Reaction

Rheumatic Fever reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,312 reports · 202 co-occurring drugs

As of the last recalculation, Rheumatic Fever appears in 4,312 FAERS reports alongside 202 co-occurring drug terms. The strongest observed disproportionality signal is DESOXIMETASONE (PRR 2,794.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Desoximetasone	3,101	2,794.8	3,341.7
Pseudoephedrine Hydrochloride	2,299	2,312.4	2,983.7
Pseudoephedrine Hcl	2,310	2,178.5	2,760.4
Cortisone Acetate	2,431	2,177.6	2,715.1
Diclofenac Potassium, Film Coated	1,761	1,706.8	2,161.5
Diclofenac Potassium Tablets	1,761	1,705.5	2,159.6
Diclofenac Potassium	1,761	1,329.0	1,589.3
Diclofenac Sodium 1%	2,767	1,041.7	1,129.6
Diclofenac Sodium Topical	2,767	1,041.6	1,129.6
Diclofenac Sodium Topical Gel, 1%	2,767	1,039.6	1,127.2
Cetirizine Hydrochloride Allergy	2,557	999.9	1,092.6
Cetirizine Hydrochloride Tablets	2,557	999.8	1,092.4
Tofacitinib Citrate	1,627	961.4	1,098.4
Diclofenac	3,282	766.7	797.3
Naproxen Sodium Tablet, Coated	1,382	724.5	807.3
Naproxen Sodium, Coated Tablets	1,382	724.5	807.3
Naproxen Sodium 220Mg	1,382	723.5	806.1
Cetirizine	3,085	671.9	699.8
Sulfasalazine	3,055	644.1	670.4
Tocilizumab	3,320	607.2	625.5
Leflunomide	3,226	587.9	606.7
Alendronate Sodium	3,184	579.4	598.3
Golimumab	3,014	561.2	581.8
Adalimumab-Adaz	2,392	490.1	513.5
Chlorhexidine Gluconate	742	473.2	515.2
Diclofenac Sodium	3,334	468.1	478.8
Adalimumab-Fkjp	2,134	439.3	460.6
Adalimumab-Aaty	2,133	429.5	449.9
Sarilumab	1,503	421.1	446.6
Acetaminophen And Codeine	822	402.2	431.4
Certolizumab Pegol	2,988	398.6	409.0
Calcium Gluconate	706	338.0	359.1
Abatacept	2,990	337.7	345.1
Cetirizine Hydrochloride	3,089	316.3	322.4
Hydrocortisone Sodium Succinate	533	312.1	331.0
Hydroxychloroquine	2,186	285.6	294.3
Hydroxychloroquine Sulfate	2,381	280.5	288.0
Rituximab	3,199	280.1	284.4
Ustekinumab	2,495	277.9	284.8
Hydrocortisone Acetate	2,024	252.4	259.7
Cetiirizine	1,422	241.3	249.7
Tofacitinib	2,897	228.9	232.6
Botulinum Toxin Type A	512	225.7	235.5
Infliximab	3,038	224.9	228.1
Isopropyl Alcohol	1,131	218.6	226.2
Quetiapine Fumarate	999	212.4	219.8
Folic Acid	3,085	207.4	210.0
Antacid	1,377	205.1	211.2
Triamcinolone Acetonide Ointment Usp, 0.05%	776	194.9	201.6
Calcium Carbonate	1,664	194.1	199.0
Alcohol	1,130	190.1	195.8
Secukinumab	2,562	187.4	190.4
Minocycline	398	181.4	187.9
Hydrocortisone	1,890	181.2	185.1
Tramadol Hydrochloride	1,035	174.3	179.3
Doxyclycline Hyclate	520	167.5	172.8
Anti-Itch	1,490	163.4	167.1
