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Which drugs are most reported with Torsade de pointes?

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 7,759 reports · 320 co-occurring drugs

As of the last recalculation, Torsade De Pointes appears in 7,759 FAERS reports alongside 320 co-occurring drug terms. The strongest observed disproportionality signal is DOFETILIDE (PRR 42.8).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Dofetilide	164	42.8	43.4
Sotalol Hydrochloride	214	35.5	35.9
Amiodarone Hydrochloride	142	34.6	35.0
Loperamide Hydrochloride Oral	109	29.0	29.3
Methadone Hydrochloride	115	28.9	29.2
Sevoflurane	87	28.4	28.7
Methadone	424	28.1	28.3
Loperamide Hcl	118	25.0	25.2
Haloperidol Lactate	200	22.2	22.4
Haloperidol	190	21.5	21.6
Magnesium Sulfate Heptahydrate	88	18.3	18.4
Magnesium Sulfate In Water For	86	18.3	18.4
Magnesium Sulfate	86	17.9	18.0
Dronedarone	67	17.8	17.9
Moxifloxacin	79	15.2	15.3
Propofol	194	14.6	14.7
Cimetidine	49	13.7	13.8
Rocuronium Bromide	59	13.5	13.6
Norepinephrine Bitartrate	71	13.3	13.4
Moxifloxacin Hydrochloride	96	12.8	12.9
Digoxin	323	12.6	12.6
Posaconazole Delayed-Release	50	12.3	12.3
Norepinephrine	48	12.1	12.2
Bicalutamide	68	12.1	12.1
Fluoxetine	286	11.9	12.0
Cefazolin	38	11.2	11.3
Ondansetron	431	11.1	11.2
Ondansetron Tablets	431	11.1	11.2
Ceftriaxone	133	11.0	11.1
Ceftriaxone Sodium	153	10.9	10.9
Indapamide	72	10.9	10.9
Ondansetron Hydrochloride	465	10.8	10.8
Posaconazole	64	10.6	10.7
Fluconazole	269	10.6	10.7
Metolazone	44	10.6	10.6
Clarithromycin	132	10.5	10.5
Citalopram Hydrobromide	383	10.0	10.1
Voriconazole	110	9.8	9.9
Ciprofolxacin	252	9.7	9.8
Ciprofloxacin Tablets	252	9.7	9.8
Diltiazem Hydrochloride Extended-Release Tablets	41	9.7	9.7
Escitslopram	204	9.6	9.7
Voriconazole Injection	77	9.6	9.6
Donepezil Hydrochloride	128	9.5	9.5
Atropine	29	9.4	9.5
Cefazolin Sodium	42	9.4	9.4
Loperamide Hydrochloride	152	9.3	9.3
Escitalopram Oxalate	242	9.2	9.2
Erythromycin	63	9.1	9.1
Levofloxacin	193	8.8	8.8
Levofloxacin In 5% Dextrose	193	8.8	8.8
Micafungin Sodium	27	8.6	8.6
Ampicillin	26	8.4	8.5
Ampicillin Sodium	26	8.4	8.5
Atropine Sulfate	33	8.2	8.2
Piperacillin And Tazobactam	39	8.2	8.2
Citalopram	400	8.2	8.2
Ciprofloxacin	272	8.2	8.2
Fluoxetine Hydrochloride	372	8.2	8.2
Remdesivir	40	8.1	8.1
Itraconazole	35	8.1	8.1
Metoclopramide	161	8.0	8.0
Ciprofloxacin Hydrochloride	280	8.0	8.0
Zidovudine	38	7.7	7.7
Dimenhydrinate	30	7.6	7.6
