OpenPV Signal Explorer
FAERS disproportionality dashboard
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Drug

Loperamide Hcl

1,102 flagged reaction(s) · 52,295 total co-reports · max PRR 861.8
Important: Reactions below are the flagged terms from this drug’s FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate disproportionality in spontaneous reporting, not causation. Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
Reaction Co-reports (a) PRR ROR Signal
1 Vaginal Flatulence 105 861.8 868.9 signal
2 Presbyacusis 57 368.6 370.3 signal
3 Heart Sounds 15 299.4 299.8 signal
4 Total Lung Capacity Increased 30 202.1 202.6 signal
5 Genitourinary Tract Neoplasm 9 199.3 199.5 signal
6 Stomatitis Haemorrhagic 11 160.2 160.4 signal
7 Pleural Thickening 45 115.9 116.3 signal
8 Female Genital Tract Fistula 112 114.1 115.1 signal
9 Stoma Site Ulcer 11 107.8 107.9 signal
10 Blood Magnesium Increased 52 100.1 100.5 signal
11 Pleural Fibrosis 59 99.6 100.0 signal
12 Prolonged Expiration 15 98.6 98.7 signal
13 Anticholinergic Syndrome 75 81.0 81.4 signal
14 Metastases To Spinal Cord 9 79.5 79.6 signal
15 Radiculopathy 105 68.0 68.5 signal
16 Proctitis 111 67.5 68.1 signal
17 Chronic Sinusitis 148 67.4 68.2 signal
18 Gastrointestinal Stoma Output Increased 16 58.7 58.7 signal
19 Pelvic Neoplasm 9 43.4 43.5 signal
20 Arrhythmic Storm 8 40.8 40.8 signal
21 Gastroenteritis Radiation 8 40.7 40.7 signal
22 Electrocardiogram Qt Interval Abnormal 12 40.6 40.6 signal
23 Macular Degeneration 270 38.0 38.8 signal
24 Bone Cyst 21 37.4 37.5 signal
25 Metastases To Abdominal Cavity 11 37.3 37.3 signal
26 Incorrect Product Administration Duration 444 36.7 37.9 signal
27 Asthma-chronic Obstructive Pulmonary Disease Overlap Syndrome 11 35.4 35.4 signal
28 Hemianopia 21 35.2 35.2 signal
29 Tumour Pain 27 34.1 34.2 signal
30 Sticky Skin 8 33.5 33.5 signal
31 Deafness Neurosensory 59 30.0 30.2 signal
32 Creatinine Renal Clearance Abnormal 8 28.5 28.5 signal
33 Vanishing Bile Duct Syndrome 18 27.0 27.0 signal
34 Epigastric Discomfort 62 26.3 26.4 signal
35 Acquired Haemophilia 15 25.3 25.3 signal
36 Torsade De Pointes 118 25.0 25.2 signal
37 Salpingectomy 8 23.2 23.2 signal
38 Osteosclerosis 21 22.1 22.1 signal
39 Nipple Disorder 8 21.4 21.4 signal
40 Product Ineffective 8 19.2 19.2 signal
41 Choroidal Effusion 9 18.7 18.7 signal
42 Exposure To Toxic Agent 36 18.5 18.6 signal
43 Brugada Syndrome 11 17.8 17.8 signal
44 Gastric Ph Decreased 11 17.7 17.7 signal
45 Electrocardiogram Qrs Complex Prolonged 54 17.5 17.5 signal
46 Vaginal Discharge 105 17.3 17.4 signal
47 Enterocutaneous Fistula 9 17.0 17.0 signal
48 Intentional Product Use Issue 872 16.4 17.5 signal
49 Oral Candidiasis 125 15.9 16.0 signal
50 Waist Circumference Increased 10 15.8 15.8 signal
51 Paraesthesia Oral 137 15.8 15.9 signal
52 Vascular Device Infection 42 15.4 15.4 signal
53 Gastrointestinal Stoma Complication 14 14.8 14.8 signal
54 Oophorectomy 8 14.8 14.8 signal
55 Megacolon 14 14.8 14.8 signal
56 Conduction Disorder 15 13.6 13.6 signal
57 Forced Expiratory Volume Decreased 23 13.4 13.4 signal
58 Catheter Related Infection 8 12.9 12.9 signal
59 Neutrophil Count Abnormal 22 12.9 12.9 signal
60 Ventricular Tachycardia 129 12.9 13.0 signal
61 Traumatic Haematoma 8 12.2 12.2 signal
62 Immune-mediated Enterocolitis 26 12.2 12.2 signal
63 Rheumatoid Factor Increased 8 11.8 11.8 signal
64 Expired Product Administered 237 11.8 12.0 signal
65 Incorrect Drug Administration Duration 193 11.2 11.3 signal
66 Clostridium Colitis 8 10.8 10.8 signal
67 Frequent Bowel Movements 168 10.3 10.4 signal
68 Colon Cancer Metastatic 10 10.3 10.3 signal
69 Long Qt Syndrome 15 10.3 10.3 signal
70 Enterocolitis 35 10.1 10.1 signal
71 Respiration Abnormal 41 9.9 9.9 signal
72 Accidental Poisoning 8 9.8 9.8 signal
73 Cardiotoxicity 51 9.5 9.5 signal
74 Pyelonephritis Acute 11 9.3 9.3 signal
75 Therapeutic Product Effect Delayed 25 9.1 9.2 signal
76 Ventricular Arrhythmia 20 9.0 9.0 signal
77 Cancer Pain 14 9.0 9.0 signal
78 Vena Cava Thrombosis 9 8.9 8.9 signal
79 Anal Haemorrhage 15 8.8 8.8 signal
80 Colitis Microscopic 25 8.8 8.8 signal
81 Small Intestinal Perforation 10 8.8 8.8 signal
82 Small Intestinal Obstruction 65 8.7 8.8 signal
83 Procedural Pain 144 8.6 8.7 signal
84 Electrocardiogram Qt Prolonged 186 8.5 8.6 signal
85 Colitis 194 8.5 8.6 signal
86 Cyst 64 8.5 8.5 signal
87 Hepatic Neoplasm Malignant 11 8.5 8.5 signal
88 Jaundice Cholestatic 18 8.4 8.4 signal
89 Ileus Paralytic 22 8.2 8.2 signal
90 Peptic Ulcer 16 7.9 7.9 signal
91 Atrioventricular Block First Degree 21 7.9 7.9 signal
92 Appetite Disorder 31 7.8 7.9 signal
93 Rhinitis Allergic 21 7.8 7.8 signal
94 Therapeutic Product Effect Variable 18 7.8 7.8 signal
95 Musculoskeletal Chest Pain 73 7.8 7.8 signal
96 Hypomania 17 7.6 7.6 signal
97 Blood Amylase Increased 8 7.6 7.6 signal
98 Fanconi Syndrome Acquired 8 7.5 7.5 signal
99 Depressive Symptom 16 7.5 7.5 signal
100 Product Packaging Difficult To Open 11 7.3 7.3 signal
101 Soft Tissue Infection 8 7.3 7.3 signal
102 Osteopenia 66 7.1 7.2 signal
103 Hypomagnesaemia 60 7.1 7.1 signal
104 Foreign Body In Throat 13 7.0 7.0 signal
105 Faecaloma 23 7.0 7.0 signal
106 Blood Bicarbonate Decreased 8 6.9 6.9 signal
107 Osteoporotic Fracture 8 6.8 6.8 signal
108 Faeces Discoloured 90 6.8 6.9 signal
109 Drug Effect Delayed 19 6.8 6.8 signal
110 Intracranial Pressure Increased 23 6.8 6.8 signal
111 Faeces Hard 16 6.8 6.8 signal
112 Left Ventricular Failure 14 6.7 6.8 signal
113 Pneumonia Viral 13 6.7 6.7 signal
114 Cholangitis 25 6.7 6.7 signal
115 Portal Vein Thrombosis 13 6.6 6.6 signal
116 Blood Potassium Increased 65 6.6 6.6 signal
117 Rales 23 6.5 6.5 signal
118 Pyoderma Gangrenosum 14 6.5 6.5 signal
119 Hypoalbuminaemia 30 6.5 6.5 signal
120 Ventricular Fibrillation 43 6.3 6.4 signal
121 Hypokalaemia 176 6.3 6.4 signal
122 Electrolyte Imbalance 44 6.3 6.3 signal
123 Decreased Immune Responsiveness 37 6.2 6.2 signal
