Ibuprofen 200 vs Naproxen 220Mg: side effects in FDA adverse event reports
At a glance
| Ibuprofen 200 | Naproxen 220Mg | |
|---|---|---|
| Drug class | Nonsteroidal Anti-inflammatory Drug | – |
| Brand names | – | Naproxen Sodium 220Mg |
| FAERS reports | 198,333 | 13,479 |
| Serious | 73% | 77% |
| Death outcome | 16,224 | 3,768 |
| Boxed warning | No | No |
Signals both drugs share
| Reaction | Ibuprofen 200 | Naproxen 220Mg | Label screen (A / B) |
|---|---|---|---|
| Pemphigus | 2,876 · PRR 31.6 | 1,831 · PRR 269.1 | Not in label — unassessed / Not in label — unassessed |
| Hand deformity | 2,789 · PRR 28.5 | 1,900 · PRR 264.6 | Not in label — unassessed / Not in label — unassessed |
| Duodenal ulcer perforation | 2,892 · PRR 68.6 | 1,751 · PRR 488.8 | Not in label — unassessed / Not in label — unassessed |
| Folliculitis | 2,860 · PRR 40.3 | 1,731 · PRR 313.7 | Not in label — unassessed / Not in label — unassessed |
| Helicobacter infection | 2,811 · PRR 40.0 | 1,742 · PRR 321.2 | Not in label — unassessed / Not in label — unassessed |
| Muscle injury | 2,935 · PRR 58.7 | 1,464 · PRR 338.4 | Not in label — unassessed / Not in label — unassessed |
| Sleep disorder due to general medical condition, insomnia type | 2,217 · PRR 55.3 | 850 · PRR 236.9 | Not in label — unassessed / Not in label — unassessed |
| Rheumatic fever | 1,258 · PRR 42.5 | 1,382 · PRR 723.5 | Not in label — unassessed / Not in label — unassessed |
| Facet joint syndrome | 742 · PRR 32.3 | 1,214 · PRR 981.1 | Not in label — unassessed / Not in label — unassessed |
| Deep vein thrombosis postoperative | 797 · PRR 72.3 | 870 · PRR 1,251.9 | Not in label — unassessed / Not in label — unassessed |
| Peripheral venous disease | 702 · PRR 22.4 | 957 · PRR 491.8 | Not in label — unassessed / Not in label — unassessed |
| Adjustment disorder with depressed mood | 689 · PRR 54.7 | 625 · PRR 702.4 | Not in label — unassessed / Not in label — unassessed |
| Dislocation of vertebra | 619 · PRR 40.5 | 664 · PRR 664.8 | Not in label — unassessed / Not in label — unassessed |
| Lupus vulgaris | 431 · PRR 59.8 | 523 · PRR 1,230.5 | Not in label — unassessed / Not in label — unassessed |
| Retinitis | 335 · PRR 26.4 | 362 · PRR 431.8 | Not in label — unassessed / Not in label — unassessed |
| Porphyria acute | 208 · PRR 18.6 | 242 · PRR 331.1 | Not in label — unassessed / Not in label — unassessed |
| Seronegative arthritis | 160 · PRR 17.4 | 220 · PRR 380.0 | Likely indication confounding / Likely indication confounding |
Labeled signals distinctive to Ibuprofen 200
- None stood out among the strongest labeled signals.
Labeled signals distinctive to Naproxen 220Mg
- None stood out among the strongest labeled signals.
Common questions
Which has more reported side effects, Ibuprofen 200 or Naproxen 220Mg?
Ibuprofen 200 has 198,333 FAERS reports and Naproxen 220Mg 13,479. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (73% vs 77%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Ibuprofen 200 and Naproxen 220Mg share?
Both drugs carry disproportionality signals for pemphigus, hand deformity, duodenal ulcer perforation, folliculitis, helicobacter infection. Shared signals often reflect a shared drug class or the condition both are used for.
Is Ibuprofen 200 or Naproxen 220Mg safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.