Reaction

Performance Status Decreased reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 4,613 reports · 171 co-occurring drugs

As of the last recalculation, Performance Status Decreased appears in 4,613 FAERS reports alongside 171 co-occurring drug terms. The strongest observed disproportionality signal is ADO-TRASTUZUMAB EMTANSINE (PRR 16.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Ado-Trastuzumab Emtansine	30	16.2	16.2
Niraparib	72	14.9	14.9
Bupivacaine	29	14.1	14.1
Gefitinib	25	12.6	12.6
Sevoflurane	23	12.5	12.6
Paroxetine Hydrochloride	221	11.5	11.5
Erlotinib Hydrochloride	30	10.9	10.9
Pemetrexed	51	10.8	10.9
Erlotinib	23	10.8	10.8
Pemetrexed Disodium	88	10.6	10.6
Gemcitabine	89	10.4	10.4
Lisdexamfetamine Dimesylate	72	10.0	10.0
Gemcitabine Hydrochloride	109	9.5	9.5
Regorafenib	23	9.0	9.0
Cisplatin	137	8.1	8.1
Cetuximab	54	7.9	7.9
Sodium Oxybate	108	7.5	7.6
Dronabinol	13	7.3	7.3
Lapatinib	24	7.0	7.0
Trifluridine And Tipiracil	16	6.7	6.8
Dexamethasone Sodium Phosphate	15	6.7	6.7
Diphenoxylate Hydrochloride And Atropine Sulfate	20	6.6	6.6
Oxaliplatin	106	6.6	6.6
Granisetron Hydrochloride	15	6.5	6.5
Everolimus Tablets	24	6.5	6.5
Carboplatin	176	6.5	6.5
Panitumumab	22	6.4	6.4
Sorafenib	29	6.3	6.3
Capecitabine	123	6.2	6.2
Baclofen	111	5.9	5.9
Doxorubicin Hydrochloride	42	5.8	5.9
Sunitinib Malate	49	5.7	5.7
Paclitaxel	121	5.6	5.6
Granisetron	13	5.6	5.6
Terazosin Hydrochloride	11	5.6	5.6
Methylphenidate Hydrochloride	71	5.5	5.5
Standardized Senna Concentrate	15	5.4	5.4
Bevacizumab	144	5.4	5.4
Crizotinib	15	5.3	5.3
Leucovorin Calcium	22	5.2	5.2
Paclitaxel (Aibumin-Bound)	92	5.1	5.1
Fentanyl Citrate	20	5.1	5.1
Docetaxel Anhydrous	72	4.9	4.9
Docetaxel	72	4.9	4.9
Pazopanib Hydrochloride	28	4.7	4.7
Fluorouracil Cream, 0.5%	78	4.7	4.7
Everolimus	52	4.7	4.7
Fluorouracil	78	4.6	4.6
Atezolizumab	39	4.6	4.6
Cabozantinib	48	4.5	4.5
Brivaracetam	9	4.5	4.5
Prochlorperazine Maleate	9	4.4	4.4
Trastuzumab	66	4.4	4.4
Goserelin	13	4.4	4.4
Cariprazine	9	4.4	4.4
Temozolomide	20	4.3	4.3
Durvalumab	19	4.2	4.2
Sennosides 8.6 Mg Tablets	19	4.1	4.1
Senna	19	4.1	4.1
Candesartan	32	4.1	4.1
Ketoconazole Foam	13	4.0	4.0
Ketoconazole Cream, 2%	13	4.0	4.0
Docusate Sodium - Sennosides	28	3.9	3.9
Senna Leaf	20	3.9	3.9
Rimegepant Sulfate	11	3.9	3.9
Fondaparinux Sodium	7	3.9	3.9
Ipilimumab	37	3.9	3.9
Bortezomib	76	3.9	3.9
Pertuzumab	23	3.8	3.8
Thalidomide	31	3.8	3.8
Oxycodone And Acetaminophen Tablets	10	3.8	3.8
Fentanyl	81	3.8	3.8
Prochlorperazine	23	3.8	3.8
Polyethylene Glycol	9	3.8	3.8
Dextroamphetamine Sulfate, Dextroamphetamine Saccharate, Amphetamine Sulfate And Amphetamine Aspartate	34	3.7	3.7
Ciprofolxacin	57	3.6	3.6
Ciprofloxacin Tablets	57	3.6	3.6