124 Dermatitis Exfoliative Generalised 13 6.2 6.2 signal
125 Abnormal Faeces 31 6.2 6.2 signal
126 Oral Intake Reduced 9 6.0 6.0 signal
127 Lung Adenocarcinoma 11 6.0 6.0 signal
128 Large Intestine Perforation 25 5.9 5.9 signal
129 Proctalgia 23 5.9 5.9 signal
130 Arteriospasm Coronary 14 5.8 5.8 signal
131 Hypophosphataemia 26 5.8 5.8 signal
132 Abdominal Infection 9 5.8 5.8 signal
133 Pulmonary Pain 10 5.7 5.7 signal
134 Gastrointestinal Pain 38 5.7 5.7 signal
135 Enteritis 22 5.7 5.7 signal
136 Bronchopneumonia 12 5.7 5.7 signal
137 Rectal Haemorrhage 148 5.6 5.7 signal
138 Haematochezia 189 5.6 5.7 signal
139 Malnutrition 38 5.6 5.6 signal
140 Bowel Movement Irregularity 26 5.6 5.6 signal
141 Ileus 41 5.5 5.5 signal
142 Large Intestinal Ulcer 9 5.5 5.5 signal
143 Faeces Soft 24 5.5 5.5 signal
144 Blood Phosphorus Increased 9 5.4 5.4 signal
145 Iron Deficiency Anaemia 30 5.4 5.4 signal
146 Drug Use Disorder 27 5.4 5.4 signal
147 Hypovolaemia 19 5.3 5.3 signal
148 Chapped Lips 14 5.3 5.3 signal
149 Diverticulum Intestinal 14 5.3 5.3 signal
150 Hyperparathyroidism Secondary 8 5.2 5.2 signal
151 Ventricular Hypertrophy 8 5.2 5.2 signal
152 Erythema Nodosum 11 5.2 5.2 signal
153 Essential Hypertension 8 5.1 5.1 signal
154 Onychoclasis 21 5.0 5.0 signal
155 Thoracic Vertebral Fracture 9 5.0 5.0 signal
156 Gastrointestinal Sounds Abnormal 15 5.0 5.0 signal
157 Colitis Ulcerative 136 5.0 5.1 signal
158 Mucous Stools 15 5.0 5.0 signal
159 Urine Output Increased 8 5.0 5.0 signal
160 Paronychia 13 4.9 4.9 signal
161 Metastases To Spine 10 4.9 4.9 signal
162 Therapeutic Product Effect Incomplete 210 4.9 4.9 signal
163 Skin Lesion 80 4.8 4.9 signal
164 Brain Natriuretic Peptide Increased 9 4.8 4.8 signal
165 Neutrophil Count Decreased 118 4.8 4.8 signal
166 Nasal Polyps 14 4.8 4.8 signal
167 Crohn's Disease 20 4.7 4.7 signal
168 Blood Creatinine Increased 188 4.7 4.8 signal
169 Frustration Tolerance Decreased 23 4.7 4.7 signal
170 Exostosis 26 4.7 4.7 signal
171 Constipation 611 4.6 4.8 signal
172 Renal Failure Chronic 22 4.6 4.6 signal
173 Dermatitis Acneiform 17 4.6 4.6 signal
174 Dehydration 374 4.6 4.7 signal
175 Lung Neoplasm 12 4.6 4.6 signal
176 Oesophageal Candidiasis 11 4.6 4.6 signal
177 Blood Magnesium Decreased 24 4.6 4.6 signal
178 Pneumonia Aspiration 69 4.5 4.6 signal
179 Oesophagitis 30 4.5 4.5 signal
180 Sarcoidosis 13 4.5 4.5 signal
181 Tumour Marker Increased 13 4.4 4.4 signal
182 Drug Effect Less Than Expected 38 4.4 4.4 signal
183 Respiratory Depression 33 4.4 4.4 signal
184 Obstructive Airways Disorder 30 4.4 4.4 signal
185 Thyroiditis 8 4.4 4.4 signal
186 Brain Herniation 8 4.4 4.4 signal
187 Normochromic Normocytic Anaemia 8 4.4 4.4 signal
188 Diarrhoea 1,710 4.4 4.9 signal
189 Keratitis 8 4.4 4.4 signal
190 Sleep Disorder Due To General Medical Condition, Insomnia Type 17 4.3 4.3 signal
191 Drug Level Above Therapeutic 12 4.3 4.3 signal
192 Anal Fistula 14 4.3 4.3 signal
193 Acidosis 20 4.3 4.3 signal
194 Toxic Epidermal Necrolysis 39 4.2 4.3 signal
195 Blood Bilirubin Increased 70 4.2 4.3 signal
196 Blood Creatinine Decreased 8 4.2 4.2 signal
197 Duodenal Ulcer 18 4.2 4.2 signal
198 Hypocalcaemia 48 4.2 4.2 signal
199 Gastroenteritis 37 4.2 4.2 signal
200 Neutropenic Sepsis 18 4.1 4.1 signal
201 Skin Erosion 8 4.1 4.1 signal
202 Drug Abuse 209 4.1 4.2 signal
203 Multiple Drug Overdose Intentional 8 4.0 4.0 signal
204 Pneumonitis 66 4.0 4.0 signal
205 Angina Unstable 16 4.0 4.0 signal
206 Infusion Related Reaction 161 4.0 4.0 signal
207 Nephritis 8 4.0 4.0 signal
208 Bronchiectasis 16 3.9 3.9 signal
209 Fistula 27 3.9 3.9 signal
210 Peripheral Sensory Neuropathy 14 3.9 3.9 signal
211 Gamma-glutamyltransferase Increased 53 3.9 3.9 signal
212 Febrile Bone Marrow Aplasia 10 3.9 3.9 signal
213 Dyspepsia 234 3.9 4.0 signal
214 Tongue Discomfort 10 3.9 3.9 signal
215 Intestinal Ischaemia 13 3.9 3.9 signal
216 Intentional Product Misuse 206 3.9 3.9 signal
217 Blood Alkaline Phosphatase Increased 59 3.9 3.9 signal
218 Febrile Neutropenia 157 3.9 3.9 signal
219 Systemic Inflammatory Response Syndrome 9 3.9 3.9 signal
220 Deformity 22 3.9 3.9 signal
221 Aphthous Ulcer 18 3.9 3.9 signal
222 C-reactive Protein Increased 85 3.8 3.9 signal
223 Pancreatitis Acute 52 3.8 3.8 signal
224 Multiple Myeloma 11 3.8 3.8 signal
225 Anaemia 442 3.8 3.9 signal
226 Hyperreflexia 8 3.8 3.8 signal
227 Sinus Bradycardia 22 3.7 3.7 signal
228 Stomatitis 137 3.7 3.7 signal
229 Erythema Multiforme 21 3.7 3.7 signal
230 Catheterisation Cardiac 10 3.7 3.7 signal
231 Anal Fissure 12 3.7 3.7 signal
232 Anal Incontinence 20 3.7 3.7 signal
233 Blood Pressure Systolic Increased 44 3.7 3.7 signal
234 Haemorrhagic Diathesis 8 3.7 3.7 signal
235 Metastases To Lymph Nodes 15 3.7 3.7 signal
236 Urine Abnormality 10 3.7 3.7 signal
237 Renal Transplant 8 3.6 3.6 signal
238 Renal Failure Acute 95 3.6 3.6 signal
239 Tenderness 23 3.6 3.6 signal
240 Pulmonary Thrombosis 24 3.6 3.6 signal
241 Hyperuricaemia 9 3.6 3.6 signal
242 Self-medication 9 3.6 3.6 signal
243 Mucosal Inflammation 57 3.6 3.6 signal
244 Gastrointestinal Perforation 9 3.6 3.6 signal
245 Bundle Branch Block Right 10 3.6 3.6 signal
246 Activated Partial Thromboplastin Time Prolonged 11 3.6 3.6 signal
247 Anorexia 28 3.5 3.5 signal
248 Flank Pain 20 3.5 3.5 signal
249 Oral Pain 48 3.5 3.5 signal
250 Intestinal Perforation 24 3.5 3.5 signal
251 Haemodynamic Instability 16 3.5 3.5 signal
252 Miosis 17 3.5 3.5 signal
253 Hepatic Function Abnormal 79 3.5 3.5 signal
254 Protein Total Decreased 8 3.5 3.5 signal
255 Disseminated Intravascular Coagulation 30 3.5 3.5 signal
256 Flatulence 120 3.5 3.5 signal
257 Non-small Cell Lung Cancer 10 3.5 3.5 signal
258 Left Ventricular Dysfunction 14 3.4 3.5 signal
259 Osteoarthritis 89 3.4 3.5 signal
260 Clavicle Fracture 8 3.4 3.4 signal
261 Hunger 28 3.4 3.4 signal
262 Pneumothorax 33 3.4 3.4 signal
263 Underdose 152 3.4 3.4 signal
