Reaction

Proctalgia reporting signals

Last recalculated 2026-09-14T18:28:35.993900+00:00 · 6,337 reports · 297 co-occurring drugs

As of the last recalculation, Proctalgia appears in 6,337 FAERS reports alongside 297 co-occurring drug terms. The strongest observed disproportionality signal is PEGINTERFERON ALFA-2A (PRR 30.2).

Important: FAERS is a spontaneous, voluntary, unverified reporting system. PRR and ROR identify reporting patterns for investigation; they are not incidence rates and do not establish causation.

Drug	Co-reports	PRR	ROR
Peginterferon Alfa-2A	462	30.2	30.5
Ribavirin	503	27.8	28.0
Mesna Injection	50	20.0	20.1
Mesna	50	19.7	19.8
Infliximab-Dyyb	168	19.4	19.5
Trimethoprim	56	15.7	15.8
Vedolizumab	381	15.4	15.5
Mesalamine	251	15.2	15.3
Cholestyramine	50	13.7	13.7
Docusate Sodium 100Mg	79	11.0	11.0
Octreotide Acetate	96	10.4	10.5
Mercaptopurine	54	10.3	10.3
Regorafenib	34	9.7	9.7
Diphenoxylate Hydrochloride And Atropine Sulfate	40	9.6	9.7
Indapamide	52	9.6	9.6
Acetaminophen And Codeine	35	9.5	9.5
Micafungin Sodium	23	8.9	9.0
Nitrofurantoin	44	8.8	8.8
Metronidazole	167	8.8	8.8
Ifosfamide	57	8.8	8.8
Nitrofurantoin (Monohydrate/Macrocrystals)	44	8.7	8.7
Panitumumab	40	8.4	8.5
Hyoscyamine Sulfate	23	8.3	8.3
Docusate Sodium	137	7.9	8.0
Hydrocortisone Acetate	168	7.8	7.8
Psyllium Husk	23	7.7	7.7
Azathioprine	197	7.5	7.6
Ciprofloxacin Hydrochloride And Hydrocortisone	46	7.3	7.3
Piperacillin Sodium,Tazobactam Sodium	57	7.1	7.1
Loperamide Hydrochloride Oral	22	7.1	7.1
Metronidazole Topical	99	6.9	6.9
Dicyclomine Hydrochloride	29	6.7	6.7
Linaclotide	52	6.4	6.5
Temazepam	73	6.4	6.4
Instalax Polyethylene Glycol 3350	24	6.4	6.4
Teduglutide	26	6.4	6.4
Docusate Sodium - Sennosides	61	6.3	6.3
Lidocaine Hydrochloride And Epinephrine Bitartrate	100	6.2	6.2
Polyethylene Glycol 400	24	6.2	6.2
Hydrocortisone	164	6.2	6.2
Trifluridine And Tipiracil	20	6.1	6.1
Hydrocortisone Cream	122	6.0	6.1
Anti-Itch	121	6.0	6.0
Anti-Pruritic	121	6.0	6.0
Antipruritic (Anti-Itch)	121	6.0	6.0
Cool Relief Gel With Aloe	121	6.0	6.0
Drs. Hydrocortisone	121	6.0	6.0
Hydrocortisone Continuous Spray	121	6.0	6.0
Hydrocortisone Spray	121	6.0	6.0
Anti-Itch Cream	121	6.0	6.0
Hydrocortisone Lotion	121	6.0	6.0
Hydrocortisone Cream 1%	121	6.0	6.0
Hydrocortisone Cream 1/2%	121	6.0	6.0
Hydrocortisone 1%	121	6.0	6.0
Doxorubicin Hydrochloride	59	6.0	6.0
Loperamide Hcl	23	5.9	5.9
