Drug
Trifluridine And Tipiracil
Important: Reactions below are the flagged terms from this drug’s
FAERS report history (min. 3 co-reports per term) — PRR/ROR indicate
disproportionality in spontaneous reporting, not causation.
Data from FDA FAERS via openFDA. Last recalculated: 2026-09-14.
| Reaction | Co-reports (a) | PRR | ROR | Signal | |
|---|---|---|---|---|---|
| 1 | Diaphragmatic Operation | 6 | 430.9 | 431.1 | signal |
| 2 | Urostomy Complication | 3 | 135.3 | 135.3 | signal |
| 3 | Tumour Obstruction | 5 | 121.2 | 121.2 | signal |
| 4 | Liver Ablation | 4 | 114.1 | 114.1 | signal |
| 5 | Colorectal Cancer Recurrent | 7 | 113.1 | 113.2 | signal |
| 6 | Stoma Site Rash | 4 | 100.7 | 100.8 | signal |
| 7 | Rectal Cancer Metastatic | 16 | 95.2 | 95.3 | signal |
| 8 | K-ras Gene Mutation | 3 | 76.5 | 76.6 | signal |
| 9 | Colorectal Cancer Metastatic | 74 | 65.7 | 66.2 | signal |
| 10 | Carcinoembryonic Antigen Increased | 50 | 52.2 | 52.5 | signal |
| 11 | Xeroderma | 6 | 44.6 | 44.6 | signal |
| 12 | Liver Operation | 6 | 39.6 | 39.6 | signal |
| 13 | Stoma Site Haemorrhage | 28 | 36.8 | 36.9 | signal |
| 14 | Colorectal Adenocarcinoma | 4 | 35.7 | 35.8 | signal |
| 15 | Colon Cancer Metastatic | 28 | 34.9 | 35.0 | signal |
| 16 | Blood Alkaline Phosphatase Abnormal | 15 | 33.4 | 33.5 | signal |
| 17 | Disease Progression | 1,794 | 30.4 | 36.3 | signal |
| 18 | Cytopenia | 175 | 29.2 | 29.7 | signal |
| 19 | Cancer Pain | 35 | 27.2 | 27.2 | signal |
| 20 | Malignant Ascites | 10 | 26.0 | 26.0 | signal |
| 21 | Infusion | 5 | 24.1 | 24.1 | signal |
| 22 | Tracheal Stenosis | 6 | 23.5 | 23.5 | signal |
| 23 | Paracentesis | 7 | 22.5 | 22.5 | signal |
| 24 | Intra-abdominal Fluid Collection | 20 | 22.4 | 22.5 | signal |
| 25 | Hepatic Cancer Recurrent | 3 | 20.9 | 20.9 | signal |
| 26 | Biliary Obstruction | 13 | 20.6 | 20.7 | signal |
| 27 | Pulmonary Artery Thrombosis | 8 | 20.6 | 20.6 | signal |
| 28 | Transfusion | 106 | 20.0 | 20.2 | signal |
| 29 | Cholangitis Acute | 7 | 18.9 | 18.9 | signal |
| 30 | Ureteric Obstruction | 13 | 18.8 | 18.8 | signal |
| 31 | Tumour Compression | 3 | 18.7 | 18.7 | signal |
| 32 | Nephrostomy | 3 | 18.2 | 18.2 | signal |
| 33 | Product Dose Confusion | 3 | 17.5 | 17.5 | signal |
| 34 | Fluid Replacement | 3 | 17.4 | 17.4 | signal |
| 35 | Bile Duct Obstruction | 16 | 16.5 | 16.5 | signal |
| 36 | Stomal Hernia | 3 | 16.3 | 16.3 | signal |
| 37 | Rectal Perforation | 4 | 14.7 | 14.7 | signal |
| 38 | Radiotherapy | 13 | 13.4 | 13.4 | signal |
| 39 | Lymphangiosis Carcinomatosa | 7 | 13.3 | 13.3 | signal |
| 40 | Metastases To Pelvis | 4 | 12.5 | 12.5 | signal |
| 41 | Carbohydrate Antigen 19-9 Increased | 3 | 11.4 | 11.4 | signal |
| 42 | Tumour Haemorrhage | 16 | 11.1 | 11.1 | signal |
| 43 | Blood Magnesium Abnormal | 3 | 10.7 | 10.7 | signal |
| 44 | Gastrointestinal Stoma Complication | 8 | 10.1 | 10.1 | signal |
| 45 | Hydronephrosis | 38 | 10.1 | 10.1 | signal |
| 46 | Campylobacter Gastroenteritis | 3 | 10.0 | 10.0 | signal |
| 47 | Red Blood Cell Count Decreased | 145 | 10.0 | 10.1 | signal |
| 48 | Sacral Pain | 3 | 10.0 | 10.0 | signal |
| 49 | Colon Cancer Stage Iv | 3 | 9.9 | 9.9 | signal |
| 50 | Pelvic Mass | 4 | 9.8 | 9.8 | signal |
| 51 | Biliary Tract Infection | 3 | 9.7 | 9.7 | signal |
| 52 | Metastases To Skin | 5 | 9.6 | 9.6 | signal |
| 53 | Lung Carcinoma Cell Type Unspecified Recurrent | 3 | 9.6 | 9.6 | signal |
| 54 | Blood Bilirubin Decreased | 3 | 9.6 | 9.6 | signal |
| 55 | Obstruction | 19 | 9.4 | 9.4 | signal |
| 56 | Complex Regional Pain Syndrome | 7 | 9.3 | 9.3 | signal |
| 57 | Procedural Vomiting | 3 | 9.2 | 9.2 | signal |
| 58 | Peritoneal Disorder | 3 | 9.1 | 9.1 | signal |
| 59 | Enterocutaneous Fistula | 4 | 9.0 | 9.0 | signal |
| 60 | Rectal Cancer | 14 | 9.0 | 9.0 | signal |
| 61 | White Blood Cell Count Decreased | 490 | 8.9 | 9.3 | signal |
| 62 | Product Distribution Issue | 40 | 8.9 | 8.9 | signal |
| 63 | Large Intestinal Obstruction | 10 | 8.9 | 8.9 | signal |
| 64 | Stoma Creation | 3 | 8.8 | 8.8 | signal |
| 65 | Product Dose Omission In Error | 114 | 8.4 | 8.5 | signal |
| 66 | Malignant Pleural Effusion | 7 | 8.2 | 8.2 | signal |
| 67 | Colostomy | 8 | 8.1 | 8.1 | signal |
| 68 | Blood Count Abnormal | 62 | 8.0 | 8.0 | signal |
| 69 | Obstruction Gastric | 5 | 7.8 | 7.8 | signal |
| 70 | Intestinal Obstruction | 143 | 7.5 | 7.6 | signal |
| 71 | Ascites | 110 | 7.4 | 7.4 | signal |
| 72 | Tumour Excision | 3 | 7.4 | 7.4 | signal |
| 73 | Anal Ulcer | 3 | 7.3 | 7.3 | signal |
| 74 | Small Intestinal Obstruction | 45 | 7.2 | 7.3 | signal |
| 75 | Penile Haemorrhage | 3 | 7.2 | 7.2 | signal |
| 76 | Peritonsillar Abscess | 3 | 7.1 | 7.1 | signal |
| 77 | Vena Cava Thrombosis | 6 | 7.1 | 7.1 | signal |
| 78 | Death | 3,086 | 7.1 | 9.5 | signal |
| 79 | Food Refusal | 3 | 7.0 | 7.0 | signal |
| 80 | Large Intestinal Haemorrhage | 8 | 7.0 | 7.0 | signal |
| 81 | Urge Incontinence | 3 | 6.9 | 6.9 | signal |
| 82 | Hepatic Cancer Metastatic | 3 | 6.9 | 6.9 | signal |
| 83 | Terminal State | 23 | 6.8 | 6.8 | signal |
| 84 | Hypertensive Emergency | 4 | 6.8 | 6.8 | signal |
| 85 | Performance Status Decreased | 16 | 6.7 | 6.8 | signal |
| 86 | Skin Toxicity | 19 | 6.7 | 6.7 | signal |
| 87 | Colon Cancer | 50 | 6.6 | 6.6 | signal |
| 88 | Contrast Media Allergy | 6 | 6.6 | 6.6 | signal |
| 89 | Tumour Marker Increased | 16 | 6.6 | 6.6 | signal |
| 90 | Urinary Bladder Haemorrhage | 7 | 6.5 | 6.5 | signal |
| 91 | Neutrophil Count Decreased | 132 | 6.4 | 6.5 | signal |
| 92 | Catheter Placement | 6 | 6.4 | 6.4 | signal |
| 93 | Oesophageal Varices Haemorrhage | 7 | 6.3 | 6.3 | signal |
| 94 | Proctitis | 9 | 6.3 | 6.3 | signal |
| 95 | Adenocarcinoma Of Colon | 6 | 6.3 | 6.3 | signal |
| 96 | Metastases To Peritoneum | 8 | 6.3 | 6.3 | signal |
| 97 | Gastrointestinal Toxicity | 15 | 6.3 | 6.3 | signal |
| 98 | Early Satiety | 6 | 6.2 | 6.2 | signal |
| 99 | Blood Loss Anaemia | 7 | 6.2 | 6.2 | signal |