264 Ascites 61 3.4 3.4 signal
265 Clostridium Difficile Colitis 22 3.4 3.4 signal
266 Cardiac Murmur 18 3.4 3.4 signal
267 Enterococcal Infection 10 3.4 3.4 signal
268 Skin Warm 12 3.4 3.4 signal
269 Abdominal Pain 479 3.4 3.5 signal
270 Anorectal Discomfort 11 3.4 3.4 signal
271 Intestinal Obstruction 77 3.4 3.4 signal
272 Melanocytic Naevus 9 3.4 3.4 signal
273 Palmar-plantar Erythrodysaesthesia Syndrome 48 3.4 3.4 signal
274 Accidental Exposure To Product By Child 14 3.4 3.4 signal
275 Faecal Incontinence 10 3.4 3.4 signal
276 Blood Calcium Decreased 23 3.3 3.4 signal
277 Inflammatory Bowel Disease 20 3.3 3.3 signal
278 Electrocardiogram Abnormal 16 3.3 3.3 signal
279 Diarrhoea Haemorrhagic 19 3.3 3.3 signal
280 Lymphoedema 14 3.3 3.3 signal
281 Blood Potassium Decreased 61 3.3 3.3 signal
282 Blood Pressure Diastolic Decreased 15 3.3 3.3 signal
283 Abdominal Tenderness 10 3.3 3.3 signal
284 Obstruction 8 3.3 3.3 signal
285 Prothrombin Time Prolonged 12 3.3 3.3 signal
286 Right Ventricular Failure 14 3.3 3.3 signal
287 Skin Fissures 37 3.2 3.2 signal
288 Bacteraemia 23 3.2 3.2 signal
289 Blood Iron Decreased 23 3.2 3.2 signal
290 Thyroid Function Test Abnormal 8 3.1 3.1 signal
291 Sensitivity To Weather Change 10 3.1 3.1 signal
292 Renal Pain 20 3.1 3.1 signal
293 Schizophrenia 23 3.1 3.1 signal
294 Cardiac Arrest 156 3.1 3.1 signal
295 Abscess Limb 8 3.1 3.1 signal
296 Neutropenia 254 3.1 3.1 signal
297 Dizziness Postural 18 3.1 3.1 signal
298 Oral Discomfort 26 3.1 3.1 signal
299 Hyponatraemia 105 3.1 3.1 signal
300 Inappropriate Antidiuretic Hormone Secretion 19 3.1 3.1 signal
301 Parosmia 14 3.0 3.1 signal
302 Blood Urea Increased 31 3.0 3.0 signal
303 Decubitus Ulcer 15 3.0 3.0 signal
304 Fluid Intake Reduced 9 3.0 3.0 signal
305 Pleural Effusion 110 3.0 3.0 signal
306 Colitis Ischaemic 12 2.9 2.9 signal
307 Affective Disorder 14 2.9 2.9 signal
308 Decreased Appetite 413 2.9 3.0 signal
309 Dysphoria 9 2.9 2.9 signal
310 Blood Lactate Dehydrogenase Increased 28 2.9 2.9 signal
311 Aspiration 19 2.9 2.9 signal
312 Atelectasis 17 2.9 2.9 signal
313 Nephrotic Syndrome 12 2.9 2.9 signal
314 Atrial Flutter 14 2.9 2.9 signal
315 Renal Impairment 146 2.9 2.9 signal
316 Renal Function Test Abnormal 8 2.9 2.9 signal
317 Weight Decreased 485 2.9 2.9 signal
318 Malabsorption 9 2.8 2.8 signal
319 Defaecation Urgency 12 2.8 2.8 signal
320 Tumour Lysis Syndrome 15 2.8 2.8 signal
321 C-reactive Protein Abnormal 11 2.8 2.8 signal
322 Urine Output Decreased 15 2.8 2.8 signal
323 Metastases To Liver 30 2.8 2.8 signal
324 White Blood Cell Count Decreased 185 2.8 2.8 signal
325 Coma 81 2.8 2.8 signal
326 Product Residue Present 9 2.8 2.8 signal
327 Pyrexia 587 2.8 2.9 signal
328 Product Administration Interrupted 13 2.8 2.8 signal
329 Wheezing 100 2.8 2.8 signal
330 Haemorrhoids 33 2.8 2.8 signal
331 Lung Infiltration 15 2.8 2.8 signal
332 Toxic Skin Eruption 17 2.8 2.8 signal
333 Metabolic Acidosis 53 2.7 2.8 signal
334 Hypothyroidism 53 2.7 2.7 signal
335 Hyperthyroidism 24 2.7 2.7 signal
336 Lower Respiratory Tract Infection 75 2.7 2.7 signal
337 Presyncope 40 2.7 2.7 signal
338 Dry Eye 80 2.7 2.7 signal
339 Taste Disorder 33 2.7 2.7 signal
340 Metastases To Lung 19 2.7 2.7 signal
341 Blood Albumin Decreased 13 2.7 2.7 signal
342 Platelet Count Decreased 175 2.7 2.7 signal
343 Choking Sensation 9 2.7 2.7 signal
344 Sepsis 182 2.7 2.7 signal
345 Alanine Aminotransferase Increased 100 2.7 2.7 signal
346 Toxic Encephalopathy 8 2.7 2.7 signal
347 Septic Shock 70 2.7 2.7 signal
348 Bacterial Infection 30 2.7 2.7 signal
349 Troponin Increased 12 2.6 2.6 signal
350 Spinal Osteoarthritis 14 2.6 2.6 signal
351 Hyperlipidaemia 19 2.6 2.6 signal
352 Abdominal Abscess 7 2.6 2.6 signal
353 Breast Cancer Metastatic 17 2.6 2.6 signal
354 Leukopenia 79 2.6 2.6 signal
355 Gastrointestinal Disorder 139 2.6 2.6 signal
356 Abdominal Distension 163 2.6 2.6 signal
357 Product Taste Abnormal 21 2.6 2.6 signal
358 Mydriasis 20 2.6 2.6 signal
359 Contraindicated Product Administered 47 2.6 2.6 signal
360 Chromaturia 35 2.5 2.5 signal
361 Trismus 8 2.5 2.5 signal
362 Hepatitis Acute 10 2.5 2.5 signal
363 Inappropriate Schedule Of Product Administration 273 2.5 2.6 signal
364 Peripheral Vascular Disorder 8 2.5 2.5 signal
365 Blood Sodium Decreased 29 2.5 2.5 signal
366 Periorbital Oedema 8 2.5 2.5 signal
367 Feeling Cold 43 2.5 2.5 signal
368 Abdominal Hernia 7 2.5 2.5 signal
369 Pneumonia Bacterial 14 2.5 2.5 signal
370 Urinary Retention 51 2.5 2.5 signal
371 Blood Lactic Acid Increased 8 2.5 2.5 signal
372 Aspartate Aminotransferase Increased 81 2.5 2.5 signal
373 Renal Tubular Necrosis 15 2.5 2.5 signal
374 Cholelithiasis 50 2.5 2.5 signal
375 Sensitive Skin 11 2.5 2.5 signal
376 Acute Graft Versus Host Disease 7 2.5 2.5 signal
377 Drug Level Increased 25 2.5 2.5 signal
378 Haematocrit Decreased 30 2.5 2.5 signal
379 Thrombocytopenia 167 2.5 2.5 signal
380 Sudden Death 16 2.5 2.5 signal
381 Squamous Cell Carcinoma Of Skin 9 2.5 2.5 signal
382 Brain Injury 15 2.5 2.5 signal
383 Cardiogenic Shock 21 2.4 2.4 signal
384 Gastric Ulcer 28 2.4 2.4 signal
385 Infusion Site Swelling 9 2.4 2.4 signal
386 Hyperkalaemia 51 2.4 2.4 signal
387 Haematemesis 37 2.4 2.4 signal
388 Post Procedural Complication 28 2.4 2.4 signal
389 Pancytopenia 81 2.4 2.4 signal
390 Oliguria 9 2.4 2.4 signal
391 Lipase Increased 11 2.4 2.4 signal
392 Weight Fluctuation 15 2.4 2.4 signal
393 Vitamin D Deficiency 14 2.4 2.4 signal
394 Skin Ulcer 37 2.4 2.4 signal
395 Polyneuropathy 17 2.3 2.3 signal
396 Encephalopathy 35 2.3 2.3 signal
397 Interstitial Lung Disease 69 2.3 2.4 signal
398 Pulmonary Toxicity 10 2.3 2.3 signal
399 Overdose 308 2.3 2.4 signal
400 Hospice Care 14 2.3 2.3 signal
401 Productive Cough 67 2.3 2.3 signal
402 Cholecystitis Acute 8 2.3 2.3 signal
403 Malignant Neoplasm Progression 144 2.3 2.3 signal
404 Liver Function Test Abnormal 41 2.3 2.3 signal
405 Mouth Ulceration 29 2.3 2.3 signal