Loperamide Hydrochloride And Dimethicone	57	5.9	5.9
Leucovorin Calcium	34	5.9	5.9
Loperamide Hydrochloride	79	5.9	5.9
Ciprofloxacin	158	5.8	5.8
Lidicaine	85	5.8	5.8
Burn Relief	85	5.8	5.8
Ciprofloxacin Hydrochloride	167	5.8	5.8
Lidocaine Hydrochloride And Epinephrine	85	5.8	5.8
Orlistat	45	5.7	5.7
Lidocaine, Menthol	85	5.7	5.7
Lidocaine Hydrochloride	103	5.7	5.7
Magnesium Sulfate In Water For	22	5.7	5.7
Magnesium Sulfate Heptahydrate	22	5.6	5.6
Magnesium Sulfate	22	5.6	5.6
Fluorouracil Cream, 0.5%	126	5.5	5.5
Fluorouracil	127	5.5	5.5
Sunitinib Malate	65	5.5	5.5
Bisacodyl Suppositories	21	5.3	5.4
Methylprednisolone Acetate	13	5.3	5.3
Biscodyl	21	5.3	5.3
Infliximab	336	5.3	5.3
Ciprofolxacin	113	5.3	5.3
Ciprofloxacin Tablets	113	5.3	5.3
Lidocaine	92	5.2	5.2
Bicalutamide	24	5.2	5.2
Lidocaine 4%	85	5.2	5.2
Tranexamic Acid	14	5.2	5.2
Bisacodyl	22	5.1	5.2
Magnesium Hydroxide	21	5.1	5.1
Cetirizine Hydrochloride Allergy	47	5.1	5.1
Cetirizine Hydrochloride Tablets	47	5.1	5.1
Antacid	73	5.1	5.1
Ursosiol	30	5.1	5.1
Polyethylene Glycol	16	4.9	4.9
Dutasteride	12	4.9	4.9
Pegaspargase	18	4.8	4.8
Clotrimazole	18	4.8	4.8
Capecitabine	132	4.8	4.8
Polyethylene Glycol 3350	137	4.8	4.8
Budesonide	83	4.7	4.7
Atropine Sulfate	15	4.6	4.6
Drs. Clotrimazole	16	4.6	4.6
Family Wellness Clotrimazole	16	4.6	4.6
Clotrimazole Topical	16	4.6	4.6
Hydrocortisone Sodium Succinate	13	4.5	4.6
Ursodiol	30	4.5	4.5
Posaconazole Delayed-Release	15	4.5	4.5
Pseudoephedrine Hydrochloride	14	4.5	4.5
Pseudoephedrine Hcl	15	4.5	4.5
Ondansetron	145	4.4	4.4
Ondansetron Tablets	145	4.4	4.4
Atropine	11	4.4	4.4
Irinotecan Hydrochloride	17	4.4	4.4
Dimenhydrinate	14	4.3	4.3
Midazolam Hydrochloride	35	4.3	4.3
Clonidine	66	4.3	4.3
Iron	85	4.2	4.2
Meropenem	41	4.2	4.2
Ondansetron Hydrochloride	154	4.2	4.2
Venetoclax	78	4.2	4.2
Oxaliplatin	92	4.1	4.1
Bevacizumab	150	4.1	4.1
Calcium Carbonate	82	4.0	4.1
Amoxicillin And Clavulanate Potassium	33	4.0	4.0
Morphine	88	3.9	3.9
Methimazole	9	3.8	3.8
Cimetidine	11	3.8	3.8
Prednisone	538	3.7	3.8
Fluconazole	79	3.7	3.7
Promethazine Hydrochloride	21	3.7	3.7
Sucralfate Oral	16	3.7	3.7
Sucralfate Oral Suspension	16	3.7	3.7
Fentanyl	109	3.7	3.7
Adalimumab	709	3.6	3.6
Adalimumab-Adaz	57	3.6	3.6
Azacitidine	31	3.4	3.4
Azacitidine For	19	3.4	3.4
Cytarabine	62	3.4	3.4
Ascorbic Acid	24	3.4	3.4
Nystatin Ointment	27	3.4	3.4
Metoclopramide Hydrochloride	79	3.4	3.4
Nystatin Cream	27	3.4	3.4
