR 1,365.5

Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.

	Reaction	Co-reports (a)	PRR	ROR	Signal
1	Anti-cyclic Citrullinated Peptide Antibody Positive	6,127	1,365.5	1,450.9	signal
2	Rheumatoid Factor Negative	151	1,245.1	1,246.9	signal
3	Red Blood Cell Sedimentation Rate	219	734.6	736.1	signal
4	Rheumatoid Factor Positive	4,432	694.5	725.3	signal
5	Pemphigus	9,382	642.9	706.5	signal
6	Swollen Joint Count Increased	2,321	606.0	619.8	signal
7	Rheumatic Fever	3,226	587.9	606.7	signal
8	Duodenal Ulcer Perforation	5,149	485.9	511.2	signal
9	C-reactive Protein	620	444.6	447.2	signal
10	Deep Vein Thrombosis Postoperative	1,325	429.2	434.7	signal
11	Lupus Vulgaris	781	392.3	395.2	signal
12	Anti-cyclic Citrullinated Peptide Antibody	431	374.1	375.7	signal
13	Swollen Joint Count	158	367.9	368.4	signal
14	Hand Deformity	8,389	367.0	399.1	signal
15	Facet Joint Syndrome	2,008	360.0	367.0	signal
16	Grip Strength	146	348.1	348.6	signal
17	Hepatic Enzyme	85	317.4	317.7	signal
18	C-reactive Protein Abnormal	3,855	309.0	320.9	signal
19	Granuloma Skin	496	304.8	306.3	signal
20	Musculoskeletal Deformity	136	277.5	277.8	signal
21	Synovitis	10,363	275.3	305.7	signal
22	Red Blood Cell Sedimentation Rate Abnormal	1,321	267.9	271.3	signal
23	X-ray Abnormal	945	228.9	231.0	signal
24	Adjustment Disorder With Depressed Mood	1,042	217.5	219.7	signal
25	Muscle Injury	4,227	215.9	225.0	signal
26	Helicobacter Infection	5,181	210.1	221.0	signal
27	Dislocation Of Vertebra	1,106	200.8	203.0	signal
28	Hypocholesterolaemia	152	197.9	198.2	signal
29	Sleep Disorder Due To General Medical Condition, Insomnia Type	3,116	190.4	196.2	signal
30	Folliculitis	4,922	184.7	193.9	signal
31	Bone Erosion	1,595	166.0	168.5	signal
32	Retinitis	683	140.1	141.0	signal
33	Joint Laxity	123	138.3	138.5	signal
34	Rheumatoid Nodule	1,120	136.1	137.5	signal
35	Contraindicated Product Administered	11,938	132.5	149.6	signal
36	Subcutaneous Drug Absorption Impaired	213	129.7	130.0	signal
37	Glossodynia	8,702	128.9	140.6	signal
38	Blood Parathyroid Hormone Decreased	576	127.2	127.9	signal
39	Peripheral Venous Disease	1,527	125.1	127.0	signal
40	Pericarditis	6,347	124.4	132.4	signal
41	Blood Iron Abnormal	357	115.4	115.8	signal
42	Drug Tolerance Decreased	998	111.8	112.9	signal
43	Ankle Arthroplasty	119	100.2	100.3	signal
44	Seronegative Arthritis	363	96.4	96.8	signal
45	Rheumatoid Lung	306	93.9	94.2	signal
46	Central Nervous System Lupus	67	90.2	90.3	signal
47	Loose Body In Joint	81	88.1	88.1	signal
48	Intestinal Sepsis	75	84.8	84.9	signal
49	Systemic Lupus Erythematosus	9,992	79.4	87.7	signal
50	Joint Destruction	418	73.5	73.8	signal
51	Breast Cancer Stage Iii	1,688	71.6	72.8	signal
52	Wound	7,252	71.1	76.3	signal
53	Anticipatory Anxiety	69	69.0	69.0	signal
54	Panniculitis	615	69.0	69.4	signal
55	Enthesopathy	397	67.7	68.0	signal
56	Tenosynovitis	694	67.5	67.9	signal
57	Grip Strength Decreased	2,182	66.9	68.3	signal
58	Porphyria Acute	328	62.7	62.9	signal
59	Wrist Deformity	146	62.0	62.1	signal
60	Presbyacusis	73	61.7	61.8	signal
61	Red Blood Cell Sedimentation Rate Increased	2,525	59.3	60.8	signal
62	Red Cell Distribution Width Decreased	105	59.0	59.1	signal
63	Ankle Deformity	73	59.0	59.0	signal
64	Deafness Transitory	194	58.9	59.0	signal
65	Joint Range Of Motion Decreased	3,000	58.3	60.0	signal
66	Rheumatoid Arthritis	25,338	58.1	76.5	signal
67	Irritable Bowel Syndrome	4,732	57.3	59.9	signal
68	Finger Deformity	1,062	56.4	57.0	signal
69	Lip Dry	1,962	56.4	57.5	signal
70	Joint Space Narrowing	65	56.2	56.2	signal
71	Onychomadesis	900	55.6	56.1	signal
72	Neck Deformity	95	53.9	53.9	signal
73	Bursitis	2,461	51.6	52.8	signal
74	Synovial Disorder	91	50.2	50.2	signal
75	Arthropathy	11,100	50.0	55.8	signal
76	Onychomycosis	846	48.2	48.5	signal
77	Hypercholesterolaemia	1,769	45.6	46.4	signal
78	Therapeutic Product Effect Decreased	8,134	45.1	48.9	signal
79	Soft Tissue Swelling	102	44.7	44.7	signal
80	Wound Infection	1,945	43.8	44.6	signal
81	Live Birth	1,465	42.9	43.5	signal
82	Overlap Syndrome	121	42.8	42.8	signal
83	Fibromyalgia	4,252	42.7	44.5	signal
84	Arthrodesis	175	41.8	41.8	signal
85	Dactylitis	165	40.6	40.7	signal
86	Drug Intolerance	15,935	39.9	46.9	signal
87	Blepharospasm	1,010	39.1	39.5	signal
88	Impaired Healing	5,310	38.8	40.8	signal
89	Joint Ankylosis	91	37.9	37.9	signal
90	Psoriatic Arthropathy	6,161	36.4	38.6	signal
91	Limb Deformity	244	36.3	36.4	signal
92	C-reactive Protein Decreased	96	34.7	34.8	signal
93	Bone Cyst	137	34.3	34.3	signal
94	Nail Disorder	1,254	33.9	34.3	signal
95	Foot Deformity	1,583	33.4	33.9	signal
96	Systemic Lupus Erythematosus Rash	114	33.3	33.3	signal
97	Autoimmune Disorder	1,347	32.9	33.3	signal
98	Hypermobility Syndrome	69	32.5	32.5	signal
99	Liver Injury	3,355	32.4	33.4	signal
100	Blood Pressure Systolic Abnormal	342	32.0	32.1	signal
101	Mean Platelet Volume Decreased	112	31.3	31.3	signal
102	Joint Swelling	15,925	30.6	36.0	signal
103	Vascular Access Complication	106	30.3	30.3	signal
104	Infusion Site Reaction	380	30.2	30.3	signal
105	Tenosynovitis Stenosans	72	29.7	29.7	signal
106	Intervertebral Disc Space Narrowing	102	29.2	29.2	signal
107	Blood Pressure Diastolic Abnormal	324	29.0	29.1	signal
108	Lower Respiratory Tract Infection	5,703	28.9	30.5	signal
109	C-reactive Protein Increased	4,553	28.8	30.0	signal
110	Hepatic Enzyme Increased	8,379	28.3	30.6	signal
111	Pulmonary Fibrosis	2,350	28.2	28.8	signal
112	Sciatica	1,936	27.9	28.4	signal
113	Treatment Failure	9,855	27.4	30.2	signal
114	Infusion Related Reaction	7,842	27.1	29.2	signal
115	Allergy To Chemicals	147	26.9	26.9	signal
116	Alanine Aminotransferase Abnormal	247	26.8	26.9	signal
117	Joint Arthroplasty	208	26.3	26.4	signal
118	Death Neonatal	158	26.0	26.1	signal
119	Pleural Thickening	78	25.9	26.0	signal
120	Exostosis	1,044	25.9	26.2	signal
121	Type 2 Diabetes Mellitus	3,848	25.8	26.8	signal
122	Swelling	10,563	25.6	28.4	signal
123	Bone Swelling	109	25.3	25.3	signal
124	Hip Arthroplasty	1,696	25.3	25.7	signal
125	Product Label Confusion	629	24.3	24.5	signal
126	Obesity	1,722	24.3	24.7	signal
127	Skin Necrosis	557	24.1	24.2	signal
128	Osteoarthritis	4,458	23.6	24.6	signal
129	Maternal Exposure Timing Unspecified	381	22.9	23.0	signal
130	Pustular Psoriasis	351	22.8	22.8	signal
131	Polyarthritis	533	22.7	22.8	signal
132	Back Injury	1,094	22.6	22.8	signal
133	Soft Tissue Disorder	113	22.6	22.6	signal
134	Knee Arthroplasty	2,102	22.5	23.0	signal
135	Pruritus Allergic	117	22.4	22.4	signal
136	Pleural Fibrosis	103	22.3	22.3	signal
137	Bloody Discharge	115	22.3	22.3	signal
138	Tuberculin Test Positive	254	22.1	22.1	signal
139	Discomfort	5,964	21.9	23.2	signal
140	Blister	5,349	21.2	22.3	signal
141	Apparent Death	347	21.1	21.1	signal
142	Mean Cell Volume Decreased	145	20.8	20.8	signal
143	Blood Cholesterol Increased	4,272	20.2	21.1	signal
144	Synovial Cyst	421	20.0	20.1	signal
145	Vasculitic Rash	70	19.9	19.9	signal
146	Stomatitis	5,470	19.9	20.9	signal
147	Musculoskeletal Stiffness	7,902	19.9	21.4	signal
