Ibuprofen vs Naproxen 220Mg: side effects in FDA adverse event reports
At a glance
| Ibuprofen | Naproxen 220Mg | |
|---|---|---|
| Drug class | Nonsteroidal Anti-inflammatory Drug | – |
| Brand names | – | Naproxen Sodium 220Mg |
| FAERS reports | 269,923 | 13,479 |
| Serious | 65% | 77% |
| Death outcome | 18,300 | 3,768 |
| Boxed warning | Yes Cardiovascular Thrombotic Events • Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including | No |
Signals both drugs share
| Reaction | Ibuprofen | Naproxen 220Mg | Label screen (A / B) |
|---|---|---|---|
| Duodenal ulcer perforation | 2,987 · PRR 53.0 | 1,751 · PRR 488.8 | Labeled — boxed warning / Not in label — unassessed |
| Sleep disorder due to general medical condition, insomnia type | 2,296 · PRR 42.8 | 850 · PRR 236.9 | Labeled (related wording) / Not in label — unassessed |
| Hand deformity | 2,887 · PRR 21.8 | 1,900 · PRR 264.6 | Not in label — unassessed / Not in label — unassessed |
| Pemphigus | 2,949 · PRR 23.9 | 1,831 · PRR 269.1 | Not in label — unassessed / Not in label — unassessed |
| Folliculitis | 2,946 · PRR 30.7 | 1,731 · PRR 313.7 | Not in label — unassessed / Not in label — unassessed |
| Helicobacter infection | 2,915 · PRR 30.8 | 1,742 · PRR 321.2 | Not in label — unassessed / Not in label — unassessed |
| Muscle injury | 3,029 · PRR 45.2 | 1,464 · PRR 338.4 | Not in label — unassessed / Not in label — unassessed |
| Rheumatic fever | 1,329 · PRR 33.7 | 1,382 · PRR 723.5 | Likely indication confounding / Not in label — unassessed |
| Lip dry | 1,115 · PRR 10.9 | 1,254 · PRR 253.4 | Not in label — unassessed / Not in label — unassessed |
| Facet joint syndrome | 827 · PRR 27.4 | 1,214 · PRR 981.1 | Not in label — unassessed / Not in label — unassessed |
| Deep vein thrombosis postoperative | 865 · PRR 61.1 | 870 · PRR 1,251.9 | Not in label — unassessed / Not in label — unassessed |
| Peripheral venous disease | 770 · PRR 18.4 | 957 · PRR 491.8 | Not in label — unassessed / Not in label — unassessed |
| Adjustment disorder with depressed mood | 747 · PRR 45.4 | 625 · PRR 702.4 | Not in label — unassessed / Not in label — unassessed |
| Dislocation of vertebra | 675 · PRR 33.6 | 664 · PRR 664.8 | Not in label — unassessed / Not in label — unassessed |
| Lupus vulgaris | 461 · PRR 48.8 | 523 · PRR 1,230.5 | Not in label — unassessed / Not in label — unassessed |
| Retinitis | 383 · PRR 22.9 | 362 · PRR 431.8 | Not in label — unassessed / Not in label — unassessed |
| Porphyria acute | 228 · PRR 15.2 | 242 · PRR 331.1 | Not in label — unassessed / Not in label — unassessed |
Labeled signals distinctive to Ibuprofen
- Glossodynia — n=3,142, PRR 12.6 Labeled (related wording)
- Fixed eruption — n=228, PRR 11.9 Labeled (related wording)
- Gastric ulcer perforation — n=216, PRR 15.8 Labeled — boxed warning
Labeled signals distinctive to Naproxen 220Mg
- None stood out among the strongest labeled signals.
Common questions
Which has more reported side effects, Ibuprofen or Naproxen 220Mg?
Ibuprofen has 269,923 FAERS reports and Naproxen 220Mg 13,479. More reports does not mean more dangerous: volume follows how widely and how long a drug has been used, prescription vs over-the-counter status, and publicity. The seriousness share (65% vs 77%) is a better like-for-like signal of the kind of problems reported.
Which side effects do Ibuprofen and Naproxen 220Mg share?
Both drugs carry disproportionality signals for duodenal ulcer perforation, sleep disorder due to general medical condition, insomnia type, hand deformity, pemphigus, folliculitis. Shared signals often reflect a shared drug class or the condition both are used for.
Is Ibuprofen or Naproxen 220Mg safer?
FAERS cannot answer that: it has no denominator and no comparator. Use this page to see which risks are already on each label and which signals are unlabeled, then check the prescribing information and your clinician for your situation.
Sources: openFDA FAERS pair statistics (OpenPV build 2026-09-14), FDA labels via openFDA, openFDA count queries for seriousness and deaths. Pair chosen because it is a commonly searched comparison. Generated 2026-10-08.