| 100 | Proctalgia | 20 | 6.1 | 6.1 | signal |
| 101 | Hyperbilirubinaemia | 32 | 6.1 | 6.1 | signal |
| 102 | Cholangitis | 19 | 6.1 | 6.1 | signal |
| 103 | Decreased Appetite | 682 | 5.8 | 6.1 | signal |
| 104 | Tumour Necrosis | 3 | 5.6 | 5.6 | signal |
| 105 | Anaemia Macrocytic | 6 | 5.6 | 5.6 | signal |
| 106 | Gallbladder Enlargement | 3 | 5.6 | 5.6 | signal |
| 107 | Radiation Injury | 3 | 5.6 | 5.6 | signal |
| 108 | Hepatic Pain | 12 | 5.5 | 5.5 | signal |
| 109 | Metastases To Lung | 32 | 5.5 | 5.5 | signal |
| 110 | Red Blood Cell Count Abnormal | 4 | 5.4 | 5.4 | signal |
| 111 | Cachexia | 14 | 5.4 | 5.4 | signal |
| 112 | Stoma Site Pain | 4 | 5.4 | 5.4 | signal |
| 113 | Enterocolitis Haemorrhagic | 4 | 5.3 | 5.3 | signal |
| 114 | Malignant Neoplasm Progression | 264 | 5.1 | 5.2 | signal |
| 115 | Escherichia Urinary Tract Infection | 11 | 5.1 | 5.1 | signal |
| 116 | Product Communication Issue | 22 | 5.1 | 5.1 | signal |
| 117 | Blood Magnesium Decreased | 22 | 5.0 | 5.0 | signal |
| 118 | Blood Bilirubin Increased | 69 | 5.0 | 5.0 | signal |
| 119 | Neutropenia | 340 | 4.9 | 5.1 | signal |
| 120 | Large Intestine Infection | 3 | 4.9 | 4.9 | signal |
| 121 | Jaundice | 67 | 4.9 | 4.9 | signal |
| 122 | Monocyte Count Decreased | 3 | 4.9 | 4.9 | signal |
| 123 | Iga Nephropathy | 4 | 4.9 | 4.9 | signal |
| 124 | Hepatic Neoplasm | 8 | 4.8 | 4.8 | signal |
| 125 | Dehydration | 325 | 4.8 | 4.9 | signal |
| 126 | Product Packaging Quantity Issue | 26 | 4.7 | 4.7 | signal |
| 127 | Gastric Ulcer Perforation | 3 | 4.7 | 4.7 | signal |
| 128 | Blood Bilirubin Abnormal | 3 | 4.7 | 4.7 | signal |
| 129 | Testicular Swelling | 3 | 4.6 | 4.6 | signal |
| 130 | Oesophageal Haemorrhage | 3 | 4.5 | 4.5 | signal |
| 131 | Jaundice Cholestatic | 8 | 4.4 | 4.5 | signal |
| 132 | Adenocarcinoma | 5 | 4.4 | 4.4 | signal |
| 133 | Platelet Count Decreased | 233 | 4.3 | 4.4 | signal |
| 134 | Body Temperature Abnormal | 4 | 4.3 | 4.3 | signal |
| 135 | Haematotoxicity | 20 | 4.2 | 4.3 | signal |
| 136 | Intestinal Perforation | 24 | 4.2 | 4.2 | signal |
| 137 | Small Intestinal Perforation | 4 | 4.2 | 4.2 | signal |
| 138 | Blood Electrolytes Decreased | 3 | 4.2 | 4.2 | signal |
| 139 | Failure To Thrive | 11 | 4.2 | 4.2 | signal |
| 140 | Gastrointestinal Obstruction | 5 | 4.1 | 4.1 | signal |
| 141 | Normocytic Anaemia | 3 | 4.1 | 4.1 | signal |
| 142 | Pelvic Venous Thrombosis | 3 | 4.1 | 4.1 | signal |
| 143 | Feeding Disorder | 41 | 4.0 | 4.1 | signal |
| 144 | Metastases To Liver | 36 | 4.0 | 4.1 | signal |
| 145 | Stent Placement | 16 | 3.9 | 3.9 | signal |
| 146 | Abdominal Infection | 5 | 3.9 | 3.9 | signal |
| 147 | Blood Iron Decreased | 23 | 3.8 | 3.8 | signal |
| 148 | Neutropenic Colitis | 4 | 3.8 | 3.8 | signal |
| 149 | Anaemia | 363 | 3.7 | 3.8 | signal |
| 150 | Full Blood Count Abnormal | 20 | 3.7 | 3.7 | signal |
| 151 | Blood Potassium Abnormal | 5 | 3.7 | 3.7 | signal |
| 152 | Hypomagnesaemia | 26 | 3.7 | 3.7 | signal |
| 153 | Haemoglobin Decreased | 192 | 3.7 | 3.7 | signal |
| 154 | Night Blindness | 3 | 3.7 | 3.7 | no signal |
| 155 | Hepatic Failure | 56 | 3.6 | 3.7 | signal |
| 156 | Palmar-plantar Erythrodysaesthesia Syndrome | 43 | 3.6 | 3.6 | signal |
| 157 | Hepatitis Cholestatic | 11 | 3.6 | 3.6 | signal |
| 158 | Dermatitis Acneiform | 11 | 3.6 | 3.6 | signal |
| 159 | Fatigue | 1,403 | 3.6 | 3.9 | signal |
| 160 | Faeces Pale | 4 | 3.6 | 3.6 | signal |
| 161 | Inappropriate Schedule Of Product Administration | 318 | 3.5 | 3.6 | signal |
| 162 | Cardiopulmonary Failure | 7 | 3.5 | 3.5 | signal |
| 163 | Small Intestine Carcinoma | 4 | 3.5 | 3.5 | signal |
| 164 | Brain Operation | 4 | 3.5 | 3.5 | signal |
| 165 | Cholecystitis Acute | 10 | 3.5 | 3.5 | signal |
| 166 | Internal Haemorrhage | 20 | 3.4 | 3.4 | signal |
| 167 | Female Genital Tract Fistula | 3 | 3.4 | 3.4 | no signal |
| 168 | Blood Test Abnormal | 24 | 3.4 | 3.4 | signal |
| 169 | Pseudomonal Sepsis | 3 | 3.4 | 3.4 | no signal |
| 170 | Jugular Vein Thrombosis | 3 | 3.3 | 3.3 | no signal |
| 171 | Immunodeficiency | 25 | 3.3 | 3.3 | signal |
| 172 | Taste Disorder | 34 | 3.3 | 3.3 | signal |
| 173 | Urinary Tract Obstruction | 4 | 3.3 | 3.3 | signal |
| 174 | Gastrointestinal Perforation | 7 | 3.3 | 3.3 | signal |
| 175 | Neuropathy Peripheral | 157 | 3.3 | 3.3 | signal |
| 176 | Varices Oesophageal | 5 | 3.3 | 3.3 | signal |
| 177 | Pneumoperitoneum | 3 | 3.2 | 3.2 | no signal |
| 178 | Stomatitis | 99 | 3.2 | 3.2 | signal |
| 179 | Onychoclasis | 11 | 3.2 | 3.2 | signal |
| 180 | Diarrhoea | 1,020 | 3.1 | 3.3 | signal |
| 181 | Constipation | 339 | 3.1 | 3.2 | signal |
| 182 | Hernia Repair | 4 | 3.0 | 3.0 | no signal |
| 183 | Ileus | 19 | 3.0 | 3.0 | signal |
| 184 | Proteinuria | 29 | 3.0 | 3.0 | signal |
| 185 | Neutropenic Sepsis | 11 | 3.0 | 3.0 | signal |
| 186 | Decreased Immune Responsiveness | 15 | 3.0 | 3.0 | signal |
| 187 | Abdominal Hernia | 7 | 3.0 | 3.0 | signal |
| 188 | Cell Death | 3 | 3.0 | 3.0 | no signal |
| 189 | Anorectal Discomfort | 8 | 2.9 | 2.9 | signal |
| 190 | Nausea | 1,178 | 2.9 | 3.2 | signal |
| 191 | Metastases To Spine | 5 | 2.9 | 2.9 | signal |
| 192 | Rectal Haemorrhage | 64 | 2.9 | 2.9 | signal |
| 193 | Gastric Perforation | 4 | 2.9 | 2.9 | no signal |
| 194 | Hyperkeratosis | 8 | 2.8 | 2.8 | signal |
| 195 | Leukopenia | 72 | 2.8 | 2.9 | signal |
| 196 | Subileus | 3 | 2.8 | 2.8 | no signal |
| 197 | Neutrophil Count Abnormal | 4 | 2.8 | 2.8 | no signal |
| 198 | Iron Deficiency Anaemia | 13 | 2.8 | 2.8 | signal |
| 199 | White Blood Cell Count Abnormal | 9 | 2.8 | 2.8 | signal |
| 200 | Hypersomnia | 40 | 2.7 | 2.8 | signal |
| 201 | Metastatic Neoplasm | 6 | 2.7 | 2.7 | signal |
| 202 | Hepatic Lesion | 6 | 2.7 | 2.7 | signal |
| 203 | Escherichia Sepsis | 4 | 2.7 | 2.7 | no signal |
| 204 | Haematemesis | 35 | 2.7 | 2.7 | signal |
| 205 | Abdominal Pain | 317 | 2.7 | 2.7 | signal |
| 206 | Abdominal Abscess | 6 | 2.7 | 2.7 | signal |
| 207 | Vomiting | 633 | 2.7 | 2.8 | signal |