148	Rheumatoid Factor Increased	99	19.5	19.5	signal
149	Shoulder Arthroplasty	234	19.4	19.5	signal
150	Lupus-like Syndrome	791	19.3	19.4	signal
151	Drug Tolerance	436	18.9	18.9	signal
152	Liver Function Test Increased	1,830	18.8	19.2	signal
153	Blood Magnesium Increased	77	18.7	18.7	signal
154	Joint Effusion	589	18.7	18.8	signal
155	Gait Inability	2,811	18.6	19.1	signal
156	Butterfly Rash	85	18.6	18.6	signal
157	Coeliac Disease	821	18.3	18.5	signal
158	Lower Limb Fracture	1,579	18.1	18.4	signal
159	Mean Cell Haemoglobin Decreased	151	18.0	18.0	signal
160	Inflammation	4,175	17.8	18.5	signal
161	Retinal Toxicity	81	17.3	17.4	signal
162	Night Sweats	2,552	17.3	17.7	signal
163	Mobility Decreased	5,616	17.1	18.0	signal
164	Walking Aid User	515	16.9	17.0	signal
165	International Normalised Ratio Fluctuation	163	16.9	16.9	signal
166	Osteosclerosis	121	16.7	16.7	signal
167	Prescribed Overdose	1,480	16.6	16.8	signal
168	Surgical Failure	88	16.5	16.5	signal
169	Loss Of Personal Independence In Daily Activities	3,526	16.1	16.6	signal
170	Maternal Exposure During Pregnancy	6,420	15.8	16.7	signal
171	Abdominal Discomfort	12,046	15.6	17.5	signal
172	Ill-defined Disorder	4,374	15.6	16.2	signal
173	Investigation Abnormal	100	15.5	15.5	signal
174	Joint Noise	137	15.3	15.3	signal
175	Joint Dislocation	738	15.1	15.2	signal
176	Foot Operation	344	15.1	15.1	signal
177	Breast Cancer Stage Ii	577	14.8	14.9	signal
178	Laryngitis	743	14.7	14.8	signal
179	Joint Stiffness	1,741	14.3	14.5	signal
180	Fine Motor Skill Dysfunction	191	14.2	14.3	signal
181	Bronchitis Chronic	162	14.2	14.2	signal
182	Gastrointestinal Disorder	5,775	14.0	14.8	signal
183	Congenital Anomaly	507	14.0	14.0	signal
184	Musculoskeletal Pain	3,422	13.9	14.3	signal
185	Deformity	599	13.7	13.8	signal
186	Ulcer Haemorrhage	430	13.6	13.7	signal
187	Mycobacterium Tuberculosis Complex Test Positive	149	13.5	13.5	signal
188	Chondropathy	170	13.3	13.3	signal
189	Peripheral Swelling	9,464	13.2	14.4	signal
190	Polyomavirus-associated Nephropathy	143	13.2	13.2	signal
191	Hepatic Fibrosis	210	13.1	13.2	signal
192	Nodule	801	13.1	13.2	signal
193	Prescribed Underdose	1,223	13.1	13.3	signal
194	Adverse Reaction	810	13.0	13.1	signal
195	Arthritis Bacterial	249	13.0	13.1	signal
196	Alopecia	11,999	13.0	14.6	signal
197	Juvenile Idiopathic Arthritis	148	12.9	12.9	signal
198	Pulmonary Toxicity	422	12.8	12.9	signal
199	Crepitations	180	12.8	12.8	signal
200	Ear Pain	1,157	12.7	12.8	signal
201	Eye Injury	179	12.7	12.7	signal
202	Pneumonia Viral	189	12.7	12.7	signal
203	Rheumatic Disorder	115	12.6	12.6	signal
204	Spondylitis	210	12.3	12.3	signal
205	Spinal Column Injury	129	12.3	12.3	signal
206	Labile Blood Pressure	68	12.2	12.2	signal
207	Osteoporotic Fracture	110	12.2	12.2	signal
208	Spinal Stenosis	233	12.1	12.2	signal
209	Drug Eruption	996	12.0	12.1	signal
210	Sensitivity To Weather Change	295	12.0	12.0	signal
211	Sinusitis	5,776	12.0	12.6	signal
212	Demyelination	231	11.9	11.9	signal
213	Therapeutic Product Effect Incomplete	3,921	11.8	12.2	signal
214	Rash Vesicular	267	11.8	11.8	signal
215	Hepatic Cirrhosis	1,022	11.6	11.7	signal
216	Muscle Spasticity	675	11.6	11.6	signal
217	Oral Mucosal Exfoliation	81	11.3	11.3	signal
218	Lung Disorder	2,606	11.3	11.5	signal
219	Disability	1,033	11.1	11.2	signal
220	Hepatic Enzyme Abnormal	255	10.8	10.9	signal
221	Drug Hypersensitivity	9,872	10.7	11.8	signal
222	Hepatitis	1,297	10.7	10.8	signal
223	Infection	7,299	10.7	11.4	signal
224	Hypersensitivity	9,372	10.7	11.6	signal
225	Prerenal Failure	70	10.6	10.6	signal
226	Thyroid Neoplasm	140	10.6	10.6	signal
227	Skin Ulcer	1,283	10.5	10.6	signal
228	Sleep Disorder	3,473	10.5	10.8	signal
229	General Physical Health Deterioration	5,650	10.4	10.9	signal
230	Liver Disorder	2,173	10.4	10.6	signal
231	Inflammatory Marker Increased	239	10.3	10.3	signal
232	Hypercalcaemia	601	10.3	10.3	signal
233	Wheezing	2,882	10.3	10.5	signal
234	Basal Cell Carcinoma	751	10.1	10.2	signal
235	Intentional Product Use Issue	4,217	10.1	10.5	signal
236	Spinal Fusion Surgery	189	9.9	9.9	signal
237	Arthritis	3,705	9.9	10.2	signal
238	Injury	3,314	9.9	10.2	signal
239	Arthritis Infective	217	9.9	9.9	signal
240	Osteoporosis	1,899	9.7	9.9	signal
241	Musculoskeletal Disorder	880	9.7	9.7	signal
242	Granuloma	159	9.7	9.7	signal
243	Therapy Non-responder	2,044	9.6	9.8	signal
244	Dermatitis Psoriasiform	93	9.6	9.6	signal
245	Taste Disorder	912	9.6	9.6	signal
246	Smear Cervix Abnormal	65	9.5	9.6	signal
247	Drug-induced Liver Injury	1,393	9.5	9.6	signal
248	Sarcoidosis	214	9.5	9.5	signal
249	Antinuclear Antibody Positive	147	9.5	9.5	signal
250	Knee Deformity	66	9.3	9.3	signal
251	Normal Newborn	241	9.3	9.3	signal
252	Ulcer	702	9.2	9.3	signal
253	Hepatotoxicity	962	9.1	9.2	signal
254	Blood Pressure Systolic Increased	846	9.1	9.1	signal
255	Incorrect Route Of Product Administration	723	9.0	9.1	signal
256	Exposure During Pregnancy	2,666	9.0	9.2	signal
257	Pulmonary Mass	636	9.0	9.0	signal
258	Latent Tuberculosis	89	8.9	8.9	signal
259	Neoplasm Skin	66	8.9	8.9	signal
260	Joint Lock	120	8.8	8.8	signal
261	Arthralgia	17,392	8.8	10.4	signal
262	Body Temperature Increased	858	8.8	8.8	signal
263	Oedema	2,246	8.7	8.9	signal
264	Lupus Nephritis	76	8.7	8.7	signal
265	Skin Papilloma	166	8.6	8.7	signal
266	Ear Infection	1,082	8.5	8.6	signal
267	Ankylosing Spondylitis	531	8.5	8.6	signal
268	Colitis Microscopic	191	8.5	8.5	signal
269	Road Traffic Accident	1,700	8.5	8.6	signal
270	Contusion	3,902	8.5	8.8	signal
271	Respiratory Disorder	1,197	8.3	8.4	signal
272	Osteolysis	81	8.3	8.3	signal
273	Physical Disability	175	8.2	8.2	signal
274	Immobile	169	8.1	8.1	signal
275	Pregnancy	784	8.1	8.1	signal
276	Viral Upper Respiratory Tract Infection	184	8.0	8.0	signal
277	Bone Density Abnormal	145	8.0	8.0	signal
278	Cartilage Injury	95	8.0	8.0	signal
279	White Blood Cell Count Abnormal	243	8.0	8.0	signal
280	Sacroiliitis	72	7.9	7.9	signal
281	Pharyngitis	472	7.9	7.9	signal
282	Neck Mass	106	7.8	7.8	signal
283	Monocyte Count Increased	134	7.7	7.7	signal
284	Nasopharyngitis	6,761	7.6	8.1	signal
285	Bronchiectasis	243	7.6	7.6	signal
286	Tenderness	378	7.5	7.6	signal
287	Diverticulitis	999	7.5	7.6	signal
288	Immunodeficiency	532	7.5	7.6	signal
289	Functional Gastrointestinal Disorder	125	7.5	7.5	signal
290	Epilepsy	1,097	7.5	7.6	signal
291	Intervertebral Disc Degeneration	334	7.5	7.5	signal
292	Cutaneous Lupus Erythematosus	70	7.4	7.4	signal
293	Lyme Disease	118	7.4	7.4	signal
294	Condition Aggravated	10,659	7.3	8.1	signal
295	Blood Pressure Diastolic Increased	162	7.3	7.3	signal
296	Wheelchair User	156	7.3	7.3	signal
297	Myositis	312	7.2	7.2	signal
298	Tongue Disorder	253	7.2	7.2	signal
299	Neck Pain	1,939	7.2	7.3	signal
300	Mouth Ulceration	725	7.2	7.2	signal
301	Product Use Issue	6,429	7.1	7.6	signal
302	Dry Mouth	2,758	7.1	7.2	signal
303	Blood Pressure Fluctuation	817	7.0	7.1	signal
304	Pain	20,469	6.9	8.4	signal
305	Tuberculosis	426	6.9	6.9	signal
306	Loss Of Employment	100	6.8	6.8	signal
307	Delirium	1,124	6.7	6.8	signal
