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Facet Joint Syndrome reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,112 reports · 222 co-occurring drugs

As of the last recalculation, Facet Joint Syndrome appears in 3,112 FAERS reports alongside 222 co-occurring drug terms. The strongest observed disproportionality signal is DICLOFENAC POTASSIUM, FILM COATED (PRR 1,748.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Diclofenac Potassium, Film Coated	1,289	1,748.2	2,066.4
Diclofenac Potassium Tablets	1,289	1,746.9	2,064.7
Desoximetasone	1,760	1,420.8	1,566.2
Diclofenac Potassium	1,289	1,361.2	1,546.7
Cortisone Acetate	1,354	1,297.7	1,458.5
Pseudoephedrine Hydrochloride	1,068	1,057.9	1,181.3
Pseudoephedrine Hcl	1,068	986.5	1,093.0
Naproxen Sodium Tablet, Coated	1,214	982.5	1,079.8
Naproxen Sodium, Coated Tablets	1,214	982.5	1,079.8
Naproxen Sodium 220Mg	1,214	981.1	1,078.1
Chlorhexidine Gluconate	773	752.5	822.4
Diclofenac Sodium 1%	1,628	638.1	668.7
Diclofenac Sodium Topical	1,628	638.1	668.7
Diclofenac Sodium Topical Gel, 1%	1,628	636.8	667.3
Tofacitinib Citrate	830	577.1	616.2
Acetaminophen And Codeine	779	570.1	609.2
Adalimumab-Adaz	1,757	510.1	527.8
Botulinum Toxin Type A	685	472.9	500.6
Cetirizine Hydrochloride Allergy	1,253	462.6	482.6
Cetirizine Hydrochloride Tablets	1,253	462.5	482.5
Diclofenac	1,966	412.8	422.5
Adalimumab-Fkjp	1,478	405.5	419.0
Adalimumab-Aaty	1,478	396.9	409.7
Cetirizine	1,804	368.6	377.4
Alendronate Sodium	1,998	368.1	375.6
Leflunomide	2,008	360.0	367.0
Sulfasalazine	1,686	313.3	320.3
Tocilizumab	1,954	306.1	311.5
Sarilumab	867	303.9	314.3
Hydrocortisone Sodium Succinate	367	295.9	307.9
Triamcinolone Acetonide Ointment Usp, 0.05%	734	274.1	283.0
Cetiirizine	1,090	264.4	271.4
Golimumab	1,618	261.8	266.8
Diclofenac Sodium	2,037	260.2	263.8
Minocycline	378	246.7	255.0
Candesartan	869	225.7	231.3
Hydroxychloroquine	1,391	224.5	228.8
Secukinumab	1,958	217.2	219.8
Certolizumab Pegol	1,708	214.8	218.0
Tramadol Hydrochloride	868	213.5	218.5
Triamcinolone Acetonide	734	207.6	212.7
Isopropyl Alcohol	754	196.6	201.1
Calcium Gluconate	316	195.1	200.4
Calcium Carbonate	1,167	185.3	188.6
Aprepitant	432	181.6	185.9
Antacid	909	180.4	183.9
Hydrocortisone Acetate	1,205	180.3	183.4
Cetirizine Hydrochloride	1,826	177.8	179.8
Rituximab	2,003	176.0	177.7
Abatacept	1,671	173.1	175.2
Alcohol	753	170.9	174.2
Atomoxetine Hydrochloride	503	168.4	172.1
Naproxen Sodium	1,649	163.1	165.0
Ustekinumab	1,380	161.2	163.4
Doxyclycline Hyclate	359	159.3	162.7
Methylprednisolone Acetate	175	154.8	158.3
Hydrocortisone	1,230	151.7	153.9
Hydroxychloroquine Sulfate	1,242	151.1	153.2
Anti-Itch	1,018	150.4	152.8
Anti-Pruritic	1,018	150.4	152.8
Antipruritic (Anti-Itch)	1,018	150.4	152.8
Cool Relief Gel With Aloe	1,018	150.4	152.8
Drs. Hydrocortisone	1,018	150.4	152.8