406 Drug Level Decreased 14 2.2 2.2 signal
407 Multi-organ Failure 24 2.2 2.2 signal
408 Splenomegaly 16 2.2 2.2 signal
409 Glucose Tolerance Impaired 8 2.2 2.2 signal
410 Device Related Infection 21 2.2 2.2 signal
411 Conjunctivitis 25 2.2 2.2 signal
412 Sleep Disorder 95 2.2 2.2 signal
413 Hepatic Failure 41 2.2 2.2 signal
414 Blood Test Abnormal 19 2.2 2.2 signal
415 Hiccups 11 2.2 2.2 signal
416 Energy Increased 8 2.2 2.2 signal
417 Thirst 24 2.2 2.2 signal
418 Gastrointestinal Infection 12 2.2 2.2 signal
419 Epilepsy 41 2.2 2.2 signal
420 Ischaemic Stroke 24 2.2 2.2 signal
421 Accidental Overdose 49 2.2 2.2 signal
422 Hypophagia 34 2.2 2.2 signal
423 Postoperative Wound Infection 9 2.2 2.2 signal
424 Limb Discomfort 41 2.2 2.2 signal
425 Inappropriate Schedule Of Drug Administration 95 2.2 2.2 signal
426 Haemoglobin Decreased 135 2.2 2.2 signal
427 Peritonitis 27 2.1 2.1 signal
428 Drug Toxicity 18 2.1 2.1 signal
429 Intentional Overdose 83 2.1 2.1 signal
430 Urosepsis 12 2.1 2.1 signal
431 Platelet Count Increased 17 2.1 2.1 signal
432 Pseudomonas Infection 11 2.1 2.1 signal
433 Generalised Oedema 16 2.1 2.1 signal
434 Blood Triglycerides Increased 23 2.1 2.1 signal
435 Poisoning Deliberate 12 2.1 2.1 signal
436 Full Blood Count Decreased 26 2.1 2.1 signal
437 Liver Disorder 57 2.1 2.1 signal
438 Lethargy 74 2.1 2.1 signal
439 Angina Pectoris 37 2.1 2.1 signal
440 Adverse Reaction 17 2.1 2.1 signal
441 Lymphopenia 18 2.1 2.1 signal
442 Muscle Strain 11 2.1 2.1 signal
443 Proteinuria 24 2.1 2.1 signal
444 Brain Oedema 16 2.1 2.1 signal
445 Irritable Bowel Syndrome 27 2.1 2.1 signal
446 Hepatotoxicity 28 2.1 2.1 signal
447 Cholecystitis 15 2.1 2.1 signal
448 Neuroleptic Malignant Syndrome 15 2.1 2.1 signal
449 Mental Status Changes 35 2.1 2.1 signal
450 Supraventricular Tachycardia 12 2.1 2.1 signal
451 Haematuria 43 2.1 2.1 signal
452 Oedema Peripheral 153 2.1 2.1 signal
453 Metastases To Central Nervous System 16 2.0 2.1 signal
454 Purpura 11 2.0 2.0 signal
455 Drug Interaction 197 2.0 2.1 signal
456 Hiatus Hernia 16 2.0 2.0 signal
457 Drug Effective For Unapproved Indication 36 2.0 2.0 signal
458 Oropharyngeal Discomfort 11 2.0 2.0 signal
459 Dyspnoea Exertional 46 2.0 2.0 signal
460 Melaena 27 2.0 2.0 signal
461 Retching 26 2.0 2.0 signal
462 Rib Fracture 25 2.0 2.0 no signal
463 Vomiting 569 2.0 2.0 no signal
464 Arteriosclerosis Coronary Artery 8 2.0 2.0 no signal
465 Coordination Abnormal 17 2.0 2.0 no signal
466 Gastrooesophageal Reflux Disease 97 2.0 2.0 no signal
467 Nausea 953 2.0 2.1 no signal
468 Altered State Of Consciousness 26 2.0 2.0 no signal
469 Lung Infection 19 2.0 2.0 no signal
470 Pulmonary Oedema 54 2.0 2.0 no signal
471 Feeding Disorder 24 2.0 2.0 no signal
472 Cardiac Failure Acute 8 2.0 2.0 no signal
473 Acute Coronary Syndrome 10 2.0 2.0 no signal
474 Sciatica 19 2.0 2.0 no signal
475 Abdominal Pain Upper 246 2.0 2.0 no signal
476 Depressed Mood 63 2.0 2.0 no signal
477 Neuropathy Peripheral 113 2.0 2.0 no signal
478 White Blood Cell Count Increased 46 2.0 2.0 no signal
479 Post-traumatic Stress Disorder 8 2.0 2.0 no signal
480 Spinal Compression Fracture 10 2.0 2.0 no signal
481 Pancreatitis 63 2.0 2.0 no signal
482 Lymphocyte Count Decreased 21 1.9 1.9 no signal
483 Product Packaging Issue 11 1.9 1.9 no signal
484 Upper Gastrointestinal Haemorrhage 20 1.9 1.9 no signal
485 Pneumonia 383 1.9 2.0 no signal
486 Haemodialysis 10 1.9 1.9 no signal
487 Sleep Disorder Due To A General Medical Condition 19 1.9 1.9 no signal
488 Grand Mal Convulsion 11 1.9 1.9 no signal
489 Myoclonus 14 1.9 1.9 no signal
490 Off Label Use 1,016 1.9 2.0 no signal
491 Upper Respiratory Tract Infection 54 1.9 1.9 no signal
492 Adrenal Insufficiency 14 1.9 1.9 no signal
493 Circulatory Collapse 20 1.9 1.9 no signal
494 Syncope 117 1.9 1.9 no signal
495 Toxicity To Various Agents 196 1.9 1.9 no signal
496 Nephropathy Toxic 13 1.9 1.9 no signal
497 Pyelonephritis 10 1.9 1.9 no signal
498 Anuria 10 1.9 1.9 no signal
499 Nail Disorder 10 1.9 1.9 no signal
500 Tachycardia 102 1.9 1.9 no signal
501 International Normalised Ratio Increased 33 1.9 1.9 no signal
502 Orthostatic Hypotension 20 1.9 1.9 no signal
503 Extrasystoles 8 1.9 1.9 no signal
504 Joint Dislocation 12 1.9 1.9 no signal
505 Hepatitis 29 1.9 1.9 no signal
506 Ear Pain 22 1.9 1.9 no signal
507 Renal Cyst 9 1.9 1.9 no signal
508 Pericardial Effusion 26 1.9 1.9 no signal
509 Oxygen Saturation Decreased 63 1.9 1.9 no signal
510 Rash Maculo-papular 25 1.9 1.9 no signal
511 Unresponsive To Stimuli 29 1.8 1.9 no signal
512 Dermatitis Bullous 8 1.8 1.8 no signal
513 Diverticulum 8 1.8 1.8 no signal
514 Body Temperature Decreased 11 1.8 1.8 no signal
515 Shock Haemorrhagic 9 1.8 1.8 no signal
516 Graft Versus Host Disease 8 1.8 1.8 no signal
517 Infection 159 1.8 1.8 no signal
518 Oropharyngeal Pain 102 1.8 1.8 no signal
519 Pulmonary Arterial Hypertension 16 1.8 1.8 no signal
520 Photosensitivity Reaction 18 1.8 1.8 no signal
521 Oedema 59 1.8 1.8 no signal
522 Depressed Level Of Consciousness 43 1.8 1.8 no signal
523 Retinal Detachment 10 1.8 1.8 no signal
524 Hypoxia 38 1.8 1.8 no signal
525 Pemphigoid 8 1.8 1.8 no signal
526 Lower Gastrointestinal Haemorrhage 8 1.8 1.8 no signal
527 Embolism 9 1.8 1.8 no signal
528 Nocturia 13 1.8 1.8 no signal
529 Bradycardia 57 1.8 1.8 no signal
530 Arrhythmia 51 1.8 1.8 no signal
531 Hydronephrosis 8 1.8 1.8 no signal
532 Rhinorrhoea 69 1.8 1.8 no signal
533 Hepatic Encephalopathy 10 1.8 1.8 no signal
534 Acute Kidney Injury 163 1.8 1.8 no signal
535 Drug Intolerance 103 1.8 1.8 no signal
536 Abdominal Pain Lower 27 1.7 1.7 no signal
537 Increased Appetite 20 1.7 1.7 no signal
538 Confusional State 171 1.7 1.7 no signal
539 Chronic Obstructive Pulmonary Disease 55 1.7 1.7 no signal
540 Cardiomegaly 13 1.7 1.7 no signal
541 Myocardial Ischaemia 12 1.7 1.7 no signal
542 Drug Ineffective 1,369 1.7 1.8 no signal
543 Hypotension 208 1.7 1.7 no signal