Anti-Pruritic	1,490	163.4	167.1
Antipruritic (Anti-Itch)	1,490	163.4	167.1
Cool Relief Gel With Aloe	1,490	163.4	167.1
Drs. Hydrocortisone	1,490	163.4	167.1
Hydrocortisone Continuous Spray	1,490	163.4	167.1
Hydrocortisone Spray	1,490	163.4	167.1
Anti-Itch Cream	1,490	163.4	167.1
Hydrocortisone Lotion	1,490	163.4	167.1
Hydrocortisone Cream 1%	1,490	163.3	167.0
Hydrocortisone Cream 1/2%	1,490	163.3	167.0
Hydrocortisone 1%	1,490	163.2	166.9
Hydrocortisone Cream	1,490	162.6	166.2
Triamcinolone Acetonide	776	147.6	151.4
Apremilast	2,152	140.7	142.8
Methotrexate Sodium	3,282	133.3	134.2
Naproxen Sodium	2,066	133.1	135.0
Pain Reliever	2,686	133.1	134.5
Acetaminophen Tablet Extended Release	2,684	132.9	134.3
Acetaminophen 500Mg	2,684	132.8	134.2
Methylprednisolone Sodium Succinate	984	132.3	135.1
Methotrexate	3,138	129.5	130.5
Risedronate Sodium	685	126.3	129.1
Vitamin C	1,519	122.7	124.7
Aprepitant	410	118.4	121.0
Celecoxib	1,848	117.8	119.5
Diltiazem Hydrochloride Extended-Release Tablets	246	110.6	113.1
Pantoprazole Sodium In 0.9% Sodium Chloride	1,036	105.9	107.7
Pantoprazole Sodium Injection	1,036	105.8	107.6
Doxycycline Hyclate	1,095	104.6	106.3
Prednisone	3,108	104.3	104.9
Doxycycline	1,095	103.5	105.2
Ramipril	1,599	98.5	99.7
Tretinoin	157	96.9	98.8
Fosaprepitant Dimeglumine	259	96.7	98.5
Thiamine Hydrochloride	233	95.5	97.3
Naproxen	1,143	95.2	96.6
Oxycodone	1,971	92.9	93.9
Oxycodone And Acetaminophen Tablets	217	92.5	94.2
Candesartan	580	90.5	92.0
Diphenhydramine Hydrochloride Capsule, Liquid Filled	353	86.8	88.2
Acetaminophen	2,807	84.8	85.4
Adalimumab	3,220	83.8	84.2
Atomoxetine Hydrochloride	346	76.2	77.3
Ascorbic Acid	331	74.3	75.4
Erenumab-Aooe	694	72.3	73.2
Etanercept	2,908	69.9	70.3
Mycophenolate Mofetil Hydrochloride	1,286	64.6	65.2
Mycophenolate Mofetil	1,269	63.5	64.1
Mirabegron	440	61.0	61.7
Azathioprine	871	59.5	60.1
Erythromycin	219	59.3	60.0
Mepolizumab	521	57.4	58.0
Pantoprazole	1,780	57.1	57.5
Moxifloxacin Hydrochloride	223	55.9	56.5
Magnesium	766	54.5	55.0
Meloxicam	557	53.0	53.5
Quetiapine	1,417	52.4	52.8
Moxifloxacin	146	51.7	52.3
Oxycodone And Acetaminophen	218	47.5	47.9
Pantoprazole Sodium	1,039	44.2	44.5
Methylprednisolone Acetate	72	44.1	44.5
Trimethoprim	104	43.6	44.0
Methylprednisolone	965	43.1	43.4
Ibuprofen Capsule	1,258	42.6	42.8
Ibuprofen Tablet, Film Coated	1,258	42.6	42.8
Ibupfrofen	1,258	42.6	42.8
Ibuprofen Tablets Usp, 200Mg	1,258	42.6	42.8
Ibuprofen Oral	1,258	42.6	42.8
Ibuprofen Capsules 200 Mg	1,258	42.5	42.8
Ibuprofen 200 Mg	1,258	42.5	42.8
Ibuprofen 200Mg	1,258	42.5	42.8
