OpenPV Signal Explorer
FAERS disproportionality dashboard
Reaction

Hepatic Enzyme reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 138 reports · 60 co-occurring drugs

As of the last recalculation, Hepatic Enzyme appears in 138 FAERS reports alongside 60 co-occurring drug terms. The strongest observed disproportionality signal is DICLOFENAC POTASSIUM, FILM COATED (PRR 3,214.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.
DrugCo-reportsPRRROR
Diclofenac Potassium, Film Coated783,214.23,244.4
Diclofenac Potassium Tablets783,211.93,242.0
Chlorhexidine Gluconate742,632.72,654.3
Diclofenac Potassium782,502.72,521.0
Pseudoephedrine Hydrochloride762,481.92,500.5
Pseudoephedrine Hcl762,314.42,330.6
Tofacitinib Citrate741,834.51,845.0
Naproxen Sodium Tablet, Coated711,627.81,636.5
Naproxen Sodium, Coated Tablets711,627.81,636.5
Naproxen Sodium 220Mg711,625.51,634.1
Botulinum Toxin Type A671,581.11,589.7
Desoximetasone711,156.61,160.9
Diclofenac Sodium 1%881,023.71,026.2
Diclofenac Sodium Topical881,023.61,026.2
Diclofenac Sodium Topical Gel, 1%881,021.71,024.2
Cetirizine Hydrochloride Allergy81975.2977.9
Cetirizine Hydrochloride Tablets81975.1977.7
Atomoxetine Hydrochloride66800.8803.0
Candesartan79779.9781.7
Triamcinolone Acetonide Ointment Usp, 0.05%64768.0770.1
Adalimumab-Adaz90737.7738.9
Tramadol Hydrochloride78717.5719.0
Acetaminophen And Codeine40696.9699.2
Cortisone Acetate40687.7690.0
Mirabegron74620.8622.0
Triamcinolone Acetonide64581.8583.0
Methylprednisolone Acetate25574.8576.6
Diclofenac96550.0550.6
Sulfasalazine93547.7548.4
Erenumab-Aooe79504.5505.2
Risedronate Sodium59499.4500.3
Mepolizumab73469.3470.0
Golimumab91468.0468.5
Quetiapine Fumarate55466.7467.5
Adalimumab-Fkjp68435.5436.2
Cetirizine85428.6429.1
Adalimumab-Aaty68426.2426.9
Methylprednisolone Sodium Succinate66410.1410.7
Naproxen81375.1375.5
Cyanocobalamin49347.3347.9
Certolizumab Pegol91341.9342.2
Calcium Gluconate22327.4328.0
Leflunomide85317.4317.7
Diclofenac Sodium96313.9314.1
Topiramate79297.7297.9
Tocilizumab85291.0291.2
Sarilumab35267.4267.8
Hydroxychloroquine Sulfate72248.1248.3
Secukinumab91247.8248.0
Abatacept83225.3225.4
Buprenorphine67211.3211.5
Hydrocortisone Sodium Succinate12210.8211.0
Isopropyl Alcohol32185.6185.8
Apremilast75168.1168.2
Alcohol32161.6161.7
Tofacitinib81158.9159.0
Ranitidine Hydrochloride37139.9140.0
Minocycline10139.4139.5
Cetiirizine30136.2136.3
Dexamethasone Sodium Phosphate693.193.2

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Data source: openFDA FAERS. See the OpenPV methodology and limitations.