| 208 | Malnutrition | 15 | 2.7 | 2.7 | signal |
| 209 | Pancytopenia | 75 | 2.6 | 2.7 | signal |
| 210 | Blood Potassium Decreased | 40 | 2.6 | 2.6 | signal |
| 211 | Therapy Partial Responder | 20 | 2.6 | 2.6 | signal |
| 212 | Asthenia | 495 | 2.6 | 2.7 | signal |
| 213 | Nephrotic Syndrome | 9 | 2.6 | 2.6 | signal |
| 214 | Acute Respiratory Failure | 25 | 2.6 | 2.6 | signal |
| 215 | Disease Complication | 6 | 2.6 | 2.6 | signal |
| 216 | Faecaloma | 7 | 2.5 | 2.5 | signal |
| 217 | Kidney Infection | 25 | 2.5 | 2.5 | signal |
| 218 | Bile Duct Stone | 4 | 2.5 | 2.5 | no signal |
| 219 | Hypophagia | 32 | 2.5 | 2.5 | signal |
| 220 | Haemoglobin Abnormal | 8 | 2.5 | 2.5 | signal |
| 221 | Fistula | 14 | 2.4 | 2.4 | signal |
| 222 | Abdominal Pain Upper | 255 | 2.4 | 2.5 | signal |
| 223 | Intestinal Haemorrhage | 7 | 2.4 | 2.4 | signal |
| 224 | Bacterial Sepsis | 4 | 2.4 | 2.4 | no signal |
| 225 | Bedridden | 16 | 2.4 | 2.4 | signal |
| 226 | Hospice Care | 12 | 2.4 | 2.4 | signal |
| 227 | Hyperpyrexia | 5 | 2.4 | 2.4 | no signal |
| 228 | Dysgeusia | 90 | 2.4 | 2.4 | signal |
| 229 | Weight Decreased | 334 | 2.4 | 2.4 | signal |
| 230 | Platelet Disorder | 3 | 2.3 | 2.3 | no signal |
| 231 | Haemorrhage Urinary Tract | 3 | 2.3 | 2.3 | no signal |
| 232 | Catheter Site Pain | 3 | 2.3 | 2.3 | no signal |
| 233 | Polyneuropathy | 14 | 2.3 | 2.3 | signal |
| 234 | Abscess Limb | 5 | 2.3 | 2.3 | no signal |
| 235 | Metastases To Central Nervous System | 15 | 2.3 | 2.3 | signal |
| 236 | Intermenstrual Bleeding | 6 | 2.3 | 2.3 | no signal |
| 237 | Functional Gastrointestinal Disorder | 4 | 2.3 | 2.3 | no signal |
| 238 | Blood Calcium Decreased | 13 | 2.3 | 2.3 | signal |
| 239 | Therapy Interrupted | 79 | 2.3 | 2.3 | signal |
| 240 | Therapy Change | 11 | 2.2 | 2.2 | signal |
| 241 | Blood Albumin Decreased | 9 | 2.2 | 2.2 | signal |
| 242 | Iron Deficiency | 5 | 2.2 | 2.2 | no signal |
| 243 | Blood Disorder | 9 | 2.2 | 2.2 | signal |
| 244 | Thrombocytopenia | 125 | 2.2 | 2.2 | signal |
| 245 | Febrile Neutropenia | 74 | 2.2 | 2.2 | signal |
| 246 | White Blood Cell Disorder | 3 | 2.2 | 2.2 | no signal |
| 247 | Therapy Cessation | 57 | 2.2 | 2.2 | signal |
| 248 | Neoplasm Progression | 39 | 2.2 | 2.2 | signal |
| 249 | Large Intestinal Ulcer | 3 | 2.2 | 2.2 | no signal |
| 250 | Chromaturia | 25 | 2.2 | 2.2 | signal |
| 251 | Skin Wrinkling | 3 | 2.2 | 2.2 | no signal |
| 252 | Flatulence | 62 | 2.2 | 2.2 | signal |
| 253 | Cholecystitis Infective | 3 | 2.1 | 2.1 | no signal |
| 254 | Appetite Disorder | 7 | 2.1 | 2.1 | no signal |
| 255 | Umbilical Hernia | 5 | 2.1 | 2.1 | no signal |
| 256 | Eyelid Margin Crusting | 3 | 2.1 | 2.1 | no signal |
| 257 | Oesophageal Stenosis | 3 | 2.1 | 2.1 | no signal |
| 258 | Pulmonary Pain | 3 | 2.1 | 2.1 | no signal |
| 259 | Duodenal Ulcer Haemorrhage | 3 | 2.1 | 2.1 | no signal |
| 260 | Metastases To Lymph Nodes | 7 | 2.1 | 2.1 | no signal |
| 261 | Brain Fog | 15 | 2.0 | 2.0 | signal |
| 262 | Oral Pain | 23 | 2.0 | 2.0 | signal |
| 263 | Pulmonary Thrombosis | 11 | 2.0 | 2.0 | no signal |
| 264 | Ulcer | 16 | 2.0 | 2.0 | no signal |
| 265 | Intentional Product Use Issue | 88 | 2.0 | 2.0 | no signal |
| 266 | Metabolic Encephalopathy | 3 | 2.0 | 2.0 | no signal |
| 267 | Bone Marrow Disorder | 3 | 2.0 | 2.0 | no signal |
| 268 | Dysaesthesia | 3 | 2.0 | 2.0 | no signal |
| 269 | Pathological Fracture | 5 | 1.9 | 1.9 | no signal |
| 270 | Urinary Tract Infection | 167 | 1.9 | 1.9 | no signal |
| 271 | Hiccups | 8 | 1.9 | 1.9 | no signal |
| 272 | Ammonia Increased | 5 | 1.9 | 1.9 | no signal |
| 273 | Portal Hypertension | 3 | 1.9 | 1.9 | no signal |
| 274 | Hyperaesthesia | 8 | 1.9 | 1.9 | no signal |
| 275 | Benign Prostatic Hyperplasia | 5 | 1.9 | 1.9 | no signal |
| 276 | Flank Pain | 9 | 1.9 | 1.9 | no signal |
| 277 | Blood Creatinine Decreased | 3 | 1.9 | 1.9 | no signal |
| 278 | Inappropriate Schedule Of Drug Administration | 69 | 1.9 | 1.9 | no signal |
| 279 | Illness | 96 | 1.9 | 1.9 | no signal |
| 280 | Tongue Discomfort | 4 | 1.9 | 1.9 | no signal |
| 281 | Testicular Pain | 3 | 1.9 | 1.9 | no signal |
| 282 | Blood Urine Present | 18 | 1.9 | 1.9 | no signal |
| 283 | Enteritis | 6 | 1.9 | 1.9 | no signal |
| 284 | Haematochezia | 52 | 1.9 | 1.9 | no signal |
| 285 | Anal Fistula | 5 | 1.8 | 1.8 | no signal |
| 286 | Dyspnoea Exertional | 35 | 1.8 | 1.8 | no signal |
| 287 | Portal Vein Thrombosis | 3 | 1.8 | 1.8 | no signal |
| 288 | Lung Neoplasm | 4 | 1.8 | 1.8 | no signal |
| 289 | Muscle Strain | 8 | 1.8 | 1.8 | no signal |
| 290 | Pleural Effusion | 56 | 1.8 | 1.8 | no signal |
| 291 | Hypokalaemia | 42 | 1.8 | 1.8 | no signal |
| 292 | Hepatomegaly | 9 | 1.8 | 1.8 | no signal |
| 293 | Gingival Swelling | 4 | 1.8 | 1.8 | no signal |
| 294 | Dysphonia | 53 | 1.8 | 1.8 | no signal |
| 295 | Haematuria | 31 | 1.8 | 1.8 | no signal |
| 296 | Blood Creatine Increased | 4 | 1.8 | 1.8 | no signal |
| 297 | Alopecia | 176 | 1.8 | 1.8 | no signal |
| 298 | Retching | 19 | 1.8 | 1.8 | no signal |
| 299 | Thrombosis | 72 | 1.8 | 1.8 | no signal |
| 300 | Urinary Tract Disorder | 4 | 1.7 | 1.7 | no signal |
| 301 | Hepatic Cyst | 3 | 1.7 | 1.7 | no signal |
| 302 | Tooth Extraction | 11 | 1.7 | 1.7 | no signal |
| 303 | Bone Marrow Failure | 18 | 1.7 | 1.7 | no signal |
| 304 | Body Temperature Increased | 18 | 1.7 | 1.7 | no signal |
| 305 | Intentional Dose Omission | 24 | 1.7 | 1.7 | no signal |
| 306 | Enterocolitis | 5 | 1.7 | 1.7 | no signal |
| 307 | Cardiac Valve Disease | 5 | 1.7 | 1.7 | no signal |
| 308 | Large Intestine Perforation | 6 | 1.7 | 1.7 | no signal |
| 309 | Aphonia | 12 | 1.7 | 1.7 | no signal |
| 310 | Skin Abrasion | 4 | 1.7 | 1.7 | no signal |
| 311 | Prescribed Underdose | 17 | 1.7 | 1.7 | no signal |
| 312 | Blood Sodium Decreased | 16 | 1.7 | 1.7 | no signal |
| 313 | Disseminated Intravascular Coagulation | 12 | 1.7 | 1.7 | no signal |
| 314 | Bacteraemia | 10 | 1.7 | 1.7 | no signal |