Alendronate Sodium Tablet	145	39.0	39.3
Ergocalciferol	1,815	38.6	38.8
Calcium	919	37.7	37.9
Diltiazem Hydrochloride	246	36.3	36.6
Ibuprofen	1,329	33.7	33.9
Fish Oil	532	32.3	32.4
Lansoprazole	927	31.7	31.9
Lorazepam	933	31.7	31.9
Sulfamethoxazole And Trimethoprim	489	31.4	31.6
Buprenorphine	523	30.9	31.1
Indomethacin	83	30.8	31.0
Topiramate	524	30.8	30.9
Cyanocobalamin	200	30.7	30.9
Mesalamine	306	28.2	28.4
Pregabalin	1,154	27.6	27.7
Lisinopril	1,150	24.4	24.5
Vedolizumab	393	24.1	24.2
Levothyroxine Sodium Anhydrous	450	24.1	24.2
Ranitidine Hydrochloride	242	22.7	22.8
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	617	21.6	21.6
Lamotrigine	509	21.0	21.1
Fluticasone Furoate	51	20.6	20.6
Prednisolone	652	20.4	20.4
Prednisolone Oral	652	20.4	20.4
Prednisolone Oral Solution	652	20.4	20.4
Oxycodone Hydrochloride	760	20.3	20.4
Cyclobenzaprine Hydrochloride	37	20.0	20.1
Zinc	100	20.0	20.1
Zinc Chloride	100	19.9	20.0
Zinc Gluconate	100	18.9	18.9
Icosapent Ethyl	33	18.8	18.9
Morphine	265	18.2	18.3
Cyclobenzaprine	175	17.6	17.7
Fluticasone Propionate Nasal	104	16.9	17.0
Magnesium Hydroxide	42	15.2	15.2
Oxycodone Hydrochloride And Acetaminophen	286	14.9	14.9
Diphenhydramine Hydrochloride	458	14.8	14.8
Lamotirigine	195	13.7	13.7
Lamotrigine Extended-Release	195	13.7	13.7
Lamotrigine Chewable Dispersible	195	13.7	13.7
Candesartan Cilexetil	67	12.5	12.5
Anakinra	41	12.0	12.1
Metformin Hydrochloride Tablets	138	12.0	12.0
Metformin Hydrochloride Extended-Release Tablets	138	12.0	12.0
Metformin Hydrochloride Tablet	138	12.0	12.0
Dexamethasone Sodium Phosphate	25	11.9	12.0
Metformin Hydrochloride	139	11.7	11.7
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	63	10.2	10.2
Trazodone Hydrochloride	32	9.9	10.0
Morphine Sulfate	232	9.7	9.7
Telmisartan	35	9.5	9.6
Ibuprofen Sodium	83	9.5	9.5
Ibuprofen Tablets, Coated	82	9.5	9.5
Salicylic Acid	94	8.7	8.8
Diphenhydramine	108	8.4	8.4
Levothyroxine Sodium	473	8.0	8.0
Albuterol	180	7.5	7.5
Bupropion	65	7.1	7.1
Hydromorphone Hydrochloride	128	6.9	6.9
Ranitidine	267	6.8	6.9
Dexamethasone 1.5 Mg	375	6.7	6.7
Dexamethasone	375	6.6	6.6
Upadacitinib	103	6.2	6.2
Fluticasone Propionate	152	5.8	5.8
Bupivacaine	10	5.2	5.2
Meperidine Hydrochloride	9	4.7	4.7
Bupropion Hydrochloride	83	4.1	4.1
Paroxetine Hydrochloride Hemihydrate	28	4.1	4.1
Paroxetine	28	4.0	4.0
Leucovorin Calcium	15	3.8	3.8
Albuterol Sulfate	223	3.8	3.8
Prednisolone Acetate	8	3.7	3.7
Metformin	223	3.1	3.1
Onabotulinumtoxina	46	2.9	2.9

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.