308	Therapeutic Response Decreased	1,940	6.7	6.8	signal
309	Food Intolerance	117	6.6	6.6	signal
310	Joint Injury	684	6.6	6.7	signal
311	Epigastric Discomfort	125	6.6	6.6	signal
312	Localised Infection	769	6.6	6.6	signal
313	Red Cell Distribution Width Increased	132	6.6	6.6	signal
314	Rash	13,723	6.6	7.4	signal
315	Postoperative Wound Infection	212	6.5	6.5	signal
316	Blood Pressure Diastolic Decreased	233	6.5	6.5	signal
317	Impaired Work Ability	665	6.4	6.5	signal
318	Hypertension	6,519	6.4	6.7	signal
319	Breath Sounds Abnormal	151	6.3	6.3	signal
320	Gastrointestinal Pain	335	6.3	6.3	signal
321	Deafness Neurosensory	100	6.3	6.3	signal
322	Body Temperature Decreased	300	6.3	6.3	signal
323	General Symptom	227	6.2	6.2	signal
324	Osteomyelitis	543	6.2	6.2	signal
325	Tendonitis	462	6.1	6.2	signal
326	Confusional State	4,797	6.1	6.4	signal
327	Hypoaesthesia	4,425	6.1	6.3	signal
328	Gastrointestinal Toxicity	138	6.1	6.1	signal
329	Cutaneous Vasculitis	104	6.0	6.0	signal
330	Hepatic Steatosis	540	6.0	6.0	signal
331	Urticaria	4,805	6.0	6.2	signal
332	Fear Of Injection	201	5.9	6.0	signal
333	Carpal Tunnel Syndrome	403	5.9	5.9	signal
334	Drug Ineffective	37,382	5.9	8.6	signal
335	Intervertebral Disc Protrusion	618	5.8	5.8	signal
336	Tendon Disorder	184	5.8	5.8	signal
337	Dyspepsia	2,749	5.8	5.9	signal
338	Weight Increased	6,240	5.8	6.1	signal
339	Interstitial Lung Disease	1,346	5.7	5.8	signal
340	Back Disorder	444	5.6	5.6	signal
341	Acne Cystic	82	5.6	5.6	signal
342	Tooth Infection	355	5.5	5.6	signal
343	Rotator Cuff Syndrome	344	5.5	5.5	signal
344	Limb Operation	127	5.5	5.5	signal
345	Bk Virus Infection	89	5.5	5.5	signal
346	Peptic Ulcer	88	5.5	5.5	signal
347	Pain In Extremity	7,696	5.4	5.7	signal
348	Injection Site Hypersensitivity	79	5.3	5.3	signal
349	Spinal Disorder	243	5.3	5.3	signal
350	Endodontic Procedure	65	5.3	5.3	signal
351	Drug Effect Incomplete	938	5.2	5.3	signal
352	Liver Function Test Abnormal	740	5.2	5.2	signal
353	Alanine Aminotransferase Increased	1,552	5.2	5.3	signal
354	Pulmonary Thrombosis	275	5.2	5.2	signal
355	Spinal Osteoarthritis	222	5.2	5.2	signal
356	Terminal State	166	5.1	5.1	signal
357	Adverse Drug Reaction	2,205	5.1	5.2	signal
358	Dermatitis Allergic	307	5.1	5.1	signal
359	Migraine	2,333	5.1	5.2	signal
360	Adverse Event	2,251	5.0	5.1	signal
361	Scoliosis	151	5.0	5.0	signal
362	Trigger Finger	97	4.9	4.9	signal
363	Adrenal Insufficiency	286	4.9	4.9	signal
364	Aspartate Aminotransferase Increased	1,263	4.9	4.9	signal
365	Vasculitis	276	4.9	4.9	signal
366	Bone Disorder	434	4.9	4.9	signal
367	Herpes Zoster	1,357	4.8	4.9	signal
368	Rash Pruritic	1,271	4.8	4.9	signal
369	Cushingoid	76	4.8	4.8	signal
370	Cyst	291	4.8	4.8	signal
371	Dyslipidaemia	119	4.8	4.8	signal
372	Skin Reaction	326	4.8	4.8	signal
373	Gait Disturbance	4,422	4.7	4.9	signal
374	Secretion Discharge	283	4.7	4.7	signal
375	Upper Respiratory Tract Infection	1,055	4.7	4.7	signal
376	Injection Site Reaction	1,568	4.7	4.7	signal
377	Abdominal Pain Upper	4,680	4.7	4.8	signal
378	Iron Deficiency	101	4.7	4.7	signal
379	Post Procedural Infection	184	4.7	4.7	signal
380	Limb Discomfort	701	4.6	4.7	signal
381	Cytomegalovirus Viraemia	99	4.6	4.6	signal
382	Femur Fracture	702	4.6	4.7	signal
383	Intervertebral Disc Disorder	97	4.6	4.6	signal
384	Spinal Column Stenosis	108	4.6	4.6	signal
385	Foot Fracture	427	4.6	4.6	signal
386	Bone Lesion	80	4.5	4.5	signal
387	Abscess Limb	94	4.5	4.5	signal
388	Plantar Fasciitis	74	4.5	4.5	signal
389	Drug Use Disorder	182	4.5	4.5	signal
390	Lung Neoplasm	94	4.5	4.5	signal
391	Musculoskeletal Discomfort	372	4.4	4.4	signal
392	Hyperkeratosis	119	4.4	4.4	signal
393	Gastric Disorder	740	4.4	4.4	signal
394	Poor Venous Access	219	4.3	4.4	signal
395	Gastrooesophageal Reflux Disease	1,699	4.3	4.4	signal
396	Leukopenia	1,050	4.3	4.3	signal
397	Encephalitis	145	4.3	4.3	signal
398	Hypertransaminasaemia	143	4.3	4.3	signal
399	Pleurisy	125	4.3	4.3	signal
400	Haemoglobin Increased	94	4.3	4.3	signal
401	Osteopenia	316	4.2	4.3	signal
402	Meniscus Injury	127	4.2	4.2	signal
403	Protein Urine Present	102	4.2	4.2	signal
404	Uveitis	276	4.2	4.2	signal
405	Multiple Allergies	160	4.2	4.2	signal
406	Muscular Weakness	2,315	4.2	4.2	signal
407	Nerve Compression	187	4.2	4.2	signal
408	Fatigue	15,756	4.2	4.7	signal
409	Aphthous Ulcer	155	4.1	4.1	signal
410	Amnesia	1,318	4.1	4.2	signal
411	Chronic Sinusitis	74	4.0	4.0	signal
412	Tooth Abscess	201	4.0	4.0	signal
413	Pneumonia	6,322	4.0	4.2	signal
414	Skin Laceration	211	4.0	4.0	signal
415	Thyroid Disorder	299	4.0	4.0	signal
416	Tooth Disorder	433	4.0	4.0	signal
417	Platelet Count Increased	253	4.0	4.0	signal
418	Anaphylactic Reaction	1,057	3.9	4.0	signal
419	Tooth Fracture	212	3.9	3.9	signal
420	Photosensitivity Reaction	316	3.9	3.9	signal
421	Purulent Discharge	82	3.9	3.9	signal
422	Bronchitis	1,421	3.9	3.9	signal
423	Escherichia Urinary Tract Infection	81	3.9	3.9	signal
424	Haemorrhagic Diathesis	68	3.9	3.9	signal
425	Weight Fluctuation	197	3.9	3.9	signal
426	Immunosuppression	163	3.8	3.8	signal
427	Pulmonary Tuberculosis	79	3.8	3.8	signal
428	Skin Infection	206	3.8	3.8	signal
429	Oral Disorder	135	3.8	3.8	signal
430	Skin Warm	106	3.7	3.7	signal
431	Pneumocystis Jirovecii Pneumonia	182	3.7	3.7	signal
432	Sleep Disorder Due To A General Medical Condition	294	3.7	3.7	signal
433	Iron Deficiency Anaemia	167	3.7	3.7	signal
434	Transaminases Increased	402	3.7	3.7	signal
435	Furuncle	143	3.7	3.7	signal
436	Diverticulum	130	3.7	3.7	signal
437	Bedridden	236	3.7	3.7	signal
438	Blood Cholesterol Abnormal	83	3.7	3.7	signal
439	Impaired Gastric Emptying	229	3.7	3.7	signal
440	Respiratory Tract Congestion	284	3.6	3.7	signal
441	Spinal Pain	208	3.6	3.6	signal
442	Pyrexia	6,143	3.6	3.8	signal
443	Medication Error	983	3.6	3.6	signal
444	Dysstasia	518	3.6	3.6	signal
445	Asthma	1,982	3.6	3.7	signal
446	Candida Infection	295	3.6	3.6	signal
447	Glaucoma	340	3.6	3.6	signal
448	Psoriasis	2,300	3.6	3.7	signal
449	Insomnia	4,654	3.6	3.7	signal
450	Lymphoma	268	3.5	3.5	signal
451	Rales	100	3.5	3.5	signal
452	Injection Site Inflammation	85	3.5	3.5	signal
453	Paraesthesia	2,694	3.5	3.6	signal
454	Oral Discomfort	235	3.4	3.5	signal
455	Emphysema	170	3.4	3.4	signal
456	Abnormal Loss Of Weight	113	3.4	3.4	signal
457	Hypokinesia	242	3.4	3.4	signal
458	Pruritus	6,271	3.4	3.5	signal
459	Cataract Operation	98	3.4	3.4	signal
460	Drug Effect Decreased	903	3.4	3.4	signal
461	Kidney Infection	322	3.3	3.4	signal
462	Gastric Ulcer	312	3.3	3.3	signal
463	Memory Impairment	2,247	3.3	3.4	signal
464	Lung Infection	256	3.3	3.3	signal
465	Laboratory Test Abnormal	478	3.3	3.3	signal
466	Skin Lesion	440	3.3	3.3	signal
467	Oral Herpes	311	3.3	3.3	signal
468	Urosepsis	147	3.2	3.3	signal
469	Incorrect Dosage Administered	78	3.2	3.2	signal
470	Drug Specific Antibody Present	103	3.2	3.2	signal
471	Rhinitis	128	3.2	3.2	signal
472	Malaise	6,961	3.2	3.4	signal
473	Cataract	937	3.2	3.2	signal
474	Feeding Disorder	313	3.2	3.2	signal
475	Stress Fracture	85	3.2	3.2	signal
476	Lumbar Vertebral Fracture	71	3.2	3.2	signal
