Reaction

Anticholinergic Syndrome reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,573 reports · 69 co-occurring drugs

As of the last recalculation, Anticholinergic Syndrome appears in 1,573 FAERS reports alongside 69 co-occurring drug terms. The strongest observed disproportionality signal is LOPERAMIDE HYDROCHLORIDE ORAL (PRR 99.1).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Loperamide Hydrochloride Oral	73	99.1	99.9
Atropine Sulfate	76	97.8	98.5
Atropine	53	87.6	88.1
Tolterodine Tartrate	55	84.0	84.5
Loperamide Hcl	75	81.0	81.4
Oxybutynin Chloride	51	79.5	80.0
Trazodone Hydrochloride	79	70.3	70.7
Amitriptyline Hydrochloride	88	70.2	70.6
Haloperidol	105	61.2	61.5
Haloperidol Lactate	106	60.7	60.9
Quetiapine Fumarate	116	56.1	56.3
Rivastigmine	68	49.9	50.1
Diphenhydramine Hydrochloride Capsule, Liquid Filled	63	40.6	40.7
Donepezil Hydrochloride	105	40.5	40.6
Rocuronium Bromide	31	35.5	35.6
Oxybutynin	72	34.1	34.1
Olanzapine	236	34.0	34.1
Quetiapine	349	30.5	30.6
Diphenhydramine	128	29.1	29.1
Asenapine Maleate	18	27.8	27.8
Hydroxyzine	93	27.4	27.4
Paroxetine Hydrochloride Hemihydrate	66	27.3	27.4
Propofol	71	26.9	26.9
Paroxetine	66	26.8	26.8
Mirtazapine	165	26.5	26.6
Risperidone	229	26.5	26.5
Midazolam Hydrochloride	50	25.3	25.4
Loperamide Hydrochloride	81	25.2	25.3
Hyoscyamine Sulfate	17	24.8	24.8
Midazolam	44	23.7	23.8
Diphenhydramine Hcl	19	22.8	22.9
Ranitidine Hydrochloride	88	22.6	22.7
Sevoflurane	13	20.9	20.9
Guanfacine	12	20.3	20.4
Quinapril Hydrochloride	12	20.3	20.3
Diphenhydramine Hydrochloride	217	19.9	20.0
Doxepin	15	19.8	19.8
Lithium	36	19.3	19.3
Lithium Bromatum	36	19.3	19.3
Paroxetine Hydrochloride	112	17.5	17.5
Fesoterodine Fumarate	14	17.2	17.3
Norepinephrine	13	16.2	16.2
Doxepin Hydrochloride	15	15.9	15.9
Venlafaxine	70	13.5	13.5
Bisacodyl Suppositories	13	13.4	13.4
Biscodyl	13	13.3	13.3
Buspirone Hydrochloride	11	13.3	13.3
Rasagiline Mesylate	11	13.2	13.2
Norepinephrine Bitartrate	14	13.0	13.0
Bisacodyl	13	12.3	12.3
Hydroxyzine Hydrochloride	12	12.2	12.2
Hydroxyzine Hydrochloride Oral	12	12.2	12.2
Escitslopram	49	11.5	11.5
Levodopa	10	11.0	11.0
Valproic Acid	25	10.7	10.7
Pramipexole	12	10.4	10.4
Amantadine	12	10.3	10.3
Amphetamine	6	9.6	9.6
Ropinirole	11	9.5	9.5
Escitalopram Oxalate	51	9.5	9.5
Aripiprazole Oral	28	9.1	9.1
Aripiprazole Orally Disintegrating	28	9.1	9.1
Cenobamate	5	8.0	8.0
Paliperidone	13	7.4	7.4
Ethyl Alcohol	15	7.4	7.4
Acetaminophen And Codeine	6	6.5	6.5
Isopropyl Alcohol	15	5.9	5.9
Alcohol	17	5.8	5.8
Clozapine	44	4.7	4.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.