Reaction

Spina Bifida reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 2,077 reports · 46 co-occurring drugs

As of the last recalculation, Spina Bifida appears in 2,077 FAERS reports alongside 46 co-occurring drug terms. The strongest observed disproportionality signal is DIVALPROEX SODIUM (PRR 115.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Divalproex Sodium	428	115.8	116.9
Nevirapine	48	54.6	54.8
Ritonavir 100 Mg	61	42.1	42.3
Lopinavir And Ritonavir	50	37.9	38.0
Darunavir	52	35.3	35.4
Misoprostol	33	34.5	34.6
Zonisamide	49	34.0	34.1
Clobazam	79	33.7	33.8
Atazanavir	47	33.5	33.6
Ritonavir	92	33.0	33.1
Efavirenz	35	32.0	32.1
Valproate Sodium	63	31.5	31.6
Hydrocodone Bitartrate And Acetaminophen	163	31.4	31.5
Zidovudine	37	28.2	28.3
Lamotirigine	184	28.1	28.2
Lamotrigine Extended-Release	184	28.1	28.2
Lamotrigine Chewable Dispersible	184	28.1	28.2
Valproic Acid	83	27.4	27.5
Raltegravir	38	23.5	23.5
Tenofovir Disoproxil Fumarate Tablets	20	23.4	23.5
Abacavir Sulfate	20	20.8	20.8
Phenobarbital	29	20.3	20.4
Lamivudine Oral	48	19.4	19.5
Hydrocodone Bitartrate	78	18.7	18.7
Phenytoin	36	17.6	17.6
Lamotrigine	202	16.9	16.9
Hydromorphone Hydrochloride	141	16.4	16.4
Levetiracetam In Sodium Chloride	118	16.1	16.1
Levetiracetam Oral	118	16.1	16.1
Levetiracetam Injection	118	16.1	16.1
Lamivudine	48	15.9	15.9
Emtricitabine And Tenofovir Disoproxil Fumarate	70	15.9	15.9
Oxycodone Hydrochloride	257	13.4	13.4
Emtricitabine And Tenofovir Alafenamide	15	13.3	13.4
Paroxetine Hydrochloride	104	12.0	12.0
Morphine Sulfate	133	11.7	11.7
Levetiracetam	137	10.9	10.9
Carbamazepine	68	10.5	10.5
Lacosamide	37	10.1	10.1
Buprenorphine	82	9.2	9.2
Oxymorphone Hydrochloride	10	8.6	8.6
Tenofovir Disoproxil Fumarate	24	7.3	7.4
Dolutegravir Sodium	5	5.6	5.6
Vigabatrin	7	4.8	4.8
Oxycodone And Acetaminophen	11	4.7	4.8
Ixekizumab	8	2.2	2.2

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.