Amphotericin B	35	7.5	7.5
Ranolazine	29	7.5	7.5
Quetiapine Fumarate	78	7.2	7.2
Abiraterone	35	6.9	6.9
Oxazepam	55	6.9	6.9
Ziprasidone	45	6.9	6.9
Azithromycin	102	6.9	6.9
Metoclopramide Hydrochloride	190	6.7	6.8
Piperacillin Sodium And Tazobactam Sodium	49	6.7	6.8
Azithromycin Monohydrate	102	6.6	6.7
Midazolam Hydrochloride	66	6.6	6.6
Ritonavir 100 Mg	36	6.5	6.5
Metronidazole Topical	112	6.4	6.4
Midazolam	59	6.3	6.3
Furosemide	851	6.3	6.3
Bisoprolol Fumarate	293	6.0	6.0
Bupropion	94	5.7	5.7
Azithromycin Dihydrate	123	5.7	5.7
Ziprasidone Mesylate	30	5.7	5.7
Glyburide	50	5.6	5.6
Olanzapine	216	5.5	5.5
Metronidazole	127	5.4	5.4
Oseltamivir	16	5.4	5.4
Hydroxychloroquine	147	5.4	5.4
Piperacillin Sodium,Tazobactam Sodium	52	5.3	5.3
Vancomycin	111	5.2	5.2
Paroxetine Hydrochloride Hemihydrate	64	5.2	5.2
Vancomycin Hydrochloride	125	5.2	5.2
Escitalopram	260	5.1	5.1
Paroxetine	64	5.1	5.1
Phytonadione	16	5.1	5.1
Captopril	18	5.0	5.0
Warfarin Sodium	83	4.8	4.8
Febuxostat Tablets 40 Mg	18	4.8	4.8
Febuxostat Tablets 80 Mg	18	4.8	4.8
Diltiazem Hydrochloride	60	4.7	4.7
Propranolol Hydrochloride	124	4.7	4.7
Lidicaine	84	4.6	4.7
Burn Relief	84	4.6	4.7
Torsemide	57	4.6	4.6
Lidocaine Hydrochloride And Epinephrine	84	4.6	4.6
Lidocaine Hydrochloride	103	4.6	4.6
Lidocaine, Menthol	84	4.6	4.6
Lidocaine Hydrochloride And Epinephrine Bitartrate	90	4.6	4.6
Quetiapine	314	4.5	4.5
Aripiprazole Oral	69	4.5	4.5
Aripiprazole Orally Disintegrating	69	4.5	4.5
Atazanavir	24	4.5	4.5
Bumetanide	44	4.5	4.5
Levetiracetam In Sodium Chloride	126	4.4	4.4
Levetiracetam Oral	126	4.4	4.4
Levetiracetam Injection	126	4.4	4.4
Sodium Bicarbonate	37	4.3	4.3
Sodium Bicarbonate Injection,	37	4.3	4.3
Lidocaine 4%	86	4.3	4.3
Lamivudine Oral	40	4.3	4.3
Venlafaxine	112	4.2	4.2
Calcium Gluconate	19	4.2	4.2
Labetalol	21	4.2	4.2
Ropinirole	24	4.2	4.2
Sumatriptan Succinate	39	4.2	4.2
Abacavir Sulfate	15	4.1	4.1
Diphenhydramine	96	4.1	4.1
Warfarin	191	4.1	4.1
Spironolactone	210	4.1	4.1
Fentanyl	147	4.1	4.1
Mirtazapine	136	4.0	4.0
Lidocaine	86	4.0	4.0
Magnesium	119	3.9	3.9
Memantine	20	3.9	3.9
Memantine Hydrochloride	20	3.9	3.9
Thiamine Hydrochloride	18	3.9	3.9
Irbesartan	64	3.9	3.9
Daspone	14	3.9	3.9
Dapsone Gel, 5%	14	3.9	3.9
Valproic Acid	45	3.8	3.9
Lamivudine	44	3.8	3.8
Methimazole	11	3.8	3.8
Desloratadine	15	3.8	3.8
Tizanidine	33	3.7	3.7
Linezolid	41	3.7	3.7
Ritonavir	40	3.7	3.7
Cefepime Hydrochloride	22	3.7	3.7
Osimertinib	43	3.6	3.6
