Reaction

Osteosclerosis reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 1,557 reports · 109 co-occurring drugs

As of the last recalculation, Osteosclerosis appears in 1,557 FAERS reports alongside 109 co-occurring drug terms. The strongest observed disproportionality signal is CHLORHEXIDINE GLUCONATE (PRR 83.4).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Chlorhexidine Gluconate	55	83.4	83.9
Diphenoxylate Hydrochloride And Atropine Sulfate	49	49.3	49.5
Letrozole	163	39.4	39.5
Exemestane	60	38.9	39.0
Fulvestrant	88	37.7	37.8
Risedronate Sodium	83	37.6	37.7
Ribociclib	83	37.1	37.2
Trazodone Hydrochloride	41	36.0	36.1
Goserelin	33	33.5	33.6
Zoledronic Acid	85	29.9	29.9
Bicalutamide	33	29.6	29.6
Letrozole Tablets	93	27.4	27.5
Doxepin Hydrochloride	25	26.9	26.9
Loperamide Hydrochloride Oral	20	26.5	26.6
Mometasone Furoate	75	25.2	25.3
Thiamine Hydrochloride	22	24.0	24.0
Clindamycin Phosphate	57	23.6	23.7
Methylprednisolone Acetate	14	23.6	23.6
Anastrozole	62	23.5	23.5
Clindamycin	47	22.8	22.8
Loperamide Hcl	21	22.1	22.1
Doxepin	16	21.3	21.3
Magnesium Hydroxide	21	21.1	21.1
Cimetidine	15	21.0	21.0
Melphalan Hydrochloride	38	20.7	20.8
Alendronate Sodium	141	20.4	20.5
Quinine	13	20.4	20.5
Melphalan	34	20.4	20.4
Ascorbic Acid	34	20.0	20.0
Thalidomide	53	19.9	20.0
Psyllium Husk	14	19.1	19.1
Anastrozole Tablets	30	19.0	19.1
Meperidine Hydrochloride	13	19.0	19.0
Cephalexin	30	18.9	18.9
Docusate Sodium - Sennosides	40	17.0	17.0
Fentanyl	115	16.8	16.8
Leflunomide	121	16.7	16.7
Celecoxib	146	16.3	16.3
Biotin	37	16.2	16.2
Pertuzumab	32	16.0	16.1
Ado-Trastuzumab Emtansine	10	16.0	16.0
Epoetin Alfa	14	15.9	16.0
Cefazolin	10	14.7	14.8
Ampicillin	9	14.6	14.6
Ampicillin Sodium	9	14.6	14.6
Trastuzumab	69	14.0	14.0
Amoxicillin And Clavulanate Potassium	28	14.0	14.0
Sulfasalazine	78	14.0	14.0
Vitamin E	32	13.9	13.9
Cefazolin Sodium	12	13.4	13.4
Indomethacin	13	13.2	13.2
Temazepam	36	13.0	13.1
Standardized Senna Concentrate	12	12.8	12.9
Filgrastim	34	12.3	12.3
Docusate Sodium	51	12.2	12.2
Abatacept	116	12.0	12.0
Capecitabine	78	11.9	12.0
Erythropoietin	18	11.8	11.8
Oxycodone Hydrochloride And Acetaminophen	82	11.7	11.7
Losartan Potassium And Hydrochlorothiazide	10	11.6	11.6
Esomeprazole	52	11.6	11.6
Ibuprofen And Diphenhydramine Citrate	19	11.0	11.0
Loperamide Hydrochloride	36	11.0	11.0
Rabeprazole Sodium	22	10.9	10.9
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	118	10.6	10.6
Oxycodone Hydrochloride	156	10.6	10.6
Clobetasol Propionate Ointment Usp, 0.05%	8	10.4	10.4
Clobetasol Propionate	8	10.4	10.4
Prochlorperazine	21	10.3	10.3
Oxycodone And Acetaminophen Tablets	9	10.1	10.2
Hydroxychloroquine	54	10.0	10.0
Zolpidem Tartrate	94	9.8	9.8
Ezetimibe And Simvastatin	11	9.7	9.7
Sennosides 8.6 Mg Tablets	15	9.7	9.7
Darbepoetin Alfa	38	9.6	9.6
Lapatinib	11	9.5	9.5
Hydroxychloroquine Sulfate	61	9.3	9.3
Methadone	29	9.2	9.2
Docetaxel Anhydrous	45	9.2	9.2
Docetaxel	45	9.2	9.2
Fluticasone Propionate And Salmeterol	28	9.1	9.1
Doxorubicin Hydrochloride	21	8.7	8.7
Oxycodone And Acetaminophen	15	8.7	8.7
Denosumab	121	8.6	8.6
Gemcitabine	24	8.3	8.3
Polatuzumab Vedotin	6	8.2	8.3
Eszopiclone	15	7.9	7.9
Bendamustine Hcl	9	7.8	7.8
Tenofovir Disoproxil Fumarate Tablets	5	7.8	7.8
Tocilizumab	62	7.5	7.5
Palbociclib	52	7.5	7.5
Gemcitabine Hydrochloride	28	7.2	7.2
Conjugated Estrogens And Medroxyprogesterone Acetate	12	6.8	6.8
Obinutuzumab	8	6.5	6.5
Tofacitinib	84	6.4	6.4
Hydromorphone Hydrochloride	41	6.1	6.1
Abiraterone	6	5.9	5.9
Paclitaxel	41	5.7	5.7
Bortezomib	37	5.6	5.6
Bendamustine Hydrochloride	5	5.6	5.6
Asfotase Alfa	4	5.3	5.4
Crizotinib	5	5.3	5.3
Panitumumab	6	5.1	5.1
Loratadine And Pseudoephedrine Sulfate	3	5.1	5.1
Alpelisib	3	4.6	4.6
Ranitidine Hydrochloride	15	3.7	3.7
Enzalutamide	15	3.4	3.4
Abiraterone Acetate	10	3.3	3.3
Orlistat	6	3.1	3.1

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.