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Which drugs are most reported with Lupus-like syndrome?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 8,902 reports · 235 co-occurring drugs

As of the last recalculation, Lupus-Like Syndrome appears in 8,902 FAERS reports alongside 235 co-occurring drug terms. The strongest observed disproportionality signal is DICLOFENAC POTASSIUM, FILM COATED (PRR 172.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Diclofenac Potassium, Film Coated	579	172.0	184.7
Diclofenac Potassium Tablets	579	171.9	184.6
Diclofenac Potassium	579	133.9	141.5
Pseudoephedrine Hydrochloride	462	110.8	116.0
Pseudoephedrine Hcl	466	104.3	108.9
Cortisone Acetate	485	97.1	101.0
Desoximetasone	648	85.7	88.7
Tofacitinib Citrate	409	76.4	78.8
Naproxen Sodium Tablet, Coated	386	69.6	71.7
Naproxen Sodium, Coated Tablets	386	69.6	71.7
Naproxen Sodium 220Mg	386	69.5	71.5
Hydrocortisone Sodium Succinate	261	66.8	68.7
Infliximab	3,336	56.5	57.4
Chlorhexidine Gluconate	202	52.9	54.0
Adalimumab-Fkjp	901	50.5	51.5
Adalimumab-Aaty	900	49.3	50.3
Adalimumab-Adaz	981	48.7	49.6
Diclofenac Sodium 1%	651	45.9	46.7
Diclofenac Sodium Topical	651	45.9	46.7
Cetirizine Hydrochloride Allergy	557	45.8	46.7
Cetirizine Hydrochloride Tablets	557	45.8	46.6
Diclofenac Sodium Topical Gel, 1%	651	45.8	46.6
Doxyclycline Hyclate	319	45.4	46.2
Minocycline	202	41.4	42.1
Diltiazem Hydrochloride Extended-Release Tablets	179	37.5	38.1
Acetaminophen And Codeine	190	37.2	37.8
Calcium Gluconate	172	34.0	34.5
Sarilumab	363	33.5	33.9
Quetiapine Fumarate	390	32.3	32.7
Fosaprepitant Dimeglumine	162	28.0	28.4
Diphenhydramine Hydrochloride Capsule, Liquid Filled	242	27.2	27.5
Triamcinolone Acetonide Ointment Usp, 0.05%	264	27.1	27.4
Aprepitant	207	26.8	27.1
Sulfasalazine	806	26.4	26.7
Isopropyl Alcohol	344	24.7	25.0
Diclofenac	763	22.6	22.8
Cetirizine	678	22.0	22.2
Hydroxychloroquine	641	21.6	21.7
Alcohol	341	21.3	21.5
Golimumab	718	21.2	21.4
Azathioprine	735	21.2	21.3
Triamcinolone Acetonide	264	20.6	20.7
Leflunomide	791	19.3	19.4
Hydroxychloroquine Sulfate	694	19.2	19.4
Ustekinumab	767	19.1	19.2
Antacid	372	19.1	19.2
Cetiirizine	328	18.8	18.9
Methylprednisolone Sodium Succinate	354	18.5	18.7
Tocilizumab	809	18.1	18.3
Oxycodone And Acetaminophen Tablets	90	17.8	18.0
Alendronate Sodium	711	17.8	17.9
Mesalamine	408	17.8	17.9
Calcium Carbonate	469	17.2	17.3
Doxycycline Hyclate	465	16.9	17.1
Certolizumab Pegol	777	16.9	17.0
Doxycycline	465	16.8	16.9
Tramadol Hydrochloride	251	16.0	16.1
Botulinum Toxin Type A	83	15.8	15.9
Hydrocortisone Acetate	453	15.3	15.4
Erythromycin	116	14.6	14.7
Pantoprazole Sodium In 0.9% Sodium Chloride	352	13.8	13.9