477	Endocarditis	80	3.2	3.2	signal
478	Oedema Peripheral	1,904	3.2	3.2	signal
479	Frequent Bowel Movements	417	3.2	3.2	signal
480	Erysipelas	78	3.1	3.1	signal
481	Mass	216	3.1	3.1	signal
482	Squamous Cell Carcinoma	145	3.1	3.1	signal
483	Gingivitis	83	3.1	3.1	signal
484	Oral Pain	341	3.1	3.1	signal
485	Eye Disorder	497	3.1	3.1	signal
486	Chest Pain	2,805	3.1	3.1	signal
487	Vomiting	7,041	3.1	3.2	signal
488	Pneumonitis	404	3.0	3.1	signal
489	Deafness	391	3.0	3.0	signal
490	Oral Candidiasis	194	3.0	3.0	signal
491	Decreased Appetite	3,443	3.0	3.1	signal
492	Onychoclasis	102	3.0	3.0	signal
493	Headache	9,224	3.0	3.2	signal
494	Covid-19 Pneumonia	175	3.0	3.0	signal
495	Spinal Operation	178	3.0	3.0	signal
496	Diarrhoea	9,442	3.0	3.2	signal
497	Skin Plaque	123	3.0	3.0	signal
498	Herpes Virus Infection	84	3.0	3.0	signal
499	White Blood Cell Count Increased	559	3.0	3.0	signal
500	Duodenal Ulcer	102	2.9	2.9	signal
501	Heart Rate Decreased	509	2.9	2.9	signal
502	Back Pain	3,339	2.9	3.0	signal
503	Staphylococcal Sepsis	71	2.9	2.9	signal
504	Groin Pain	126	2.9	2.9	signal
505	Peripheral Vascular Disorder	74	2.9	2.9	signal
506	Pathological Fracture	72	2.9	2.9	signal
507	Cellulitis	713	2.9	2.9	signal
508	Hip Surgery	75	2.9	2.9	signal
509	Blood Iron Decreased	166	2.9	2.9	signal
510	Off Label Use	12,216	2.9	3.1	signal
511	Movement Disorder	454	2.9	2.9	signal
512	Tendon Rupture	174	2.9	2.9	signal
513	Decreased Immune Responsiveness	137	2.9	2.9	signal
514	Skin Mass	93	2.8	2.8	signal
515	Maternal Exposure Before Pregnancy	95	2.8	2.8	signal
516	Anal Abscess	75	2.8	2.8	signal
517	Weight Decreased	3,887	2.8	2.9	signal
518	Gamma-glutamyltransferase Increased	309	2.8	2.8	signal
519	Injection Site Irritation	176	2.8	2.8	signal
520	Accident	165	2.8	2.8	signal
521	Polyneuropathy	164	2.8	2.8	signal
522	Muscle Spasms	2,522	2.8	2.8	signal
523	Staphylococcal Infection	454	2.8	2.8	signal
524	Blood Alkaline Phosphatase Increased	338	2.8	2.8	signal
525	Respiratory Tract Infection	351	2.7	2.8	signal
526	Injection Site Haematoma	198	2.7	2.8	signal
527	Ankle Fracture	209	2.7	2.7	signal
528	Fracture	255	2.7	2.7	signal
529	Phlebitis	69	2.7	2.7	signal
530	Immune System Disorder	177	2.7	2.7	signal
531	Depression	3,073	2.7	2.8	signal
532	Hernia	258	2.7	2.7	signal
533	Eye Infection	150	2.7	2.7	signal
534	Multiple Fractures	221	2.7	2.7	signal
535	Sputum Discoloured	126	2.7	2.7	signal
536	Asthenia	5,004	2.7	2.8	signal
537	Diabetes Mellitus	1,014	2.7	2.7	signal
538	Haematocrit Decreased	264	2.7	2.7	signal
539	Product Use In Unapproved Indication	3,222	2.7	2.7	signal
540	Rash Maculo-papular	292	2.7	2.7	signal
541	Nausea	10,376	2.7	2.9	signal
542	Dry Eye	637	2.7	2.7	signal
543	Rectal Haemorrhage	563	2.7	2.7	signal
544	Scab	148	2.7	2.7	signal
545	Vitamin D Decreased	111	2.6	2.6	signal
546	Blood Test Abnormal	181	2.6	2.6	signal
547	Cystitis	412	2.6	2.6	signal
548	Oxygen Saturation Decreased	719	2.6	2.6	signal
549	Nephrolithiasis	589	2.6	2.6	signal
550	Ligament Sprain	127	2.6	2.6	signal
551	Meningitis	86	2.6	2.6	signal
552	Type 1 Diabetes Mellitus	77	2.6	2.6	signal
553	Hypogammaglobulinaemia	82	2.6	2.6	signal
554	Sinus Congestion	173	2.6	2.6	signal
555	Limb Injury	344	2.6	2.6	signal
556	Dyspnoea	7,133	2.6	2.7	signal
557	Influenza	1,407	2.6	2.6	signal
558	Nerve Injury	140	2.6	2.6	signal
559	Gastrointestinal Infection	112	2.5	2.5	signal
560	Pharyngeal Oedema	195	2.5	2.5	signal
561	Hypertensive Crisis	139	2.5	2.5	signal
562	Blood Pressure Increased	1,904	2.5	2.6	signal
563	Stress	892	2.5	2.5	signal
564	Renal Cyst	98	2.5	2.5	signal
565	Gastroenteritis Viral	222	2.5	2.5	signal
566	Abdominal Pain	2,846	2.5	2.5	signal
567	Sinus Headache	73	2.5	2.5	signal
568	Pyelonephritis	105	2.5	2.5	signal
569	Spinal Compression Fracture	102	2.5	2.5	signal
570	Respiratory Rate Increased	108	2.5	2.5	signal
571	Injection Site Warmth	249	2.5	2.5	signal
572	Dermatitis	249	2.4	2.4	signal
573	Productive Cough	564	2.4	2.4	signal
574	Lymphoedema	82	2.4	2.4	signal
575	Fungal Infection	395	2.4	2.4	signal
576	Streptococcal Infection	66	2.4	2.4	signal
577	Injection Site Pruritus	787	2.4	2.4	signal
578	Local Swelling	209	2.4	2.4	signal
579	Ecchymosis	81	2.4	2.4	signal
580	Pancreatitis	619	2.4	2.4	signal
581	Skin Disorder	387	2.4	2.4	signal
582	Herpes Simplex	75	2.3	2.3	signal
583	Abdominal Distension	1,196	2.3	2.3	signal
584	Feeling Hot	706	2.3	2.3	signal
585	Pelvic Fracture	89	2.3	2.3	signal
586	Mouth Haemorrhage	84	2.3	2.3	signal
587	Gastroenteritis	165	2.3	2.3	signal
588	Dental Caries	125	2.3	2.3	signal
589	Hypovolaemia	66	2.3	2.3	signal
590	Hepatic Function Abnormal	417	2.3	2.3	signal
591	Vitamin D Deficiency	109	2.3	2.3	signal
592	Cardiac Murmur	97	2.3	2.3	signal
593	Blood Lactate Dehydrogenase Increased	177	2.3	2.3	signal
594	Visual Impairment	1,357	2.2	2.3	signal
595	Scar	189	2.2	2.2	signal
596	Hypophagia	279	2.2	2.2	signal
597	Toothache	198	2.2	2.2	signal
598	Septic Shock	468	2.2	2.2	signal
599	Tooth Extraction	134	2.2	2.2	signal
600	Red Blood Cell Count Decreased	308	2.2	2.2	signal
601	Lung Infiltration	95	2.2	2.2	signal
602	Drug Exposure During Pregnancy	368	2.2	2.2	signal
603	Nephropathy	100	2.2	2.2	signal
604	Rhinorrhoea	675	2.1	2.1	signal
605	Musculoskeletal Chest Pain	161	2.1	2.1	signal
606	Haemophagocytic Lymphohistiocytosis	75	2.1	2.1	signal
607	Lymphadenopathy	367	2.1	2.1	signal
608	Neuralgia	250	2.1	2.1	signal
609	Blood Albumin Decreased	81	2.1	2.1	signal
610	Colitis Ulcerative	456	2.1	2.1	signal
611	Pneumonia Bacterial	93	2.1	2.1	signal
612	Pancytopenia	566	2.1	2.1	signal
613	Pulmonary Congestion	134	2.1	2.1	signal
614	Atelectasis	98	2.0	2.0	signal
615	Deep Vein Thrombosis	660	2.0	2.1	signal
616	Therapeutic Response Shortened	321	2.0	2.0	signal
617	Muscle Strain	87	2.0	2.0	signal
618	Arthropod Bite	74	2.0	2.0	signal
619	Cough	2,796	2.0	2.1	signal
620	Haemoglobin Decreased	1,027	2.0	2.0	signal
621	Underdose	727	2.0	2.0	signal
622	Pain In Jaw	282	2.0	2.0	signal
623	Drug Resistance	255	2.0	2.0	signal
624	Injection Site Discolouration	123	2.0	2.0	signal
625	Eating Disorder	207	2.0	2.0	no signal
626	Pathogen Resistance	88	2.0	2.0	no signal
627	Gallbladder Disorder	173	2.0	2.0	no signal
628	Dizziness	4,799	2.0	2.0	no signal
629	Nasal Congestion	564	2.0	2.0	no signal
630	Urinary Tract Infection	1,628	1.9	2.0	no signal
631	Post Procedural Complication	183	1.9	1.9	no signal
632	Sepsis	1,055	1.9	1.9	no signal
633	Fall	3,132	1.9	1.9	no signal
634	Hypothyroidism	299	1.9	1.9	no signal
635	Oropharyngeal Pain	860	1.9	1.9	no signal
636	Injection Site Erythema	1,145	1.9	1.9	no signal
637	Hysterectomy	80	1.9	1.9	no signal
638	Bacterial Infection	172	1.9	1.9	no signal
639	Abortion Induced	87	1.9	1.9	no signal
640	Malignant Melanoma	123	1.9	1.9	no signal
641	Conjunctivitis	168	1.9	1.9	no signal
642	Hydronephrosis	68	1.8	1.8	no signal
643	Blood Creatinine Increased	596	1.8	1.8	no signal
644	Seasonal Allergy	128	1.8	1.8	no signal
645	Pleural Effusion	548	1.8	1.8	no signal
646	Neoplasm Malignant	600	1.8	1.8	no signal