| 315 | Glossitis | 3 | 1.7 | 1.7 | no signal |
| 316 | Full Blood Count Decreased | 17 | 1.7 | 1.7 | no signal |
| 317 | Viral Upper Respiratory Tract Infection | 4 | 1.6 | 1.6 | no signal |
| 318 | Faeces Soft | 6 | 1.6 | 1.6 | no signal |
| 319 | Accidental Underdose | 12 | 1.6 | 1.6 | no signal |
| 320 | Hospitalisation | 125 | 1.6 | 1.6 | no signal |
| 321 | Amylase Increased | 3 | 1.6 | 1.6 | no signal |
| 322 | Haemorrhoidal Haemorrhage | 4 | 1.6 | 1.6 | no signal |
| 323 | Haemorrhage | 85 | 1.6 | 1.6 | no signal |
| 324 | Generalised Oedema | 10 | 1.6 | 1.6 | no signal |
| 325 | Fluid Intake Reduced | 4 | 1.6 | 1.6 | no signal |
| 326 | Concomitant Disease Aggravated | 5 | 1.6 | 1.6 | no signal |
| 327 | Bladder Disorder | 8 | 1.6 | 1.6 | no signal |
| 328 | Haematocrit Decreased | 16 | 1.6 | 1.6 | no signal |
| 329 | Aneurysm | 4 | 1.6 | 1.6 | no signal |
| 330 | Parosmia | 6 | 1.6 | 1.6 | no signal |
| 331 | Renal Impairment | 66 | 1.6 | 1.6 | no signal |
| 332 | Bowel Movement Irregularity | 6 | 1.5 | 1.5 | no signal |
| 333 | Oesophageal Ulcer | 3 | 1.5 | 1.5 | no signal |
| 334 | General Physical Health Deterioration | 89 | 1.5 | 1.5 | no signal |
| 335 | Musculoskeletal Chest Pain | 12 | 1.5 | 1.5 | no signal |
| 336 | Faeces Hard | 3 | 1.5 | 1.5 | no signal |
| 337 | Sepsis | 86 | 1.5 | 1.5 | no signal |
| 338 | Abdominal Distension | 80 | 1.5 | 1.5 | no signal |
| 339 | Mucosal Inflammation | 20 | 1.5 | 1.5 | no signal |
| 340 | Spinal Cord Compression | 3 | 1.5 | 1.5 | no signal |
| 341 | Deep Vein Thrombosis | 50 | 1.5 | 1.5 | no signal |
| 342 | Brain Neoplasm | 7 | 1.5 | 1.5 | no signal |
| 343 | Gastrointestinal Haemorrhage | 64 | 1.5 | 1.5 | no signal |
| 344 | Epistaxis | 57 | 1.5 | 1.5 | no signal |
| 345 | Arteriospasm Coronary | 3 | 1.5 | 1.5 | no signal |
| 346 | Incontinence | 8 | 1.5 | 1.5 | no signal |
| 347 | Gingival Pain | 6 | 1.5 | 1.5 | no signal |
| 348 | Haemoptysis | 21 | 1.5 | 1.5 | no signal |
| 349 | Hepatic Encephalopathy | 7 | 1.5 | 1.5 | no signal |
| 350 | Abdominal Pain Lower | 19 | 1.5 | 1.5 | no signal |
| 351 | Gallbladder Operation | 3 | 1.5 | 1.5 | no signal |
| 352 | Pyrexia | 258 | 1.5 | 1.5 | no signal |
| 353 | Liver Disorder | 33 | 1.5 | 1.5 | no signal |
| 354 | Organ Failure | 3 | 1.5 | 1.5 | no signal |
| 355 | Pulmonary Mass | 11 | 1.5 | 1.5 | no signal |
| 356 | Shock Haemorrhagic | 6 | 1.5 | 1.5 | no signal |
| 357 | Escherichia Infection | 6 | 1.4 | 1.4 | no signal |
| 358 | Dizziness Postural | 7 | 1.4 | 1.4 | no signal |
| 359 | Ischaemic Stroke | 13 | 1.4 | 1.4 | no signal |
| 360 | Thrombotic Microangiopathy | 7 | 1.4 | 1.4 | no signal |
| 361 | Urinary Retention | 24 | 1.4 | 1.4 | no signal |
| 362 | Aortic Dissection | 3 | 1.4 | 1.4 | no signal |
| 363 | Acute Coronary Syndrome | 6 | 1.4 | 1.4 | no signal |
| 364 | Defaecation Urgency | 5 | 1.4 | 1.4 | no signal |
| 365 | Gastric Ulcer Haemorrhage | 4 | 1.4 | 1.4 | no signal |
| 366 | Granulocytopenia | 4 | 1.4 | 1.4 | no signal |
| 367 | Electrolyte Imbalance | 8 | 1.4 | 1.4 | no signal |
| 368 | Gait Inability | 23 | 1.4 | 1.4 | no signal |
| 369 | Neoplasm | 8 | 1.4 | 1.4 | no signal |
| 370 | Immunosuppression | 6 | 1.4 | 1.4 | no signal |
| 371 | Gastric Haemorrhage | 8 | 1.4 | 1.4 | no signal |
| 372 | Blood Lactate Dehydrogenase Increased | 11 | 1.4 | 1.4 | no signal |
| 373 | Immobile | 3 | 1.4 | 1.4 | no signal |
| 374 | Underdose | 50 | 1.3 | 1.3 | no signal |
| 375 | Peripheral Sensory Neuropathy | 4 | 1.3 | 1.3 | no signal |
| 376 | Hypovolaemia | 4 | 1.3 | 1.3 | no signal |
| 377 | Gastric Ulcer | 13 | 1.3 | 1.3 | no signal |
| 378 | Groin Pain | 6 | 1.3 | 1.3 | no signal |
| 379 | Ageusia | 17 | 1.3 | 1.3 | no signal |
| 380 | Myelosuppression | 23 | 1.3 | 1.3 | no signal |
| 381 | Weight Fluctuation | 7 | 1.3 | 1.3 | no signal |
| 382 | Wheelchair User | 3 | 1.3 | 1.3 | no signal |
| 383 | Infection | 96 | 1.3 | 1.3 | no signal |
| 384 | Renal Disorder | 31 | 1.3 | 1.3 | no signal |
| 385 | Food Allergy | 5 | 1.3 | 1.3 | no signal |
| 386 | Lethargy | 38 | 1.3 | 1.3 | no signal |
| 387 | Candida Infection | 11 | 1.3 | 1.3 | no signal |
| 388 | Clostridium Difficile Colitis | 7 | 1.3 | 1.3 | no signal |
| 389 | Hypoalbuminaemia | 5 | 1.3 | 1.3 | no signal |
| 390 | Renal Function Test Abnormal | 3 | 1.3 | 1.3 | no signal |
| 391 | Agranulocytosis | 12 | 1.3 | 1.3 | no signal |
| 392 | Fluid Retention | 33 | 1.3 | 1.3 | no signal |
| 393 | Device Related Infection | 10 | 1.3 | 1.3 | no signal |
| 394 | Septic Shock | 28 | 1.3 | 1.3 | no signal |
| 395 | Yellow Skin | 3 | 1.3 | 1.3 | no signal |
| 396 | Nasal Dryness | 4 | 1.3 | 1.3 | no signal |
| 397 | Sciatica | 10 | 1.2 | 1.2 | no signal |
| 398 | Hypovolaemic Shock | 3 | 1.2 | 1.2 | no signal |
| 399 | Cholestasis | 12 | 1.2 | 1.2 | no signal |
| 400 | Dysuria | 23 | 1.2 | 1.2 | no signal |
| 401 | Post Procedural Complication | 12 | 1.2 | 1.2 | no signal |
| 402 | Hepatic Function Abnormal | 23 | 1.2 | 1.2 | no signal |
| 403 | Atelectasis | 6 | 1.2 | 1.2 | no signal |
| 404 | Injection Site Haematoma | 9 | 1.2 | 1.2 | no signal |
| 405 | Incorrect Dosage Administered | 3 | 1.2 | 1.2 | no signal |
| 406 | Liver Function Test Increased | 13 | 1.2 | 1.2 | no signal |
| 407 | Leukocytosis | 11 | 1.2 | 1.2 | no signal |
| 408 | Hepatic Enzyme Abnormal | 3 | 1.2 | 1.2 | no signal |
| 409 | Product Administration Error | 12 | 1.2 | 1.2 | no signal |
| 410 | Malaise | 263 | 1.2 | 1.2 | no signal |
| 411 | Peritonitis Bacterial | 6 | 1.2 | 1.2 | no signal |
| 412 | Upper Gastrointestinal Haemorrhage | 10 | 1.2 | 1.2 | no signal |
| 413 | Abdominal Discomfort | 99 | 1.2 | 1.2 | no signal |
| 414 | Night Sweats | 19 | 1.2 | 1.2 | no signal |
| 415 | Acute Kidney Injury | 89 | 1.1 | 1.2 | no signal |
| 416 | Peripheral Coldness | 8 | 1.1 | 1.1 | no signal |
| 417 | Blood Lactic Acid Increased | 3 | 1.1 | 1.1 | no signal |
| 418 | Urine Output Decreased | 5 | 1.1 | 1.1 | no signal |
| 419 | Nephrolithiasis | 26 | 1.1 | 1.1 | no signal |