Bicalutamide	12	3.6	3.6
Nivolumab	75	3.5	3.5
Irinotecan Hydrochloride	10	3.5	3.5
Ziprasidone Mesylate	11	3.5	3.5
Magnesium Oxide	32	3.5	3.5
Dexamethasone 1.5 Mg	215	3.4	3.4
Bendamustine Hydrochloride	9	3.4	3.4
Ketoconazole	13	3.4	3.4
Dexamethasone	215	3.4	3.4
Fulvestrant	24	3.3	3.3
Doxorubicin	64	3.3	3.3
Lamotrigine	93	3.2	3.2
Sumatriptan	27	3.2	3.2
Bendamustine Hcl	11	3.2	3.2
Lithium Carbonate	12	3.2	3.2
Trametinib	17	3.2	3.2
Sennosides	21	3.2	3.2
Enzalutamide	41	3.2	3.2
Cefepime	10	3.2	3.2
Bupropion Hydrochloride	68	3.1	3.1
Fam-Trastuzumab Deruxtecan-Nxki	7	3.1	3.1
Osimertinib	22	3.1	3.1
Propofol	25	3.1	3.1
Etoposide	50	3.1	3.1
Metoclopramide Hydrochloride	52	3.1	3.1
Azacitidine	20	3.1	3.1
Tadalafil	67	3.0	3.1
Zoledronic Acid	27	3.0	3.0
Dabrafenib	14	3.0	3.0
Glyburide	16	3.0	3.0
Azacitidine For	12	3.0	3.0
Memantine	9	3.0	3.0
Memantine Hydrochloride	9	3.0	3.0
Loperamide Hydrochloride And Dimethicone	21	3.0	3.0
Exemestane	14	3.0	3.0
Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, And Amphetamine Sulfate	23	2.9	3.0
Pembrolizumab	67	2.9	2.9
Filgrastim	24	2.9	2.9
Lithium	16	2.9	2.9
Lithium Bromatum	16	2.9	2.9
Ribociclib	20	2.9	2.9
Rasagiline Mesylate	7	2.8	2.8
Ziprasidone	11	2.8	2.8
Eplerenone	8	2.8	2.8
Cefepime Hydrochloride	10	2.8	2.8
Ixazomib	17	2.7	2.7
Modafinil	19	2.7	2.7
Bleomycin Sulfate	6	2.6	2.6
Olaparib	12	2.6	2.6
Alpelisib	5	2.6	2.6
Armodafinil	12	2.6	2.6
Instalax Polyethylene Glycol 3350	7	2.5	2.5
Polyethylene Glycol 400	7	2.5	2.5
Cyclophosphamide Injection, Solution	96	2.5	2.5
Cyclophosphamide	96	2.5	2.5
Cyclophosphamide For Injection	96	2.5	2.5
Vincristine Sulfate	16	2.5	2.5
Acyclovir	61	2.4	2.4
Vemurafenib	6	2.3	2.3
Inclisiran	4	2.3	2.3
Dronedarone	5	2.2	2.2
Brentuximab Vedotin	5	2.2	2.2
Hydromorphone Hydrochloride	44	2.2	2.2
Ifosfamide	10	2.1	2.1
Lutetium Lu 177 Vipivotide Tetraxetan	6	2.1	2.1
Eltrombopag Olamine	10	2.0	2.0
Imatinib Mesylate	12	1.9	1.9
Darbepoetin Alfa	23	1.9	1.9
Pomalidomide	43	1.9	1.9
Nintedanib	13	1.9	1.9
Methylphenidate	12	1.9	1.9
Belimumab	13	1.9	1.9
Lenalidomide	170	1.8	1.8
Fluticasone Propionate And Salmeterol	17	1.8	1.8
Ticagrelor	13	1.8	1.8
Lacosamide	15	1.8	1.8
Varenicline Tartrate	32	1.8	1.8
Romiplostim	6	1.8	1.8
Lenvatinib	13	1.8	1.8
Daratumumab	15	1.7	1.7
Abiraterone	5	1.7	1.7
Cenobamate	3	1.6	1.6
Axitinib	7	1.6	1.6
Carfilzomib	10	1.6	1.6
Abiraterone Acetate	14	1.5	1.5
Rucaparib	3	1.5	1.5
Lurasidone Hydrochloride	7	1.5	1.5
Polatuzumab Vedotin	3	1.4	1.4
Encorafenib	3	1.4	1.4
Tapentadol Hydrochloride	10	1.3	1.3
Dasatinib	10	1.2	1.2
Glatiramer Acetate	15	1.1	1.1
Pegfilgrastim	23	1.1	1.1
Orlistat	6	1.0	1.0

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.