647	Blood Urine Present	171	1.8	1.8	no signal
648	Hiatus Hernia	116	1.8	1.8	no signal
649	Stent Placement	72	1.8	1.8	no signal
650	Increased Tendency To Bruise	82	1.8	1.8	no signal
651	Bone Density Decreased	281	1.8	1.8	no signal
652	Frustration Tolerance Decreased	71	1.8	1.8	no signal
653	Eye Haemorrhage	118	1.8	1.8	no signal
654	Viral Infection	293	1.8	1.8	no signal
655	Motor Dysfunction	89	1.8	1.8	no signal
656	Fluid Retention	447	1.8	1.8	no signal
657	White Blood Cell Count Decreased	950	1.8	1.8	no signal
658	Pseudomonas Infection	74	1.8	1.8	no signal
659	Mucosal Inflammation	227	1.8	1.8	no signal
660	Body Height Decreased	94	1.8	1.8	no signal
661	Injection Site Induration	112	1.7	1.7	no signal
662	Pharyngitis Streptococcal	93	1.7	1.7	no signal
663	Quality Of Life Decreased	115	1.7	1.7	no signal
664	Spinal Fracture	170	1.7	1.7	no signal
665	Pulmonary Embolism	811	1.7	1.7	no signal
666	Arterial Occlusive Disease	67	1.7	1.7	no signal
667	Cytomegalovirus Infection	141	1.7	1.7	no signal
668	Renal Impairment	708	1.7	1.7	no signal
669	Upper Limb Fracture	169	1.7	1.7	no signal
670	Erythema	1,720	1.7	1.7	no signal
671	Rib Fracture	172	1.7	1.7	no signal
672	Clostridium Difficile Infection	181	1.7	1.7	no signal
673	Abscess	133	1.7	1.7	no signal
674	Cholelithiasis	273	1.7	1.7	no signal
675	Injection Site Swelling	630	1.7	1.7	no signal
676	Escherichia Infection	68	1.7	1.7	no signal
677	Affective Disorder	65	1.7	1.7	no signal
678	Wrist Fracture	99	1.7	1.7	no signal
679	Glomerular Filtration Rate Decreased	100	1.7	1.7	no signal
680	Gastritis	216	1.7	1.7	no signal
681	Anaphylactic Shock	210	1.7	1.7	no signal
682	Muscle Atrophy	103	1.7	1.7	no signal
683	Hyperlipidaemia	98	1.7	1.7	no signal
684	Hypocalcaemia	154	1.6	1.7	no signal
685	Blood Pressure Abnormal	161	1.6	1.6	no signal
686	Sleep Apnoea Syndrome	155	1.6	1.6	no signal
687	Loss Of Consciousness	1,038	1.6	1.6	no signal
688	Multi-organ Failure	142	1.6	1.6	no signal
689	Heart Rate Irregular	183	1.6	1.6	no signal
690	Cytopenia	96	1.6	1.6	no signal
691	Intestinal Perforation	90	1.6	1.6	no signal
692	Thyroid Cancer	97	1.6	1.6	no signal
693	Diarrhoea Haemorrhagic	75	1.6	1.6	no signal
694	Skin Swelling	68	1.6	1.6	no signal
695	Therapy Partial Responder	120	1.6	1.6	no signal
696	Thrombosis	642	1.6	1.6	no signal
697	Pruritus Generalised	174	1.6	1.6	no signal
698	Neuropathy Peripheral	749	1.6	1.6	no signal
699	Gingival Bleeding	108	1.6	1.6	no signal
700	Progressive Multifocal Leukoencephalopathy	65	1.6	1.6	no signal
701	Injection Site Rash	239	1.6	1.6	no signal
702	Knee Operation	76	1.6	1.6	no signal
703	Ovarian Cancer	72	1.6	1.6	no signal
704	Hepatocellular Injury	110	1.6	1.6	no signal
705	Surgery	448	1.6	1.6	no signal
706	Injection Site Bruising	602	1.5	1.5	no signal
707	Heart Rate Increased	753	1.5	1.5	no signal
708	Flank Pain	71	1.5	1.5	no signal
709	Device Related Infection	117	1.5	1.5	no signal
710	Foetal Exposure During Pregnancy	614	1.5	1.5	no signal
711	Photophobia	141	1.5	1.5	no signal
712	Renal Failure	1,010	1.5	1.5	no signal
713	Colitis	283	1.5	1.5	no signal
714	Chronic Obstructive Pulmonary Disease	391	1.5	1.5	no signal
715	Generalised Oedema	92	1.5	1.5	no signal
716	Hypokalaemia	339	1.5	1.5	no signal
717	Poor Quality Sleep	158	1.5	1.5	no signal
718	Pneumothorax	117	1.5	1.5	no signal
719	Anxiety	2,101	1.5	1.5	no signal
720	Acute Respiratory Distress Syndrome	130	1.5	1.5	no signal
721	Temperature Intolerance	75	1.5	1.5	no signal
722	Dyspnoea Exertional	275	1.5	1.5	no signal
723	Acute Hepatic Failure	99	1.5	1.5	no signal
724	Arteriosclerosis	68	1.5	1.5	no signal
725	Disease Recurrence	344	1.5	1.5	no signal
726	Eye Inflammation	68	1.5	1.5	no signal
727	Oesophagitis	78	1.4	1.4	no signal
728	Influenza Like Illness	584	1.4	1.4	no signal
729	Haemorrhoids	138	1.4	1.4	no signal
730	Tachycardia	625	1.4	1.4	no signal
731	Aphonia	98	1.4	1.4	no signal
732	Injection Site Urticaria	170	1.4	1.4	no signal
733	Neutrophil Count Increased	72	1.4	1.4	no signal
734	Coagulopathy	116	1.4	1.4	no signal
735	Cholecystectomy	78	1.4	1.4	no signal
736	Osteonecrosis Of Jaw	170	1.4	1.4	no signal
737	Activities Of Daily Living Impaired	137	1.4	1.4	no signal
738	Product Quality Issue	917	1.4	1.4	no signal
739	Pulmonary Hypertension	142	1.4	1.4	no signal
740	Jaundice	183	1.4	1.4	no signal
741	Hepatomegaly	66	1.3	1.3	no signal
742	Hepatic Failure	202	1.3	1.4	no signal
743	Skin Cancer	144	1.3	1.3	no signal
744	Coronary Artery Occlusion	92	1.3	1.3	no signal
745	Blood Potassium Increased	108	1.3	1.3	no signal
746	Sinus Disorder	132	1.3	1.3	no signal
747	Angina Pectoris	192	1.3	1.3	no signal
748	Epistaxis	494	1.3	1.3	no signal
749	Splenomegaly	77	1.3	1.3	no signal
750	Treatment Noncompliance	357	1.3	1.3	no signal
751	Macular Degeneration	78	1.3	1.3	no signal
752	Skin Fissures	123	1.3	1.3	no signal
753	Skin Haemorrhage	94	1.3	1.3	no signal
754	Injection Site Extravasation	81	1.3	1.3	no signal
755	Petechiae	67	1.3	1.3	no signal
756	Cardiomyopathy	95	1.3	1.3	no signal
757	Laceration	61	1.3	1.3	no signal
758	Cholecystitis	76	1.3	1.3	no signal
759	Myelodysplastic Syndrome	92	1.3	1.3	no signal
760	Bone Marrow Failure	130	1.3	1.3	no signal
761	Osteonecrosis	210	1.3	1.3	no signal
762	Retinal Detachment	58	1.3	1.3	no signal
763	Posterior Reversible Encephalopathy Syndrome	60	1.3	1.3	no signal
764	Vertigo	384	1.3	1.3	no signal
765	Coronary Artery Disease	192	1.3	1.3	no signal
766	Procedural Pain	174	1.3	1.3	no signal
767	Anaemia	1,200	1.3	1.3	no signal
768	Mitral Valve Incompetence	71	1.3	1.3	no signal
769	Post Procedural Haemorrhage	73	1.3	1.3	no signal
770	Gout	112	1.3	1.3	no signal
771	Swelling Face	405	1.3	1.3	no signal
772	Throat Irritation	277	1.3	1.3	no signal
773	Rash Erythematous	289	1.2	1.2	no signal
774	Renal Disorder	288	1.2	1.2	no signal
775	Injection Site Pain	1,858	1.2	1.2	no signal
776	Anorexia	80	1.2	1.2	no signal
777	Lymphopenia	86	1.2	1.2	no signal
778	Acute Respiratory Failure	117	1.2	1.2	no signal
779	Abasia	153	1.2	1.2	no signal
780	Bronchospasm	87	1.2	1.2	no signal
781	Intentional Dose Omission	166	1.2	1.2	no signal
782	Ovarian Cyst	61	1.2	1.2	no signal
783	Myocardial Ischaemia	69	1.2	1.2	no signal
784	Hip Fracture	193	1.2	1.2	no signal
785	Thrombocytopenia	668	1.2	1.2	no signal
786	Middle Insomnia	111	1.2	1.2	no signal
787	Peripheral Coldness	82	1.2	1.2	no signal
788	End Stage Renal Disease	109	1.2	1.2	no signal
789	Feeling Jittery	113	1.2	1.2	no signal
790	Sneezing	132	1.2	1.2	no signal
791	Syncope	589	1.2	1.2	no signal
792	Restless Legs Syndrome	107	1.2	1.2	no signal
793	Chills	690	1.2	1.2	no signal
794	Feeling Abnormal	1,413	1.2	1.2	no signal
795	Palpitations	681	1.2	1.2	no signal
796	Unevaluable Event	439	1.2	1.2	no signal
797	Myocardial Infarction	1,020	1.2	1.2	no signal
798	Blood Potassium Decreased	174	1.2	1.2	no signal
799	Atrial Fibrillation	563	1.2	1.2	no signal
800	Illness	579	1.2	1.2	no signal
801	Pharyngeal Swelling	55	1.2	1.2	no signal
802	Hunger	77	1.2	1.2	no signal
803	Eczema	288	1.2	1.2	no signal
804	Cardiac Failure	460	1.2	1.2	no signal