| 420 | Dermatitis Allergic | 7 | 1.1 | 1.1 | no signal |
| 421 | Intestinal Resection | 3 | 1.1 | 1.1 | no signal |
| 422 | Peripheral Swelling | 86 | 1.1 | 1.1 | no signal |
| 423 | Gastrointestinal Infection | 5 | 1.1 | 1.1 | no signal |
| 424 | Anal Abscess | 3 | 1.1 | 1.1 | no signal |
| 425 | Gingivitis | 3 | 1.1 | 1.1 | no signal |
| 426 | Blood Potassium Increased | 9 | 1.1 | 1.1 | no signal |
| 427 | Hypotension | 111 | 1.1 | 1.1 | no signal |
| 428 | Back Injury | 6 | 1.1 | 1.1 | no signal |
| 429 | Tongue Disorder | 4 | 1.1 | 1.1 | no signal |
| 430 | Intentional Underdose | 4 | 1.1 | 1.1 | no signal |
| 431 | Gastrointestinal Pain | 6 | 1.1 | 1.1 | no signal |
| 432 | Dental Caries | 6 | 1.1 | 1.1 | no signal |
| 433 | Back Pain | 126 | 1.1 | 1.1 | no signal |
| 434 | Sunburn | 4 | 1.1 | 1.1 | no signal |
| 435 | Hepatic Cirrhosis | 10 | 1.1 | 1.1 | no signal |
| 436 | Nephropathy | 5 | 1.0 | 1.0 | no signal |
| 437 | Troponin Increased | 4 | 1.0 | 1.0 | no signal |
| 438 | Hip Fracture | 17 | 1.0 | 1.0 | no signal |
| 439 | Exercise Tolerance Decreased | 3 | 1.0 | 1.0 | no signal |
| 440 | Blood Alkaline Phosphatase Increased | 13 | 1.0 | 1.0 | no signal |
| 441 | Pneumonia Aspiration | 13 | 1.0 | 1.0 | no signal |
| 442 | Gingival Bleeding | 7 | 1.0 | 1.0 | no signal |
| 443 | Pulmonary Haemorrhage | 4 | 1.0 | 1.0 | no signal |
| 444 | Musculoskeletal Pain | 27 | 1.0 | 1.0 | no signal |
| 445 | Cholecystitis | 6 | 1.0 | 1.0 | no signal |
| 446 | Blood Pressure Abnormal | 10 | 1.0 | 1.0 | no signal |
| 447 | Hyperchlorhydria | 3 | 1.0 | 1.0 | no signal |
| 448 | Pneumothorax | 8 | 1.0 | 1.0 | no signal |
| 449 | Covid-19 Pneumonia | 6 | 1.0 | 1.0 | no signal |
| 450 | Colitis | 19 | 1.0 | 1.0 | no signal |
| 451 | Device Occlusion | 7 | 1.0 | 1.0 | no signal |
| 452 | Renal Cyst | 4 | 1.0 | 1.0 | no signal |
| 453 | Feeling Cold | 14 | 1.0 | 1.0 | no signal |
| 454 | Abscess | 8 | 1.0 | 1.0 | no signal |
| 455 | Cystitis | 16 | 1.0 | 1.0 | no signal |
| 456 | Vaginal Discharge | 5 | 1.0 | 1.0 | no signal |
| 457 | Platelet Count Abnormal | 3 | 1.0 | 1.0 | no signal |
| 458 | C-reactive Protein Increased | 18 | 1.0 | 1.0 | no signal |
| 459 | Respiratory Failure | 36 | 1.0 | 1.0 | no signal |
| 460 | Glossodynia | 11 | 1.0 | 1.0 | no signal |
| 461 | Encephalopathy | 12 | 1.0 | 1.0 | no signal |
| 462 | Dyspepsia | 48 | 1.0 | 1.0 | no signal |
| 463 | Blood Creatinine Increased | 32 | 1.0 | 1.0 | no signal |
| 464 | Polyuria | 4 | 1.0 | 1.0 | no signal |
| 465 | Pigmentation Disorder | 3 | 1.0 | 1.0 | no signal |
| 466 | Renal Pain | 5 | 0.9 | 0.9 | no signal |
| 467 | Hypertension | 100 | 0.9 | 0.9 | no signal |
| 468 | Aspartate Aminotransferase Increased | 25 | 0.9 | 0.9 | no signal |
| 469 | Eating Disorder | 10 | 0.9 | 0.9 | no signal |
| 470 | Multiple Organ Dysfunction Syndrome | 13 | 0.9 | 0.9 | no signal |
| 471 | Pyelonephritis | 4 | 0.9 | 0.9 | no signal |
| 472 | Aspergillus Infection | 3 | 0.9 | 0.9 | no signal |
| 473 | Laryngitis | 5 | 0.9 | 0.9 | no signal |
| 474 | Drug Dose Omission | 77 | 0.9 | 0.9 | no signal |
| 475 | Orthostatic Hypotension | 8 | 0.9 | 0.9 | no signal |
| 476 | Tumour Lysis Syndrome | 4 | 0.9 | 0.9 | no signal |
| 477 | Immune System Disorder | 6 | 0.9 | 0.9 | no signal |
| 478 | Melaena | 10 | 0.9 | 0.9 | no signal |
| 479 | Oedema Peripheral | 55 | 0.9 | 0.9 | no signal |
| 480 | Muscular Weakness | 51 | 0.9 | 0.9 | no signal |
| 481 | Pneumonia | 145 | 0.9 | 0.9 | no signal |
| 482 | Surgery | 26 | 0.9 | 0.9 | no signal |
| 483 | Blister | 25 | 0.9 | 0.9 | no signal |
| 484 | Pulmonary Oedema | 20 | 0.9 | 0.9 | no signal |
| 485 | Pain | 273 | 0.9 | 0.9 | no signal |
| 486 | Ulcer Haemorrhage | 3 | 0.9 | 0.9 | no signal |
| 487 | Renal Failure | 59 | 0.9 | 0.9 | no signal |
| 488 | Laboratory Test Abnormal | 13 | 0.9 | 0.9 | no signal |
| 489 | Pulmonary Embolism | 42 | 0.9 | 0.9 | no signal |
| 490 | Pneumonia Bacterial | 4 | 0.9 | 0.9 | no signal |
| 491 | Pericardial Effusion | 10 | 0.9 | 0.9 | no signal |
| 492 | Urosepsis | 4 | 0.9 | 0.9 | no signal |
| 493 | Dysphagia | 41 | 0.9 | 0.9 | no signal |
| 494 | Cough | 121 | 0.9 | 0.8 | no signal |
| 495 | Bacterial Infection | 8 | 0.8 | 0.8 | no signal |
| 496 | Hepatitis | 11 | 0.8 | 0.8 | no signal |
| 497 | Disorientation | 17 | 0.8 | 0.8 | no signal |
| 498 | Metastases To Bone | 7 | 0.8 | 0.8 | no signal |
| 499 | Hypoaesthesia | 64 | 0.8 | 0.8 | no signal |
| 500 | Cholelithiasis | 14 | 0.8 | 0.8 | no signal |
| 501 | Duodenal Ulcer | 3 | 0.8 | 0.8 | no signal |
| 502 | Metastasis | 3 | 0.8 | 0.8 | no signal |
| 503 | Angina Pectoris | 12 | 0.8 | 0.8 | no signal |
| 504 | Clostridium Difficile Infection | 9 | 0.8 | 0.8 | no signal |
| 505 | Faeces Discoloured | 9 | 0.8 | 0.8 | no signal |
| 506 | Spinal Operation | 5 | 0.8 | 0.8 | no signal |
| 507 | Neuralgia | 10 | 0.8 | 0.8 | no signal |
| 508 | Rash Pustular | 3 | 0.8 | 0.8 | no signal |
| 509 | Dysstasia | 12 | 0.8 | 0.8 | no signal |
| 510 | Haemorrhoids | 8 | 0.8 | 0.8 | no signal |
| 511 | Chills | 48 | 0.8 | 0.8 | no signal |
| 512 | Oral Disorder | 3 | 0.8 | 0.8 | no signal |
| 513 | Product Use Issue | 76 | 0.8 | 0.8 | no signal |
| 514 | Psychiatric Symptom | 3 | 0.8 | 0.8 | no signal |
| 515 | Contusion | 39 | 0.8 | 0.8 | no signal |
| 516 | Acute Myocardial Infarction | 12 | 0.8 | 0.8 | no signal |
| 517 | Confusional State | 65 | 0.8 | 0.8 | no signal |
| 518 | Hyperkalaemia | 14 | 0.8 | 0.8 | no signal |
| 519 | Procedural Pain | 11 | 0.8 | 0.8 | no signal |
| 520 | Hepatic Enzyme Increased | 27 | 0.8 | 0.8 | no signal |
| 521 | Dry Throat | 4 | 0.8 | 0.8 | no signal |
| 522 | Product Dose Omission | 26 | 0.8 | 0.8 | no signal |
| 523 | Temperature Intolerance | 4 | 0.8 | 0.8 | no signal |
| 524 | Hyponatraemia | 22 | 0.8 | 0.8 | no signal |
| 525 | Gout | 7 | 0.8 | 0.8 | no signal |
| 526 | Folliculitis | 4 | 0.8 | 0.8 | no signal |
| 527 | Treatment Noncompliance | 21 | 0.8 | 0.8 | no signal |