Nystatin	28	3.4	3.4
Erythropoietin	21	3.4	3.4
Cetiirizine	43	3.4	3.4
Lorazepam	178	3.3	3.3
Sennosides	30	3.3	3.3
Olmesartan Medoxomil	36	3.3	3.3
Sucralfate	24	3.3	3.3
Cetirizine	77	3.3	3.3
Vincristine Sulfate	29	3.3	3.3
Nilotinib	29	3.2	3.2
Posaconazole	16	3.2	3.2
Piperacillin Sodium And Tazobactam Sodium	19	3.2	3.2
Sorafenib	20	3.2	3.2
Cabozantinib	46	3.2	3.2
Sennosides 8.6 Mg Tablets	20	3.1	3.1
Busulfan	15	3.1	3.1
Adalimumab-Fkjp	44	3.1	3.1
Lubiprostone	9	3.1	3.1
Doxorubicin	84	3.1	3.1
Senna	20	3.1	3.1
Calcium	136	3.1	3.1
Midazolam	23	3.0	3.0
Cyanocobalamin	30	3.0	3.0
Irbesartan	40	3.0	3.0
Diphenhydramine	56	2.9	2.9
Adalimumab-Aaty	42	2.9	2.9
Everolimus	45	2.9	2.9
Methocarbamol	20	2.9	2.9
Filgrastim	33	2.9	2.9
Dronabinol	7	2.9	2.9
Prochlorperazine Maleate	8	2.9	2.9
Senna Leaf	20	2.9	2.9
Aprepitant	16	2.9	2.9
Sodium Chloride	68	2.8	2.8
Cetuximab	27	2.8	2.8
Losartan Potassium And Hydrochlorothiazide	10	2.8	2.8
Sodium Chloride Tablet	63	2.8	2.8
Sodium Chloride Tablets	63	2.8	2.8
Piperacillin And Tazobactam	11	2.8	2.8
Metoclopramide	47	2.8	2.8
Vancomycin Hydrochloride	56	2.8	2.8
Calcitriol Capsules 0.25 Mcg	17	2.8	2.8
Calcitriol Capsules 0.5 Mcg	17	2.8	2.8
Calcitriol	17	2.8	2.8
Iron Sucrose	8	2.8	2.8
Atenolol	110	2.7	2.7
Acetaminophen Tablet Extended Release	207	2.7	2.7
Pain Reliever	207	2.7	2.7
Acetaminophen 500Mg	207	2.7	2.7
Acetaminophen, Guaifenesin, And Phenylephrine Hydrochloride	129	2.7	2.7
Upadacitinib	66	2.7	2.7
Clindamycin Phosphate	27	2.7	2.7
Alpelisib	7	2.6	2.6
Multivitamin	40	2.6	2.6
Ferrous Sulfate	40	2.6	2.6
Cyclophosphamide Injection, Solution	139	2.6	2.6
Cyclophosphamide	139	2.6	2.6
Cyclophosphamide For Injection	139	2.6	2.6
Magnesium	65	2.6	2.6
Dextrose Monohydrate, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	7	2.6	2.6
Acetaminophen	335	2.5	2.5
Granisetron Hydrochloride	8	2.5	2.5
Leuprolide Acetate	59	2.5	2.5
Quinapril Hydrochloride	6	2.5	2.5
Nirmatrelvir And Ritonavir	41	2.5	2.5
Abemaciclib	15	2.5	2.5
Fluticasone Furoate	9	2.4	2.4
Mupirocin	10	2.4	2.4
Valacyclovir Hydrochloride	52	2.4	2.4
Lovastatin	19	2.4	2.4
Zolpidem Tartrate	99	2.4	2.4
Sulfamethoxazole And Trimethoprim	62	2.4	2.4
Ustekinumab	75	2.4	2.4
Hydrochlorothiazide	106	2.4	2.4
Lenvatinib	24	2.4	2.4
Ramipril	90	2.4	2.4
Ceftriaxone Sodium	28	2.4	2.4
Isotretinoin	36	2.4	2.4
Mupirocin Calcium	10	2.4	2.4
Fosaprepitant Dimeglumine	10	2.4	2.4
Niraparib	16	2.4	2.4