544 Jaundice 28 1.7 1.7 no signal
545 Malaise 456 1.7 1.7 no signal
546 Haemolysis 8 1.7 1.7 no signal
547 Incorrect Dose Administered 232 1.7 1.7 no signal
548 Dysuria 38 1.7 1.7 no signal
549 Fatigue 800 1.7 1.7 no signal
550 Brain Fog 15 1.7 1.7 no signal
551 Gastritis 27 1.7 1.7 no signal
552 Hyperglycaemia 37 1.7 1.7 no signal
553 Clostridium Difficile Infection 22 1.7 1.7 no signal
554 Delirium 35 1.7 1.7 no signal
555 Shock 23 1.7 1.7 no signal
556 Herpes Zoster 58 1.7 1.7 no signal
557 Urinary Tract Infection 171 1.6 1.7 no signal
558 Abdominal Discomfort 168 1.6 1.7 no signal
559 Colon Cancer 15 1.6 1.6 no signal
560 Gout 18 1.6 1.6 no signal
561 Cystitis 32 1.6 1.6 no signal
562 Pneumocystis Jirovecii Pneumonia 10 1.6 1.6 no signal
563 Hemiparesis 17 1.6 1.6 no signal
564 Osteomyelitis 18 1.6 1.6 no signal
565 Mobility Decreased 71 1.6 1.6 no signal
566 Bone Pain 58 1.6 1.6 no signal
567 Motor Dysfunction 10 1.6 1.6 no signal
568 Stevens-johnson Syndrome 22 1.6 1.6 no signal
569 Drug Ineffective For Unapproved Indication 55 1.6 1.6 no signal
570 Hypothermia 10 1.6 1.6 no signal
571 Prescribed Overdose 19 1.6 1.6 no signal
572 Red Blood Cell Count Decreased 28 1.6 1.6 no signal
573 Chills 114 1.6 1.6 no signal
574 Asthenia 365 1.6 1.6 no signal
575 General Physical Health Deterioration 111 1.6 1.6 no signal
576 Tendonitis 15 1.6 1.6 no signal
577 Ventricular Extrasystoles 10 1.6 1.6 no signal
578 Tachypnoea 13 1.6 1.6 no signal
579 Blood Pressure Fluctuation 23 1.6 1.6 no signal
580 Muscle Atrophy 12 1.6 1.6 no signal
581 Hair Colour Changes 12 1.6 1.6 no signal
582 Disease Progression 112 1.6 1.6 no signal
583 Renal Failure 127 1.6 1.6 no signal
584 Full Blood Count Abnormal 10 1.6 1.6 no signal
585 Cytokine Release Syndrome 18 1.5 1.6 no signal
586 Abscess 15 1.5 1.5 no signal
587 Rhabdomyolysis 39 1.5 1.5 no signal
588 Lactic Acidosis 30 1.5 1.5 no signal
589 Cardiac Failure 75 1.5 1.5 no signal
590 Night Sweats 30 1.5 1.5 no signal
591 Somnolence 186 1.5 1.5 no signal
592 Ataxia 11 1.5 1.5 no signal
593 Cytopenia 11 1.5 1.5 no signal
594 Peripheral Swelling 141 1.5 1.5 no signal
595 Metastases To Bone 15 1.5 1.5 no signal
596 Musculoskeletal Stiffness 80 1.5 1.5 no signal
597 Atrial Fibrillation 89 1.5 1.5 no signal
598 Neoplasm Progression 32 1.5 1.5 no signal
599 Hepatomegaly 9 1.5 1.5 no signal
600 Erythema 187 1.5 1.5 no signal
601 Photophobia 17 1.5 1.5 no signal
602 Disorientation 36 1.5 1.5 no signal
603 Anhedonia 24 1.5 1.5 no signal
604 Blood Pressure Decreased 60 1.5 1.5 no signal
605 Acute Respiratory Distress Syndrome 16 1.5 1.5 no signal
606 Deep Vein Thrombosis 59 1.5 1.5 no signal
607 Therapeutic Product Effect Decreased 40 1.5 1.5 no signal
608 Renal Disorder 42 1.5 1.5 no signal
609 Ejection Fraction Decreased 14 1.5 1.5 no signal
610 Gallbladder Disorder 16 1.5 1.5 no signal
611 Quality Of Life Decreased 12 1.5 1.5 no signal
612 Lip Dry 8 1.5 1.5 no signal
613 Intentional Self-injury 18 1.5 1.5 no signal
614 Cholestasis 17 1.5 1.5 no signal
615 Acute Respiratory Failure 17 1.5 1.5 no signal
616 Influenza 99 1.5 1.5 no signal
617 Dermatitis Allergic 11 1.4 1.4 no signal
618 Hypertension 187 1.4 1.5 no signal
619 Pain In Jaw 25 1.4 1.4 no signal
620 Heart Rate Irregular 20 1.4 1.4 no signal
621 Bone Marrow Failure 18 1.4 1.4 no signal
622 Body Temperature Increased 18 1.4 1.4 no signal
623 Discomfort 53 1.4 1.4 no signal
624 Dysphonia 51 1.4 1.4 no signal
625 Injection Site Discomfort 9 1.4 1.4 no signal
626 Agranulocytosis 16 1.4 1.4 no signal
627 Petechiae 9 1.4 1.4 no signal
628 Pulmonary Hypertension 18 1.4 1.4 no signal
629 Hepatic Steatosis 16 1.4 1.4 no signal
630 Intervertebral Disc Degeneration 8 1.4 1.4 no signal
631 Vasculitis 10 1.4 1.4 no signal
632 Transfusion 9 1.4 1.4 no signal
633 Seasonal Allergy 12 1.4 1.4 no signal
634 Incontinence 9 1.4 1.4 no signal
635 Sneezing 19 1.4 1.4 no signal
636 Respiratory Tract Infection 22 1.4 1.4 no signal
637 Arthropathy 47 1.4 1.4 no signal
638 Poor Quality Sleep 18 1.4 1.4 no signal
639 Product Use Complaint 13 1.4 1.4 no signal
640 Muscle Rigidity 10 1.4 1.4 no signal
641 Seizure 96 1.4 1.4 no signal
642 Dysphagia 79 1.4 1.4 no signal
643 Contusion 80 1.4 1.4 no signal
644 Balance Disorder 72 1.4 1.4 no signal
645 Pulmonary Embolism 79 1.4 1.4 no signal
646 Face Oedema 14 1.4 1.4 no signal
647 Aphasia 25 1.4 1.4 no signal
648 Multiple Organ Dysfunction Syndrome 23 1.4 1.4 no signal
649 Dyspnoea 466 1.4 1.4 no signal
650 Myelosuppression 28 1.3 1.4 no signal
651 Blister 46 1.3 1.3 no signal
652 Speech Disorder 43 1.3 1.3 no signal
653 Loss Of Personal Independence In Daily Activities 39 1.3 1.3 no signal
654 Plasma Cell Myeloma 32 1.3 1.3 no signal
655 Treatment Failure 67 1.3 1.3 no signal
656 Pain Of Skin 22 1.3 1.3 no signal
657 Limb Injury 22 1.3 1.3 no signal
658 Acute Hepatic Failure 11 1.3 1.3 no signal
659 Respiratory Failure 59 1.3 1.3 no signal
660 Cough 226 1.3 1.3 no signal
661 Throat Irritation 36 1.3 1.3 no signal
662 Mental Disorder 35 1.3 1.3 no signal
663 Thinking Abnormal 15 1.3 1.3 no signal
664 Nervousness 42 1.3 1.3 no signal
665 Ageusia 20 1.3 1.3 no signal
666 Haemorrhage Intracranial 12 1.3 1.3 no signal
667 Gastrointestinal Haemorrhage 67 1.3 1.3 no signal
668 Diverticulitis 22 1.3 1.3 no signal
669 Muscle Spasms 146 1.3 1.3 no signal
670 Status Epilepticus 9 1.3 1.3 no signal
671 Hepatic Enzyme Increased 54 1.3 1.3 no signal
672 Drug Eruption 14 1.3 1.3 no signal
673 Hypoaesthesia 119 1.3 1.3 no signal
674 Dermatitis Contact 9 1.3 1.3 no signal
675 Stress 57 1.3 1.3 no signal
676 Loss Of Consciousness 101 1.3 1.3 no signal
677 Haemoptysis 22 1.3 1.3 no signal
678 Tooth Abscess 8 1.3 1.3 no signal
679 Anaphylactic Reaction 43 1.3 1.3 no signal
680 Poor Quality Product Administered 8 1.3 1.3 no signal
681 Fall 260 1.3 1.3 no signal
682 Withdrawal Syndrome 33 1.3 1.3 no signal
683 Ear Discomfort 8 1.3 1.3 no signal