Trazodone Hydrochloride	21	3.6	3.6
Potassium Chloride, Dextrose Monohydrate	122	3.6	3.6
Potassium Chloride Oral	122	3.6	3.6
Potassium Chloride Extended-Release	122	3.6	3.6
Bisacodyl Suppositories	17	3.5	3.5
Loperamide Hydrochloride And Dimethicone	42	3.5	3.5
Dapsone	14	3.5	3.5
Biscodyl	17	3.5	3.5
Lorazepam	228	3.5	3.5
Hydroxyzine	61	3.5	3.5
Quinine	11	3.4	3.4
Isosorbide Dinitrate	25	3.4	3.4
Sertraline	148	3.4	3.4
Acetylcysteine	12	3.4	3.4
Cefepime	18	3.4	3.4
Cytarabine	75	3.4	3.4
Adrenalinum	51	3.3	3.3
Fentanyl Citrate	22	3.3	3.3
Insulin	68	3.3	3.3
Risperidone	160	3.3	3.3
Theophylline	14	3.3	3.3
Bisacodyl	17	3.2	3.2
Amitriptyline Hydrochloride	21	3.2	3.2
Metoprolol Succinate Er Tablets	74	3.2	3.2
Doxepin	12	3.2	3.2
Naproxen Sodium Tablet, Coated	16	3.2	3.2
Naproxen Sodium, Coated Tablets	16	3.2	3.2
Naproxen Sodium 220Mg	16	3.2	3.2
Diphenhydramine Hcl	13	3.1	3.1
Hydrochlorothiazide	166	3.1	3.1
Prochlorperazine	32	3.1	3.1
Abiraterone Acetate	47	3.1	3.1
Metoroprolol Tartrate	75	3.1	3.1
Nitroglycerin	61	3.1	3.1
Felodipine Extended-Release Tablets	13	3.1	3.1
Felodipine	13	3.1	3.1
Dextrose	15	3.1	3.1
Levetiracetam	150	3.1	3.1
Febuxostat	19	3.0	3.0
Morphine	84	3.0	3.0
Theophylline Anhydrous	14	3.0	3.0
Loratadine Oral	55	3.0	3.0
Dextrose Monohydrate	15	3.0	3.0
Isosorbide Mononitrate	23	3.0	3.0
Oseltamivir Phosphate	27	3.0	3.0
Potassium Chloride	124	3.0	3.0
Clindamycin Phosphate	36	2.9	2.9
Metoprolol Succinate	93	2.9	2.9
Ganciclovir	11	2.9	2.9
Metoprolol	265	2.9	2.9
Venlafaxine Hydrochloride	139	2.9	2.9
Clindamycin	30	2.8	2.8
Dapagliflozin	33	2.8	2.8
Famotidine	122	2.8	2.8
Metoprolol Tartrate	280	2.8	2.8
Dalteparin Sodium	11	2.8	2.8
Ganciclovir Sodium	11	2.8	2.8
Meropenem	33	2.8	2.8
Doxepin Hydrochloride	13	2.8	2.8
Paroxetine Hydrochloride	93	2.8	2.8
Candesartan Cilexetil	27	2.8	2.8
0Xygen	50	2.7	2.7
Oxygen	50	2.7	2.7
Heparin Sodium	14	2.7	2.7
Trimethoprim	12	2.7	2.7
Metoprolol Tartrate Injection	190	2.7	2.7
Polyethylene Glycol	11	2.7	2.7
Gentamicin Sulfate	16	2.7	2.7
Pravastatin Sodium	20	2.7	2.7
Clopidogrel Bisulfate	101	2.7	2.7
Gentamicin	13	2.7	2.7
Cetirizine Hcl	9	2.6	2.6
Carvedilol	131	2.6	2.6
Apixaban	65	2.6	2.6
Amphetamine	8	2.6	2.6
Ciprofloxacin Hydrochloride And Hydrocortisone	20	2.6	2.6
Hydrocortisone Sodium Succinate	9	2.6	2.6
Esomeprazole	59	2.6	2.6
Lamotirigine	68	2.6	2.6
Lamotrigine Extended-Release	68	2.6	2.6
Lamotrigine Chewable Dispersible	68	2.6	2.6
Lubiprostone	9	2.6	2.6