Cetirizine Hydrochloride	114	2.3	2.3
Nebivolol	11	2.3	2.3
Dexamethasone Sodium Phosphate	7	2.3	2.3
Febuxostat Tablets 40 Mg	7	2.3	2.3
Febuxostat Tablets 80 Mg	7	2.3	2.3
Miconazole Nitrate	6	2.3	2.3
Minocycline	8	2.3	2.3
Prochlorperazine	19	2.3	2.3
Finasteride	41	2.2	2.2
Vancomycin	39	2.2	2.2
Risankizumab-Rzaa	55	2.2	2.2
Goserelin	9	2.2	2.2
Granisetron	7	2.2	2.2
Morphine Sulfate	80	2.2	2.2
Famotidine	77	2.2	2.2
Etoposide	48	2.2	2.2
Lapatinib	10	2.1	2.1
Oxycodone	118	2.1	2.1
Pazopanib Hydrochloride	17	2.1	2.1
Dexlansoprazole	26	2.1	2.1
Atorvastatin Calcium	152	2.0	2.0
Fish Oil	56	2.0	2.0
Cisplatin	48	2.0	2.0
Fludarabine Phosphate	24	2.0	2.0
Hydromorphone Hydrochloride	55	2.0	2.0
Ibuprofen Tablets, Coated	25	1.9	1.9
Ibuprofen Sodium	25	1.9	1.9
Aflibercept	18	1.9	1.9
Lisinopril	172	1.9	1.9
Canagliflozin	17	1.9	1.9
Axitinib	11	1.9	1.9
Acyclovir	64	1.8	1.8
Carboplatin	71	1.8	1.8
Bosutinib	5	1.8	1.8
Fesoterodine Fumarate	6	1.8	1.8
Amlodipine Besylate And Valsartan	6	1.8	1.8
Lisdexamfetamine Dimesylate	17	1.7	1.7
Certolizumab Pegol	59	1.7	1.7
Dabigatran Etexilate Mesylate	36	1.6	1.6
Pancrelipase	19	1.6	1.6
Oxycodone Hydrochloride And Acetaminophen	48	1.6	1.6
Ozanimod Hydrochloride	4	1.6	1.6
Rifaximin	10	1.6	1.6
Dabigatran Etexilate	37	1.6	1.6
Empagliflozin	31	1.5	1.5
Naltrexone	13	1.4	1.4
Copper	18	1.4	1.4
Paclitaxel	41	1.4	1.4
Cortisone Acetate	5	1.3	1.3
Dasatinib	15	1.3	1.3
Pemetrexed Disodium	15	1.3	1.3
Dronedarone	4	1.3	1.3
Paclitaxel (Aibumin-Bound)	32	1.3	1.3
Atezolizumab	15	1.3	1.3
Nintedanib	12	1.3	1.3
Oral Semaglutide	28	1.3	1.3
Temozolomide	8	1.2	1.2
Deferasirox	10	1.2	1.2
Enzalutamide	22	1.2	1.2
Vibegron	3	1.2	1.2
Cabotegravir	3	1.2	1.2
Patiromer	5	1.2	1.2
Pembrolizumab	37	1.2	1.2
Oxycodone Hydrochloride	75	1.1	1.1
Relugolix	8	1.1	1.1
Diroximel Fumarate	4	1.1	1.1
Emtricitabine And Tenofovir Disoproxil Fumarate	13	0.9	0.9
Ipilimumab	12	0.9	0.9
Bictegravir Sodium, Emtricitabine, And Tenofovir Alafenamide Fumarate	5	0.9	0.9
Emtricitabine And Tenofovir Alafenamide	3	0.9	0.9
Pegfilgrastim	26	0.9	0.9
Oxymorphone Hydrochloride	3	0.8	0.8
Apalutamide	3	0.8	0.8
Onabotulinumtoxina	19	0.8	0.8
Abiraterone Acetate	9	0.7	0.7
Levonorgestrel	42	0.7	0.7
Icodextrin, Sodium Chloride, Sodium Lactate, Calcium Chloride, Magnesium Chloride	5	0.5	0.5
Etonogestrel	7	0.5	0.5

Related reactions

Data source: openFDA FAERS. See the OpenPV methodology and limitations.