805	Myalgia	968	1.1	1.2	no signal
806	Erythema Multiforme	53	1.1	1.1	no signal
807	Cholestasis	108	1.1	1.1	no signal
808	Covid-19	1,000	1.1	1.1	no signal
809	Crying	206	1.1	1.1	no signal
810	Cardiomegaly	70	1.1	1.1	no signal
811	Blood Triglycerides Increased	100	1.1	1.1	no signal
812	Feeling Cold	156	1.1	1.1	no signal
813	Nervous System Disorder	175	1.1	1.1	no signal
814	Acute Myocardial Infarction	165	1.1	1.1	no signal
815	Proteinuria	105	1.1	1.1	no signal
816	Neoplasm	64	1.1	1.1	no signal
817	Throat Tightness	150	1.1	1.1	no signal
818	Inappropriate Schedule Of Product Administration	976	1.1	1.1	no signal
819	Burning Sensation	387	1.1	1.1	no signal
820	Eosinophilia	96	1.1	1.1	no signal
821	Malnutrition	61	1.1	1.1	no signal
822	Renal Pain	58	1.1	1.1	no signal
823	Skin Discolouration	252	1.1	1.1	no signal
824	Incorrect Product Administration Duration	111	1.1	1.1	no signal
825	Respiratory Failure	399	1.1	1.1	no signal
826	Hyperhidrosis	705	1.1	1.1	no signal
827	Dysphonia	319	1.1	1.1	no signal
828	Pulmonary Oedema	244	1.1	1.1	no signal
829	Swollen Tongue	170	1.1	1.1	no signal
830	Blindness Unilateral	76	1.1	1.1	no signal
831	Rash Macular	185	1.1	1.1	no signal
832	Inflammatory Bowel Disease	52	1.1	1.1	no signal
833	Pericardial Effusion	121	1.1	1.1	no signal
834	Leukocytosis	95	1.1	1.1	no signal
835	Neutropenia	704	1.0	1.0	no signal
836	Eye Discharge	52	1.0	1.0	no signal
837	Cardiac Failure Congestive	411	1.0	1.0	no signal
838	Affect Lability	49	1.0	1.0	no signal
839	Electrolyte Imbalance	58	1.0	1.0	no signal
840	Chest Discomfort	514	1.0	1.0	no signal
841	Decreased Activity	54	1.0	1.0	no signal
842	Diabetes Mellitus Inadequate Control	89	1.0	1.0	no signal
843	Drug Reaction With Eosinophilia And Systemic Symptoms	128	1.0	1.0	no signal
844	Tooth Loss	104	1.0	1.0	no signal
845	Hospitalisation	754	1.0	1.0	no signal
846	Breast Cancer	465	1.0	1.0	no signal
847	Sars-cov-2 Test Positive	66	1.0	1.0	no signal
848	Angioedema	217	1.0	1.0	no signal
849	Haematochezia	270	1.0	1.0	no signal
850	Transient Ischaemic Attack	166	1.0	1.0	no signal
851	Aspiration	53	1.0	1.0	no signal
852	Haematemesis	124	1.0	1.0	no signal
853	Bone Loss	74	1.0	1.0	no signal
854	Appendicitis	45	1.0	1.0	no signal
855	Blood Bilirubin Increased	131	1.0	1.0	no signal
856	Scratch	50	1.0	1.0	no signal
857	Dizziness Postural	46	1.0	1.0	no signal
858	Ear Discomfort	49	1.0	1.0	no signal
859	Product Dose Omission In Error	128	1.0	1.0	no signal
860	Arrhythmia	226	1.0	1.0	no signal
861	Brain Oedema	60	1.0	1.0	no signal
862	Intraocular Pressure Increased	61	1.0	1.0	no signal
863	Gastric Haemorrhage	55	1.0	1.0	no signal
864	Rash Generalised	124	1.0	1.0	no signal
865	Hypoaesthesia Oral	71	0.9	0.9	no signal
866	Cold Sweat	83	0.9	0.9	no signal
867	Blood Urea Increased	79	0.9	0.9	no signal
868	Bacteraemia	55	0.9	0.9	no signal
869	Multiple Organ Dysfunction Syndrome	130	0.9	0.9	no signal
870	Cardiovascular Disorder	119	0.9	0.9	no signal
871	Haemoptysis	130	0.9	0.9	no signal
872	Injection Site Nodule	51	0.9	0.9	no signal
873	Toxic Epidermal Necrolysis	70	0.9	0.9	no signal
874	Lymphocyte Count Decreased	82	0.9	0.9	no signal
875	Subarachnoid Haemorrhage	47	0.9	0.9	no signal
876	Lip Swelling	152	0.9	0.9	no signal
877	Injection Site Haemorrhage	362	0.9	0.9	no signal
878	Injection Site Discomfort	47	0.9	0.9	no signal
879	Pulmonary Arterial Hypertension	66	0.9	0.9	no signal
880	Bone Pain	264	0.9	0.9	no signal
881	Paraesthesia Oral	64	0.9	0.9	no signal
882	Pelvic Pain	81	0.9	0.9	no signal
883	Rash Papular	100	0.9	0.9	no signal
884	Upper Gastrointestinal Haemorrhage	75	0.9	0.9	no signal
885	Dry Throat	45	0.9	0.9	no signal
886	Platelet Count Decreased	472	0.9	0.9	no signal
887	Bladder Disorder	44	0.9	0.9	no signal
888	Blood Pressure Decreased	290	0.9	0.9	no signal
889	Product Prescribing Error	103	0.9	0.9	no signal
890	Drug Interaction	690	0.9	0.9	no signal
891	Fistula	49	0.9	0.9	no signal
892	Mood Swings	138	0.9	0.9	no signal
893	Pollakiuria	180	0.9	0.9	no signal
894	Dysphagia	409	0.9	0.9	no signal
895	Depressed Mood	226	0.9	0.9	no signal
896	Nervousness	225	0.9	0.9	no signal
897	Hot Flush	322	0.9	0.9	no signal
898	Skin Exfoliation	353	0.9	0.9	no signal
899	Cardiac Disorder	398	0.9	0.9	no signal
900	Lung Neoplasm Malignant	175	0.9	0.9	no signal
901	Tubulointerstitial Nephritis	79	0.8	0.8	no signal
902	Tinnitus	193	0.8	0.8	no signal
903	Hypoxia	147	0.8	0.8	no signal
904	Dysuria	153	0.8	0.8	no signal
905	Colon Cancer	62	0.8	0.8	no signal
906	Nephropathy Toxic	46	0.8	0.8	no signal
907	Thrombotic Microangiopathy	40	0.8	0.8	no signal
908	Agranulocytosis	76	0.8	0.8	no signal
909	Hemiparesis	70	0.8	0.8	no signal
910	Paralysis	59	0.8	0.8	no signal
911	Speech Disorder	213	0.8	0.8	no signal
912	Drug Ineffective For Unapproved Indication	226	0.8	0.8	no signal
913	Abortion Spontaneous	163	0.8	0.8	no signal
914	Hypotension	809	0.8	0.8	no signal
915	Ageusia	101	0.8	0.8	no signal
916	Hypomagnesaemia	56	0.8	0.8	no signal
917	Breast Pain	43	0.8	0.8	no signal
918	Coma	192	0.8	0.8	no signal
919	Eye Pain	221	0.8	0.8	no signal
920	Haematoma	104	0.8	0.8	no signal
921	Supraventricular Tachycardia	38	0.8	0.8	no signal
922	Dermatitis Contact	45	0.8	0.8	no signal
923	Pallor	108	0.8	0.8	no signal
924	Clostridium Difficile Colitis	42	0.8	0.8	no signal
925	Hepatitis C	48	0.8	0.8	no signal
926	Renal Failure Acute	169	0.8	0.8	no signal
927	Gastrointestinal Haemorrhage	330	0.8	0.8	no signal
928	Cardiogenic Shock	56	0.8	0.8	no signal
929	Hypoacusis	168	0.8	0.8	no signal
930	Blood Calcium Decreased	44	0.8	0.8	no signal
931	Thirst	68	0.8	0.8	no signal
932	Intentional Product Misuse	331	0.8	0.8	no signal
933	Blindness	155	0.8	0.8	no signal
934	Urinary Incontinence	112	0.8	0.8	no signal
935	Tachypnoea	51	0.8	0.8	no signal
936	Somnolence	751	0.8	0.8	no signal
937	Device Malfunction	250	0.7	0.7	no signal
938	Dehydration	493	0.7	0.7	no signal
939	Disseminated Intravascular Coagulation	52	0.7	0.7	no signal
940	Sensory Disturbance	59	0.7	0.7	no signal
941	Eye Swelling	135	0.7	0.7	no signal
942	Encephalopathy	89	0.7	0.7	no signal
943	Head Discomfort	64	0.7	0.7	no signal
944	Ischaemic Stroke	64	0.7	0.7	no signal
945	Eye Pruritus	118	0.7	0.7	no signal
946	Head Injury	113	0.7	0.7	no signal
947	Insurance Issue	53	0.7	0.7	no signal
948	Faeces Discoloured	77	0.7	0.7	no signal
949	Intestinal Obstruction	133	0.7	0.7	no signal
950	Balance Disorder	307	0.7	0.7	no signal
951	Needle Issue	101	0.7	0.7	no signal
952	Shock	80	0.7	0.7	no signal
953	Diplopia	90	0.7	0.7	no signal
954	Sinus Tachycardia	49	0.7	0.7	no signal
955	Sluggishness	35	0.7	0.7	no signal
956	Haematuria	117	0.7	0.7	no signal
957	Stevens-johnson Syndrome	76	0.7	0.7	no signal
958	Impaired Quality Of Life	49	0.7	0.7	no signal
959	Blood Glucose Abnormal	63	0.7	0.7	no signal
960	Cerebrovascular Accident	577	0.7	0.7	no signal
961	Lethargy	195	0.7	0.7	no signal
962	Hyperthyroidism	49	0.7	0.7	no signal
963	Peritonitis	70	0.7	0.7	no signal
964	Sudden Death	36	0.7	0.7	no signal
965	Micturition Urgency	38	0.7	0.7	no signal