Pantoprazole Sodium Injection	352	13.8	13.9
Abatacept	749	13.7	13.8
Hydrocortisone	490	13.5	13.6
Diclofenac Sodium	788	13.3	13.4
Diltiazem Hydrochloride	185	12.7	12.8
Anti-Itch	345	12.5	12.5
Anti-Pruritic	345	12.5	12.5
Antipruritic (Anti-Itch)	345	12.5	12.5
Cool Relief Gel With Aloe	345	12.5	12.5
Drs. Hydrocortisone	345	12.5	12.5
Hydrocortisone Continuous Spray	345	12.5	12.5
Hydrocortisone Spray	345	12.5	12.5
Anti-Itch Cream	345	12.5	12.5
Hydrocortisone Lotion	345	12.5	12.5
Hydrocortisone Cream 1%	345	12.5	12.5
Hydrocortisone Cream 1/2%	345	12.5	12.5
Hydrocortisone 1%	345	12.5	12.5
Hydrocortisone Cream	346	12.5	12.5
Cetirizine Hydrochloride	717	11.0	11.0
Secukinumab	692	10.8	10.8
Adalimumab	2,426	10.6	10.7
Apremilast	609	10.4	10.4
Celecoxib	551	10.4	10.4
Tofacitinib	744	10.2	10.2
Vitamin C	376	9.9	10.0
Ascorbic Acid	96	9.7	9.8
Bupropion	179	9.6	9.6
Risedronate Sodium	123	9.4	9.4
Oxycodone And Acetaminophen	91	9.2	9.2
Vedolizumab	328	9.2	9.2
Folic Acid	877	9.0	9.0
Rituximab	725	8.6	8.7
Mycophenolate Mofetil Hydrochloride	469	8.5	8.5
Methotrexate	1,308	8.3	8.4
Naproxen Sodium	484	8.3	8.3
Mycophenolate Mofetil	458	8.3	8.3
Meloxicam	201	8.3	8.3
Terbinafine Hydrochloride	31	8.2	8.2
Moxifloxacin Hydrochloride	70	8.1	8.2
Ramipril	407	8.0	8.0
Methotrexate Sodium	1,389	7.7	7.8
Thiamine Hydrochloride	41	7.7	7.8
Trimethoprim	37	7.4	7.4
Atomoxetine Hydrochloride	74	7.3	7.3
Indomethacin	41	7.3	7.3
Candesartan	105	7.0	7.0
Infliximab-Dyyb	83	6.7	6.7
Moxifloxacin	40	6.7	6.7
Quetiapine	520	6.6	6.7
Prednisone	1,232	6.5	6.5
Methylprednisolone	368	6.5	6.5
Morphine	196	6.3	6.3
Daspone	26	6.3	6.3
Dapsone Gel, 5%	26	6.3	6.3
Diphenhydramine Hydrochloride	424	6.2	6.2
Pantoprazole Sodium	377	6.2	6.2
Erenumab-Aooe	142	6.1	6.1
Tretinoin	21	6.1	6.1
Pantoprazole	614	6.0	6.0
Alendronate Sodium Tablet	47	6.0	6.0
Magnesium	200	5.8	5.8
Isoniazid	40	5.8	5.8
Naproxen	191	5.8	5.8
Dapsone	26	5.7	5.7
Calcium	350	5.7	5.7
Mercaptopurine	42	5.7	5.7
Morphine Sulfate	286	5.7	5.7
Oxycodone	423	5.5	5.5
Acetaminophen 500Mg	564	5.4	5.5
Acetaminophen Tablet Extended Release	563	5.4	5.5
Pain Reliever	563	5.4	5.4
Cyanocobalamin	73	5.2	5.2
Mirabegron	82	5.0	5.0
Icosapent Ethyl	18	5.0	5.0
Bupropion Hydrochloride	205	4.9	5.0
Etanercept	1,108	4.8	4.8
Lansoprazole	349	4.7	4.7
Hydromorphone Hydrochloride	183	4.7	4.7
Lorazepam	343	4.6	4.6
Thiamine Hydrochloride, Riboflavin 5 Phosphate Sodium, Dexpanthenol And Niacinamide	59	4.6	4.6
Methimazole	15	4.5	4.5
Diphenhydramine	118	4.4	4.4
Rifampicin	19	4.4	4.4
Ibuprofen 200 Mg	351	4.2	4.2
Salicylic Acid	95	4.2	4.2
Ibuprofen Capsule	350	4.2	4.2
Ibuprofen Tablet, Film Coated	350	4.2	4.2
