Reaction

Epigastric Discomfort reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 3,871 reports · 132 co-occurring drugs

As of the last recalculation, Epigastric Discomfort appears in 3,871 FAERS reports alongside 132 co-occurring drug terms. The strongest observed disproportionality signal is LOPERAMIDE HYDROCHLORIDE ORAL (PRR 32.6).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Loperamide Hydrochloride Oral	61	32.6	32.8
Trazodone Hydrochloride	85	29.9	30.0
Diphenoxylate Hydrochloride And Atropine Sulfate	68	27.1	27.3
Loperamide Hcl	62	26.3	26.4
Thiamine Hydrochloride	52	22.8	22.8
Risedronate Sodium	126	22.5	22.6
Mometasone Furoate	138	18.4	18.5
Ascorbic Acid	70	16.5	16.5
Biotin	72	12.6	12.7
Standardized Senna Concentrate	29	12.5	12.5
Esomeprazole	139	12.5	12.5
Brinzolamide	20	12.4	12.5
Esomeprazole Magnesium Capsule, Delayed Release	33	12.3	12.4
Esomeprazole Magnesium Delayed Release Capsules	33	12.3	12.4
Esomeprazole Magnesium Dihydrate	33	12.3	12.3
Sulfasalazine	156	11.1	11.1
Loperamide Hydrochloride	78	9.6	9.6
Celecoxib	217	9.3	9.3
Fentanyl	160	9.1	9.1
Tocilizumab	179	8.8	8.8
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	201	7.1	7.1
Hydroxychloroquine	95	7.0	7.0
Hydroxychloroquine Sulfate	113	6.8	6.8
Oxycodone And Acetaminophen Tablets	15	6.8	6.8
Sucralfate	30	6.8	6.8
Acetaminophen, Aspirin (Nsaid) And Caffeine	21	6.7	6.7
Leflunomide	125	6.6	6.6
Nebivolol	19	6.4	6.4
Ibuprofen Tablets, Coated	49	6.3	6.3
Ibuprofen Sodium	49	6.2	6.2
Esomeprazole Magnesium	255	6.2	6.2
Zinc	28	6.1	6.1
Zinc Chloride	28	6.1	6.1
Abatacept	149	6.0	6.0
Zinc Gluconate	28	5.8	5.8
Indomethacin	14	5.7	5.7
Sucralfate Oral	15	5.7	5.7
Vitamin E	33	5.7	5.7
Sucralfate Oral Suspension	15	5.7	5.7
Naproxen Sodium Tablet	54	5.5	5.5
Terazosin Hydrochloride	9	5.5	5.5
Diroximel Fumarate	12	5.4	5.4
Acetaminophen, Aspirin, And Caffeine	21	5.4	5.4
Deferasirox	25	5.1	5.1
Clarithromycin	31	4.9	4.9
Tolterodine Tartrate	8	4.8	4.8
Loratadine And Pseudoephedrine Sulfate	7	4.7	4.7
Digoxin	62	4.7	4.7
Fexofenadine	14	4.6	4.6
Telmisartan	15	4.5	4.5
Pantoprazole	200	4.4	4.4
Drospirenone And Ethinyl Estradiol	36	4.4	4.4
Octreotide Acetate	25	4.4	4.4
Sitagliptin And Metformin Hydrochloride	17	4.3	4.3
Terbinafine Hydrochloride	7	4.2	4.2
Latanoprost	39	4.2	4.2
Ibuprofen And Diphenhydramine Citrate	18	4.2	4.2
Oxycodone Hydrochloride	161	4.1	4.1
Naproxen Sodium	103	4.0	4.0
Nebivolol Hydrochloride	24	3.8	3.8
Tofacitinib	128	3.8	3.8
Gabapentin	247	3.8	3.8
Amikacin	12	3.8	3.8
Dicyclomine Hydrochloride	10	3.8	3.8
Ibuprofen	182	3.7	3.7
Gentamicin	9	3.7	3.7
Riociguat	22	3.6	3.6
Ursosiol	13	3.6	3.6
Bosutinib	6	3.6	3.6
Amlodipine Besylate And Benazepril Hydrochloride	6	3.5	3.5
Famotidine	75	3.5	3.5
Oxycodone And Acetaminophen	15	3.5	3.5
Pirfenidone	26	3.4	3.5
Lanreotide Acetate	5	3.4	3.4
Niraparib	14	3.4	3.4
Eplerenone	8	3.4	3.4
Zoledronic Acid	25	3.4	3.4
Dabrafenib	13	3.3	3.3
Dexlansoprazole	25	3.2	3.2
Prasugrel Hydrochloride	6	3.2	3.2
Bleomycin Sulfate	6	3.1	3.1
Lapatinib	9	3.1	3.1
Voxelotor	13	3.1	3.1
Avapritinib	7	3.1	3.1
Nintedanib	18	3.1	3.1
Ribociclib	18	3.1	3.1
Imatinib	10	3.1	3.1
Gefitinib	5	3.0	3.0
Nilotinib	16	2.9	2.9
Amlodipine Besylate And Valsartan	6	2.9	2.9
Agalsidase Beta	5	2.9	2.9
Imatinib Mesylate	15	2.9	2.9
Pazopanib Hydrochloride	14	2.8	2.8
Regorafenib	6	2.8	2.8
Eszopiclone	13	2.8	2.8
Oxaliplatin	37	2.7	2.7
Trametinib	12	2.7	2.7
Polyethylene Glycol 3350	47	2.7	2.7
Linaclotide	13	2.6	2.6
Oral Semaglutide	35	2.6	2.6
Pemetrexed Disodium	18	2.5	2.5
Dimethyl Fumarate	57	2.5	2.5
Pemetrexed	10	2.5	2.5
Selexipag	12	2.5	2.5
Paclitaxel (Aibumin-Bound)	35	2.3	2.3
Paclitaxel	40	2.2	2.2
Botulinum Toxin Type A	5	2.2	2.2
Dabigatran Etexilate	31	2.2	2.2
Dabigatran Etexilate Mesylate	29	2.2	2.2
Dronedarone	4	2.1	2.1
Irinotecan Hydrochloride	5	2.1	2.1
Ivacaftor	3	2.0	2.0
Apremilast	54	2.0	2.0
Nicotine Polacrilex	14	2.0	2.0
Travoprost	3	1.9	1.9
Ranitidine	67	1.8	1.8
Vismodegib	3	1.8	1.8
Etanercept	183	1.7	1.7
Orlistat	8	1.7	1.7
Axitinib	6	1.7	1.7
Lenvatinib	10	1.6	1.6
Abaloparatide	8	1.5	1.5
Emtricitabine And Tenofovir Alafenamide	3	1.4	1.4
Varenicline Tartrate	21	1.4	1.4
Medroxyprogesterone Acetate	13	1.4	1.4
Abemaciclib	5	1.3	1.3
Dulaglutide	22	1.3	1.3
Cinacalcet Hydrochloride	11	1.3	1.3
Nirmatrelvir And Ritonavir	12	1.2	1.2
Relugolix	4	0.9	0.9
Tirzepatide	23	0.8	0.8
Droxidopa	3	0.7	0.7

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.