Reaction

Cogwheel Rigidity reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,040 reports · 46 co-occurring drugs

As of the last recalculation, Cogwheel Rigidity appears in 1,040 FAERS reports alongside 46 co-occurring drug terms. The strongest observed disproportionality signal is HALOPERIDOL (PRR 95.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Haloperidol	104	95.1	95.5
Haloperidol Lactate	105	94.3	94.7
Asenapine Maleate	24	56.7	56.9
Paroxetine Hydrochloride Hemihydrate	84	54.8	55.0
Paroxetine	84	53.7	53.8
Aripiprazole Oral	99	52.9	53.0
Aripiprazole Orally Disintegrating	99	52.9	53.0
Lithium Carbonate	41	50.3	50.4
Risperidone	245	47.9	48.0
Quinapril Hydrochloride	16	41.2	41.3
Quetiapine Fumarate	57	40.8	40.9
Rasagiline Mesylate	21	38.5	38.6
Aripiprazole	175	34.2	34.2
Olanzapine	154	33.5	33.5
Quetiapine	226	29.7	29.8
Paroxetine Hydrochloride	120	29.7	29.7
Trimethoprim	17	29.3	29.4
Lithium	35	28.7	28.8
Lithium Bromatum	35	28.7	28.8
Amitriptyline Hydrochloride	24	28.0	28.0
Mirtazapine	107	25.9	26.0
Brexpiprazole	21	25.8	25.8
Rivastigmine	22	23.9	23.9
Divalproex Sodium	52	23.5	23.5
Insulin Glargine-Yfgn	25	23.4	23.4
Diazepam Oral Solution (Concentrate)	90	22.1	22.1
Diazepam Oral	90	22.1	22.1
Amantadine	16	21.0	21.0
Clonazepam	141	20.2	20.2
Lurasidone Hydrochloride	20	19.5	19.5
Cefuroxime	11	19.5	19.5
Levodopa	11	18.4	18.4
Valproate Sodium	18	17.7	17.7
Valproic Acid	27	17.6	17.6
Diazepam	94	16.9	16.9
Ziprasidone Mesylate	11	15.6	15.6
Tramadol Hydrochloride	28	15.3	15.3
Ziprasidone	13	14.9	15.0
Paliperidone	16	13.9	13.9
Escitslopram	38	13.5	13.5
Clozapine	75	12.8	12.8
Rocuronium Bromide	7	12.0	12.0
Carbidopa And Levodopa	25	10.8	10.8
Memantine	7	10.3	10.3
Memantine Hydrochloride	7	10.3	10.3
Paliperidone Palmitate	13	8.2	8.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.