Ibupfrofen	350	4.2	4.2
Ibuprofen Tablets Usp, 200Mg	350	4.2	4.2
Ibuprofen Oral	350	4.2	4.2
Ibuprofen Capsules 200 Mg	350	4.2	4.2
Ibuprofen 200Mg	350	4.2	4.2
Cyclobenzaprine Hydrochloride	16	4.2	4.2
Fexofenadine	29	4.1	4.1
Fluticasone Furoate	21	4.1	4.1
Rifampin	25	4.0	4.0
Pregabalin	446	4.0	4.0
Ergocalciferol	606	3.9	3.9
Acetaminophen	696	3.9	3.9
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	257	3.8	3.8
Oxycodone Hydrochloride And Acetaminophen	152	3.6	3.6
Ibuprofen	405	3.6	3.6
Topiramate	141	3.6	3.6
Lisinopril	449	3.6	3.6
Albuterol	180	3.6	3.6
Anakinra	25	3.5	3.5
Mepolizumab	74	3.5	3.5
Prednisolone	262	3.5	3.5
Prednisolone Oral	262	3.5	3.5
Prednisolone Oral Solution	262	3.5	3.5
Candesartan Cilexetil	38	3.4	3.4
Lamotirigine	102	3.4	3.4
Lamotrigine Extended-Release	102	3.4	3.4
Lamotrigine Chewable Dispersible	102	3.4	3.4
Cyclobenzaprine	71	3.3	3.3
Magnesium Hydroxide	19	3.3	3.3
Methylprednisolone Acetate	11	3.2	3.2
Voriconazole Injection	29	3.1	3.1
Sulfamethoxazole And Trimethoprim	111	3.1	3.1
Lamotrigine	172	3.1	3.1
Chlorthalidone	15	3.0	3.0
Ivacaftor	10	2.9	2.9
Levothyroxine Sodium Anhydrous	124	2.9	2.9
Ibuprofen Tablets, Coated	51	2.8	2.8
Ibuprofen Sodium	51	2.8	2.8
Fish Oil	105	2.7	2.7
Labetalol	15	2.6	2.6
Nifedipine	52	2.6	2.6
Ranitidine Hydrochloride	57	2.5	2.5
Human Immunoglobulin G	21	2.4	2.4
Upadacitinib	82	2.4	2.4
Oxycodone Hydrochloride	212	2.3	2.3
Amiodarone Hydrochloride	11	2.3	2.3
Anastrozole Tablets	21	2.3	2.3
Trazodone Hydrochloride	15	2.2	2.2
Pyrazinamide	9	2.2	2.2
Voriconazole	29	2.2	2.2
Colchicine	24	2.1	2.1
Telmisartan	16	2.1	2.1
Lisinopril And Hydrochlorothiazide	9	2.1	2.1
Amikacin	15	2.1	2.1
Phenytoin	18	2.0	2.0
Albuterol Sulfate	250	2.0	2.0
Dicyclomine Hydrochloride	12	2.0	2.0
Buprenorphine	77	2.0	2.0
Cholestyramine	10	1.9	1.9
Pemetrexed Disodium	31	1.9	1.9
Magnesium Sulfate Heptahydrate	10	1.8	1.8
Levothyroxine Sodium	235	1.8	1.8
Risankizumab-Rzaa	61	1.7	1.8
Iron Sucrose	7	1.7	1.7
Isosorbide Mononitrate	15	1.7	1.7
Anastrozole	26	1.7	1.7
Omeprazole	235	1.6	1.6
Ursosiol	13	1.6	1.6
Ursodiol	14	1.5	1.5
Levocetirizine Dihydrochloride	15	1.5	1.5
Modafinil	20	1.4	1.4
Omeprazole Magnesium	274	1.4	1.4
Pemetrexed	12	1.3	1.3
Brivaracetam	5	1.3	1.3
Clobazam	13	1.2	1.2
Interferon Beta-1B	10	1.2	1.2
Peginterferon Beta-1A	6	1.1	1.1
Rifaximin	8	0.9	0.9
Bimekizumab	8	0.9	0.9
Isotretinoin	17	0.8	0.8
Pembrolizumab	36	0.8	0.8
Elexacaftor, Tezacaftor, And Ivacaftor	4	0.7	0.7
Onabotulinumtoxina	18	0.5	0.5
Drospirenone And Ethinyl Estradiol	10	0.5	0.5
Ixekizumab	8	0.5	0.5
Hydrocodone Bitartrate	8	0.4	0.4
Guselkumab	6	0.4	0.4

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.