Hydrocortisone Continuous Spray	1,018	150.4	152.8
Hydrocortisone Spray	1,018	150.4	152.8
Anti-Itch Cream	1,018	150.4	152.8
Hydrocortisone Lotion	1,018	150.4	152.7
Hydrocortisone Cream 1%	1,018	150.4	152.7
Hydrocortisone Cream 1/2%	1,018	150.4	152.7
Hydrocortisone 1%	1,018	150.3	152.6
Hydrocortisone Cream	1,018	149.7	152.0
Celecoxib	1,517	149.4	151.2
Erenumab-Aooe	863	144.6	146.9
Quetiapine Fumarate	517	140.3	142.8
Mirabegron	635	137.7	139.9
Methylprednisolone Sodium Succinate	703	130.5	132.6
Fosaprepitant Dimeglumine	244	128.7	131.0
Naproxen	1,009	126.7	128.3
Mepolizumab	723	126.5	128.3
Oxycodone	1,653	125.0	126.1
Infliximab	1,773	124.9	125.9
Folic Acid	1,834	118.4	119.2
Tretinoin	136	117.1	119.1
Vitamin C	1,046	114.2	115.5
Tofacitinib	1,570	113.9	114.8
Apremilast	1,377	112.1	113.2
Risedronate Sodium	411	101.7	103.1
Pantoprazole Sodium In 0.9% Sodium Chloride	720	100.8	101.9
Pantoprazole Sodium Injection	720	100.7	101.9
Oxycodone And Acetaminophen Tablets	162	95.8	97.2
Diltiazem Hydrochloride Extended-Release Tablets	152	93.9	95.1
Doxycycline Hyclate	710	90.9	91.8
Doxycycline	710	89.9	90.8
Acetaminophen Tablet Extended Release	1,632	88.9	89.4
Pain Reliever	1,632	88.8	89.4
Acetaminophen 500Mg	1,632	88.8	89.4
Ramipril	1,077	88.4	89.2
Ascorbic Acid	278	87.7	88.7
Thiamine Hydrochloride	137	77.0	77.8
Moxifloxacin Hydrochloride	213	75.4	76.2
Moxifloxacin	148	73.7	74.5
Trimethoprim	122	72.0	72.8
Methotrexate	1,856	71.6	71.9
Methotrexate Sodium	1,964	71.6	71.9
Buprenorphine	689	63.7	64.2
Azathioprine	644	61.4	61.8
Cyanocobalamin	274	60.9	61.4
Erythromycin	155	58.1	58.6
Mycophenolate Mofetil Hydrochloride	847	56.8	57.2
Acetaminophen	1,725	56.6	56.8
Mycophenolate Mofetil	840	56.3	56.6
Topiramate	622	55.5	55.9
Prednisone	1,801	55.5	55.7
Diphenhydramine Hydrochloride Capsule, Liquid Filled	157	51.7	52.1
Methylprednisolone	793	51.2	51.4
Oxycodone And Acetaminophen	166	50.3	50.6
Lamotrigine	744	49.3	49.6
Pantoprazole	1,159	48.2	48.4
Adalimumab	1,918	45.6	45.8
Magnesium	472	45.1	45.3
Pantoprazole Sodium	743	43.7	43.9
Icosapent Ethyl	54	43.2	43.4
Fish Oil	475	41.3	41.5
Meloxicam	315	40.2	40.5
Indomethacin	76	39.3	39.5
Etanercept	1,651	38.2	38.3
Lorazepam	740	35.8	36.0
Ranitidine Hydrochloride	258	34.5	34.7
Lansoprazole	709	34.2	34.3
Diltiazem Hydrochloride	166	33.8	34.0
Cyclobenzaprine	226	32.6	32.7
Magnesium Hydroxide	64	32.4	32.6
Ibuprofen Capsule	742	32.4	32.5
Ibuprofen Tablet, Film Coated	742	32.4	32.5
Ibupfrofen	742	32.4	32.5
Ibuprofen Tablets Usp, 200Mg	742	32.4	32.5
Ibuprofen Oral	742	32.3	32.5
Sulfamethoxazole And Trimethoprim	362	32.3	32.5
Ibuprofen Capsules 200 Mg	742	32.3	32.5
Ibuprofen 200 Mg	742	32.3	32.5
Ibuprofen 200Mg	742	32.3	32.4
Quetiapine	696	30.8	31.0
Alendronate Sodium Tablet	81	30.0	30.1
Ergocalciferol	1,123	30.0	30.1
Ibuprofen	827	27.4	27.5
Calcium	503	26.8	26.9
Lamotirigine	257	26.1	26.2