| 528 | Gastrointestinal Inflammation | 3 | 0.8 | 0.8 | no signal |
| 529 | Petechiae | 4 | 0.8 | 0.8 | no signal |
| 530 | Dyspnoea | 217 | 0.8 | 0.7 | no signal |
| 531 | Apnoea | 3 | 0.8 | 0.8 | no signal |
| 532 | Productive Cough | 18 | 0.7 | 0.7 | no signal |
| 533 | Complication Associated With Device | 5 | 0.7 | 0.7 | no signal |
| 534 | Fall | 125 | 0.7 | 0.7 | no signal |
| 535 | Decreased Activity | 4 | 0.7 | 0.7 | no signal |
| 536 | Frequent Bowel Movements | 10 | 0.7 | 0.7 | no signal |
| 537 | Skin Discolouration | 17 | 0.7 | 0.7 | no signal |
| 538 | Decubitus Ulcer | 3 | 0.7 | 0.7 | no signal |
| 539 | Wound Infection | 4 | 0.7 | 0.7 | no signal |
| 540 | Skin Lesion | 10 | 0.7 | 0.7 | no signal |
| 541 | Off Label Use | 318 | 0.7 | 0.7 | no signal |
| 542 | Glaucoma | 7 | 0.7 | 0.7 | no signal |
| 543 | Coagulopathy | 6 | 0.7 | 0.7 | no signal |
| 544 | Transaminases Increased | 8 | 0.7 | 0.7 | no signal |
| 545 | Wound | 10 | 0.7 | 0.7 | no signal |
| 546 | Dizziness | 179 | 0.7 | 0.7 | no signal |
| 547 | Dry Mouth | 29 | 0.7 | 0.7 | no signal |
| 548 | Dry Skin | 46 | 0.7 | 0.7 | no signal |
| 549 | Myocardial Ischaemia | 4 | 0.7 | 0.7 | no signal |
| 550 | Blood Pressure Decreased | 23 | 0.7 | 0.7 | no signal |
| 551 | Covid-19 | 61 | 0.7 | 0.7 | no signal |
| 552 | Blood Calcium Increased | 3 | 0.7 | 0.7 | no signal |
| 553 | Cardiotoxicity | 3 | 0.7 | 0.7 | no signal |
| 554 | Somnolence | 68 | 0.7 | 0.7 | no signal |
| 555 | Cellulitis | 17 | 0.7 | 0.7 | no signal |
| 556 | Facial Pain | 3 | 0.7 | 0.7 | no signal |
| 557 | Gastroenteritis Viral | 6 | 0.7 | 0.7 | no signal |
| 558 | Liver Injury | 8 | 0.7 | 0.6 | no signal |
| 559 | Hyperglycaemia | 12 | 0.6 | 0.6 | no signal |
| 560 | Pelvic Pain | 6 | 0.6 | 0.6 | no signal |
| 561 | Pain In Extremity | 97 | 0.6 | 0.6 | no signal |
| 562 | Atrial Fibrillation | 32 | 0.6 | 0.6 | no signal |
| 563 | Lung Disorder | 16 | 0.6 | 0.6 | no signal |
| 564 | Thyroid Disorder | 5 | 0.6 | 0.6 | no signal |
| 565 | Bone Pain | 19 | 0.6 | 0.6 | no signal |
| 566 | Oropharyngeal Pain | 30 | 0.6 | 0.6 | no signal |
| 567 | Mental Status Changes | 9 | 0.6 | 0.6 | no signal |
| 568 | Gait Disturbance | 62 | 0.6 | 0.6 | no signal |
| 569 | Intervertebral Disc Protrusion | 7 | 0.6 | 0.6 | no signal |
| 570 | Muscle Atrophy | 4 | 0.6 | 0.6 | no signal |
| 571 | Fracture | 6 | 0.6 | 0.6 | no signal |
| 572 | Brain Oedema | 4 | 0.6 | 0.6 | no signal |
| 573 | Muscle Spasms | 58 | 0.6 | 0.6 | no signal |
| 574 | Hepatotoxicity | 7 | 0.6 | 0.6 | no signal |
| 575 | Supraventricular Tachycardia | 3 | 0.6 | 0.6 | no signal |
| 576 | Hypoxia | 11 | 0.6 | 0.6 | no signal |
| 577 | Chest Pain | 58 | 0.6 | 0.6 | no signal |
| 578 | Hernia | 6 | 0.6 | 0.6 | no signal |
| 579 | Cerebrovascular Accident | 53 | 0.6 | 0.6 | no signal |
| 580 | Therapeutic Response Unexpected | 14 | 0.6 | 0.6 | no signal |
| 581 | Colorectal Cancer | 15 | 0.6 | 0.6 | no signal |
| 582 | Skin Ulcer | 8 | 0.6 | 0.6 | no signal |
| 583 | Syncope | 31 | 0.6 | 0.6 | no signal |
| 584 | Cerebral Haemorrhage | 11 | 0.6 | 0.6 | no signal |
| 585 | Blood Pressure Increased | 47 | 0.6 | 0.6 | no signal |
| 586 | Gastritis | 8 | 0.6 | 0.6 | no signal |
| 587 | Urinary Incontinence | 9 | 0.6 | 0.6 | no signal |
| 588 | Tooth Infection | 4 | 0.6 | 0.6 | no signal |
| 589 | Heart Rate Increased | 30 | 0.6 | 0.6 | no signal |
| 590 | Body Temperature Decreased | 3 | 0.6 | 0.6 | no signal |
| 591 | Drug Intolerance | 29 | 0.6 | 0.6 | no signal |
| 592 | Skin Disorder | 10 | 0.6 | 0.6 | no signal |
| 593 | Hunger | 4 | 0.6 | 0.6 | no signal |
| 594 | Blood Urea Increased | 5 | 0.6 | 0.6 | no signal |
| 595 | Pneumonitis | 8 | 0.6 | 0.6 | no signal |
| 596 | Myocardial Infarction | 52 | 0.6 | 0.6 | no signal |
| 597 | Sluggishness | 3 | 0.6 | 0.6 | no signal |
| 598 | Rhinorrhoea | 19 | 0.6 | 0.6 | no signal |
| 599 | Gastrointestinal Disorder | 26 | 0.6 | 0.6 | no signal |
| 600 | Subarachnoid Haemorrhage | 3 | 0.6 | 0.6 | no signal |
| 601 | Tooth Abscess | 3 | 0.6 | 0.6 | no signal |
| 602 | Blood Pressure Fluctuation | 7 | 0.6 | 0.6 | no signal |
| 603 | Interstitial Lung Disease | 14 | 0.6 | 0.6 | no signal |
| 604 | Presyncope | 7 | 0.6 | 0.6 | no signal |
| 605 | Pollakiuria | 12 | 0.6 | 0.6 | no signal |
| 606 | Coordination Abnormal | 4 | 0.6 | 0.6 | no signal |
| 607 | Heart Rate Decreased | 10 | 0.6 | 0.6 | no signal |
| 608 | Hypothyroidism | 9 | 0.6 | 0.6 | no signal |
| 609 | Loss Of Consciousness | 36 | 0.6 | 0.6 | no signal |
| 610 | Cognitive Disorder | 13 | 0.5 | 0.5 | no signal |
| 611 | Subdural Haematoma | 4 | 0.5 | 0.5 | no signal |
| 612 | Swelling | 26 | 0.5 | 0.5 | no signal |
| 613 | Altered State Of Consciousness | 6 | 0.5 | 0.5 | no signal |
| 614 | Body Height Decreased | 3 | 0.5 | 0.5 | no signal |
| 615 | Drug Ineffective | 365 | 0.5 | 0.5 | no signal |
| 616 | Alanine Aminotransferase Increased | 17 | 0.5 | 0.5 | no signal |
| 617 | Gastrooesophageal Reflux Disease | 22 | 0.5 | 0.5 | no signal |
| 618 | Accidental Overdose | 10 | 0.5 | 0.5 | no signal |
| 619 | Tooth Fracture | 3 | 0.5 | 0.5 | no signal |
| 620 | Unresponsive To Stimuli | 7 | 0.5 | 0.5 | no signal |
| 621 | Cataract | 16 | 0.5 | 0.5 | no signal |
| 622 | Nephropathy Toxic | 3 | 0.5 | 0.5 | no signal |
| 623 | Adverse Drug Reaction | 24 | 0.5 | 0.5 | no signal |
| 624 | Balance Disorder | 23 | 0.5 | 0.5 | no signal |
| 625 | Transient Ischaemic Attack | 9 | 0.5 | 0.5 | no signal |
| 626 | Cardiac Arrest | 22 | 0.5 | 0.5 | no signal |
| 627 | Mobility Decreased | 19 | 0.5 | 0.5 | no signal |
| 628 | Scab | 3 | 0.5 | 0.5 | no signal |
| 629 | Pancreatitis | 14 | 0.5 | 0.5 | no signal |
| 630 | Dermatitis Contact | 3 | 0.5 | 0.5 | no signal |
| 631 | Insomnia | 70 | 0.5 | 0.5 | no signal |
| 632 | Musculoskeletal Disorder | 5 | 0.5 | 0.5 | no signal |
| 633 | Cardiac Failure Congestive | 21 | 0.5 | 0.5 | no signal |
| 634 | Limb Discomfort | 8 | 0.5 | 0.5 | no signal |
| 635 | Vaginal Haemorrhage | 11 | 0.5 | 0.5 | no signal |