684 Cytomegalovirus Infection 13 1.3 1.3 no signal
685 Economic Problem 12 1.3 1.3 no signal
686 Glaucoma 15 1.3 1.3 no signal
687 Hyperbilirubinaemia 8 1.3 1.3 no signal
688 Sinus Tachycardia 11 1.3 1.3 no signal
689 Folliculitis 8 1.3 1.3 no signal
690 Cellulitis 39 1.3 1.3 no signal
691 Hot Flush 58 1.3 1.3 no signal
692 Drug Effect Decreased 42 1.3 1.3 no signal
693 Chest Pain 142 1.3 1.3 no signal
694 Joint Swelling 92 1.3 1.3 no signal
695 Cyanosis 12 1.2 1.2 no signal
696 Blood Thyroid Stimulating Hormone Increased 7 1.2 1.2 no signal
697 Coronary Artery Disease 23 1.2 1.2 no signal
698 Ulcer 12 1.2 1.2 no signal
699 Appendicitis 7 1.2 1.2 no signal
700 Nasal Congestion 44 1.2 1.2 no signal
701 Product Administration Error 15 1.2 1.2 no signal
702 Skin Disorder 25 1.2 1.2 no signal
703 Blood Cholesterol Increased 35 1.2 1.2 no signal
704 Sars-cov-2 Test Positive 10 1.2 1.2 no signal
705 Eating Disorder 16 1.2 1.2 no signal
706 Joint Range Of Motion Decreased 10 1.2 1.2 no signal
707 Immunodeficiency 11 1.2 1.2 no signal
708 Decreased Activity 8 1.2 1.2 no signal
709 Malignant Melanoma 10 1.2 1.2 no signal
710 Liver Injury 18 1.2 1.2 no signal
711 Urinary Incontinence 22 1.2 1.2 no signal
712 Arteriosclerosis 7 1.2 1.2 no signal
713 Pain In Extremity 219 1.2 1.2 no signal
714 Hypoglycaemia 36 1.2 1.2 no signal
715 Fibromyalgia 18 1.2 1.2 no signal
716 Uveitis 10 1.2 1.2 no signal
717 Heart Rate Increased 73 1.2 1.2 no signal
718 Arthritis 58 1.2 1.2 no signal
719 Gait Disturbance 141 1.2 1.2 no signal
720 Generalised Tonic-clonic Seizure 12 1.2 1.2 no signal
721 Headache 459 1.2 1.2 no signal
722 Hernia 14 1.2 1.2 no signal
723 Back Pain 169 1.2 1.2 no signal
724 Pain 444 1.2 1.2 no signal
725 Inflammation 37 1.2 1.2 no signal
726 Epistaxis 54 1.2 1.2 no signal
727 Pollakiuria 30 1.2 1.2 no signal
728 Synovitis 13 1.2 1.2 no signal
729 Respiratory Arrest 20 1.2 1.2 no signal
730 Device Occlusion 10 1.2 1.2 no signal
731 Tooth Disorder 16 1.2 1.2 no signal
732 Hospitalisation 109 1.2 1.2 no signal
733 Lung Disorder 35 1.2 1.2 no signal
734 Dry Mouth 57 1.2 1.2 no signal
735 Swollen Tongue 22 1.2 1.2 no signal
736 Hypotonia 7 1.1 1.1 no signal
737 Impaired Quality Of Life 10 1.1 1.1 no signal
738 Diplopia 18 1.1 1.1 no signal
739 Arthralgia 287 1.1 1.1 no signal
740 Dry Skin 91 1.1 1.1 no signal
741 Emphysema 7 1.1 1.1 no signal
742 Cataract 41 1.1 1.1 no signal
743 Apathy 10 1.1 1.1 no signal
744 Post Procedural Haemorrhage 8 1.1 1.1 no signal
745 Drug-induced Liver Injury 21 1.1 1.1 no signal
746 Pulmonary Congestion 9 1.1 1.1 no signal
747 Euphoric Mood 7 1.1 1.1 no signal
748 Poor Venous Access 7 1.1 1.1 no signal
749 Chest Discomfort 69 1.1 1.1 no signal
750 Acute Myocardial Infarction 20 1.1 1.1 no signal
751 Transaminases Increased 15 1.1 1.1 no signal
752 Insurance Issue 10 1.1 1.1 no signal
753 Covid-19 119 1.1 1.1 no signal
754 Pulmonary Mass 10 1.1 1.1 no signal
755 Nasopharyngitis 124 1.1 1.1 no signal
756 Insomnia 179 1.1 1.1 no signal
757 Glossodynia 15 1.1 1.1 no signal
758 Impaired Healing 22 1.1 1.1 no signal
759 Choking 13 1.1 1.1 no signal
760 Sinus Congestion 9 1.1 1.1 no signal
761 Therapy Partial Responder 10 1.1 1.1 no signal
762 Leukocytosis 12 1.1 1.1 no signal
763 Toothache 12 1.1 1.1 no signal
764 Condition Aggravated 200 1.1 1.1 no signal
765 Rash Macular 23 1.1 1.1 no signal
766 Glomerular Filtration Rate Decreased 8 1.1 1.1 no signal
767 Restless Legs Syndrome 12 1.1 1.1 no signal
768 Dizziness 328 1.1 1.1 no signal
769 Suicide Attempt 40 1.1 1.1 no signal
770 Dysgeusia 49 1.1 1.1 no signal
771 Nephrolithiasis 30 1.1 1.1 no signal
772 Joint Injury 14 1.1 1.1 no signal
773 Peripheral Coldness 9 1.1 1.1 no signal
774 Coronary Artery Occlusion 9 1.1 1.1 no signal
775 Heart Rate Decreased 23 1.1 1.1 no signal
776 Rash Pruritic 35 1.1 1.1 no signal
777 Hypercalcaemia 8 1.1 1.1 no signal
778 Skin Laceration 7 1.1 1.1 no signal
779 Body Height Decreased 7 1.1 1.1 no signal
780 No Therapeutic Response 8 1.1 1.1 no signal
781 Muscular Weakness 73 1.1 1.1 no signal
782 Hepatic Cirrhosis 12 1.1 1.1 no signal
783 Injection Site Extravasation 8 1.1 1.1 no signal
784 Vertigo 39 1.0 1.0 no signal
785 Nephropathy 6 1.0 1.0 no signal
786 Bipolar Disorder 7 1.0 1.0 no signal
787 Blood Glucose Fluctuation 7 1.0 1.0 no signal
788 Squamous Cell Carcinoma 6 1.0 1.0 no signal
789 Tooth Fracture 7 1.0 1.0 no signal
790 Rash 275 1.0 1.0 no signal
791 Blood Pressure Increased 97 1.0 1.0 no signal
792 Dialysis 9 1.0 1.0 no signal
793 Posterior Reversible Encephalopathy Syndrome 6 1.0 1.0 no signal
794 Alopecia 124 1.0 1.0 no signal
795 Eosinophilia 11 1.0 1.0 no signal
796 Nerve Injury 7 1.0 1.0 no signal
797 Skin Infection 7 1.0 1.0 no signal
798 Autoimmune Disorder 6 1.0 1.0 no signal
799 Infusion Site Pain 8 1.0 1.0 no signal
800 Treatment Noncompliance 34 1.0 1.0 no signal
801 Convulsion 36 1.0 1.0 no signal
802 Affect Lability 6 1.0 1.0 no signal
803 Sensory Disturbance 10 1.0 1.0 no signal
804 Transient Ischaemic Attack 21 1.0 1.0 no signal
805 Hypokinesia 9 1.0 1.0 no signal
806 Thrombotic Microangiopathy 6 1.0 1.0 no signal
807 Cardio-respiratory Arrest 26 1.0 1.0 no signal
808 Respiratory Distress 17 1.0 1.0 no signal
809 Haematoma 16 1.0 1.0 no signal
810 Agitation 45 1.0 1.0 no signal
811 Hypersensitivity 113 1.0 1.0 no signal
812 Liver Function Test Increased 13 1.0 1.0 no signal
813 Cardiomyopathy 9 1.0 1.0 no signal
814 Ligament Sprain 6 1.0 1.0 no signal
815 Neck Pain 34 1.0 1.0 no signal
816 Neoplasm 7 1.0 1.0 no signal
817 Osteoporosis 25 1.0 1.0 no signal
818 Palpitations 71 1.0 1.0 no signal
819 Weight Increased 135 1.0 1.0 no signal
820 Myalgia 103 1.0 1.0 no signal
821 Bronchitis 45 1.0 1.0 no signal
822 Osteonecrosis 20 1.0 1.0 no signal
823 Skin Cancer 13 1.0 1.0 no signal
824 Paraesthesia 95 1.0 1.0 no signal
825 Prescribed Underdose 12 1.0 1.0 no signal
826 Tremor 100 1.0 1.0 no signal