966	Ascites	98	0.7	0.7	no signal
967	Chromaturia	75	0.7	0.7	no signal
968	Obstructive Airways Disorder	37	0.7	0.7	no signal
969	Cerebral Infarction	81	0.7	0.7	no signal
970	Acute Kidney Injury	504	0.7	0.7	no signal
971	Blood Sodium Decreased	62	0.7	0.7	no signal
972	Pain Of Skin	89	0.7	0.7	no signal
973	Ocular Hyperaemia	153	0.7	0.7	no signal
974	Toxic Skin Eruption	33	0.7	0.7	no signal
975	Blood Creatine Phosphokinase Increased	95	0.7	0.7	no signal
976	Face Oedema	55	0.7	0.7	no signal
977	Anosmia	47	0.7	0.7	no signal
978	Therapy Interrupted	223	0.7	0.6	no signal
979	Full Blood Count Abnormal	34	0.6	0.6	no signal
980	Psychotic Disorder	95	0.6	0.6	no signal
981	Myocarditis	36	0.6	0.6	no signal
982	Fear	86	0.6	0.6	no signal
983	Ventricular Extrasystoles	33	0.6	0.6	no signal
984	Mental Disorder	138	0.6	0.6	no signal
985	Device Occlusion	44	0.6	0.6	no signal
986	International Normalised Ratio Increased	91	0.6	0.6	no signal
987	Product Dispensing Error	68	0.6	0.6	no signal
988	Eye Irritation	174	0.6	0.6	no signal
989	Injection Site Mass	115	0.6	0.6	no signal
990	Hypoglycaemia	150	0.6	0.6	no signal
991	Choking	60	0.6	0.6	no signal
992	Internal Haemorrhage	35	0.6	0.6	no signal
993	Retching	65	0.6	0.6	no signal
994	Toxicity To Various Agents	510	0.6	0.6	no signal
995	Ataxia	36	0.6	0.6	no signal
996	Mood Altered	82	0.6	0.6	no signal
997	Melaena	66	0.6	0.6	no signal
998	Presyncope	72	0.6	0.6	no signal
999	Product Dose Omission	197	0.6	0.6	no signal
1000	Myelosuppression	101	0.6	0.6	no signal
1001	Muscle Tightness	48	0.6	0.6	no signal
1002	Acne	226	0.6	0.6	no signal
1003	Vision Blurred	403	0.6	0.6	no signal
1004	Suicidal Ideation	270	0.6	0.6	no signal
1005	Haemorrhage	307	0.6	0.6	no signal
1006	Thinking Abnormal	55	0.6	0.6	no signal
1007	Hypersomnia	84	0.6	0.6	no signal
1008	Respiratory Distress	81	0.6	0.6	no signal
1009	Blood Thyroid Stimulating Hormone Increased	27	0.6	0.6	no signal
1010	Premature Baby	88	0.6	0.6	no signal
1011	Eyelid Oedema	34	0.6	0.6	no signal
1012	Caesarean Section	34	0.6	0.6	no signal
1013	Flatulence	163	0.6	0.6	no signal
1014	Incorrect Dose Administered	646	0.6	0.6	no signal
1015	Tremor	473	0.6	0.6	no signal
1016	Abdominal Pain Lower	71	0.6	0.6	no signal
1017	Cyanosis	44	0.6	0.6	no signal
1018	Circulatory Collapse	47	0.6	0.6	no signal
1019	Initial Insomnia	28	0.6	0.6	no signal
1020	Product Dose Omission Issue	780	0.6	0.5	no signal
1021	Brain Neoplasm	25	0.5	0.5	no signal
1022	Menorrhagia	54	0.5	0.5	no signal
1023	Dry Skin	353	0.5	0.5	no signal
1024	No Therapeutic Response	33	0.5	0.5	no signal
1025	Blood Count Abnormal	41	0.5	0.5	no signal
1026	Infusion Site Pain	34	0.5	0.5	no signal
1027	Eyelid Ptosis	27	0.5	0.5	no signal
1028	Disorientation	105	0.5	0.5	no signal
1029	Orthostatic Hypotension	46	0.5	0.5	no signal
1030	Visual Acuity Reduced	88	0.5	0.5	no signal
1031	Brain Injury	26	0.5	0.5	no signal
1032	Disease Progression	305	0.5	0.5	no signal
1033	Dysgeusia	193	0.5	0.5	no signal
1034	Psychomotor Hyperactivity	43	0.5	0.5	no signal
1035	Therapeutic Response Unexpected	116	0.5	0.5	no signal
1036	Aphasia	78	0.5	0.5	no signal
1037	Device Failure	39	0.5	0.5	no signal
1038	Hepatic Encephalopathy	24	0.5	0.5	no signal
1039	Transfusion	27	0.5	0.5	no signal
1040	Flushing	261	0.5	0.5	no signal
1041	Chronic Kidney Disease	195	0.5	0.5	no signal
1042	Hepatic Cytolysis	31	0.5	0.5	no signal
1043	Overdose	536	0.5	0.5	no signal
1044	Vitreous Floaters	24	0.5	0.5	no signal
1045	Drug Dose Omission	413	0.5	0.5	no signal
1046	Constipation	531	0.5	0.5	no signal
1047	Renal Tubular Necrosis	24	0.5	0.5	no signal
1048	Ileus	30	0.5	0.5	no signal
1049	Muscle Rigidity	29	0.5	0.5	no signal
1050	Cardio-respiratory Arrest	102	0.5	0.5	no signal
1051	Pancreatitis Acute	54	0.5	0.5	no signal
1052	Dysarthria	91	0.5	0.5	no signal
1053	Wrong Technique In Drug Usage Process	89	0.5	0.5	no signal
1054	Hyponatraemia	135	0.5	0.5	no signal
1055	Gastrointestinal Carcinoma	22	0.5	0.5	no signal
1056	Multiple Sclerosis	114	0.5	0.5	no signal
1057	Hair Texture Abnormal	32	0.5	0.5	no signal
1058	Small Intestinal Obstruction	29	0.5	0.5	no signal
1059	Device Issue	206	0.5	0.5	no signal
1060	Brain Fog	34	0.5	0.5	no signal
1061	Ocular Discomfort	25	0.5	0.5	no signal
1062	Inappropriate Schedule Of Drug Administration	165	0.5	0.5	no signal
1063	Lacrimation Increased	68	0.5	0.5	no signal
1064	Neutrophil Count Decreased	92	0.5	0.5	no signal
1065	Product Packaging Issue	21	0.5	0.5	no signal
1066	Drug Toxicity	31	0.5	0.5	no signal
1067	Rhabdomyolysis	93	0.4	0.4	no signal
1068	Ventricular Tachycardia	37	0.4	0.4	no signal
1069	No Adverse Event	395	0.4	0.4	no signal
1070	Glycosylated Haemoglobin Increased	56	0.4	0.4	no signal
1071	Seizure	255	0.4	0.4	no signal
1072	Salivary Hypersecretion	22	0.4	0.4	no signal
1073	Generalised Tonic-clonic Seizure	36	0.4	0.4	no signal
1074	Skeletal Injury	23	0.4	0.4	no signal
1075	Hyperglycaemia	79	0.4	0.4	no signal
1076	Panic Attack	79	0.4	0.4	no signal
1077	Accidental Overdose	79	0.4	0.4	no signal
1078	Dementia	60	0.4	0.4	no signal
1079	Breast Cancer Female	57	0.4	0.4	no signal
1080	Product Availability Issue	47	0.4	0.4	no signal
1081	Increased Appetite	39	0.4	0.4	no signal
1082	Therapy Cessation	106	0.4	0.4	no signal
1083	Ventricular Fibrillation	23	0.4	0.4	no signal
1084	Metastases To Liver	36	0.4	0.4	no signal
1085	Drug Level Increased	34	0.4	0.4	no signal
1086	Urinary Retention	68	0.4	0.4	no signal
1087	Complication Associated With Device	27	0.4	0.4	no signal
1088	Dialysis	29	0.4	0.4	no signal
1089	Blood Glucose Increased	384	0.4	0.4	no signal
1090	Impaired Driving Ability	23	0.4	0.4	no signal
1091	Pancreatic Carcinoma	57	0.4	0.4	no signal
1092	Incorrect Product Storage	26	0.4	0.4	no signal
1093	Coordination Abnormal	27	0.4	0.4	no signal
1094	Device Defective	31	0.4	0.4	no signal
1095	Device Breakage	75	0.4	0.4	no signal
1096	Metastases To Lung	22	0.4	0.4	no signal
1097	Vaginal Haemorrhage	81	0.4	0.4	no signal
1098	Injury Associated With Device	38	0.4	0.4	no signal
1099	Cardiac Arrest	156	0.4	0.4	no signal
1100	Delusion	29	0.4	0.4	no signal
1101	Emotional Disorder	58	0.4	0.4	no signal
1102	Metabolic Acidosis	59	0.4	0.4	no signal
1103	Ejection Fraction Decreased	29	0.4	0.4	no signal
1104	Cognitive Disorder	86	0.4	0.4	no signal
1105	Hyperbilirubinaemia	19	0.4	0.4	no signal
1106	Product Complaint	46	0.4	0.4	no signal
1107	Blood Glucose Fluctuation	20	0.4	0.4	no signal
1108	Nocturia	22	0.4	0.4	no signal
1109	Grand Mal Convulsion	17	0.4	0.4	no signal
1110	Central Nervous System Lesion	25	0.4	0.4	no signal
1111	Leukaemia	17	0.4	0.4	no signal
1112	Sexual Dysfunction	21	0.4	0.4	no signal
1113	Anger	61	0.4	0.4	no signal
1114	Dyskinesia	72	0.4	0.4	no signal
1115	Mental Impairment	43	0.4	0.4	no signal
1116	Rebound Effect	20	0.4	0.4	no signal
1117	Skin Burning Sensation	125	0.4	0.4	no signal
1118	Hair Colour Changes	22	0.4	0.4	no signal
1119	Bipolar Disorder	19	0.3	0.3	no signal
1120	Diabetic Ketoacidosis	41	0.3	0.3	no signal
1121	Drug Dependence	278	0.3	0.3	no signal