| 636 | Drug Dispensing Error | 4 | 0.5 | 0.5 | no signal |
| 637 | Acute Myeloid Leukaemia | 4 | 0.5 | 0.5 | no signal |
| 638 | Splenomegaly | 3 | 0.5 | 0.5 | no signal |
| 639 | Bronchitis | 19 | 0.5 | 0.5 | no signal |
| 640 | Blood Pressure Systolic Increased | 5 | 0.5 | 0.5 | no signal |
| 641 | Neoplasm Malignant | 17 | 0.5 | 0.5 | no signal |
| 642 | Memory Impairment | 35 | 0.5 | 0.5 | no signal |
| 643 | Lung Infection | 4 | 0.5 | 0.5 | no signal |
| 644 | Metabolic Acidosis | 8 | 0.5 | 0.5 | no signal |
| 645 | Sinus Disorder | 5 | 0.5 | 0.5 | no signal |
| 646 | Macular Degeneration | 3 | 0.5 | 0.5 | no signal |
| 647 | Spinal Fracture | 5 | 0.5 | 0.5 | no signal |
| 648 | Extra Dose Administered | 10 | 0.5 | 0.5 | no signal |
| 649 | Lactic Acidosis | 8 | 0.5 | 0.5 | no signal |
| 650 | Cardiac Failure | 20 | 0.5 | 0.5 | no signal |
| 651 | Speech Disorder | 13 | 0.5 | 0.5 | no signal |
| 652 | Sensory Disturbance | 4 | 0.5 | 0.5 | no signal |
| 653 | Localised Infection | 6 | 0.5 | 0.5 | no signal |
| 654 | Nocturia | 3 | 0.5 | 0.5 | no signal |
| 655 | Cerebral Infarction | 6 | 0.5 | 0.5 | no signal |
| 656 | Back Disorder | 4 | 0.5 | 0.5 | no signal |
| 657 | Rib Fracture | 5 | 0.5 | 0.5 | no signal |
| 658 | Hypercalcaemia | 3 | 0.5 | 0.5 | no signal |
| 659 | Secretion Discharge | 3 | 0.5 | 0.5 | no signal |
| 660 | Libido Decreased | 3 | 0.5 | 0.5 | no signal |
| 661 | Cyst | 3 | 0.5 | 0.5 | no signal |
| 662 | Dermatitis | 5 | 0.5 | 0.5 | no signal |
| 663 | Incorrect Dose Administered | 54 | 0.5 | 0.5 | no signal |
| 664 | Liver Function Test Abnormal | 7 | 0.5 | 0.5 | no signal |
| 665 | Nasopharyngitis | 44 | 0.5 | 0.5 | no signal |
| 666 | Mouth Ulceration | 5 | 0.5 | 0.5 | no signal |
| 667 | Cardio-respiratory Arrest | 10 | 0.5 | 0.5 | no signal |
| 668 | Musculoskeletal Discomfort | 4 | 0.5 | 0.5 | no signal |
| 669 | Headache | 145 | 0.5 | 0.4 | no signal |
| 670 | Coma | 11 | 0.5 | 0.5 | no signal |
| 671 | Oral Candidiasis | 3 | 0.5 | 0.5 | no signal |
| 672 | Product Dose Omission Issue | 65 | 0.4 | 0.4 | no signal |
| 673 | Drug Eruption | 4 | 0.4 | 0.4 | no signal |
| 674 | Lymphocyte Count Decreased | 4 | 0.4 | 0.4 | no signal |
| 675 | Lymphadenopathy | 8 | 0.4 | 0.4 | no signal |
| 676 | Gamma-glutamyltransferase Increased | 5 | 0.4 | 0.4 | no signal |
| 677 | Sars-cov-2 Test Positive | 3 | 0.4 | 0.4 | no signal |
| 678 | Feeling Abnormal | 54 | 0.4 | 0.4 | no signal |
| 679 | Thirst | 4 | 0.4 | 0.4 | no signal |
| 680 | Tooth Disorder | 5 | 0.4 | 0.4 | no signal |
| 681 | Quality Of Life Decreased | 3 | 0.4 | 0.4 | no signal |
| 682 | Rash Pruritic | 12 | 0.4 | 0.4 | no signal |
| 683 | Hair Texture Abnormal | 3 | 0.4 | 0.4 | no signal |
| 684 | Pain Of Skin | 6 | 0.4 | 0.4 | no signal |
| 685 | Sinus Congestion | 3 | 0.4 | 0.4 | no signal |
| 686 | Acute Hepatic Failure | 3 | 0.4 | 0.4 | no signal |
| 687 | Pallor | 6 | 0.4 | 0.4 | no signal |
| 688 | Respiratory Distress | 6 | 0.4 | 0.4 | no signal |
| 689 | Diverticulitis | 6 | 0.4 | 0.4 | no signal |
| 690 | Central Nervous System Lesion | 3 | 0.4 | 0.4 | no signal |
| 691 | Dementia | 6 | 0.4 | 0.4 | no signal |
| 692 | Influenza | 24 | 0.4 | 0.4 | no signal |
| 693 | Sleep Disorder | 15 | 0.4 | 0.4 | no signal |
| 694 | Mass | 3 | 0.4 | 0.4 | no signal |
| 695 | Burning Sensation | 15 | 0.4 | 0.4 | no signal |
| 696 | Lymphopenia | 3 | 0.4 | 0.4 | no signal |
| 697 | Increased Appetite | 4 | 0.4 | 0.4 | no signal |
| 698 | Skin Fissures | 4 | 0.4 | 0.4 | no signal |
| 699 | Chronic Obstructive Pulmonary Disease | 11 | 0.4 | 0.4 | no signal |
| 700 | Eructation | 4 | 0.4 | 0.4 | no signal |
| 701 | Arthralgia | 87 | 0.4 | 0.4 | no signal |
| 702 | Rash | 91 | 0.4 | 0.4 | no signal |
| 703 | Herpes Zoster | 12 | 0.4 | 0.4 | no signal |
| 704 | Impaired Quality Of Life | 3 | 0.4 | 0.4 | no signal |
| 705 | International Normalised Ratio Increased | 6 | 0.4 | 0.4 | no signal |
| 706 | White Blood Cell Count Increased | 8 | 0.4 | 0.4 | no signal |
| 707 | Apathy | 3 | 0.4 | 0.4 | no signal |
| 708 | Hepatic Cancer | 5 | 0.4 | 0.4 | no signal |
| 709 | Myalgia | 35 | 0.4 | 0.4 | no signal |
| 710 | Gastroenteritis | 3 | 0.4 | 0.4 | no signal |
| 711 | Disturbance In Attention | 11 | 0.4 | 0.4 | no signal |
| 712 | Oedema | 11 | 0.4 | 0.4 | no signal |
| 713 | Lacrimation Increased | 6 | 0.4 | 0.4 | no signal |
| 714 | Seizure | 23 | 0.4 | 0.4 | no signal |
| 715 | Hallucination | 15 | 0.4 | 0.4 | no signal |
| 716 | Hypoaesthesia Oral | 3 | 0.4 | 0.4 | no signal |
| 717 | Neck Pain | 11 | 0.4 | 0.4 | no signal |
| 718 | Chronic Kidney Disease | 15 | 0.4 | 0.4 | no signal |
| 719 | Drug-induced Liver Injury | 6 | 0.4 | 0.4 | no signal |
| 720 | Hyperhidrosis | 25 | 0.4 | 0.4 | no signal |
| 721 | Lymphoma | 3 | 0.4 | 0.4 | no signal |
| 722 | Femur Fracture | 6 | 0.4 | 0.4 | no signal |
| 723 | Tooth Loss | 4 | 0.4 | 0.4 | no signal |
| 724 | Head Injury | 6 | 0.4 | 0.4 | no signal |
| 725 | Loss Of Personal Independence In Daily Activities | 9 | 0.4 | 0.4 | no signal |
| 726 | Arrhythmia | 9 | 0.4 | 0.4 | no signal |
| 727 | Obesity | 3 | 0.4 | 0.4 | no signal |
| 728 | Dysarthria | 7 | 0.4 | 0.4 | no signal |
| 729 | Limb Injury | 5 | 0.4 | 0.4 | no signal |
| 730 | Amnesia | 12 | 0.4 | 0.4 | no signal |
| 731 | Ill-defined Disorder | 11 | 0.4 | 0.4 | no signal |
| 732 | Lip Swelling | 6 | 0.4 | 0.4 | no signal |
| 733 | Vertigo | 11 | 0.4 | 0.4 | no signal |
| 734 | Respiratory Arrest | 5 | 0.4 | 0.4 | no signal |
| 735 | Toxicity To Various Agents | 30 | 0.4 | 0.3 | no signal |
| 736 | Face Oedema | 3 | 0.3 | 0.3 | no signal |
| 737 | Upper Respiratory Tract Infection | 8 | 0.3 | 0.3 | no signal |
| 738 | Gastric Disorder | 6 | 0.3 | 0.3 | no signal |
| 739 | Product Prescribing Error | 4 | 0.3 | 0.3 | no signal |
| 740 | Tachycardia | 15 | 0.3 | 0.3 | no signal |
| 741 | Gallbladder Disorder | 3 | 0.3 | 0.3 | no signal |
| 742 | Respiratory Disorder | 5 | 0.3 | 0.3 | no signal |
| 743 | Hypoglycaemia | 8 | 0.3 | 0.3 | no signal |
