Secukinumab vs Golimumab: side effects in FDA adverse event reports
At a glance
| Secukinumab | Golimumab | |
|---|---|---|
| Drug class | Interleukin-17A Antagonist | Tumor Necrosis Factor Blocker |
| Brand names | Cosentyx | Simponi Aria |
| FAERS reports | 160,389 | 12,299 |
| Serious | 40% | 76% |
| Death outcome | 8,611 | 2,587 |
| Boxed warning | No | Yes SERIOUS INFECTIONS and MALIGNANCY WARNING: SERIOUS INFECTIONS and MALIGNANCY See full prescribing information for complete boxed warning. Serious infections lea |
Signals both drugs share
| Reaction | Secukinumab | Golimumab | Label screen (A / B) |
|---|---|---|---|
| Peripheral venous disease | 1,577 · PRR 85.3 | 1,317 · PRR 121.3 | Not in label — unassessed / Labeled (related wording) |
| Hepatic enzyme | 91 · PRR 247.8 | 91 · PRR 468.0 | Not in label — unassessed / Labeled (related wording) |
| Pemphigus | 3,846 · PRR 58.4 | 8,315 · PRR 508.1 | Not in label — unassessed / Not in label — unassessed |
| Synovitis | 4,134 · PRR 38.7 | 7,401 · PRR 171.8 | Not in label — unassessed / Not in label — unassessed |
| Hand deformity | 3,628 · PRR 50.0 | 7,128 · PRR 297.8 | Not in label — unassessed / Not in label — unassessed |
| Helicobacter infection | 3,048 · PRR 55.6 | 4,593 · PRR 203.0 | Not in label — unassessed / Not in label — unassessed |
| Duodenal ulcer perforation | 3,024 · PRR 91.7 | 4,452 · PRR 385.1 | Not in label — unassessed / Not in label — unassessed |
| Folliculitis | 3,017 · PRR 53.8 | 4,315 · PRR 177.4 | Not in label — unassessed / Not in label — unassessed |
| Muscle injury | 2,384 · PRR 53.4 | 3,841 · PRR 217.9 | Not in label — unassessed / Not in label — unassessed |
| Rheumatic fever | 2,562 · PRR 187.4 | 3,014 · PRR 561.2 | Not in label — unassessed / Likely indication confounding |
| Facet joint syndrome | 1,958 · PRR 217.2 | 1,618 · PRR 261.8 | Not in label — unassessed / Not in label — unassessed |
| Deep vein thrombosis postoperative | 1,207 · PRR 211.9 | 1,186 · PRR 382.2 | Not in label — unassessed / Not in label — unassessed |
| Dislocation of vertebra | 1,022 · PRR 111.4 | 981 · PRR 195.1 | Not in label — unassessed / Not in label — unassessed |
| Adjustment disorder with depressed mood | 943 · PRR 115.3 | 978 · PRR 233.6 | Not in label — unassessed / Not in label — unassessed |
| Bone erosion | 806 · PRR 38.3 | 1,080 · PRR 108.0 | Not in label — unassessed / Not in label — unassessed |
| Lupus vulgaris | 726 · PRR 207.0 | 743 · PRR 415.7 | Not in label — unassessed / Not in label — unassessed |
| Retinitis | 675 · PRR 88.8 | 617 · PRR 144.6 | Not in label — unassessed / Not in label — unassessed |
| Seronegative arthritis | 346 · PRR 58.1 | 393 · PRR 132.8 | Likely indication confounding / Likely indication confounding |
| Subcutaneous drug absorption impaired | 244 · PRR 106.2 | 212 · PRR 157.2 | Not in label — unassessed / Not in label — unassessed |
| Swollen joint count | 132 · PRR 152.2 | 130 · PRR 278.1 | Not in label — unassessed / Not in label — unassessed |
Labeled signals distinctive to Secukinumab
- None stood out among the strongest labeled signals.
Labeled signals distinctive to Golimumab
- Granuloma skin — n=288, PRR 131.3 Labeled (related wording)
- Malignant mediastinal neoplasm — n=56, PRR 265.4 Labeled (related wording)
Common questions
Which has more reported side effects, Secukinumab or Golimumab?
Secukinumab has 160,389 FAERS reports and Golimumab 12,299. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (40% vs 76%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Secukinumab and Golimumab share?
Both drugs carry disproportionality signals for peripheral venous disease, hepatic enzyme, pemphigus, synovitis, hand deformity. Shared signals often reflect a shared drug class or the condition both are used for.
Is Secukinumab or Golimumab safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.