Reaction

Product Size Issue reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 5,247 reports · 61 co-occurring drugs

As of the last recalculation, Product Size Issue appears in 5,247 FAERS reports alongside 61 co-occurring drug terms. The strongest observed disproportionality signal is LOPERAMIDE HYDROCHLORIDE AND DIMETHICONE (PRR 62.0).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Loperamide Hydrochloride And Dimethicone	458	62.0	62.9
Enzalutamide	612	46.6	47.1
Icosapent Ethyl	97	46.0	46.6
Guaifenesin	117	15.5	15.6
Abiraterone Acetate	125	12.3	12.4
Nirmatrelvir And Ritonavir	145	10.9	10.9
Thyroid, Porcine	28	10.5	10.5
Voxelotor	47	8.4	8.4
Loperamide Hydrochloride	90	8.1	8.1
Ibuprofen Sodium	84	7.9	7.9
Ibuprofen Tablets, Coated	83	7.9	7.9
Naproxen Sodium, Dextromethorphan Hydrobromide, Guaifenesin	39	7.6	7.6
Naproxen Sodium, Pseudoephedrine Hydrochloride	39	7.6	7.6
Rifaximin	38	7.2	7.3
Ibuprofen And Diphenhydramine Citrate	41	7.0	7.0
Apalutamide	20	6.8	6.8
Tafamidis	20	6.8	6.8
Estradiol	142	6.7	6.7
Fexofenadine Hcl	13	5.6	5.6
Sitagliptin And Metformin Hydrochloride	26	4.8	4.8
Bicalutamide	18	4.7	4.7
Fexofenadine Hydrochloride	23	4.2	4.2
Pancrelipase	40	4.1	4.1
Desloratadine	11	4.1	4.1
Darunavir	15	3.9	3.9
Raltegravir	16	3.9	3.9
Naltrexone Hydrochloride And Bupropion Hydrochloride	8	3.7	3.7
Encorafenib	9	3.6	3.6
Dolutegravir Sodium	8	3.5	3.5
Naproxen Sodium Tablet	46	3.5	3.5
Estradiol Gel 0.1%	37	3.3	3.3
Estradiol Transdermal	37	3.3	3.3
Velpatasvir And Sofosbuvir	10	3.1	3.1
Hydroxyurea	16	3.0	3.0
Vibegron	6	3.0	3.0
Abiraterone	10	2.9	2.9
Liothyronine Sodium	6	2.7	2.7
Loratadine And Pseudoephedrine Sulfate	5	2.5	2.5
Mirabegron	24	2.5	2.5
Ranolazine	6	2.3	2.3
Glecaprevir And Pibrentasvir	6	2.2	2.2
Rivaroxaban	112	2.2	2.2
Memantine	7	2.0	2.0
Memantine Hydrochloride	7	2.0	2.0
Dronedarone	5	1.9	1.9
Palbociclib	46	1.9	1.9
Buprenorphine	44	1.9	1.9
Crizotinib	6	1.9	1.9
Rucaparib	4	1.8	1.8
Siponimod	4	1.8	1.8
Sevelamer Carbonate	5	1.7	1.7
Conjugated Estrogens And Medroxyprogesterone Acetate	10	1.7	1.7
Niraparib	9	1.6	1.6
Copper	16	1.5	1.5
Oxycodone Hydrochloride	76	1.4	1.4
Bimatoprost	9	1.2	1.2
Ledipasvir And Sofosbuvir	6	1.2	1.2
Emtricitabine And Tenofovir Disoproxil Fumarate	14	1.2	1.2
Isotretinoin	13	1.0	1.0
Relugolix	6	1.0	1.0
Adapalene	8	0.2	0.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.