Rabeprazole	21	2.5	2.5
Amikacin	16	2.5	2.5
Basiliximab	11	2.5	2.5
Nicotine Polacrilex Mini	14	2.5	2.5
Nicotine Polarilex	14	2.5	2.5
Enoxaparin Sodium	53	2.5	2.5
Vemurafenib	11	2.5	2.5
Ketoprofen	12	2.5	2.5
Nitrofurantoin	15	2.4	2.4
Rivastigmine	17	2.4	2.4
Nitrofurantoin (Monohydrate/Macrocrystals)	15	2.4	2.4
Oxcarbazepine	29	2.4	2.4
Lactulose	34	2.4	2.4
Nevirapine	8	2.4	2.4
Drs. Clotrimazole	10	2.3	2.3
Family Wellness Clotrimazole	10	2.3	2.3
Clotrimazole Topical	10	2.3	2.3
Fondaparinux Sodium	7	2.3	2.3
Simvastatin	213	2.3	2.3
Phenytoin	18	2.3	2.3
Chlorthalidone	10	2.3	2.3
Clonidine	44	2.3	2.3
Epinephrine	56	2.3	2.3
Clopidogrel	166	2.3	2.3
Diphenhydramine Hydrochloride	139	2.3	2.3
Candesartan	30	2.3	2.3
Telmisartan	15	2.3	2.3
Aripiprazole	101	2.2	2.2
Busulfan	13	2.2	2.2
Rifampin	12	2.2	2.2
Clotrimazole	10	2.2	2.2
Carbamazepine	54	2.2	2.2
Ramipril	99	2.2	2.2
Levothyroxine Sodium Anhydrous	80	2.2	2.2
Fosaprepitant Dimeglumine	11	2.1	2.1
Fexofenadine	13	2.1	2.1
Tranexamic Acid	7	2.1	2.1
Extended Phenytoin Sodium	13	2.1	2.1
Sodium Chloride	60	2.0	2.0
Hydroxyzine Hydrochloride	10	2.0	2.0
Hydroxyzine Hydrochloride Oral	10	2.0	2.0
Atenolol	100	2.0	2.0
Lansoprazole	132	2.0	2.0
Valsartan Oral	40	2.0	2.0
Sumatriptan	28	2.0	2.0
Alprazolam	148	1.9	1.9
Erlotinib	7	1.9	1.9
Ticagrelor	23	1.9	1.9
Lisinopril	214	1.9	1.9
Sodium Chloride Tablet	51	1.9	1.9
Sodium Chloride Tablets	51	1.9	1.9
Doxazosin Mesylate	25	1.9	1.9
Oxaliplatin	51	1.8	1.9
Isopropyl Alcohol	23	1.8	1.8
Doxazosin	19	1.8	1.8
Omeprazole	231	1.8	1.8
Goserelin	9	1.8	1.8
Ethyl Alcohol	18	1.8	1.8
Hydroxyurea	14	1.8	1.8
Pegaspargase	8	1.8	1.8
Instalax Polyethylene Glycol 3350	8	1.7	1.7
Bupivacaine	6	1.7	1.7
Polyethylene Glycol 400	8	1.7	1.7
Loratadine	67	1.7	1.7
Losartan Potassium	48	1.6	1.6
Benzonatate	10	1.6	1.6
Blinatumomab	6	1.5	1.5
Acyclovir	64	1.5	1.5
Erlotinib Hydrochloride	7	1.5	1.5
Gefitinib	5	1.5	1.5
Aprepitant	10	1.5	1.5
Eszopiclone	13	1.4	1.4
Alcohol	19	1.3	1.3
Fluorouracil Cream, 0.5%	37	1.3	1.3
Paliperidone	11	1.3	1.3
Paliperidone Palmitate	15	1.3	1.3
Fluorouracil	36	1.2	1.2
Doxorubicin Hydrochloride	15	1.2	1.2
Sevelamer Carbonate	5	1.2	1.2
Lacosamide	16	1.2	1.2
Dabigatran Etexilate	33	1.1	1.1
Tolvaptan	6	1.1	1.1
Venetoclax	25	1.1	1.1
Buprenorphine	37	1.1	1.1
Ranitidine	77	1.0	1.0
Clozapine	47	1.0	1.0
Nicotine Polacrilex	14	1.0	1.0
Axitinib	7	1.0	1.0
Cinacalcet Hydrochloride	10	0.6	0.6

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.