Infliximab vs Secukinumab: side effects in FDA adverse event reports
At a glance
| Infliximab | Secukinumab | |
|---|---|---|
| Drug class | Tumor Necrosis Factor Blocker | Interleukin-17A Antagonist |
| Brand names | Renflexis | Cosentyx |
| FAERS reports | 217,056 | 160,389 |
| Serious | 89% | 40% |
| Death outcome | 13,761 | 8,611 |
| Boxed warning | Yes SERIOUS INFECTIONS and MALIGNANCY WARNING: SERIOUS INFECTIONS and MALIGNANCY See full prescribing information for complete boxed warning. Increased risk of seri | No |
Signals both drugs share
| Reaction | Infliximab | Secukinumab | Label screen (A / B) |
|---|---|---|---|
| Rheumatic fever | 3,038 · PRR 224.9 | 2,562 · PRR 187.4 | Labeled (related wording) / Not in label — unassessed |
| Swollen joint count | 135 · PRR 117.9 | 132 · PRR 152.2 | Labeled (related wording) / Not in label — unassessed |
| Synovitis | 9,005 · PRR 96.4 | 4,134 · PRR 38.7 | Not in label — unassessed / Not in label — unassessed |
| Pemphigus | 8,799 · PRR 239.1 | 3,846 · PRR 58.4 | Not in label — unassessed / Not in label — unassessed |
| Hand deformity | 7,477 · PRR 129.7 | 3,628 · PRR 50.0 | Not in label — unassessed / Not in label — unassessed |
| Helicobacter infection | 4,856 · PRR 88.0 | 3,048 · PRR 55.6 | Not in label — unassessed / Not in label — unassessed |
| Duodenal ulcer perforation | 4,679 · PRR 171.9 | 3,024 · PRR 91.7 | Not in label — unassessed / Not in label — unassessed |
| Folliculitis | 4,112 · PRR 63.8 | 3,017 · PRR 53.8 | Not in label — unassessed / Not in label — unassessed |
| Muscle injury | 3,385 · PRR 67.7 | 2,384 · PRR 53.4 | Not in label — unassessed / Not in label — unassessed |
| Facet joint syndrome | 1,773 · PRR 124.9 | 1,958 · PRR 217.2 | Not in label — unassessed / Not in label — unassessed |
| Deep vein thrombosis postoperative | 1,228 · PRR 163.6 | 1,207 · PRR 211.9 | Not in label — unassessed / Not in label — unassessed |
| Dislocation of vertebra | 1,023 · PRR 82.3 | 1,022 · PRR 111.4 | Not in label — unassessed / Not in label — unassessed |
| Bone erosion | 1,235 · PRR 51.5 | 806 · PRR 38.3 | Not in label — unassessed / Not in label — unassessed |
| Adjustment disorder with depressed mood | 964 · PRR 88.6 | 943 · PRR 115.3 | Not in label — unassessed / Not in label — unassessed |
| Lupus vulgaris | 713 · PRR 145.6 | 726 · PRR 207.0 | Not in label — unassessed / Not in label — unassessed |
| Retinitis | 660 · PRR 63.0 | 675 · PRR 88.8 | Not in label — unassessed / Not in label — unassessed |
| Subcutaneous drug absorption impaired | 219 · PRR 64.8 | 244 · PRR 106.2 | Not in label — unassessed / Not in label — unassessed |
| Grip strength | 136 · PRR 137.9 | 147 · PRR 229.4 | Not in label — unassessed / Not in label — unassessed |
Labeled signals distinctive to Infliximab
- Lupus-like syndrome — n=3,336, PRR 56.5 Labeled adverse reaction
- Hepatosplenic t-cell lymphoma — n=184, PRR 94.3 Labeled — boxed warning
Labeled signals distinctive to Secukinumab
- None stood out among the strongest labeled signals.
Common questions
Which has more reported side effects, Infliximab or Secukinumab?
Infliximab has 217,056 FAERS reports and Secukinumab 160,389. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (89% vs 40%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Infliximab and Secukinumab share?
Both drugs carry disproportionality signals for rheumatic fever, swollen joint count, synovitis, pemphigus, hand deformity. Shared signals often reflect a shared drug class or the condition both are used for.
Is Infliximab or Secukinumab safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.