Lamotrigine Extended-Release	257	26.1	26.2
Lamotrigine Chewable Dispersible	257	26.1	26.2
Pregabalin	798	26.0	26.1
Metformin Hydrochloride Tablets	199	24.7	24.8
Metformin Hydrochloride Extended-Release Tablets	199	24.7	24.8
Metformin Hydrochloride Tablet	199	24.7	24.8
Zinc	88	24.5	24.6
Zinc Chloride	88	24.4	24.4
Cyclobenzaprine Hydrochloride	32	24.1	24.1
Metformin Hydrochloride	199	24.0	24.0
Zinc Gluconate	89	23.4	23.5
Mesalamine	184	23.2	23.3
Fluticasone Furoate	40	22.4	22.4
Morphine	231	22.3	22.4
Oxycodone Hydrochloride	566	21.1	21.1
Fluticasone Propionate Nasal	90	20.4	20.5
Prednisolone	467	20.2	20.2
Prednisolone Oral	467	20.2	20.2
Prednisolone Oral Solution	467	20.2	20.2
Oxycodone Hydrochloride And Acetaminophen	272	20.1	20.1
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	76	17.2	17.2
Lisinopril	634	17.1	17.2
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	360	16.9	16.9
Vedolizumab	200	16.5	16.6
Candesartan Cilexetil	63	16.3	16.4
Dexamethasone Sodium Phosphate	24	15.9	16.0
Levothyroxine Sodium Anhydrous	217	15.5	15.5
Ibuprofen Sodium	87	13.9	14.0
Ibuprofen Tablets, Coated	86	13.9	13.9
Ranitidine	367	13.9	13.9
Hydromorphone Hydrochloride	156	11.9	11.9
Fluticasone Propionate	211	11.6	11.6
Diphenhydramine Hydrochloride	263	11.5	11.5
Diphenhydramine	99	10.8	10.8
Trazodone Hydrochloride	23	9.9	9.9
Albuterol	158	9.2	9.2
Anakinra	22	8.9	8.9
Leucovorin Calcium	23	8.1	8.1
Bupivacaine	11	7.9	7.9
Cimetidine	11	7.7	7.7
Doxepin	11	7.3	7.3
Meperidine Hydrochloride	10	7.3	7.3
Doxepin Hydrochloride	13	6.9	6.9
Esomeprazole Magnesium Capsule, Delayed Release	14	6.5	6.5
Esomeprazole Magnesium Delayed Release Capsules	14	6.5	6.5
Esomeprazole Magnesium Dihydrate	14	6.4	6.5
Levothyroxine Sodium	273	6.3	6.3
Docusate Sodium - Sennosides	29	6.1	6.1
Infliximab-Dyyb	26	6.0	6.0
Amitriptyline Hydrochloride	15	5.7	5.7
Albuterol Sulfate	227	5.4	5.4
Psyllium Husk	8	5.4	5.4
Dexamethasone 1.5 Mg	219	5.3	5.3
Dexamethasone	219	5.2	5.2
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Disoproxil Fumarate	7	5.2	5.2
Metformin	257	5.2	5.2
Methocarbamol	17	5.0	5.0
Exemestane	16	5.0	5.0
Fulvestrant	24	4.9	4.9
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	13	4.8	4.8
Isosorbide Dinitrate	13	4.5	4.5
Acetaminophen, Chlorpheniramine Maleate, Phenylephrine Hcl	33	4.4	4.5
Morphine Sulfate	67	3.8	3.8
Dexlansoprazole	22	3.5	3.5
Emtricitabine And Tenofovir Alafenamide	6	3.5	3.5
Thalidomide	19	3.5	3.5
Loratadine And Pseudoephedrine Sulfate	4	3.4	3.4
Elvitegravir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide	5	3.3	3.3
Onabotulinumtoxina	37	3.2	3.2
Upadacitinib	39	3.2	3.2
Emtricitabine And Tenofovir Disoproxil Fumarate	19	2.8	2.8
Asfotase Alfa	4	2.7	2.7
Travoprost	3	2.3	2.3
Tenofovir Disoproxil Fumarate	10	2.0	2.0
Salicylic Acid	14	1.8	1.8

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.