1122	Madarosis	20	0.3	0.3	no signal
1123	Product Administration Error	34	0.3	0.3	no signal
1124	Depressed Level Of Consciousness	67	0.3	0.3	no signal
1125	Muscle Twitching	39	0.3	0.3	no signal
1126	Cerebral Haemorrhage	60	0.3	0.3	no signal
1127	Acute Myeloid Leukaemia	26	0.3	0.3	no signal
1128	Drug Level Decreased	17	0.3	0.3	no signal
1129	Mental Status Changes	46	0.3	0.3	no signal
1130	Metastases To Central Nervous System	21	0.3	0.3	no signal
1131	Drug Effect Less Than Expected	23	0.3	0.3	no signal
1132	Respiratory Arrest	45	0.3	0.3	no signal
1133	Blood Glucose Decreased	77	0.3	0.3	no signal
1134	Breast Cancer Stage I	15	0.3	0.3	no signal
1135	Nightmare	55	0.3	0.3	no signal
1136	Irritability	95	0.3	0.3	no signal
1137	Disturbance In Attention	85	0.3	0.3	no signal
1138	Convulsion	91	0.3	0.3	no signal
1139	Fluid Overload	23	0.3	0.3	no signal
1140	Death	1,323	0.3	0.3	no signal
1141	Haemorrhage Intracranial	23	0.3	0.3	no signal
1142	Accidental Exposure To Product	152	0.3	0.3	no signal
1143	Myoclonus	18	0.3	0.3	no signal
1144	Vaginal Discharge	15	0.3	0.3	no signal
1145	Altered State Of Consciousness	32	0.3	0.3	no signal
1146	Hallucination	111	0.3	0.3	no signal
1147	Metastases To Bone	24	0.3	0.3	no signal
1148	Product Storage Error	125	0.3	0.3	no signal
1149	Neurotoxicity	25	0.3	0.3	no signal
1150	Amenorrhoea	24	0.3	0.3	no signal
1151	Agitation	104	0.3	0.3	no signal
1152	Pneumonia Aspiration	35	0.3	0.3	no signal
1153	Subdural Haematoma	20	0.3	0.3	no signal
1154	Drug Prescribing Error	27	0.3	0.3	no signal
1155	Hypothermia	14	0.3	0.3	no signal
1156	Skin Irritation	62	0.3	0.3	no signal
1157	Status Epilepticus	15	0.3	0.3	no signal
1158	Hyperkalaemia	46	0.3	0.3	no signal
1159	Breast Cancer Metastatic	14	0.3	0.3	no signal
1160	Prostatic Specific Antigen Increased	18	0.3	0.3	no signal
1161	Prostate Cancer	105	0.3	0.3	no signal
1162	Device Dislocation	56	0.3	0.3	no signal
1163	Gastric Cancer	32	0.3	0.3	no signal
1164	Emotional Distress	151	0.2	0.2	no signal
1165	Hereditary Angioedema	13	0.2	0.2	no signal
1166	Renal Injury	37	0.2	0.2	no signal
1167	Wrong Technique In Device Usage Process	56	0.2	0.2	no signal
1168	Dysmenorrhoea	16	0.2	0.2	no signal
1169	Wrong Technique In Product Usage Process	247	0.2	0.2	no signal
1170	Eructation	23	0.2	0.2	no signal
1171	Hypotonia	12	0.2	0.2	no signal
1172	Premature Delivery	19	0.2	0.2	no signal
1173	Incorrect Dose Administered By Device	30	0.2	0.2	no signal
1174	Product Prescribing Issue	24	0.2	0.2	no signal
1175	Personality Change	11	0.2	0.2	no signal
1176	Circumstance Or Information Capable Of Leading To Medication Error	39	0.2	0.2	no signal
1177	Meningioma	17	0.2	0.2	no signal
1178	Therapy Change	11	0.2	0.2	no signal
1179	Poisoning	14	0.2	0.2	no signal
1180	Full Blood Count Decreased	22	0.2	0.2	no signal
1181	Lactic Acidosis	35	0.2	0.2	no signal
1182	Bradycardia	57	0.2	0.2	no signal
1183	Device Leakage	45	0.2	0.2	no signal
1184	Respiratory Depression	13	0.2	0.2	no signal
1185	Renal Cancer	51	0.2	0.2	no signal
1186	Restlessness	38	0.2	0.2	no signal
1187	Inability To Afford Medication	10	0.2	0.2	no signal
1188	Device Deployment Issue	12	0.2	0.2	no signal
1189	Drug Administration Error	31	0.2	0.2	no signal
1190	Bladder Cancer	59	0.2	0.2	no signal
1191	Economic Problem	15	0.2	0.2	no signal
1192	Plasma Cell Myeloma	38	0.2	0.2	no signal
1193	Haematotoxicity	9	0.2	0.2	no signal
1194	Application Site Pain	21	0.2	0.2	no signal
1195	Incontinence	10	0.2	0.2	no signal
1196	Mydriasis	12	0.2	0.2	no signal
1197	Unresponsive To Stimuli	24	0.2	0.2	no signal
1198	Suicide Attempt	55	0.2	0.2	no signal
1199	Febrile Neutropenia	59	0.2	0.2	no signal
1200	Hepatic Cancer	21	0.2	0.2	no signal
1201	Hallucination, Visual	18	0.2	0.2	no signal
1202	Electrocardiogram Qt Prolonged	30	0.2	0.2	no signal
1203	Sinus Bradycardia	8	0.2	0.2	no signal
1204	Apathy	12	0.2	0.2	no signal
1205	Hallucination, Auditory	13	0.2	0.2	no signal
1206	Erectile Dysfunction	21	0.2	0.2	no signal
1207	Exposure Via Skin Contact	18	0.2	0.2	no signal
1208	Drug Effective For Unapproved Indication	23	0.2	0.2	no signal
1209	Drug Dispensing Error	12	0.2	0.2	no signal
1210	Oesophageal Carcinoma	23	0.2	0.2	no signal
1211	Withdrawal Syndrome	32	0.2	0.2	no signal
1212	Metrorrhagia	13	0.2	0.2	no signal
1213	Extrapyramidal Disorder	18	0.1	0.1	no signal
1214	Product Substitution Issue	41	0.1	0.1	no signal
1215	Hospice Care	7	0.1	0.1	no signal
1216	Product Use Complaint	11	0.1	0.1	no signal
1217	Peritonitis Bacterial	7	0.1	0.1	no signal
1218	Pharmaceutical Product Complaint	18	0.1	0.1	no signal
1219	Drug Administered At Inappropriate Site	7	0.1	0.1	no signal
1220	Device Delivery System Issue	17	0.1	0.1	no signal
1221	Product Packaging Quantity Issue	7	0.1	0.1	no signal
1222	Paranoia	11	0.1	0.1	no signal
1223	Incorrect Route Of Drug Administration	23	0.1	0.1	no signal
1224	Expired Product Administered	21	0.1	0.1	no signal
1225	Incorrect Drug Administration Duration	18	0.1	0.1	no signal
1226	Syringe Issue	11	0.1	0.1	no signal
1227	Dermatitis Atopic	31	0.1	0.1	no signal
1228	Application Site Pruritus	14	0.1	0.1	no signal
1229	Intentional Drug Misuse	13	0.1	0.1	no signal
1230	Dependence	34	0.1	0.1	no signal
1231	Device Difficult To Use	40	0.1	0.1	no signal
1232	Menstruation Irregular	16	0.1	0.1	no signal
1233	Abnormal Dreams	16	0.1	0.1	no signal
1234	Schizophrenia	7	0.1	0.1	no signal
1235	Dystonia	11	0.1	0.1	no signal
1236	Abnormal Behaviour	22	0.1	0.1	no signal
1237	Aggression	27	0.1	0.1	no signal
1238	Application Site Erythema	13	0.1	0.1	no signal
1239	Mania	8	0.1	0.1	no signal
1240	Serotonin Syndrome	9	0.1	0.1	no signal
1241	Device Use Error	16	0.1	0.1	no signal
1242	Sedation	12	0.1	0.1	no signal
1243	Neoplasm Progression	16	0.1	0.1	no signal
1244	Intentional Overdose	28	0.1	0.1	no signal
1245	Drug Dose Omission By Device	33	0.1	0.1	no signal
1246	Tardive Dyskinesia	12	0.1	0.1	no signal
1247	Product Physical Issue	8	0.1	0.1	no signal
1248	Abnormal Weight Gain	5	0.1	0.1	no signal
1249	Inappropriate Antidiuretic Hormone Secretion	4	0.1	0.1	no signal
1250	Euphoric Mood	4	0.1	0.1	no signal
1251	Product Administered At Inappropriate Site	7	0.1	0.1	no signal
1252	Product Odour Abnormal	4	0.1	0.1	no signal
1253	Unintended Pregnancy	4	0.1	0.1	no signal
1254	Extra Dose Administered	15	0.1	0.1	no signal
1255	Application Site Rash	5	0.1	0.1	no signal
1256	Drug Withdrawal Syndrome	32	0.1	0.1	no signal
1257	Device Use Issue	6	0.1	0.1	no signal
1258	Product Preparation Error	7	0.1	0.1	no signal
1259	Complication Of Device Insertion	6	0.1	0.1	no signal
1260	Libido Decreased	4	0.1	0.1	no signal
1261	Product Adhesion Issue	11	0.1	0.1	no signal
1262	Parkinsonism	3	0.1	0.1	no signal
1263	Product Taste Abnormal	4	0.1	0.1	no signal
1264	Intentional Self-injury	6	0.1	0.1	no signal
1265	Completed Suicide	25	0.1	0.1	no signal
1266	Poor Quality Product Administered	3	0.1	0.1	no signal
1267	Device Mechanical Issue	3	0.0	0.0	no signal
1268	Multiple Sclerosis Relapse	11	0.0	0.0	no signal
1269	Colorectal Cancer	4	0.0	0.0	no signal