827 Hallucination 45 1.0 1.0 no signal
828 Restlessness 22 1.0 1.0 no signal
829 Pericarditis 10 1.0 1.0 no signal
830 Upper Limb Fracture 12 1.0 1.0 no signal
831 Candida Infection 10 1.0 1.0 no signal
832 Asthma 67 1.0 1.0 no signal
833 Rash Erythematous 28 1.0 1.0 no signal
834 Hypoaesthesia Oral 9 1.0 1.0 no signal
835 Product Dose Omission In Error 16 1.0 1.0 no signal
836 Hypersomnia 17 1.0 1.0 no signal
837 Dry Throat 6 1.0 1.0 no signal
838 Skin Exfoliation 49 1.0 1.0 no signal
839 Movement Disorder 19 1.0 1.0 no signal
840 Pallor 16 1.0 1.0 no signal
841 Dysarthria 22 1.0 1.0 no signal
842 Wrist Fracture 7 1.0 1.0 no signal
843 Neutrophil Count Increased 6 1.0 1.0 no signal
844 Musculoskeletal Discomfort 10 1.0 1.0 no signal
845 Dysstasia 17 1.0 1.0 no signal
846 Eructation 11 0.9 0.9 no signal
847 Swelling 54 0.9 0.9 no signal
848 Pulmonary Fibrosis 11 0.9 0.9 no signal
849 Psychotic Disorder 17 0.9 0.9 no signal
850 Road Traffic Accident 24 0.9 0.9 no signal
851 Cerebral Infarction 14 0.9 0.9 no signal
852 Lip Swelling 19 0.9 0.9 no signal
853 Carpal Tunnel Syndrome 8 0.9 0.9 no signal
854 Type 2 Diabetes Mellitus 19 0.9 0.9 no signal
855 Poisoning 7 0.9 0.9 no signal
856 Spinal Fracture 11 0.9 0.9 no signal
857 Fluid Retention 28 0.9 0.9 no signal
858 Pelvic Pain 10 0.9 0.9 no signal
859 Panic Attack 20 0.9 0.9 no signal
860 Cardiovascular Disorder 14 0.9 0.9 no signal
861 Drug Hypersensitivity 106 0.9 0.9 no signal
862 Staphylococcal Infection 18 0.9 0.9 no signal
863 End Stage Renal Disease 10 0.9 0.9 no signal
864 Laboratory Test Abnormal 16 0.9 0.9 no signal
865 Dyskinesia 22 0.9 0.9 no signal
866 Coagulopathy 9 0.9 0.9 no signal
867 Foot Deformity 6 0.9 0.9 no signal
868 Product Prescribing Issue 11 0.9 0.9 no signal
869 Head Injury 17 0.9 0.9 no signal
870 Deafness 14 0.9 0.9 no signal
871 Irritability 32 0.9 0.9 no signal
872 Cerebral Haemorrhage 19 0.9 0.9 no signal
873 Memory Impairment 73 0.9 0.9 no signal
874 Tooth Infection 7 0.9 0.9 no signal
875 Anger 18 0.9 0.9 no signal
876 Myocarditis 6 0.9 0.9 no signal
877 Sputum Discoloured 5 0.9 0.9 no signal
878 Foot Fracture 10 0.9 0.9 no signal
879 Anxiety 150 0.9 0.9 no signal
880 Sleep Apnoea Syndrome 10 0.9 0.9 no signal
881 Urticaria 87 0.9 0.9 no signal
882 Pharyngeal Swelling 5 0.9 0.9 no signal
883 Rheumatoid Arthritis 59 0.9 0.9 no signal
884 Gastric Haemorrhage 6 0.8 0.8 no signal
885 Product Dose Omission Issue 147 0.8 0.8 no signal
886 Drug Effect Incomplete 19 0.8 0.8 no signal
887 Acute Myeloid Leukaemia 8 0.8 0.8 no signal
888 Basal Cell Carcinoma 8 0.8 0.8 no signal
889 Viral Infection 17 0.8 0.8 no signal
890 Cold Sweat 9 0.8 0.8 no signal
891 Injury 36 0.8 0.8 no signal
892 Diabetes Mellitus Inadequate Control 9 0.8 0.8 no signal
893 Product Prescribing Error 12 0.8 0.8 no signal
894 Central Nervous System Lesion 7 0.8 0.8 no signal
895 Covid-19 Pneumonia 6 0.8 0.8 no signal
896 Product Use In Unapproved Indication 123 0.8 0.8 no signal
897 Dementia 14 0.8 0.8 no signal
898 Lacrimation Increased 15 0.8 0.8 no signal
899 Aphonia 7 0.8 0.8 no signal
900 Intervertebral Disc Protrusion 11 0.8 0.8 no signal
901 Mental Impairment 12 0.8 0.8 no signal
902 Cerebrovascular Accident 84 0.8 0.8 no signal
903 Vision Blurred 67 0.8 0.8 no signal
904 Helicobacter Infection 5 0.8 0.8 no signal
905 Initial Insomnia 5 0.8 0.8 no signal
906 Ear Infection 13 0.8 0.8 no signal
907 Subdural Haematoma 7 0.8 0.8 no signal
908 Secretion Discharge 6 0.8 0.8 no signal
909 Dermatitis 10 0.8 0.8 no signal
910 Tooth Extraction 6 0.8 0.8 no signal
911 Pharyngitis 6 0.8 0.8 no signal
912 Cardiac Failure Congestive 39 0.8 0.8 no signal
913 Hyperhidrosis 62 0.8 0.8 no signal
914 Neoplasm Malignant 32 0.8 0.8 no signal
915 Lymphadenopathy 17 0.8 0.8 no signal
916 Visual Impairment 59 0.8 0.8 no signal
917 Abasia 12 0.8 0.8 no signal
918 Depression 109 0.8 0.8 no signal
919 Incorrect Route Of Product Administration 8 0.8 0.8 no signal
920 Musculoskeletal Pain 25 0.8 0.8 no signal
921 Abnormal Dreams 13 0.8 0.8 no signal
922 Scar 8 0.8 0.8 no signal
923 Disturbance In Attention 25 0.8 0.8 no signal
924 Swelling Face 30 0.8 0.8 no signal
925 Neurotoxicity 8 0.8 0.8 no signal
926 Lung Neoplasm Malignant 19 0.8 0.8 no signal
927 Amnesia 30 0.8 0.8 no signal
928 Kidney Infection 9 0.8 0.8 no signal
929 Aggression 23 0.8 0.8 no signal
930 Myocardial Infarction 80 0.7 0.7 no signal
931 Neuralgia 11 0.7 0.7 no signal
932 Cognitive Disorder 21 0.7 0.7 no signal
933 Emotional Disorder 14 0.7 0.7 no signal
934 Feeling Abnormal 108 0.7 0.7 no signal
935 Illness 45 0.7 0.7 no signal
936 Blood Creatine Phosphokinase Increased 13 0.7 0.7 no signal
937 Gastroenteritis Viral 8 0.7 0.7 no signal
938 Flushing 45 0.7 0.7 no signal
939 Cholecystectomy 5 0.7 0.7 no signal
940 Feeling Hot 27 0.7 0.7 no signal
941 Hip Fracture 14 0.7 0.7 no signal
942 Product Use Issue 81 0.7 0.7 no signal
943 Blood Glucose Abnormal 8 0.7 0.7 no signal
944 Ovarian Cancer 4 0.7 0.7 no signal
945 Chronic Kidney Disease 33 0.7 0.7 no signal
946 Personality Change 4 0.7 0.7 no signal
947 Eyelid Oedema 5 0.7 0.7 no signal
948 Skin Reaction 6 0.7 0.7 no signal
949 Abnormal Behaviour 17 0.7 0.7 no signal
950 Adverse Drug Reaction 38 0.7 0.7 no signal
951 Pruritus 160 0.7 0.7 no signal
952 Fracture 8 0.7 0.7 no signal
953 Thrombosis 34 0.7 0.7 no signal
954 Fungal Infection 14 0.7 0.7 no signal
955 Death 362 0.7 0.7 no signal
956 Blood Urine Present 8 0.7 0.7 no signal
957 Feeling Jittery 8 0.7 0.7 no signal
958 Myelodysplastic Syndrome 6 0.7 0.7 no signal
959 Skin Discolouration 19 0.7 0.7 no signal
960 Influenza Like Illness 34 0.7 0.7 no signal
961 Wrong Technique In Product Usage Process 83 0.7 0.7 no signal
962 Parkinsonism 4 0.7 0.7 no signal
963 Hepatitis C 5 0.7 0.7 no signal
964 Hepatic Cytolysis 5 0.7 0.7 no signal
965 Mood Swings 13 0.7 0.7 no signal
966 Throat Tightness 11 0.7 0.7 no signal
967 Diabetes Mellitus 31 0.7 0.7 no signal