| 744 | Restless Legs Syndrome | 3 | 0.3 | 0.3 | no signal |
| 745 | End Stage Renal Disease | 3 | 0.3 | 0.3 | no signal |
| 746 | Hepatic Steatosis | 3 | 0.3 | 0.3 | no signal |
| 747 | Thinking Abnormal | 3 | 0.3 | 0.3 | no signal |
| 748 | Product Use In Unapproved Indication | 39 | 0.3 | 0.3 | no signal |
| 749 | Hypocalcaemia | 3 | 0.3 | 0.3 | no signal |
| 750 | Unevaluable Event | 12 | 0.3 | 0.3 | no signal |
| 751 | Influenza Like Illness | 13 | 0.3 | 0.3 | no signal |
| 752 | Therapy Non-responder | 7 | 0.3 | 0.3 | no signal |
| 753 | Mood Swings | 5 | 0.3 | 0.3 | no signal |
| 754 | Skin Exfoliation | 13 | 0.3 | 0.3 | no signal |
| 755 | Anaphylactic Shock | 4 | 0.3 | 0.3 | no signal |
| 756 | Drug Resistance | 4 | 0.3 | 0.3 | no signal |
| 757 | Movement Disorder | 5 | 0.3 | 0.3 | no signal |
| 758 | Choking | 3 | 0.3 | 0.3 | no signal |
| 759 | Ear Pain | 3 | 0.3 | 0.3 | no signal |
| 760 | Oral Herpes | 3 | 0.3 | 0.3 | no signal |
| 761 | Anxiety | 44 | 0.3 | 0.3 | no signal |
| 762 | Depressed Level Of Consciousness | 6 | 0.3 | 0.3 | no signal |
| 763 | Staphylococcal Infection | 5 | 0.3 | 0.3 | no signal |
| 764 | Fungal Infection | 5 | 0.3 | 0.3 | no signal |
| 765 | Activities Of Daily Living Impaired | 3 | 0.3 | 0.3 | no signal |
| 766 | Blood Glucose Decreased | 7 | 0.3 | 0.3 | no signal |
| 767 | Drug Interaction | 23 | 0.3 | 0.3 | no signal |
| 768 | Peritonitis | 3 | 0.3 | 0.3 | no signal |
| 769 | Rash Macular | 5 | 0.3 | 0.3 | no signal |
| 770 | Adverse Event | 13 | 0.3 | 0.3 | no signal |
| 771 | Pain In Jaw | 4 | 0.3 | 0.3 | no signal |
| 772 | Poor Quality Sleep | 3 | 0.3 | 0.3 | no signal |
| 773 | Paraesthesia | 22 | 0.3 | 0.3 | no signal |
| 774 | Cardiac Disorder | 13 | 0.3 | 0.3 | no signal |
| 775 | Tremor | 23 | 0.3 | 0.3 | no signal |
| 776 | Product Dispensing Error | 3 | 0.3 | 0.3 | no signal |
| 777 | Migraine | 13 | 0.3 | 0.3 | no signal |
| 778 | Pruritus Generalised | 3 | 0.3 | 0.3 | no signal |
| 779 | Inflammation | 7 | 0.3 | 0.3 | no signal |
| 780 | Depression | 31 | 0.3 | 0.3 | no signal |
| 781 | Hypersensitivity | 25 | 0.3 | 0.3 | no signal |
| 782 | Pancreatitis Acute | 3 | 0.3 | 0.3 | no signal |
| 783 | Nervousness | 7 | 0.3 | 0.3 | no signal |
| 784 | Heart Rate Irregular | 3 | 0.3 | 0.3 | no signal |
| 785 | Coronary Artery Disease | 4 | 0.3 | 0.3 | no signal |
| 786 | Chest Discomfort | 13 | 0.3 | 0.2 | no signal |
| 787 | Pruritus | 48 | 0.2 | 0.2 | no signal |
| 788 | Intentional Product Misuse | 11 | 0.2 | 0.2 | no signal |
| 789 | Abnormal Behaviour | 5 | 0.2 | 0.2 | no signal |
| 790 | Stress | 9 | 0.2 | 0.2 | no signal |
| 791 | Vision Blurred | 17 | 0.2 | 0.2 | no signal |
| 792 | Impaired Healing | 4 | 0.2 | 0.2 | no signal |
| 793 | Lung Neoplasm Malignant | 5 | 0.2 | 0.2 | no signal |
| 794 | Viral Infection | 4 | 0.2 | 0.2 | no signal |
| 795 | Hot Flush | 9 | 0.2 | 0.2 | no signal |
| 796 | Anger | 4 | 0.2 | 0.2 | no signal |
| 797 | Delirium | 4 | 0.2 | 0.2 | no signal |
| 798 | Haematoma | 3 | 0.2 | 0.2 | no signal |
| 799 | Feeling Hot | 7 | 0.2 | 0.2 | no signal |
| 800 | Therapeutic Product Effect Decreased | 5 | 0.2 | 0.2 | no signal |
| 801 | Lower Respiratory Tract Infection | 5 | 0.2 | 0.2 | no signal |
| 802 | Oxygen Saturation Decreased | 6 | 0.2 | 0.2 | no signal |
| 803 | Erythema | 22 | 0.2 | 0.2 | no signal |
| 804 | No Adverse Event | 19 | 0.2 | 0.2 | no signal |
| 805 | Sinusitis | 11 | 0.2 | 0.2 | no signal |
| 806 | Condition Aggravated | 32 | 0.2 | 0.2 | no signal |
| 807 | Diabetes Mellitus | 8 | 0.2 | 0.2 | no signal |
| 808 | Palpitations | 12 | 0.2 | 0.2 | no signal |
| 809 | Nasal Congestion | 6 | 0.2 | 0.2 | no signal |
| 810 | Renal Injury | 3 | 0.2 | 0.2 | no signal |
| 811 | Joint Swelling | 12 | 0.2 | 0.2 | no signal |
| 812 | Aphasia | 3 | 0.2 | 0.2 | no signal |
| 813 | Visual Impairment | 12 | 0.2 | 0.2 | no signal |
| 814 | Drug Administration Error | 3 | 0.2 | 0.2 | no signal |
| 815 | Nervous System Disorder | 3 | 0.2 | 0.2 | no signal |
| 816 | Agitation | 7 | 0.2 | 0.2 | no signal |
| 817 | Depressed Mood | 5 | 0.2 | 0.2 | no signal |
| 818 | Osteoarthritis | 4 | 0.2 | 0.2 | no signal |
| 819 | Eye Disorder | 3 | 0.2 | 0.2 | no signal |
| 820 | Eye Pain | 5 | 0.2 | 0.2 | no signal |
| 821 | Weight Increased | 20 | 0.2 | 0.2 | no signal |
| 822 | Injection Site Bruising | 7 | 0.2 | 0.2 | no signal |
| 823 | Rash Erythematous | 4 | 0.2 | 0.2 | no signal |
| 824 | Treatment Failure | 7 | 0.2 | 0.2 | no signal |
| 825 | Disease Recurrence | 4 | 0.2 | 0.2 | no signal |
| 826 | Panic Attack | 3 | 0.2 | 0.2 | no signal |
| 827 | Musculoskeletal Stiffness | 7 | 0.2 | 0.2 | no signal |
| 828 | Flushing | 8 | 0.2 | 0.2 | no signal |
| 829 | Device Breakage | 3 | 0.2 | 0.1 | no signal |
| 830 | Arthritis | 6 | 0.1 | 0.1 | no signal |
| 831 | Overdose | 16 | 0.1 | 0.1 | no signal |
| 832 | Blindness | 3 | 0.1 | 0.1 | no signal |
| 833 | Road Traffic Accident | 3 | 0.1 | 0.1 | no signal |
| 834 | Mental Disorder | 3 | 0.1 | 0.1 | no signal |
| 835 | Throat Irritation | 3 | 0.1 | 0.1 | no signal |
| 836 | Irritability | 4 | 0.1 | 0.1 | no signal |
| 837 | Discomfort | 4 | 0.1 | 0.1 | no signal |
| 838 | Acne | 5 | 0.1 | 0.1 | no signal |
| 839 | Dry Eye | 3 | 0.1 | 0.1 | no signal |
| 840 | Blood Glucose Increased | 10 | 0.1 | 0.1 | no signal |
| 841 | Wheezing | 3 | 0.1 | 0.1 | no signal |
| 842 | Urticaria | 8 | 0.1 | 0.1 | no signal |
| 843 | Product Storage Error | 4 | 0.1 | 0.1 | no signal |
| 844 | Infusion Related Reaction | 3 | 0.1 | 0.1 | no signal |
| 845 | Device Malfunction | 3 | 0.1 | 0.1 | no signal |
| 846 | Skin Burning Sensation | 3 | 0.1 | 0.1 | no signal |
| 847 | Emotional Distress | 5 | 0.1 | 0.1 | no signal |
| 848 | Wrong Technique In Product Usage Process | 8 | 0.1 | 0.1 | no signal |
| 849 | Product Quality Issue | 5 | 0.1 | 0.1 | no signal |
| 850 | Rheumatoid Arthritis | 3 | 0.1 | 0.1 | no signal |
| 851 | Drug Hypersensitivity | 4 | 0.0 | 0.0 | no signal |