968 Product Availability Issue 9 0.7 0.7 no signal
969 Product Physical Issue 8 0.7 0.7 no signal
970 Rash Papular 9 0.7 0.7 no signal
971 Peritonitis Bacterial 4 0.7 0.7 no signal
972 Wound 11 0.6 0.6 no signal
973 Device Failure 6 0.6 0.6 no signal
974 Eye Pruritus 13 0.6 0.6 no signal
975 Cardiac Disorder 37 0.6 0.6 no signal
976 Anaphylactic Shock 10 0.6 0.6 no signal
977 Blood Count Abnormal 6 0.6 0.6 no signal
978 Muscle Twitching 9 0.6 0.6 no signal
979 Thyroid Disorder 6 0.6 0.6 no signal
980 Lymphoma 6 0.6 0.6 no signal
981 Burning Sensation 27 0.6 0.6 no signal
982 Tooth Loss 8 0.6 0.6 no signal
983 Dysmenorrhoea 5 0.6 0.6 no signal
984 Therapy Non-responder 17 0.6 0.6 no signal
985 Bone Disorder 7 0.6 0.6 no signal
986 Eczema 19 0.6 0.6 no signal
987 Eye Haemorrhage 5 0.6 0.6 no signal
988 Localised Infection 9 0.6 0.6 no signal
989 Hair Texture Abnormal 5 0.6 0.6 no signal
990 Tinnitus 17 0.6 0.6 no signal
991 Adverse Event 34 0.6 0.6 no signal
992 Completed Suicide 31 0.6 0.6 no signal
993 Mood Altered 10 0.6 0.6 no signal
994 Respiratory Disorder 11 0.6 0.6 no signal
995 Serotonin Syndrome 7 0.6 0.6 no signal
996 Osteonecrosis Of Jaw 9 0.6 0.6 no signal
997 Drug Withdrawal Syndrome 32 0.6 0.6 no signal
998 Sinusitis 37 0.6 0.6 no signal
999 Dystonia 7 0.6 0.6 no signal
1000 Migraine 34 0.6 0.6 no signal
1001 Hypertensive Crisis 4 0.6 0.6 no signal
1002 Blindness Unilateral 5 0.6 0.6 no signal
1003 Disability 7 0.6 0.6 no signal
1004 Impaired Driving Ability 4 0.6 0.6 no signal
1005 Internal Haemorrhage 4 0.6 0.6 no signal
1006 Skin Haemorrhage 5 0.6 0.6 no signal
1007 Blood Glucose Increased 65 0.6 0.6 no signal
1008 Local Swelling 6 0.6 0.6 no signal
1009 Fluid Overload 5 0.6 0.6 no signal
1010 Renal Injury 10 0.5 0.5 no signal
1011 Brain Neoplasm 3 0.5 0.5 no signal
1012 Haemorrhage 34 0.5 0.5 no signal
1013 Medication Error 18 0.5 0.5 no signal
1014 Abortion Spontaneous 13 0.5 0.5 no signal
1015 Delusion 5 0.5 0.5 no signal
1016 Libido Decreased 4 0.5 0.5 no signal
1017 Abortion Induced 3 0.5 0.5 no signal
1018 Leukaemia 3 0.5 0.5 no signal
1019 No Adverse Event 56 0.5 0.5 no signal
1020 Bone Density Decreased 10 0.5 0.5 no signal
1021 Therapeutic Response Unexpected 14 0.5 0.5 no signal
1022 Surgery 18 0.5 0.5 no signal
1023 Joint Stiffness 8 0.5 0.5 no signal
1024 Rash Generalised 8 0.5 0.5 no signal
1025 Unevaluable Event 23 0.5 0.5 no signal
1026 Complication Associated With Device 4 0.5 0.5 no signal
1027 Multiple Fractures 5 0.5 0.5 no signal
1028 Crying 11 0.5 0.5 no signal
1029 Visual Acuity Reduced 10 0.5 0.5 no signal
1030 Ovarian Cyst 3 0.5 0.5 no signal
1031 Eye Swelling 11 0.5 0.5 no signal
1032 Intentional Dose Omission 8 0.5 0.5 no signal
1033 Gastric Disorder 10 0.5 0.5 no signal
1034 Suicidal Ideation 26 0.5 0.5 no signal
1035 Tardive Dyskinesia 8 0.5 0.5 no signal
1036 Emotional Distress 34 0.5 0.5 no signal
1037 Ocular Hyperaemia 13 0.5 0.5 no signal
1038 Glycosylated Haemoglobin Increased 7 0.5 0.5 no signal
1039 Acne 21 0.5 0.5 no signal
1040 Gait Inability 9 0.4 0.4 no signal
1041 Angioedema 12 0.4 0.4 no signal
1042 Product Dose Omission 18 0.4 0.4 no signal
1043 Bone Loss 4 0.4 0.4 no signal
1044 Femur Fracture 8 0.4 0.4 no signal
1045 Madarosis 3 0.4 0.4 no signal
1046 Nervous System Disorder 8 0.4 0.4 no signal
1047 Hallucination, Auditory 4 0.4 0.4 no signal
1048 Extra Dose Administered 10 0.4 0.4 no signal
1049 Diabetic Ketoacidosis 6 0.4 0.4 no signal
1050 Blood Glucose Decreased 12 0.4 0.4 no signal
1051 Activities Of Daily Living Impaired 5 0.4 0.4 no signal
1052 Pregnancy 5 0.4 0.4 no signal
1053 Blindness 10 0.4 0.4 no signal
1054 Injection Site Discolouration 3 0.4 0.4 no signal
1055 Muscle Spasticity 3 0.4 0.4 no signal
1056 Skin Irritation 11 0.4 0.4 no signal
1057 Injection Site Irritation 3 0.4 0.4 no signal
1058 Eye Pain 13 0.4 0.4 no signal
1059 Eye Irritation 13 0.4 0.4 no signal
1060 Hypoacusis 10 0.4 0.4 no signal
1061 Therapeutic Response Decreased 14 0.4 0.4 no signal
1062 Therapy Interrupted 16 0.4 0.4 no signal
1063 Sopor 3 0.4 0.4 no signal
1064 Psoriasis 28 0.4 0.3 no signal
1065 Needle Issue 6 0.3 0.3 no signal
1066 Disease Recurrence 10 0.3 0.3 no signal
1067 Pancreatic Carcinoma 6 0.3 0.3 no signal
1068 Extrapyramidal Disorder 5 0.3 0.3 no signal
1069 Drug Dependence 32 0.3 0.3 no signal
1070 Exposure During Pregnancy 12 0.3 0.3 no signal
1071 Therapeutic Response Shortened 6 0.3 0.3 no signal
1072 Amenorrhoea 3 0.3 0.3 no signal
1073 Drug Exposure During Pregnancy 6 0.3 0.3 no signal
1074 Multiple Sclerosis Relapse 12 0.3 0.3 no signal
1075 Syringe Issue 3 0.3 0.3 no signal
1076 Injection Site Pain 51 0.3 0.3 no signal
1077 Incorrect Route Of Drug Administration 6 0.3 0.3 no signal
1078 Colorectal Cancer 8 0.3 0.3 no signal
1079 Dependence 9 0.3 0.3 no signal
1080 Injection Site Pruritus 10 0.2 0.2 no signal
1081 Product Storage Error 13 0.2 0.2 no signal
1082 Injection Site Warmth 3 0.2 0.2 no signal
1083 Multiple Sclerosis 7 0.2 0.2 no signal
1084 Injection Site Swelling 11 0.2 0.2 no signal
1085 Product Preparation Error 3 0.2 0.2 no signal
1086 Accidental Exposure To Product 14 0.2 0.2 no signal
1087 Injection Site Bruising 11 0.2 0.2 no signal
1088 Wrong Technique In Drug Usage Process 5 0.2 0.2 no signal
1089 Injection Site Reaction 9 0.2 0.2 no signal
1090 Injection Site Erythema 16 0.2 0.2 no signal
1091 Device Issue 11 0.2 0.2 no signal
1092 Maternal Exposure During Pregnancy 11 0.2 0.2 no signal
1093 Injection Site Urticaria 3 0.2 0.2 no signal
1094 Prostate Cancer 10 0.2 0.2 no signal
1095 Gastric Cancer 3 0.2 0.2 no signal
1096 Breast Cancer 11 0.2 0.2 no signal
1097 Device Dislocation 5 0.2 0.2 no signal
1098 Pharmaceutical Product Complaint 3 0.2 0.2 no signal
1099 Gynaecomastia 3 0.2 0.2 no signal
1100 Injection Site Haemorrhage 7 0.1 0.1 no signal
1101 Drug Dose Omission 14 0.1 0.1 no signal
1102 Product Quality Issue 8 0.1 0.1 no signal